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Protein

Zinc finger homeobox protein 2

Gene

ZFHX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri821 – 84525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri870 – 89425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1009 – 103224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1191 – 121727C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1248 – 127225C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1480 – 150324C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1595 – 165460Homeobox 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1670 – 169627C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1769 – 179123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1857 – 191660Homeobox 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2065 – 212460Homeobox 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2451 – 247222C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2495 – 251925C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger homeobox protein 2
Alternative name(s):
Zinc finger homeodomain protein 2
Short name:
ZFH-2
Gene namesi
Name:ZFHX2
Synonyms:KIAA1056, KIAA1762, ZNF409
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20152. ZFHX2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25722572Zinc finger homeobox protein 2PRO_0000047243Add
BLAST

Proteomic databases

PaxDbiQ9C0A1.
PRIDEiQ9C0A1.

PTM databases

PhosphoSiteiQ9C0A1.

Expressioni

Gene expression databases

BgeeiQ9C0A1.
CleanExiHS_ZFHX2.
ExpressionAtlasiQ9C0A1. baseline and differential.
GenevestigatoriQ9C0A1.

Organism-specific databases

HPAiHPA000720.
HPA005146.

Interactioni

Protein-protein interaction databases

BioGridi124533. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9C0A1.
SMRiQ9C0A1. Positions 444-483, 497-542, 973-1038, 1238-1272, 1600-1658, 1853-1914, 2063-2122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi605 – 710106Pro-richAdd
BLAST
Compositional biasi1061 – 114484Pro-richAdd
BLAST
Compositional biasi1321 – 1471151Pro-richAdd
BLAST
Compositional biasi1699 – 175961Glu-richAdd
BLAST
Compositional biasi1921 – 201898Pro-richAdd
BLAST
Compositional biasi2193 – 2424232Pro-richAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 3 homeobox DNA-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri821 – 84525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri870 – 89425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1009 – 103224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1191 – 121727C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1248 – 127225C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1480 – 150324C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1670 – 169627C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1769 – 179123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2451 – 247222C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2495 – 251925C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG272646.
GeneTreeiENSGT00530000063717.
HOGENOMiHOG000128272.
HOVERGENiHBG063719.
InParanoidiQ9C0A1.
KOiK09379.
OMAiHNVVPEC.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ9C0A1.
TreeFamiTF323288.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR027028. ZFHX2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PANTHERiPTHR24208:SF86. PTHR24208:SF86. 1 hit.
PfamiPF00046. Homeobox. 3 hits.
[Graphical view]
SMARTiSM00389. HOX. 3 hits.
SM00355. ZnF_C2H2. 15 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 3 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 3 hits.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C0A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATLNSASTT GTTPSPGHNA PSLPSDTFSS STPSDPVTKD PPAASSTSEN
60 70 80 90 100
MRSSEPGGQL LESGCGLVPP KEIGEPQEGP DCGHFPPNDP GVEKDKEQEE
110 120 130 140 150
EEEGLPPMDL SNHLFFTAGG EAYLVAKLSL PGGSELLLPK GFPWGEAGIK
160 170 180 190 200
EEPSLPFLAY PPPSHLTALH IQHGFDPIQG FSSSDQILSH DTSAPSPAAC
