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Protein

Contactin-associated protein-like 4

Gene

CNTNAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 4
Alternative name(s):
Cell recognition molecule Caspr4
Gene namesi
Name:CNTNAP4
Synonyms:CASPR4, KIAA1763
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000152910.18
HGNCiHGNC:18747 CNTNAP4
MIMi610518 gene
neXtProtiNX_Q9C0A0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 1241ExtracellularSequence analysisAdd BLAST1216
Transmembranei1242 – 1262HelicalSequence analysisAdd BLAST21
Topological domaini1263 – 1308CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi85445
OpenTargetsiENSG00000152910
PharmGKBiPA134874662

Polymorphism and mutation databases

BioMutaiCNTNAP4
DMDMi209572753

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001951026 – 1308Contactin-associated protein-like 4Add BLAST1283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 177By similarity
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 364By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi515 ↔ 547By similarity
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi553 ↔ 564By similarity
Disulfide bondi558 ↔ 573By similarity
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi575 ↔ 585By similarity
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi637N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Glycosylationi1023N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1167 ↔ 1202By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9C0A0
PeptideAtlasiQ9C0A0
PRIDEiQ9C0A0

PTM databases

iPTMnetiQ9C0A0
PhosphoSitePlusiQ9C0A0

Expressioni

Gene expression databases

BgeeiENSG00000152910
CleanExiHS_CNTNAP4
ExpressionAtlasiQ9C0A0 baseline and differential
GenevisibleiQ9C0A0 HS

Organism-specific databases

HPAiHPA031859
HPA057342

Interactioni

Subunit structurei

Interacts with TIAM1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TIAM1Q130092EBI-16035743,EBI-1050007

Protein-protein interaction databases

BioGridi124532, 6 interactors
DIPiDIP-31652N
IntActiQ9C0A0, 5 interactors
MINTiQ9C0A0
STRINGi9606.ENSP00000418741

Structurei

Secondary structure

11308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1304 – 1307Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NXQX-ray2.10D/E/F1301-1308[»]
ProteinModelPortaliQ9C0A0
SMRiQ9C0A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 177F5/8 type CPROSITE-ProRule annotationAdd BLAST147
Domaini212 – 364Laminin G-like 1PROSITE-ProRule annotationAdd BLAST153
Domaini398 – 547Laminin G-like 2PROSITE-ProRule annotationAdd BLAST150
Domaini549 – 586EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini587 – 792Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST206
Domaini793 – 957Laminin G-like 3PROSITE-ProRule annotationAdd BLAST165
Domaini958 – 997EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini1046 – 1202Laminin G-like 4PROSITE-ProRule annotationAdd BLAST157

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516 Eukaryota
ENOG410XPHG LUCA
GeneTreeiENSGT00760000118991
HOGENOMiHOG000230964
HOVERGENiHBG057718
InParanoidiQ9C0A0
PhylomeDBiQ9C0A0
TreeFamiTF321823

