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Protein

BMP/retinoic acid-inducible neural-specific protein 2

Gene

BRINP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 2
Alternative name(s):
DBCCR1-like protein 2
Gene namesi
Name:BRINP2
Synonyms:DBCCR1L2, FAM5B, KIAA1747
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13746. BRINP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671895.

Polymorphism and mutation databases

BioMutaiFAM5B.
DMDMi85700961.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 783750BMP/retinoic acid-inducible neural-specific protein 2PRO_0000045770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence analysis
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence analysis
Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence analysis
Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence analysis
Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9C0B6.
PRIDEiQ9C0B6.

PTM databases

iPTMnetiQ9C0B6.
PhosphoSiteiQ9C0B6.

Expressioni

Gene expression databases

BgeeiQ9C0B6.
CleanExiHS_FAM5B.
GenevisibleiQ9C0B6. HS.

Organism-specific databases

HPAiHPA050681.

Interactioni

Protein-protein interaction databases

BioGridi121768. 6 interactions.
STRINGi9606.ENSP00000354481.

Structurei

3D structure databases

ProteinModelPortaliQ9C0B6.
SMRiQ9C0B6. Positions 109-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 281197MACPFAdd
BLAST

Sequence similaritiesi

Belongs to the BRINP family.Curated
Contains 1 MACPF domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ9C0B6.
OMAiGNFPDWE.
OrthoDBiEOG764720.
PhylomeDBiQ9C0B6.
TreeFamiTF331600.

Family and domain databases

InterProiIPR033237. BRINP.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0B6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRWQCGTRFR GLRPAVAPWT ALLALGLPGW VLAVSATAAA VVPEQHASVA
60 70 80 90 100
GQHPLDWLLT DRGPFHRAQE YADFMERYRQ GFTTRYRIYR EFARWKVNNL
110 120 130 140 150
ALERKDFFSL PLPLAPEFIR NIRLLGRRPN LQQVTENLIK KYGTHFLLSA
160 170 180 190 200
TLGGEESLTI FVDKQKLGRK TETTGGASII GGSGNSTAVS LETLHQLAAS
210 220 230 240 250
YFIDRESTLR RLHHIQIATG AIKVTETRTG PLGCSNYDNL DSVSSVLVQS
260 270 280 290 300
PENKVQLLGL QVLLPEYLRE RFVAAALSYI TCSSEGELVC KENDCWCKCS
310 320 330 340 350
PTFPECNCPD ADIQAMEDSL LQIQDSWATH NRQFEESEEF QALLKRLPDD
360 370 380 390 400
RFLNSTAISQ FWAMDTSLQH RYQQLGAGLK VLFKKTHRIL RRLFNLCKRC
410 420 430 440 450
HRQPRFRLPK ERSLSYWWNR IQSLLYCGES TFPGTFLEQS HSCTCPYDQS
460 470 480 490 500
SCQGPIPCAL GEGPACAHCA PDNSTRCGSC NPGYVLAQGL CRPEVAESLE
510 520 530 540 550
NFLGLETDLQ DLELKYLLQK QDSRIEVHSI FISNDMRLGS WFDPSWRKRM
560 570 580 590 600
LLTLKSNKYK PGLVHVMLAL SLQICLTKNS TLEPVMAIYV NPFGGSHSES
610 620 630 640 650
WFMPVNEGSF PDWERTNVDA AAQCQNWTIT LGNRWKTFFE TVHVYLRSRI
660 670 680 690 700
KSLDDSSNET IYYEPLEMTD PSKNLGYMKI NTLQVFGYSL PFDPDAIRDL
710 720 730 740 750
ILQLDYPYTQ GSQDSALLQL IELRDRVNQL SPPGKVRLDL FSCLLRHRLK
760 770 780
LANNEVGRIQ SSLRAFNSKL PNPVEYETGK LCS
Length:783
Mass (Da):89,005
Last modified:January 24, 2006 - v2
Checksum:iB8362095ADC97FCD
GO
Isoform 2 (identifier: Q9C0B6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MRWQCGTRFR...THFLLSATLG → MVRAGGRAWQ...VTNTLVLFTI