210 220 230 240 250
EERHGAFWSY QLAPNPPGDP KDGPMGNSGG NHVAVFWLCL LCRLGFSKPQ
260 270 280 290 300
AFMDHTQSHG VKLTPAQYQG LSGSPAVLQE GDEGCKALIS FLEPKLPARP
310 320 330 340 350
SSDIPLDNSS TVNMEANVAQ TEDGPPEAEV QALILLDEEV MALSPPSPPT
360 370 380 390 400
ATWDPSPTQA KESPVAAGEA GPDWFPEGQE EDGGLCPPLN QSSPTSKEGG
410 420 430 440 450
TLPAPVGSPE DPSDPPQPYR LADDYTPAPA AFQGLSLSSH MSLLHSRNSC
460 470 480 490 500
KTLKCPKCNW HYKYQQTLDV HMREKHPESN SHCSYCSAGG AHPRLARGES
510 520 530 540 550
YNCGYKPYRC DVCNYSTTTK GNLSIHMQSD KHLANLQGFQ AGPGGQGSPP
560 570 580 590 600
EASLPPSAGD KEPKTKSSWQ CKVCSYETNI SRNLRIHMTS EKHMQNVLML
610 620 630 640 650
HQGLPLGLPP GLMGPGPPPP PGATPTSPPE LFQYFGPQAL GQPQTPLAGP
660 670 680 690 700
GLRPDKPLEA QLLLNGFHHV GAPARKFPTS APGSLSPDAH LPPSQLLGSS
710 720 730 740 750
SDSLPTSPPP DDSLSLKVFR CLVCQAFSTD SLELLLYHCS IGRSLPEAEW
760 770 780 790 800
KEVAGDTHRC KLCCYGTQLK ANFQLHLKTD KHAQKYQLAA HLREGGGAMG
810 820 830 840 850
TPSPASLGDG APYGSVSPLH LRCNICDFES NSKEKMQLHA RGAAHEENSQ
860 870 880 890 900
IYKFLLDMEG AEAGAELGLY HCLLCAWETP SRLAVLQHLR TPAHRDAQAQ
910 920 930 940 950
RRLQLLQNGP TTEEGLAALQ SILSFSHGQL RTPGKAPVTP LAEPPTPEKD
960 970 980 990 1000
AQNKTEQLAS EETENKTGPS RDSANQTTVY CCPYCSFLSP ESSQVRAHTL
1010 1020 1030 1040 1050
SQHAVQPKYR CPLCQEQLVG RPALHFHLSH LHNVVPECVE KLLLVATTVE
1060 1070 1080 1090 1100
MTFTTKVLSA PTLSPLDNGQ EPPTHGPEPT PSRDQAAEGP NLTPEASPDP
1110 1120 1130 1140 1150
LPEPPLASVE VPDKPSGSPG QPPSPAPSPV PEPDAQAEDV APPPTMAEEE
1160 1170 1180 1190 1200
EGTTGELRSA EPAPADSRHP LTYRKTTNFA LDKFLDPARP YKCTVCKESF
1210 1220 1230 1240 1250
TQKNILLVHY NSVSHLHKMK KAAIDPSAPA RGEAGAPPTT TAATDKPFKC
1260 1270 1280 1290 1300
TVCRVSYNQS STLEIHMRSV LHQTRSRGTK TDSKIEGPER SQEEPKEGET
1310 1320 1330 1340 1350
EGEVGTEKKG PDTSGFISGL PFLSPPPPPL DLHRFPAPLF TPPVLPPFPL
1360 1370 1380 1390 1400
VPESLLKLQQ QQLLLPFYLH DLKVGPKLTL AGPAPVLSLP AATPPPPPQP
1410 1420 1430 1440 1450
PKAELAEREW ERPPMAKEGN EAGPSSPPDP LPNEAARTAA KALLENFGFE
1460 1470 1480 1490 1500
LVIQYNEGKQ AVPPPPTPPP PEALGGGDKL ACGACGKLFS NMLILKTHEE
1510 1520 1530 1540 1550
HVHRRFLPFE ALSRYAAQFR KSYDSLYPPL AEPPKPPDGS LDSPVPHLGP
1560 1570 1580 1590 1600
PFLVPEPEAG GTRAPEERSR AGGHWPIEEE ESSRGNLPPL VPAGRRFSRT
1610 1620 1630 1640 1650
KFTEFQTQAL QSFFETSAYP KDGEVERLAS LLGLASRVVV VWFQNARQKA
1660 1670 1680 1690 1700
RKNACEGGSM PTGGGTGGAS GCRRCHATFS CVFELVRHLK KCYDDQTLEE
1710 1720 1730 1740 1750
EEEEAERGEE EEEVEEEEVE EEQGLEPPAG PEGPLPEPPD GEELSQAEAT
1760 1770 1780 1790 1800
KAGGKEPEEK ATPSPSPAHT CDQCAISFSS QDLLTSHRRL HFLPSLQPSA
1810 1820 1830 1840 1850
PPQLLDLPLL VFGERNPLVA ATSPMPGPPL KRKHEDGSLS PTGSEAGGGG
1860 1870 1880 1890 1900
EGEPPRDKRL RTTILPEQLE ILYRWYMQDS NPTRKMLDCI SEEVGLKKRV
1910 1920 1930 1940 1950
VQVWFQNTRA RERKGQFRST PGGVPSPAVK PPATATPASL PKFNLLLGKV
1960 1970 1980 1990 2000
DDGTGREAPK REAPAFPYPT ATLASGPQPF LPPGKEATTP TPEPPLPLLP
2010 2020 2030 2040 2050
PPPPSEEEGP EEPPKASPES EACSLSAGDL SDSSASSLAE PESPGAGGTS
2060 2070 2080 2090 2100
GGPGGGTGVP DGMGQRRYRT QMSSLQLKIM KACYEAYRTP TMQECEVLGE
2110 2120 2130 2140 2150
EIGLPKRVIQ VWFQNARAKE KKAKLQGTAA GSTGGSSEGL LAAQRTDCPY
2160 2170 2180 2190 2200
CDVKYDFYVS CRGHLFSRQH LAKLKEAVRA QLKSESKCYD LAPAPEAPPA
2210 2220 2230 2240 2250
LKAPPATTPA SMPLGAAPTL PRLAPVLLSG PALAQPPLGN LAPFNSGPAA
2260 2270 2280 2290 2300
SSGLLGLATS VLPTTTVVQT AGPGRPLPQR PMPDQTNTST AGTTDPVPGP
2310 2320 2330 2340 2350
PTEPLGDKVS SERKPVAGPT SSSNDALKNL KALKTTVPAL LGGQFLPFPL
2360 2370 2380 2390 2400
PPAGGTAPPA VFGPQLQGAY FQQLYGMKKG LFPMNPMIPQ TLIGLLPNAL
2410 2420 2430 2440 2450
LQPPPQPPEP TATAPPKPPE LPAPGEGEAG EVDELLTGST GISTVDVTHR
2460 2470 2480 2490 2500
YLCRQCKMAF DGEAPATAHQ RSFCFFGRGS GGSMPPPLRV PICTYHCLAC
2510 2520 2530 2540 2550
EVLLSGREAL ASHLRSSAHR RKAAPPQGGP PISITNAATA ASAAVAFAKE
2560 2570
EARLPHTDSN PKTTTTSTLL AL
Length:2,572
Mass (Da):274,176
Last modified:July 13, 2010 - v3
Checksum:i239C8050F65B25C2
GO
Isoform 2 (identifier: Q9C0A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     854-862: FLLDMEGAE → RTETGLLIK
     863-2572: Missing.

