Q9C0A1 (ZFHX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger homeobox protein 2

Alternative name(s):
Zinc finger homeodomain protein 2
Short name=ZFH-2

Gene names

Name:	ZFHX2
Synonyms:	KIAA1056, KIAA1762, ZNF409

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2572 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 13 C2H2-type zinc fingers. Contains 3 homeobox DNA-binding domains.
Sequence caution	The sequence BAA83008.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0A1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0A1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     854-862: FLLDMEGAE → RTETGLLIK
     863-2572: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2572	2572	Zinc finger homeobox protein 2		PRO_0000047243
Regions
	Zinc finger	821 – 845	25	C2H2-type 4
	Zinc finger	870 – 894	25	C2H2-type 5
	Zinc finger	1009 – 1032	24	C2H2-type 6
	Zinc finger	1191 – 1217	27	C2H2-type 7
	Zinc finger	1248 – 1272	25	C2H2-type 8
	Zinc finger	1480 – 1503	24	C2H2-type 9
	DNA binding	1595 – 1654	60	Homeobox 1
	Zinc finger	1670 – 1696	27	C2H2-type 10; degenerate
	Zinc finger	1769 – 1791	23	C2H2-type 11
	DNA binding	1857 – 1916	60	Homeobox 2
	DNA binding	2065 – 2124	60	Homeobox 3
	Zinc finger	2451 – 2472	22	C2H2-type 12; degenerate
	Zinc finger	2495 – 2519	25	C2H2-type 13
	Compositional bias	605 – 710	106	Pro-rich
	Compositional bias	1061 – 1144	84	Pro-rich
	Compositional bias	1321 – 1471	151	Pro-rich
	Compositional bias	1699 – 1759	61	Glu-rich
	Compositional bias	1921 – 2018	98	Pro-rich
	Compositional bias	2193 – 2424	232	Pro-rich
Natural variations
	Alternative sequence	854 – 862	9	FLLDMEGAE → RTETGLLIK in isoform 2.		VSP_039496
	Alternative sequence	863 – 2572	1710	Missing in isoform 2.		VSP_039497
Experimental info
	Sequence conflict	473	1	R → Q in BAA83008. Ref.1
	Sequence conflict	550	1	P → T in BAA83008. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 3. Checksum: 239C8050F65B25C2	FASTA	2,572	274,176
	10 20 30 40 50 60 MATLNSASTT GTTPSPGHNA PSLPSDTFSS STPSDPVTKD PPAASSTSEN MRSSEPGGQL 70 80 90 100 110 120 LESGCGLVPP KEIGEPQEGP DCGHFPPNDP GVEKDKEQEE EEEGLPPMDL SNHLFFTAGG 130 140 150 160 170 180 EAYLVAKLSL PGGSELLLPK GFPWGEAGIK EEPSLPFLAY PPPSHLTALH IQHGFDPIQG 190 200 210 220 230 240 FSSSDQILSH DTSAPSPAAC EERHGAFWSY QLAPNPPGDP KDGPMGNSGG NHVAVFWLCL 250 260 270 280 290 300 LCRLGFSKPQ AFMDHTQSHG VKLTPAQYQG LSGSPAVLQE GDEGCKALIS FLEPKLPARP 310 320 330 340 350 360 SSDIPLDNSS