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Protein

Palmitoyltransferase ZDHHC5

Gene

ZDHHC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC5 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 5
Short name:
DHHC-5
Zinc finger protein 375
Gene namesi
Name:ZDHHC5
Synonyms:KIAA1748, ZNF375
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18472. ZDHHC5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 38ExtracellularSequence analysis4
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 148CytoplasmicSequence analysisAdd BLAST89
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 191ExtracellularSequence analysisAdd BLAST22
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 715CytoplasmicSequence analysisAdd BLAST503

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • dendrite Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25921.
OpenTargetsiENSG00000156599.
PharmGKBiPA38338.

Polymorphism and mutation databases

BioMutaiZDHHC5.
DMDMi28202103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128681 – 715Palmitoyltransferase ZDHHC5Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphotyrosineBy similarity1
Modified residuei247PhosphoserineCombined sources1
Modified residuei294PhosphothreonineBy similarity1
Modified residuei296PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei303PhosphothreonineBy similarity1
Modified residuei345PhosphoserineCombined sources1
Modified residuei348PhosphothreonineCombined sources1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei380PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei411PhosphothreonineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei429PhosphoserineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei436PhosphothreonineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei617Omega-N-methylarginineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei659PhosphothreonineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei697Omega-N-methylarginineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9C0B5.
MaxQBiQ9C0B5.
PaxDbiQ9C0B5.
PeptideAtlasiQ9C0B5.
PRIDEiQ9C0B5.

PTM databases

iPTMnetiQ9C0B5.
PhosphoSitePlusiQ9C0B5.
SwissPalmiQ9C0B5.

Expressioni

Gene expression databases

BgeeiENSG00000156599.
CleanExiHS_ZDHHC5.
ExpressionAtlasiQ9C0B5. baseline and differential.
GenevisibleiQ9C0B5. HS.

Organism-specific databases

HPAiHPA014670.

Interactioni

Protein-protein interaction databases

BioGridi117422. 22 interactors.
IntActiQ9C0B5. 16 interactors.
STRINGi9606.ENSP00000287169.

Structurei

3D structure databases

ProteinModelPortaliQ9C0B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000234346.
HOVERGENiHBG057186.
InParanoidiQ9C0B5.
KOiK20030.
OMAiVPTGPTH.
OrthoDBiEOG091G02XW.
PhylomeDBiQ9C0B5.
TreeFamiTF354263.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0B5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAESGKRFK PSKYVPVSAA AIFLVGATTL FFAFTCPGLS LYVSPAVPIY
60 70 80 90 100
NAIMFLFVLA NFSMATFMDP GIFPRAEEDE DKEDDFRAPL YKTVEIKGIQ
110 120 130 140 150
VRMKWCATCR FYRPPRCSHC SVCDNCVEEF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLTAHI MGVFGFGLLY VLYHIEELSG VRTAVTMAVM CVAGLFFIPV
210 220 230 240 250
AGLTGFHVVL VARGRTTNEQ VTGKFRGGVN PFTNGCCNNV SRVLCSSPAP
260 270 280 290 300
RYLGRPKKEK TIVIRPPFLR PEVSDGQITV KIMDNGIQGE LRRTKSKGSL
310 320 330 340 350
EITESQSADA EPPPPPKPDL SRYTGLRTHL GLATNEDSSL LAKDSPPTPT
360 370 380 390 400
MYKYRPGYSS SSTSAAMPHS SSAKLSRGDS LKEPTSIAES SRHPSYRSEP
410 420 430 440 450
SLEPESFRSP TFGKSFHFDP LSSGSRSSSL KSAQGTGFEL GQLQSIRSEG
460 470 480 490 500
TTSTSYKSLA NQTRNGSLSY DSLLTPSDSP DFESVQAGPE PDPPLGYTSP
510 520 530 540 550
FLSARLAQQR EAERHPRLVP TGPTHREPSP VRYDNLSRHI VASLQEREKL
560 570 580 590 600
LRQSPPLPGR EEEPGLGDSG IQSTPGSGHA PRTSSSSDDS KRSPLGKTPL
610 620 630 640 650
GRPAVPRFGK PDGLRGRGVG SPEPGPTAPY LGRSMSYSSQ KAQPGVSETE
660 670 680 690 700
EVALQPLLTP KDEVQLKTTY SKSNGQPKSL GSASPGPGQP PLSSPTRGGV
710
KKVSGVGGTT YEISV
Length:715
Mass (Da):77,545
Last modified:February 1, 2003 - v2
Checksum:i9E4FB0C9AC8EFE28
GO
Isoform 2 (identifier: Q9C0B5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):71,952
Checksum:i9BC8E828B718A32E
GO