Note: No experimental confirmation available.
Show »
Length:678
Mass (Da):76,521
Checksum:iF34E4C754AC2612C
GO

Sequence cautioni

The sequence BAB21838.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711Y → C.
Corresponds to variant rs16850984 [ dbSNP | Ensembl ].
VAR_049022
Natural varianti390 – 3901L → V.
Corresponds to variant rs3176443 [ dbSNP | Ensembl ].
VAR_049023

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 153153MRWQC…SATLG → MVRAGGRAWQQGLHSLSAVS ILAKGFMFLLVGDSRAESVT NTLVLFTI in isoform 2. 1 PublicationVSP_017026Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB161694 mRNA. Translation: BAD34946.1.
AB051534 mRNA. Translation: BAB21838.1. Different initiation.
AK123336 mRNA. Translation: BAC85583.1.
AL022143 Genomic DNA. Translation: CAI18922.1.
BC028036 mRNA. Translation: AAH28036.1.
AL035289 mRNA. Translation: CAA22893.1.
AF131833 mRNA. Translation: AAD20055.1.
CCDSiCCDS1320.1. [Q9C0B6-1]
RefSeqiNP_066988.1. NM_021165.3. [Q9C0B6-1]
XP_005245436.1. XM_005245379.1. [Q9C0B6-1]
XP_011508127.1. XM_011509825.1. [Q9C0B6-1]
UniGeneiHs.495918.

Genome annotation databases

EnsembliENST00000361539; ENSP00000354481; ENSG00000198797. [Q9C0B6-1]
GeneIDi57795.
KEGGihsa:57795.
UCSCiuc001glf.3. human. [Q9C0B6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB161694 mRNA. Translation: BAD34946.1.
AB051534 mRNA. Translation: BAB21838.1. Different initiation.
AK123336 mRNA. Translation: BAC85583.1.
AL022143 Genomic DNA. Translation: CAI18922.1.
BC028036 mRNA. Translation: AAH28036.1.
AL035289 mRNA. Translation: CAA22893.1.
AF131833 mRNA. Translation: AAD20055.1.
CCDSiCCDS1320.1. [Q9C0B6-1]
RefSeqiNP_066988.1. NM_021165.3. [Q9C0B6-1]
XP_005245436.1. XM_005245379.1. [Q9C0B6-1]
XP_011508127.1. XM_011509825.1. [Q9C0B6-1]
UniGeneiHs.495918.

3D structure databases

ProteinModelPortaliQ9C0B6.
SMRiQ9C0B6. Positions 109-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121768. 6 interactions.
STRINGi9606.ENSP00000354481.

PTM databases

iPTMnetiQ9C0B6.
PhosphoSiteiQ9C0B6.

Polymorphism and mutation databases

BioMutaiFAM5B.
DMDMi85700961.

Proteomic databases

PaxDbiQ9C0B6.
PRIDEiQ9C0B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361539; ENSP00000354481; ENSG00000198797. [Q9C0B6-1]
GeneIDi57795.
KEGGihsa:57795.
UCSCiuc001glf.3. human. [Q9C0B6-1]

Organism-specific databases

CTDi57795.
GeneCardsiBRINP2.
H-InvDBHIX0001360.
HGNCiHGNC:13746. BRINP2.
HPAiHPA050681.
neXtProtiNX_Q9C0B6.
PharmGKBiPA142671895.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ9C0B6.
OMAiGNFPDWE.
OrthoDBiEOG764720.
PhylomeDBiQ9C0B6.
TreeFamiTF331600.

Miscellaneous databases

GenomeRNAii57795.
NextBioi64734.
PROiQ9C0B6.

Gene expression databases

BgeeiQ9C0B6.
CleanExiHS_FAM5B.
GenevisibleiQ9C0B6. HS.

Family and domain databases

InterProiIPR033237. BRINP.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens DBCCR1L2 mRNA for DBCCR1-like 2."
    Inazawa J., Imoto I.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Rhodes S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-783 (ISOFORM 1).
  7. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 578-783.
    Tissue: Brain.

Entry informationi

Entry nameiBRNP2_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B6
Secondary accession number(s): O95560
, Q6ZWC1, Q7LCZ9, Q8N360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 11, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.