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Protein

RING finger protein unkempt homolog

Gene

UNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 113C3H1-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri124 – 154C3H1-type 2PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri215 – 241C3H1-type 3PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri251 – 285C3H1-type 4PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri293 – 321C3H1-type 5PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri766 – 801RING-type; degenerateAdd BLAST36

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • mRNA CDS binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • cell morphogenesis involved in neuron differentiation Source: UniProtKB
  • negative regulation of cytoplasmic translation Source: GO_Central
  • neuron migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein unkempt homolog
Alternative name(s):
Zinc finger CCCH domain-containing protein 5
Gene namesi
Name:UNK
Synonyms:KIAA1753, ZC3H5, ZC3HDC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29369. UNK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132478.
PharmGKBiPA162408651.

Polymorphism and mutation databases

BioMutaiUNK.
DMDMi47117622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138991 – 810RING finger protein unkempt homologAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240PhosphoserineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0B0.
MaxQBiQ9C0B0.
PaxDbiQ9C0B0.
PeptideAtlasiQ9C0B0.
PRIDEiQ9C0B0.

PTM databases

iPTMnetiQ9C0B0.
PhosphoSitePlusiQ9C0B0.

Expressioni

Gene expression databases

BgeeiENSG00000132478.
CleanExiHS_UNK.
ExpressionAtlasiQ9C0B0. baseline and differential.
GenevisibleiQ9C0B0. HS.

Organism-specific databases

HPAiHPA023636.
HPA027962.

Interactioni

Protein-protein interaction databases

BioGridi124536. 293 interactors.
IntActiQ9C0B0. 3 interactors.
MINTiMINT-2816977.
STRINGi9606.ENSP00000293218.

Structurei

3D structure databases

ProteinModelPortaliQ9C0B0.
SMRiQ9C0B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili643 – 723Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi70 – 73Poly-Arg4

Sequence similaritiesi

Belongs to the unkempt family.Curated
Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 113C3H1-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri124 – 154C3H1-type 2PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri215 – 241C3H1-type 3PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri251 – 285C3H1-type 4PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri293 – 321C3H1-type 5PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri766 – 801RING-type; degenerateAdd BLAST36

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1100. Eukaryota.
KOG1595. Eukaryota.
ENOG410XR0Z. LUCA.
GeneTreeiENSGT00390000012005.
HOGENOMiHOG000115711.
HOVERGENiHBG061441.
InParanoidiQ9C0B0.
OMAiTTYVLGN.
OrthoDBiEOG091G0468.
PhylomeDBiQ9C0B0.
TreeFamiTF314982.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGPGPGGS AASSAPPAAT AQVLQAQPEK PQHYTYLKEF RTEQCPLFVQ
60 70 80 90 100
HKCTQHRPYT CFHWHFVNQR RRRSIRRRDG TFNYSPDVYC TKYDEATGLC
110 120 130 140 150
PEGDECPFLH RTTGDTERRY HLRYYKTGIC IHETDSKGNC TKNGLHCAFA
160 170 180 190 200
HGPHDLRSPV YDIRELQAME ALQNGQTTVE GSIEGQSAGA ASHAMIEKIL
210 220 230 240 250
SEEPRWQETA YVLGNYKTEP CKKPPRLCRQ GYACPYYHNS KDRRRSPRKH
260 270 280 290 300
KYRSSPCPNV KHGDEWGDPG KCENGDACQY CHTRTEQQFH PEIYKSTKCN
310 320 330 340 350
DMQQSGSCPR GPFCAFAHVE QPPLSDDLQP SSAVSSPTQP GPVLYMPSAA
360 370 380 390 400
GDSVPVSPSS PHAPDLSALL CRNSSLGSPS NLCGSPPGSI RKPPNLEGIV
410 420 430 440 450
FPGESGLAPG SYKKAPGFER EDQVGAEYLK NFKCQAKLKP HSLEPRSQEQ
460 470 480 490 500
PLLQPKQDML GILPAGSPLT SSISSSITSS LAATPPSPVG TSSVPGMNAN
510 520 530 540 550
ALPFYPTSDT VESVIESALD DLDLNEFGVA ALEKTFDNST VPHPGSITIG
560 570 580 590 600
GSLLQSSAPV NIPGSLGSSA SFHSASPSPP VSLSSHFLQQ PQGHLSQSEN
610 620 630 640 650
TFLGTSASHG SLGLNGMNSS IWEHFASGSF SPGTSPAFLS GPGAAELARL
660 670 680 690 700
RQELDEANST IKQWEESWKQ AKQACDAWKK EAEEAGERAS AAGAECELAR
710 720 730 740 750
EQRDALEVQV KKLQEELERL HAGPEPQALP AFSDLEALSL STLYSLQKQL
760 770 780 790 800
RAHLEQVDKA VFHMQSVKCL KCQEQKRAVL PCQHAALCEL CAEGSECPIC
810
QPGRAHTLQS
Length:810
Mass (Da):88,084
Last modified:May 10, 2004 - v2
Checksum:i468F556E68403FD4
GO