Sequence cautioni

The sequence BAB21839 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD18778 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti508 – 509QQ → TR in CAB56033 (PubMed:17974005).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069351 – 53Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051535 mRNA. Translation: BAB21839.1. Different initiation.
AY894889 mRNA. Translation: AAX73368.1.
AK023130 mRNA. Translation: BAB14420.1.
AK172807 mRNA. Translation: BAD18778.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73771.1.
BC026967 mRNA. Translation: AAH26967.1.
AL117662 mRNA. Translation: CAB56033.1.
CCDSiCCDS7965.1. [Q9C0B5-1]
PIRiT17343.
RefSeqiNP_056272.2. NM_015457.2. [Q9C0B5-1]
XP_011543201.1. XM_011544899.1. [Q9C0B5-1]
XP_011543202.1. XM_011544900.1. [Q9C0B5-1]
XP_011543203.1. XM_011544901.1. [Q9C0B5-1]
UniGeneiHs.27239.

Genome annotation databases

EnsembliENST00000287169; ENSP00000287169; ENSG00000156599. [Q9C0B5-1]
ENST00000527985; ENSP00000432202; ENSG00000156599. [Q9C0B5-2]
GeneIDi25921.
KEGGihsa:25921.
UCSCiuc001nkx.2. human. [Q9C0B5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051535 mRNA. Translation: BAB21839.1. Different initiation.
AY894889 mRNA. Translation: AAX73368.1.
AK023130 mRNA. Translation: BAB14420.1.
AK172807 mRNA. Translation: BAD18778.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73771.1.
BC026967 mRNA. Translation: AAH26967.1.
AL117662 mRNA. Translation: CAB56033.1.
CCDSiCCDS7965.1. [Q9C0B5-1]
PIRiT17343.
RefSeqiNP_056272.2. NM_015457.2. [Q9C0B5-1]
XP_011543201.1. XM_011544899.1. [Q9C0B5-1]
XP_011543202.1. XM_011544900.1. [Q9C0B5-1]
XP_011543203.1. XM_011544901.1. [Q9C0B5-1]
UniGeneiHs.27239.

3D structure databases

ProteinModelPortaliQ9C0B5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117422. 22 interactors.
IntActiQ9C0B5. 16 interactors.
STRINGi9606.ENSP00000287169.

PTM databases

iPTMnetiQ9C0B5.
PhosphoSitePlusiQ9C0B5.
SwissPalmiQ9C0B5.

Polymorphism and mutation databases

BioMutaiZDHHC5.
DMDMi28202103.

Proteomic databases

EPDiQ9C0B5.
MaxQBiQ9C0B5.
PaxDbiQ9C0B5.
PeptideAtlasiQ9C0B5.
PRIDEiQ9C0B5.

Protocols and materials databases

DNASUi25921.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287169; ENSP00000287169; ENSG00000156599. [Q9C0B5-1]
ENST00000527985; ENSP00000432202; ENSG00000156599. [Q9C0B5-2]
GeneIDi25921.
KEGGihsa:25921.
UCSCiuc001nkx.2. human. [Q9C0B5-1]

Organism-specific databases

CTDi25921.
DisGeNETi25921.
GeneCardsiZDHHC5.
HGNCiHGNC:18472. ZDHHC5.
HPAiHPA014670.
MIMi614586. gene.
neXtProtiNX_Q9C0B5.
OpenTargetsiENSG00000156599.
PharmGKBiPA38338.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000234346.
HOVERGENiHBG057186.
InParanoidiQ9C0B5.
KOiK20030.
OMAiVPTGPTH.
OrthoDBiEOG091G02XW.
PhylomeDBiQ9C0B5.
TreeFamiTF354263.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156599-MONOMER.

Miscellaneous databases

ChiTaRSiZDHHC5. human.
GenomeRNAii25921.
PROiQ9C0B5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156599.
CleanExiHS_ZDHHC5.
ExpressionAtlasiQ9C0B5. baseline and differential.
GenevisibleiQ9C0B5. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC5_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B5
Secondary accession number(s): Q2TGF0
, Q6ZMF0, Q8TAK8, Q9H923, Q9UFI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.