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Protein

RING finger protein unkempt homolog

Gene

UNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 113C3H1-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri124 – 154C3H1-type 2PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri215 – 241C3H1-type 3PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri251 – 285C3H1-type 4PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri293 – 321C3H1-type 5PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri766 – 801RING-type; degenerateAdd BLAST36

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • mRNA CDS binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

  • cell morphogenesis involved in neuron differentiation Source: UniProtKB
  • negative regulation of cytoplasmic translation Source: GO_Central
  • neuron migration Source: Ensembl

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processTranslation regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein unkempt homolog
Alternative name(s):
Zinc finger CCCH domain-containing protein 5
Gene namesi
Name:UNK
Synonyms:KIAA1753, ZC3H5, ZC3HDC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132478.9
HGNCiHGNC:29369 UNK
MIMi616375 gene
neXtProtiNX_Q9C0B0

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132478
PharmGKBiPA162408651

Polymorphism and mutation databases

BioMutaiUNK
DMDMi47117622

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138991 – 810RING finger protein unkempt homologAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240PhosphoserineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0B0
MaxQBiQ9C0B0
PaxDbiQ9C0B0
PeptideAtlasiQ9C0B0
PRIDEiQ9C0B0

PTM databases

iPTMnetiQ9C0B0
PhosphoSitePlusiQ9C0B0

Expressioni

Gene expression databases

BgeeiENSG00000132478
CleanExiHS_UNK
ExpressionAtlasiQ9C0B0 baseline and differential
GenevisibleiQ9C0B0 HS

Organism-specific databases

HPAiHPA023636
HPA027962

Interactioni

Protein-protein interaction databases

BioGridi124536, 293 interactors
IntActiQ9C0B0, 4 interactors
STRINGi9606.ENSP00000293218

Structurei

3D structure databases

ProteinModelPortaliQ9C0B0
SMRiQ9C0B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili643 – 723Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi70 – 73Poly-Arg4

Sequence similaritiesi

Belongs to the unkempt family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 113C3H1-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri124 – 154C3H1-type 2PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri215 – 241C3H1-type 3PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri251 – 285C3H1-type 4PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri293 – 321C3H1-type 5PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri766 – 801RING-type; degenerateAdd BLAST36

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1100 Eukaryota
KOG1595 Eukaryota
ENOG410XR0Z LUCA
GeneTreeiENSGT00390000012005
HOGENOMiHOG000115711
HOVERGENiHBG061441
InParanoidiQ9C0B0
OMAiTYVLGNY
OrthoDBiEOG091G0468
PhylomeDBiQ9C0B0
TreeFamiTF314982

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 5 hits
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 5 hits

Sequencei

Sequence statusi: Complete.

Q9C0B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGPGPGGS AASSAPPAAT AQVLQAQPEK PQHYTYLKEF RTEQCPLFVQ
60 70 80 90 100
HKCTQHRPYT CFHWHFVNQR RRRSIRRRDG TFNYSPDVYC TKYDEATGLC
110 120 130 140 150
PEGDECPFLH RTTGDTERRY HLRYYKTGIC IHETDSKGNC TKNGLHCAFA
160 170 180 190 200
HGPHDLRSPV YDIRELQAME ALQNGQTTVE GSIEGQSAGA ASHAMIEKIL
210 220 230 240 250
SEEPRWQETA YVLGNYKTEP CKKPPRLCRQ GYACPYYHNS KDRRRSPRKH
260 270 280 290 300
KYRSSPCPNV KHGDEWGDPG KCENGDACQY CHTRTEQQFH PEIYKSTKCN
310 320 330 340 350
DMQQSGSCPR GPFCAFAHVE QPPLSDDLQP SSAVSSPTQP GPVLYMPSAA
360 370 380 390 400
GDSVPVSPSS PHAPDLSALL CRNSSLGSPS NLCGSPPGSI RKPPNLEGIV
410 420 430 440 450
FPGESGLAPG SYKKAPGFER EDQVGAEYLK NFKCQAKLKP HSLEPRSQEQ
460 470 480 490 500
PLLQPKQDML GILPAGSPLT SSISSSITSS LAATPPSPVG TSSVPGMNAN
510 520 530 540 550
ALPFYPTSDT VESVIESALD DLDLNEFGVA ALEKTFDNST VPHPGSITIG
560 570 580 590 600
GSLLQSSAPV NIPGSLGSSA SFHSASPSPP VSLSSHFLQQ PQGHLSQSEN
610 620 630 640 650
TFLGTSASHG SLGLNGMNSS IWEHFASGSF SPGTSPAFLS GPGAAELARL
660 670 680 690 700
RQELDEANST IKQWEESWKQ AKQACDAWKK EAEEAGERAS AAGAECELAR
710 720 730 740 750
EQRDALEVQV KKLQEELERL HAGPEPQALP AFSDLEALSL STLYSLQKQL
760 770 780 790 800
RAHLEQVDKA VFHMQSVKCL KCQEQKRAVL PCQHAALCEL CAEGSECPIC
810
QPGRAHTLQS
Length:810
Mass (Da):88,084
Last modified:May 10, 2004 - v2
Checksum:i468F556E68403FD4
GO

Sequence cautioni

The sequence AAH53362 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB21844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051540 mRNA Translation: BAB21844.1 Different initiation.
BC053362 mRNA Translation: AAH53362.1 Different initiation.
CCDSiCCDS45778.2
RefSeqiNP_001073888.2, NM_001080419.2
UniGeneiHs.584768
Hs.732048

Genome annotation databases

EnsembliENST00000589666; ENSP00000464893; ENSG00000132478
GeneIDi85451
KEGGihsa:85451
UCSCiuc021udd.3 human

Similar proteinsi

Entry informationi

Entry nameiUNK_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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