TVNMEANVAQ TEDGPPEAEV QALILLDEEV MALSPPSPPT ATWDPSPTQA 370 380 390 400 410 420 KESPVAAGEA GPDWFPEGQE EDGGLCPPLN QSSPTSKEGG TLPAPVGSPE DPSDPPQPYR 430 440 450 460 470 480 LADDYTPAPA AFQGLSLSSH MSLLHSRNSC KTLKCPKCNW HYKYQQTLDV HMREKHPESN 490 500 510 520 530 540 SHCSYCSAGG AHPRLARGES YNCGYKPYRC DVCNYSTTTK GNLSIHMQSD KHLANLQGFQ 550 560 570 580 590 600 AGPGGQGSPP EASLPPSAGD KEPKTKSSWQ CKVCSYETNI SRNLRIHMTS EKHMQNVLML 610 620 630 640 650 660 HQGLPLGLPP GLMGPGPPPP PGATPTSPPE LFQYFGPQAL GQPQTPLAGP GLRPDKPLEA 670 680 690 700 710 720 QLLLNGFHHV GAPARKFPTS APGSLSPDAH LPPSQLLGSS SDSLPTSPPP DDSLSLKVFR 730 740 750 760 770 780 CLVCQAFSTD SLELLLYHCS IGRSLPEAEW KEVAGDTHRC KLCCYGTQLK ANFQLHLKTD 790 800 810 820 830 840 KHAQKYQLAA HLREGGGAMG TPSPASLGDG APYGSVSPLH LRCNICDFES NSKEKMQLHA 850 860 870 880 890 900 RGAAHEENSQ IYKFLLDMEG AEAGAELGLY HCLLCAWETP SRLAVLQHLR TPAHRDAQAQ 910 920 930 940 950 960 RRLQLLQNGP TTEEGLAALQ SILSFSHGQL RTPGKAPVTP LAEPPTPEKD AQNKTEQLAS 970 980 990 1000 1010 1020 EETENKTGPS RDSANQTTVY CCPYCSFLSP ESSQVRAHTL SQHAVQPKYR CPLCQEQLVG 1030 1040 1050 1060 1070 1080 RPALHFHLSH LHNVVPECVE KLLLVATTVE MTFTTKVLSA PTLSPLDNGQ EPPTHGPEPT 1090 1100 1110 1120 1130 1140 PSRDQAAEGP NLTPEASPDP LPEPPLASVE VPDKPSGSPG QPPSPAPSPV PEPDAQAEDV 1150 1160 1170 1180 1190 1200 APPPTMAEEE EGTTGELRSA EPAPADSRHP LTYRKTTNFA LDKFLDPARP YKCTVCKESF 1210 1220 1230 1240 1250 1260 TQKNILLVHY NSVSHLHKMK KAAIDPSAPA RGEAGAPPTT TAATDKPFKC TVCRVSYNQS 1270 1280 1290 1300 1310 1320 STLEIHMRSV LHQTRSRGTK TDSKIEGPER SQEEPKEGET EGEVGTEKKG PDTSGFISGL 1330 1340 1350 1360 1370 1380 PFLSPPPPPL DLHRFPAPLF TPPVLPPFPL VPESLLKLQQ QQLLLPFYLH DLKVGPKLTL 1390 1400 1410 1420 1430 1440 AGPAPVLSLP AATPPPPPQP PKAELAEREW ERPPMAKEGN EAGPSSPPDP LPNEAARTAA 1450 1460 1470 1480 1490 1500 KALLENFGFE LVIQYNEGKQ AVPPPPTPPP PEALGGGDKL ACGACGKLFS NMLILKTHEE 1510 1520 1530 1540 1550 1560 HVHRRFLPFE ALSRYAAQFR KSYDSLYPPL AEPPKPPDGS LDSPVPHLGP PFLVPEPEAG 1570 1580 1590 1600 1610 1620 GTRAPEERSR AGGHWPIEEE ESSRGNLPPL VPAGRRFSRT KFTEFQTQAL QSFFETSAYP 1630 1640 1650 1660 1670 1680 KDGEVERLAS LLGLASRVVV VWFQNARQKA RKNACEGGSM PTGGGTGGAS GCRRCHATFS 1690 1700 1710 1720 1730 1740 CVFELVRHLK KCYDDQTLEE EEEEAERGEE EEEVEEEEVE EEQGLEPPAG PEGPLPEPPD 1750 1760 1770 1780 1790 1800 GEELSQAEAT KAGGKEPEEK ATPSPSPAHT CDQCAISFSS QDLLTSHRRL HFLPSLQPSA 1810 1820 1830 1840 1850 1860 PPQLLDLPLL VFGERNPLVA ATSPMPGPPL KRKHEDGSLS PTGSEAGGGG EGEPPRDKRL 1870 1880 1890 1900 1910 1920 RTTILPEQLE ILYRWYMQDS