Show »
Length:862
Mass (Da):91,826
Checksum:i4F3A14A941E610B7
GO

Sequence cautioni

The sequence BAA83008.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731R → Q in BAA83008. (PubMed:11214970)Curated
Sequence conflicti550 – 5501P → T in BAA83008. (PubMed:11214970)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei854 – 8629FLLDMEGAE → RTETGLLIK in isoform 2. 1 PublicationVSP_039496
Alternative sequencei863 – 25721710Missing in isoform 2. 1 PublicationVSP_039497Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028979 mRNA. Translation: BAA83008.2. Different initiation.
AB051549 mRNA. Translation: BAB21853.1.
AL132855 Genomic DNA. No translation available.
AL135999 Genomic DNA. No translation available.
CCDSiCCDS55907.1. [Q9C0A1-1]
RefSeqiNP_207646.2. NM_033400.2. [Q9C0A1-1]
XP_005268191.1. XM_005268134.1. [Q9C0A1-1]
UniGeneiHs.508937.

Genome annotation databases

EnsembliENST00000419474; ENSP00000413418; ENSG00000136367. [Q9C0A1-1]
GeneIDi85446.
KEGGihsa:85446.
UCSCiuc010akq.3. human. [Q9C0A1-1]

Polymorphism databases

DMDMi300669698.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028979 mRNA. Translation: BAA83008.2. Different initiation.
AB051549 mRNA. Translation: BAB21853.1.
AL132855 Genomic DNA. No translation available.
AL135999 Genomic DNA. No translation available.
CCDSiCCDS55907.1. [Q9C0A1-1]
RefSeqiNP_207646.2. NM_033400.2. [Q9C0A1-1]
XP_005268191.1. XM_005268134.1. [Q9C0A1-1]
UniGeneiHs.508937.

3D structure databases

ProteinModelPortaliQ9C0A1.
SMRiQ9C0A1. Positions 444-483, 497-542, 973-1038, 1238-1272, 1600-1658, 1853-1914, 2063-2122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124533. 1 interaction.

PTM databases

PhosphoSiteiQ9C0A1.

Polymorphism databases

DMDMi300669698.

Proteomic databases

PaxDbiQ9C0A1.
PRIDEiQ9C0A1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419474; ENSP00000413418; ENSG00000136367. [Q9C0A1-1]
GeneIDi85446.
KEGGihsa:85446.
UCSCiuc010akq.3. human. [Q9C0A1-1]

Organism-specific databases

CTDi85446.
GeneCardsiGC14M023990.
H-InvDBHIX0011544.
HIX0172362.
HGNCiHGNC:20152. ZFHX2.
HPAiHPA000720.
HPA005146.
neXtProtiNX_Q9C0A1.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272646.
GeneTreeiENSGT00530000063717.
HOGENOMiHOG000128272.
HOVERGENiHBG063719.
InParanoidiQ9C0A1.
KOiK09379.
OMAiHNVVPEC.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ9C0A1.
TreeFamiTF323288.

Miscellaneous databases

GenomeRNAii85446.
NextBioi76049.
PROiQ9C0A1.

Gene expression databases

BgeeiQ9C0A1.
CleanExiHS_ZFHX2.
ExpressionAtlasiQ9C0A1. baseline and differential.
GenevestigatoriQ9C0A1.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR027028. ZFHX2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PANTHERiPTHR24208:SF86. PTHR24208:SF86. 1 hit.
PfamiPF00046. Homeobox. 3 hits.
[Graphical view]
SMARTiSM00389. HOX. 3 hits.
SM00355. ZnF_C2H2. 15 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 3 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 3 hits.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1113-2572 (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZFHX2_HUMAN
AccessioniPrimary (citable) accession number: Q9C0A1
Secondary accession number(s): Q9UPU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: July 13, 2010
Last modified: January 7, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.