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Q9C0A1

- ZFHX2_HUMAN

UniProt

Q9C0A1 - ZFHX2_HUMAN

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Protein

Zinc finger homeobox protein 2

Gene
ZFHX2, KIAA1056, KIAA1762, ZNF409
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri821 – 84525C2H2-type 4Add
BLAST
Zinc fingeri870 – 89425C2H2-type 5Add
BLAST
Zinc fingeri1009 – 103224C2H2-type 6Add
BLAST
Zinc fingeri1191 – 121727C2H2-type 7Add
BLAST
Zinc fingeri1248 – 127225C2H2-type 8Add
BLAST
Zinc fingeri1480 – 150324C2H2-type 9Add
BLAST
DNA bindingi1595 – 165460Homeobox 1Add
BLAST
Zinc fingeri1670 – 169627C2H2-type 10; degenerateAdd
BLAST
Zinc fingeri1769 – 179123C2H2-type 11Add
BLAST
DNA bindingi1857 – 191660Homeobox 2Add
BLAST
DNA bindingi2065 – 212460Homeobox 3Add
BLAST
Zinc fingeri2451 – 247222C2H2-type 12; degenerateAdd
BLAST
Zinc fingeri2495 – 251925C2H2-type 13Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger homeobox protein 2
Alternative name(s):
Zinc finger homeodomain protein 2
Short name:
ZFH-2
Gene namesi
Name:ZFHX2
Synonyms:KIAA1056, KIAA1762, ZNF409
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20152. ZFHX2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25722572Zinc finger homeobox protein 2PRO_0000047243Add
BLAST

Proteomic databases

PaxDbiQ9C0A1.
PRIDEiQ9C0A1.

PTM databases

PhosphoSiteiQ9C0A1.

Expressioni

Gene expression databases

ArrayExpressiQ9C0A1.
BgeeiQ9C0A1.
CleanExiHS_ZFHX2.
GenevestigatoriQ9C0A1.

Organism-specific databases

HPAiHPA000720.
HPA005146.