Sequence cautioni

The sequence AAH53362 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB21844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051540 mRNA. Translation: BAB21844.1. Different initiation.
BC053362 mRNA. Translation: AAH53362.1. Different initiation.
CCDSiCCDS45778.2.
RefSeqiNP_001073888.2. NM_001080419.2.
UniGeneiHs.584768.
Hs.732048.

Genome annotation databases

EnsembliENST00000589666; ENSP00000464893; ENSG00000132478.
GeneIDi85451.
KEGGihsa:85451.
UCSCiuc021udd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051540 mRNA. Translation: BAB21844.1. Different initiation.
BC053362 mRNA. Translation: AAH53362.1. Different initiation.
CCDSiCCDS45778.2.
RefSeqiNP_001073888.2. NM_001080419.2.
UniGeneiHs.584768.
Hs.732048.

3D structure databases

ProteinModelPortaliQ9C0B0.
SMRiQ9C0B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124536. 293 interactors.
IntActiQ9C0B0. 3 interactors.
MINTiMINT-2816977.
STRINGi9606.ENSP00000293218.

PTM databases

iPTMnetiQ9C0B0.
PhosphoSitePlusiQ9C0B0.

Polymorphism and mutation databases

BioMutaiUNK.
DMDMi47117622.

Proteomic databases

EPDiQ9C0B0.
MaxQBiQ9C0B0.
PaxDbiQ9C0B0.
PeptideAtlasiQ9C0B0.
PRIDEiQ9C0B0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000589666; ENSP00000464893; ENSG00000132478.
GeneIDi85451.
KEGGihsa:85451.
UCSCiuc021udd.3. human.

Organism-specific databases

CTDi85451.
GeneCardsiUNK.
HGNCiHGNC:29369. UNK.
HPAiHPA023636.
HPA027962.
MIMi616375. gene.
neXtProtiNX_Q9C0B0.
OpenTargetsiENSG00000132478.
PharmGKBiPA162408651.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1100. Eukaryota.
KOG1595. Eukaryota.
ENOG410XR0Z. LUCA.
GeneTreeiENSGT00390000012005.
HOGENOMiHOG000115711.
HOVERGENiHBG061441.
InParanoidiQ9C0B0.
OMAiTTYVLGN.
OrthoDBiEOG091G0468.
PhylomeDBiQ9C0B0.
TreeFamiTF314982.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132478-MONOMER.

Miscellaneous databases

ChiTaRSiUNK. human.
GenomeRNAii85451.
PROiQ9C0B0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132478.
CleanExiHS_UNK.
ExpressionAtlasiQ9C0B0. baseline and differential.
GenevisibleiQ9C0B0. HS.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUNK_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.