NPTRKMLDCI SEEVGLKKRV VQVWFQNTRA RERKGQFRST 1930 1940 1950 1960 1970 1980 PGGVPSPAVK PPATATPASL PKFNLLLGKV DDGTGREAPK REAPAFPYPT ATLASGPQPF 1990 2000 2010 2020 2030 2040 LPPGKEATTP TPEPPLPLLP PPPPSEEEGP EEPPKASPES EACSLSAGDL SDSSASSLAE 2050 2060 2070 2080 2090 2100 PESPGAGGTS GGPGGGTGVP DGMGQRRYRT QMSSLQLKIM KACYEAYRTP TMQECEVLGE 2110 2120 2130 2140 2150 2160 EIGLPKRVIQ VWFQNARAKE KKAKLQGTAA GSTGGSSEGL LAAQRTDCPY CDVKYDFYVS 2170 2180 2190 2200 2210 2220 CRGHLFSRQH LAKLKEAVRA QLKSESKCYD LAPAPEAPPA LKAPPATTPA SMPLGAAPTL 2230 2240 2250 2260 2270 2280 PRLAPVLLSG PALAQPPLGN LAPFNSGPAA SSGLLGLATS VLPTTTVVQT AGPGRPLPQR 2290 2300 2310 2320 2330 2340 PMPDQTNTST AGTTDPVPGP PTEPLGDKVS SERKPVAGPT SSSNDALKNL KALKTTVPAL 2350 2360 2370 2380 2390 2400 LGGQFLPFPL PPAGGTAPPA VFGPQLQGAY FQQLYGMKKG LFPMNPMIPQ TLIGLLPNAL 2410 2420 2430 2440 2450 2460 LQPPPQPPEP TATAPPKPPE LPAPGEGEAG EVDELLTGST GISTVDVTHR YLCRQCKMAF 2470 2480 2490 2500 2510 2520 DGEAPATAHQ RSFCFFGRGS GGSMPPPLRV PICTYHCLAC EVLLSGREAL ASHLRSSAHR 2530 2540 2550 2560 2570 RKAAPPQGGP PISITNAATA ASAAVAFAKE EARLPHTDSN PKTTTTSTLL AL
	Isoform 2 [UniParc]. Checksum: 4F3A14A941E610B7	FASTA	862	91,826
	10 20 30 40 50 60 MATLNSASTT GTTPSPGHNA PSLPSDTFSS STPSDPVTKD PPAASSTSEN MRSSEPGGQL 70 80 90 100 110 120 LESGCGLVPP KEIGEPQEGP DCGHFPPNDP GVEKDKEQEE EEEGLPPMDL SNHLFFTAGG 130 140 150 160 170 180 EAYLVAKLSL PGGSELLLPK GFPWGEAGIK EEPSLPFLAY PPPSHLTALH IQHGFDPIQG 190 200 210 220 230 240 FSSSDQILSH DTSAPSPAAC EERHGAFWSY QLAPNPPGDP KDGPMGNSGG NHVAVFWLCL 250 260 270 280 290 300 LCRLGFSKPQ AFMDHTQSHG VKLTPAQYQG LSGSPAVLQE GDEGCKALIS FLEPKLPARP 310 320 330 340 350 360 SSDIPLDNSS TVNMEANVAQ TEDGPPEAEV QALILLDEEV MALSPPSPPT ATWDPSPTQA 370 380 390 400 410 420 KESPVAAGEA GPDWFPEGQE EDGGLCPPLN QSSPTSKEGG TLPAPVGSPE DPSDPPQPYR 430 440 450 460 470 480 LADDYTPAPA AFQGLSLSSH MSLLHSRNSC KTLKCPKCNW HYKYQQTLDV HMREKHPESN 490 500 510 520 530 540 SHCSYCSAGG AHPRLARGES YNCGYKPYRC DVCNYSTTTK GNLSIHMQSD KHLANLQGFQ 550 560 570 580 590 600 AGPGGQGSPP EASLPPSAGD KEPKTKSSWQ CKVCSYETNI SRNLRIHMTS EKHMQNVLML 610 620 630 640 650 660 HQGLPLGLPP GLMGPGPPPP PGATPTSPPE LFQYFGPQAL GQPQTPLAGP GLRPDKPLEA 670 680 690 700 710 720 QLLLNGFHHV GAPARKFPTS APGSLSPDAH LPPSQLLGSS SDSLPTSPPP DDSLSLKVFR 730 740 750 760 770 780 CLVCQAFSTD SLELLLYHCS IGRSLPEAEW KEVAGDTHRC KLCCYGTQLK ANFQLHLKTD 790 800 810 820 830 840 KHAQKYQLAA HLREGGGAMG TPSPASLGDG APYGSVSPLH LRCNICDFES NSKEKMQLHA 850 860 RGAAHEENSQ IYKRTETGLL IK