Interactioni

Protein-protein interaction databases

BioGridi124533. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9C0A1.
SMRiQ9C0A1. Positions 444-542, 757-782, 977-1038, 1189-1217, 1238-1272, 1600-1658, 1853-1914, 2063-2122.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi605 – 710106Pro-richAdd
BLAST
Compositional biasi1061 – 114484Pro-richAdd
BLAST
Compositional biasi1321 – 1471151Pro-richAdd
BLAST
Compositional biasi1699 – 175961Glu-richAdd
BLAST
Compositional biasi1921 – 201898Pro-richAdd
BLAST
Compositional biasi2193 – 2424232Pro-richAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG272646.
HOGENOMiHOG000128272.
HOVERGENiHBG063719.
InParanoidiQ9UPU6.
KOiK09379.
OMAiVVPECVE.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ9C0A1.
TreeFamiTF323288.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR027028. ZFHX2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PANTHERiPTHR24208:SF86. PTHR24208:SF86. 1 hit.
PfamiPF00046. Homeobox. 3 hits.
[Graphical view]
SMARTiSM00389. HOX. 3 hits.
SM00355. ZnF_C2H2. 15 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 3 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 3 hits.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C0A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATLNSASTT GTTPSPGHNA PSLPSDTFSS STPSDPVTKD PPAASSTSEN     50
MRSSEPGGQL LESGCGLVPP KEIGEPQEGP DCGHFPPNDP GVEKDKEQEE 100
EEEGLPPMDL SNHLFFTAGG EAYLVAKLSL PGGSELLLPK GFPWGEAGIK 150
EEPSLPFLAY PPPSHLTALH IQHGFDPIQG FSSSDQILSH DTSAPSPAAC 200
EERHGAFWSY QLAPNPPGDP KDGPMGNSGG NHVAVFWLCL LCRLGFSKPQ 250
AFMDHTQSHG VKLTPAQYQG LSGSPAVLQE GDEGCKALIS FLEPKLPARP 300
SSDIPLDNSS TVNMEANVAQ TEDGPPEAEV QALILLDEEV MALSPPSPPT 350
ATWDPSPTQA KESPVAAGEA GPDWFPEGQE EDGGLCPPLN QSSPTSKEGG 400
TLPAPVGSPE DPSDPPQPYR LADDYTPAPA AFQGLSLSSH MSLLHSRNSC 450
KTLKCPKCNW HYKYQQTLDV HMREKHPESN SHCSYCSAGG AHPRLARGES 500
YNCGYKPYRC DVCNYSTTTK GNLSIHMQSD KHLANLQGFQ AGPGGQGSPP 550
EASLPPSAGD KEPKTKSSWQ CKVCSYETNI SRNLRIHMTS EKHMQNVLML 600
HQGLPLGLPP GLMGPGPPPP PGATPTSPPE LFQYFGPQAL GQPQTPLAGP 650
GLRPDKPLEA QLLLNGFHHV GAPARKFPTS APGSLSPDAH LPPSQLLGSS 700
SDSLPTSPPP DDSLSLKVFR CLVCQAFSTD SLELLLYHCS IGRSLPEAEW 750
KEVAGDTHRC KLCCYGTQLK ANFQLHLKTD KHAQKYQLAA HLREGGGAMG 800
TPSPASLGDG APYGSVSPLH LRCNICDFES NSKEKMQLHA RGAAHEENSQ 850
IYKFLLDMEG AEAGAELGLY HCLLCAWETP SRLAVLQHLR TPAHRDAQAQ 900
RRLQLLQNGP TTEEGLAALQ SILSFSHGQL RTPGKAPVTP LAEPPTPEKD 950
AQNKTEQLAS EETENKTGPS RDSANQTTVY CCPYCSFLSP ESSQVRAHTL 1000
SQHAVQPKYR CPLCQEQLVG RPALHFHLSH LHNVVPECVE KLLLVATTVE 1050
MTFTTKVLSA PTLSPLDNGQ EPPTHGPEPT PSRDQAAEGP NLTPEASPDP 1100
LPEPPLASVE VPDKPSGSPG QPPSPAPSPV PEPDAQAEDV APPPTMAEEE 1150
EGTTGELRSA EPAPADSRHP LTYRKTTNFA LDKFLDPARP YKCTVCKESF 1200
TQKNILLVHY NSVSHLHKMK KAAIDPSAPA RGEAGAPPTT TAATDKPFKC 1250
TVCRVSYNQS STLEIHMRSV LHQTRSRGTK TDSKIEGPER SQEEPKEGET 1300
EGEVGTEKKG PDTSGFISGL PFLSPPPPPL DLHRFPAPLF TPPVLPPFPL 1350
VPESLLKLQQ QQLLLPFYLH DLKVGPKLTL AGPAPVLSLP AATPPPPPQP 1400
PKAELAEREW ERPPMAKEGN EAGPSSPPDP LPNEAARTAA KALLENFGFE 1450
LVIQYNEGKQ AVPPPPTPPP PEALGGGDKL ACGACGKLFS NMLILKTHEE 1500
HVHRRFLPFE ALSRYAAQFR KSYDSLYPPL AEPPKPPDGS LDSPVPHLGP 1550
PFLVPEPEAG GTRAPEERSR AGGHWPIEEE ESSRGNLPPL VPAGRRFSRT 1600
KFTEFQTQAL QSFFETSAYP KDGEVERLAS LLGLASRVVV VWFQNARQKA 1650
RKNACEGGSM PTGGGTGGAS GCRRCHATFS CVFELVRHLK KCYDDQTLEE 1700
EEEEAERGEE EEEVEEEEVE EEQGLEPPAG PEGPLPEPPD GEELSQAEAT 1750
KAGGKEPEEK ATPSPSPAHT CDQCAISFSS QDLLTSHRRL HFLPSLQPSA 1800
PPQLLDLPLL VFGERNPLVA ATSPMPGPPL KRKHEDGSLS PTGSEAGGGG 1850
EGEPPRDKRL RTTILPEQLE ILYRWYMQDS NPTRKMLDCI SEEVGLKKRV 1900
VQVWFQNTRA RERKGQFRST PGGVPSPAVK PPATATPASL PKFNLLLGKV 1950
DDGTGREAPK REAPAFPYPT ATLASGPQPF LPPGKEATTP TPEPPLPLLP 2000
PPPPSEEEGP EEPPKASPES EACSLSAGDL SDSSASSLAE PESPGAGGTS 2050
GGPGGGTGVP DGMGQRRYRT QMSSLQLKIM KACYEAYRTP TMQECEVLGE 2100
EIGLPKRVIQ VWFQNARAKE KKAKLQGTAA GSTGGSSEGL LAAQRTDCPY 2150
CDVKYDFYVS CRGHLFSRQH LAKLKEAVRA QLKSESKCYD LAPAPEAPPA 2200
LKAPPATTPA SMPLGAAPTL PRLAPVLLSG PALAQPPLGN LAPFNSGPAA 2250
SSGLLGLATS VLPTTTVVQT AGPGRPLPQR PMPDQTNTST AGTTDPVPGP 2300
PTEPLGDKVS SERKPVAGPT SSSNDALKNL KALKTTVPAL LGGQFLPFPL 2350
PPAGGTAPPA VFGPQLQGAY FQQLYGMKKG LFPMNPMIPQ TLIGLLPNAL 2400
LQPPPQPPEP TATAPPKPPE LPAPGEGEAG EVDELLTGST GISTVDVTHR 2450
YLCRQCKMAF DGEAPATAHQ RSFCFFGRGS GGSMPPPLRV PICTYHCLAC 2500
EVLLSGREAL ASHLRSSAHR RKAAPPQGGP PISITNAATA ASAAVAFAKE 2550
EARLPHTDSN PKTTTTSTLL AL 2572
Length:2,572
Mass (Da):274,176
Last modified:July 13, 2010 - v3
Checksum:i239C8050F65B25C2
GO
Isoform 2 (identifier: Q9C0A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     854-862: FLLDMEGAE → RTETGLLIK
     863-2572: Missing.