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028875 CASPR4
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G
PANTHERiPTHR43925:SF2 PTHR43925:SF2, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 5 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL
60 70 80 90 100
SSSHGPGFAR LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY
110 120 130 140 150
GSSNWVTSYL LMFSDSGWNW KQYRQEDSIW GFSGNANADS VVYYRLQPSI
160 170 180 190 200
KARFLRFIPL EWNPKGRIGM RIEVFGCAYR SEVVDLDGKS SLLYRFDQKS
210 220 230 240 250
LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR LFLLINSGEA
260 270 280 290 300
KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE
310 320 330 340 350
FNLMNLDYEI SFGGIPAPGK SVSFPHRNFH GCLENLYYNG VDIIDLAKQQ
360 370 380 390 400
KPQIIAMGNV SFSCSQPQSM PVTFLSSRSY LALPDFSGEE EVSATFQFRT
410 420 430 440 450
WNKAGLLLFS ELQLISGGIL LFLSDGKLKS NLYQPGKLPS DITAGVELND
460 470 480 490 500
GQWHSVSLSA KKNHLSVAVD GQMASAAPLL GPEQIYSGGT YYFGGCPDKS
510 520 530 540 550
FGSKCKSPLG GFQGCMRLIS ISGKVVDLIS VQQGSLGNFS DLQIDSCGIS
560 570 580 590 600
DRCLPNYCEH GGECSQSWST FHCNCTNTGY RGATCHNSIY EQSCEAYKHR
610 620 630 640 650
GNTSGFYYID SDGSGPLEPF LLYCNMTETA WTIIQHNGSD LTRVRNTNPE
660 670 680 690 700
NPYAGFFEYV ASMEQLQATI NRAEHCEQEF TYYCKKSRLV NKQDGTPLSW
710 720 730 740 750
WVGRTNETQT YWGGSSPDLQ KCTCGLEGNC IDSQYYCNCD ADRNEWTNDT
760 770 780 790 800
GLLAYKEHLP VTKIVITDTG RLHSEAAYKL GPLLCQGDRS FWNSASFDTE
810 820 830 840 850
ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGIADFI RIELRSPTVV
860 870 880 890 900
TFSFDVGNGP FEISVQSPTH FNDNQWHHVR VERNMKEASL QVDQLTPKTQ
910 920 930 940 950
PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGM TLDLEERAQV
960 970 980 990 1000
TPEVQPGCRG HCSSYGKLCR NGGKCRERPI GFFCDCTFSA YTGPFCSNEI
1010 1020 1030 1040 1050
SAYFGSGSSV IYNFQENYLL SKNSSSHAAS FHGDMKLSRE MIKFSFRTTR
1060 1070 1080 1090 1100
TPSLLLFVSS FYKEYLSVII AKNGSLQIRY KLNKYQEPDV VNFDFKNMAD
1110 1120 1130 1140 1150
GQLHHIMINR EEGVVFIEID DNRRRQVHLS SGTEFSAVKS LVLGRILEHS
1160 1170 1180 1190 1200
DVDQDTALAG AQGFTGCLSA VQLSHVAPLK AALHPSHPDP VTVTGHVTES
1210 1220 1230 1240 1250
SCMAQPGTDA TSRERTHSFA DHSGTIDDRE PLANAIKSDS AVIGGLIAVV
1260 1270 1280 1290 1300
IFILLCITAI AVRIYQQKRL YKRSEAKRSE NVDSAEAVLK SELNIQNAVN

ENQKEYFF
Length:1,308
Mass (Da):145,274
Last modified:October 14, 2008 - v3
Checksum:iC135FD64184E82B1
GO
Isoform 2 (identifier: Q9C0A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MGSVTGAVLKTLLLLSTQNWNRVEAGNS → MWN
     310-357: Missing.

Show »
Length:1,235
Mass (Da):137,495
Checksum:i97955649BF1D90D1
GO

Sequence cautioni

The sequence BAB21854 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244L → R in BAC55271 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061371276L → V. Corresponds to variant dbSNP:rs34251012Ensembl.1
Natural variantiVAR_050268513Q → H. Corresponds to variant dbSNP:rs6564343Ensembl.1
Natural variantiVAR_061372786Q → R2 PublicationsCorresponds to variant dbSNP:rs12933808Ensembl.1
Natural variantiVAR_0502691155D → E2 PublicationsCorresponds to variant dbSNP:rs7202925Ensembl.1
Natural variantiVAR_0502701300N → S. Corresponds to variant dbSNP:rs34198820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0444641 – 28MGSVT…EAGNS → MWN in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_044465310 – 357Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100093 mRNA Translation: BAC55271.1
AB051550 mRNA Translation: BAB21854.2 Different initiation.
AC010528 Genomic DNA No translation available.
AC106741 Genomic DNA No translation available.
CCDSiCCDS10924.2 [Q9C0A0-2]
CCDS73915.1 [Q9C0A0-1]
RefSeqiNP_207837.2, NM_033401.4 [Q9C0A0-1]
NP_620481.2, NM_138994.4 [Q9C0A0-2]
UniGeneiHs.461389

Genome annotation databases

EnsembliENST00000478060; ENSP00000418741; ENSG00000152910 [Q9C0A0-2]
ENST00000611870; ENSP00000479811; ENSG00000152910 [Q9C0A0-1]
GeneIDi85445
KEGGihsa:85445
UCSCiuc010chb.2 human [Q9C0A0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiCNTP4_HUMAN
AccessioniPrimary (citable) accession number: Q9C0A0
Secondary accession number(s): E9PFZ6, Q86YZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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