References

[1]

"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1113-2572 (ISOFORM 1). Tissue: Brain.

[2]

"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB028979 mRNA. Translation: BAA83008.2. Different initiation. AB051549 mRNA. Translation: BAB21853.1. AL132855 Genomic DNA. No translation available. AL135999 Genomic DNA. No translation available.
IPI	IPI00007109. IPI00926149.
RefSeq	NP_207646.2. NM_033400.2.
UniGene	Hs.508937.
3D structure databases
ProteinModelPortal	Q9C0A1.
SMR	Q9C0A1. Positions 444-542, 976-1038, 1238-1272, 1600-1658, 1853-1914, 2063-2122.
ModBase	Search...
PTM databases
PhosphoSite	Q9C0A1.
Polymorphism databases
DMDM	300669698.
Proteomic databases
PaxDb	Q9C0A1.
PRIDE	Q9C0A1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000419474; ENSP00000413418; ENSG00000136367.
GeneID	85446.
KEGG	hsa:85446.
UCSC	uc010akq.3. human.
Organism-specific databases
CTD	85446.
GeneCards	GC14M023990.
H-InvDB	HIX0011544. HIX0172362.
HGNC	HGNC:20152. ZFHX2.
HPA	HPA000720. HPA005146.
neXtProt	NX_Q9C0A1.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG272646.
HOGENOM	HOG000128272.
HOVERGEN	HBG063719.
InParanoid	Q9UPU6.
KO	K09379.
OMA	PLCQEQL.
OrthoDB	EOG4GHZNM.
Gene expression databases
ArrayExpress	Q9C0A1.
Bgee	Q9C0A1.
CleanEx	HS_ZFHX2.
Genevestigator	Q9C0A1.
GermOnline	ENSG00000136367. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 3 hits. 3.30.160.60. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR027028. ZFHX2. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. IPR003604. Znf_U1. [Graphical view]
PANTHER	PTHR24208:SF42. PTHR24208:SF42. 1 hit.
Pfam	PF00046. Homeobox. 3 hits. [Graphical view]
SMART	SM00389. HOX. 3 hits. SM00355. ZnF_C2H2. 15 hits. SM00451. ZnF_U1. 7 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 3 hits.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 3 hits. PS00028. ZINC_FINGER_C2H2_1. 9 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	85446.
NextBio	76049.

Entry information

Entry name

ZFHX2_HUMAN

Accession

Primary (citable) accession number: Q9C0A1
Secondary accession number(s): Q9UPU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.