Show »
Length:862
Mass (Da):91,826
Checksum:i4F3A14A941E610B7
GO

Sequence cautioni

The sequence BAA83008.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei854 – 8629FLLDMEGAE → RTETGLLIK in isoform 2. VSP_039496
Alternative sequencei863 – 25721710Missing in isoform 2. VSP_039497Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731R → Q in BAA83008. 1 Publication
Sequence conflicti550 – 5501P → T in BAA83008. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028979 mRNA. Translation: BAA83008.2. Different initiation.
AB051549 mRNA. Translation: BAB21853.1.
AL132855 Genomic DNA. No translation available.
AL135999 Genomic DNA. No translation available.
CCDSiCCDS55907.1. [Q9C0A1-1]
RefSeqiNP_207646.2. NM_033400.2. [Q9C0A1-1]
XP_005268191.1. XM_005268134.1. [Q9C0A1-1]
UniGeneiHs.508937.

Genome annotation databases

EnsembliENST00000419474; ENSP00000413418; ENSG00000136367. [Q9C0A1-1]
GeneIDi85446.
KEGGihsa:85446.
UCSCiuc010akq.3. human. [Q9C0A1-1]

Polymorphism databases

DMDMi300669698.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028979 mRNA. Translation: BAA83008.2 . Different initiation.
AB051549 mRNA. Translation: BAB21853.1 .
AL132855 Genomic DNA. No translation available.
AL135999 Genomic DNA. No translation available.
CCDSi CCDS55907.1. [Q9C0A1-1 ]
RefSeqi NP_207646.2. NM_033400.2. [Q9C0A1-1 ]
XP_005268191.1. XM_005268134.1. [Q9C0A1-1 ]
UniGenei Hs.508937.

3D structure databases

ProteinModelPortali Q9C0A1.
SMRi Q9C0A1. Positions 444-542, 757-782, 977-1038, 1189-1217, 1238-1272, 1600-1658, 1853-1914, 2063-2122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124533. 1 interaction.

PTM databases

PhosphoSitei Q9C0A1.

Polymorphism databases

DMDMi 300669698.

Proteomic databases

PaxDbi Q9C0A1.
PRIDEi Q9C0A1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000419474 ; ENSP00000413418 ; ENSG00000136367 . [Q9C0A1-1 ]
GeneIDi 85446.
KEGGi hsa:85446.
UCSCi uc010akq.3. human. [Q9C0A1-1 ]

Organism-specific databases

CTDi 85446.
GeneCardsi GC14M023990.
H-InvDB HIX0011544.
HIX0172362.
HGNCi HGNC:20152. ZFHX2.
HPAi HPA000720.
HPA005146.
neXtProti NX_Q9C0A1.
HUGEi Search...
Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272646.
HOGENOMi HOG000128272.
HOVERGENi HBG063719.
InParanoidi Q9UPU6.
KOi K09379.
OMAi VVPECVE.
OrthoDBi EOG7FR7FH.
PhylomeDBi Q9C0A1.
TreeFami TF323288.

Miscellaneous databases

GenomeRNAii 85446.
NextBioi 76049.
PROi Q9C0A1.

Gene expression databases

ArrayExpressi Q9C0A1.
Bgeei Q9C0A1.
CleanExi HS_ZFHX2.
Genevestigatori Q9C0A1.

Family and domain databases

Gene3Di 1.10.10.60. 3 hits.
3.30.160.60. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR027028. ZFHX2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view ]
PANTHERi PTHR24208:SF86. PTHR24208:SF86. 1 hit.
Pfami PF00046. Homeobox. 3 hits.
[Graphical view ]
SMARTi SM00389. HOX. 3 hits.
SM00355. ZnF_C2H2. 15 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 3 hits.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 3 hits.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1113-2572 (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZFHX2_HUMAN
AccessioniPrimary (citable) accession number: Q9C0A1
Secondary accession number(s): Q9UPU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: July 13, 2010
Last modified: July 9, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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