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Protein

BMP/retinoic acid-inducible neural-specific protein 2

Gene

BRINP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest

Protein family/group databases

TCDBi1.C.39.17.2 the membrane attack complex/perforin (macpf) family

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 2
Alternative name(s):
DBCCR1-like protein 2
Gene namesi
Name:BRINP2
Synonyms:DBCCR1L2, FAM5B, KIAA1747
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198797.6
HGNCiHGNC:13746 BRINP2
neXtProtiNX_Q9C0B6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198797
PharmGKBiPA142671895

Polymorphism and mutation databases

BioMutaiFAM5B
DMDMi85700961

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004577034 – 783BMP/retinoic acid-inducible neural-specific protein 2Add BLAST750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi579N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9C0B6
PeptideAtlasiQ9C0B6
PRIDEiQ9C0B6
ProteomicsDBi79991
79992 [Q9C0B6-2]

PTM databases

iPTMnetiQ9C0B6
PhosphoSitePlusiQ9C0B6

Expressioni

Gene expression databases

BgeeiENSG00000198797
CleanExiHS_FAM5B
GenevisibleiQ9C0B6 HS

Organism-specific databases

HPAiHPA050681
HPA061920

Interactioni

Protein-protein interaction databases

BioGridi121768, 6 interactors
IntActiQ9C0B6, 1 interactor
MINTiQ9C0B6
STRINGi9606.ENSP00000354481

Structurei

3D structure databases

ProteinModelPortaliQ9C0B6
SMRiQ9C0B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 281MACPFAdd BLAST197

Sequence similaritiesi

Belongs to the BRINP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X Eukaryota
ENOG410XQ74 LUCA
GeneTreeiENSGT00390000008571
HOGENOMiHOG000049122
HOVERGENiHBG081412
InParanoidiQ9C0B6
OMAiGNFPDWE
OrthoDBiEOG091G02AS
PhylomeDBiQ9C0B6
TreeFamiTF331600

Family and domain databases

InterProiView protein in InterPro
IPR033237 BRINP
IPR020864 MACPF
PANTHERiPTHR15564 PTHR15564, 1 hit
PfamiView protein in Pfam
PF01823 MACPF, 1 hit
SMARTiView protein in SMART
SM00457 MACPF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0B6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRWQCGTRFR GLRPAVAPWT ALLALGLPGW VLAVSATAAA VVPEQHASVA
60 70 80 90 100
GQHPLDWLLT DRGPFHRAQE YADFMERYRQ GFTTRYRIYR EFARWKVNNL
110 120 130 140 150
ALERKDFFSL PLPLAPEFIR NIRLLGRRPN LQQVTENLIK KYGTHFLLSA
160 170 180 190 200
TLGGEESLTI FVDKQKLGRK TETTGGASII GGSGNSTAVS LETLHQLAAS
210 220 230 240 250
YFIDRESTLR RLHHIQIATG AIKVTETRTG PLGCSNYDNL DSVSSVLVQS
260 270 280 290 300
PENKVQLLGL QVLLPEYLRE RFVAAALSYI TCSSEGELVC KENDCWCKCS
310 320 330 340 350
PTFPECNCPD ADIQAMEDSL LQIQDSWATH NRQFEESEEF QALLKRLPDD
360 370 380 390 400
RFLNSTAISQ FWAMDTSLQH RYQQLGAGLK VLFKKTHRIL RRLFNLCKRC
410 420 430 440 450
HRQPRFRLPK ERSLSYWWNR IQSLLYCGES TFPGTFLEQS HSCTCPYDQS
460 470 480 490 500
SCQGPIPCAL GEGPACAHCA PDNSTRCGSC NPGYVLAQGL CRPEVAESLE
510 520 530 540 550
NFLGLETDLQ DLELKYLLQK QDSRIEVHSI FISNDMRLGS WFDPSWRKRM
560 570 580 590 600
LLTLKSNKYK PGLVHVMLAL SLQICLTKNS TLEPVMAIYV NPFGGSHSES
610 620 630 640 650
WFMPVNEGSF PDWERTNVDA AAQCQNWTIT LGNRWKTFFE TVHVYLRSRI
660 670 680 690 700
KSLDDSSNET IYYEPLEMTD PSKNLGYMKI NTLQVFGYSL PFDPDAIRDL
710 720 730 740 750
ILQLDYPYTQ GSQDSALLQL IELRDRVNQL SPPGKVRLDL FSCLLRHRLK
760 770 780
LANNEVGRIQ SSLRAFNSKL PNPVEYETGK LCS
Length:783
Mass (Da):89,005
Last modified:January 24, 2006 - v2
Checksum:iB8362095ADC97FCD
GO
Isoform 2 (identifier: Q9C0B6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MRWQCGTRFR...THFLLSATLG → MVRAGGRAWQ...VTNTLVLFTI

Note: No experimental confirmation available.
Show »
Length:678
Mass (Da):76,521
Checksum:iF34E4C754AC2612C
GO

Sequence cautioni

The sequence BAB21838 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04902271Y → C. Corresponds to variant dbSNP:rs16850984Ensembl.1
Natural variantiVAR_049023390L → V. Corresponds to variant dbSNP:rs3176443Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0170261 – 153MRWQC…SATLG → MVRAGGRAWQQGLHSLSAVS ILAKGFMFLLVGDSRAESVT NTLVLFTI in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB161694 mRNA Translation: BAD34946.1
AB051534 mRNA Translation: BAB21838.1 Different initiation.
AK123336 mRNA Translation: BAC85583.1
AL022143 Genomic DNA No translation available.
BC028036 mRNA Translation: AAH28036.1
AL035289 mRNA Translation: CAA22893.1
AF131833 mRNA Translation: AAD20055.1
CCDSiCCDS1320.1 [Q9C0B6-1]
RefSeqiNP_066988.1, NM_021165.3 [Q9C0B6-1]
XP_005245436.1, XM_005245379.1 [Q9C0B6-1]
UniGeneiHs.495918

Genome annotation databases

EnsembliENST00000361539; ENSP00000354481; ENSG00000198797 [Q9C0B6-1]
GeneIDi57795
KEGGihsa:57795
UCSCiuc001glf.3 human [Q9C0B6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBRNP2_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B6
Secondary accession number(s): O95560
, Q6ZWC1, Q7LCZ9, Q8N360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: June 20, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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