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Protein

Contactin-associated protein-like 4

Gene

CNTNAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 4
Alternative name(s):
Cell recognition molecule Caspr4
Gene namesi
Name:CNTNAP4
Synonyms:CASPR4, KIAA1763
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18747. CNTNAP4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 12411216ExtracellularSequence analysisAdd
BLAST
Transmembranei1242 – 126221HelicalSequence analysisAdd
BLAST
Topological domaini1263 – 130846CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874662.

Polymorphism and mutation databases

BioMutaiCNTNAP4.
DMDMi209572753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 13081283Contactin-associated protein-like 4PRO_0000019510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 177By similarity
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence analysis
Disulfide bondi332 ↔ 364By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi515 ↔ 547By similarity
Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi553 ↔ 564By similarity
Disulfide bondi558 ↔ 573By similarity
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi575 ↔ 585By similarity
Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence analysis
Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence analysis
Glycosylationi637 – 6371N-linked (GlcNAc...)Sequence analysis
Glycosylationi706 – 7061N-linked (GlcNAc...)Sequence analysis
Glycosylationi748 – 7481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Glycosylationi1023 – 10231N-linked (GlcNAc...)Sequence analysis
Glycosylationi1073 – 10731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1167 ↔ 1202By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9C0A0.
PaxDbiQ9C0A0.
PeptideAtlasiQ9C0A0.
PRIDEiQ9C0A0.

PTM databases

iPTMnetiQ9C0A0.
PhosphoSiteiQ9C0A0.

Expressioni

Gene expression databases

BgeeiENSG00000152910.
CleanExiHS_CNTNAP4.
ExpressionAtlasiQ9C0A0. baseline and differential.
GenevisibleiQ9C0A0. HS.

Organism-specific databases

HPAiHPA031859.
HPA057342.

Interactioni

Subunit structurei

Interacts with TIAM1.2 Publications

Protein-protein interaction databases

BioGridi124532. 6 interactions.
DIPiDIP-31652N.
IntActiQ9C0A0. 4 interactions.
MINTiMINT-241176.
STRINGi9606.ENSP00000418741.

Structurei

Secondary structure

1
1308
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1304 – 13074Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NXQX-ray2.10D/E/F1301-1308[»]
ProteinModelPortaliQ9C0A0.
SMRiQ9C0A0. Positions 56-587, 793-1178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 177147F5/8 type CPROSITE-ProRule annotationAdd
BLAST
Domaini212 – 364153Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini398 – 547150Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini549 – 58638EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini587 – 792206Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini793 – 957165Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini958 – 99740EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1046 – 1202157Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ9C0A0.
PhylomeDBiQ9C0A0.
TreeFamiTF321823.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028875. CASPR4.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF659. PTHR10127:SF659. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL
60 70 80 90 100
SSSHGPGFAR LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY
110 120 130 140 150
GSSNWVTSYL LMFSDSGWNW KQYRQEDSIW GFSGNANADS VVYYRLQPSI
160 170 180 190 200
KARFLRFIPL EWNPKGRIGM RIEVFGCAYR SEVVDLDGKS SLLYRFDQKS
210 220 230 240 250
LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR LFLLINSGEA
260 270 280 290 300
KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE
310 320 330 340 350
FNLMNLDYEI SFGGIPAPGK SVSFPHRNFH GCLENLYYNG VDIIDLAKQQ
360 370 380 390 400
KPQIIAMGNV SFSCSQPQSM PVTFLSSRSY LALPDFSGEE EVSATFQFRT
410 420 430 440 450
WNKAGLLLFS ELQLISGGIL LFLSDGKLKS NLYQPGKLPS DITAGVELND
460 470 480 490 500
GQWHSVSLSA KKNHLSVAVD GQMASAAPLL GPEQIYSGGT YYFGGCPDKS
510 520 530 540 550
FGSKCKSPLG GFQGCMRLIS ISGKVVDLIS VQQGSLGNFS DLQIDSCGIS
560 570 580 590 600
DRCLPNYCEH GGECSQSWST FHCNCTNTGY RGATCHNSIY EQSCEAYKHR
610 620 630 640 650
GNTSGFYYID SDGSGPLEPF LLYCNMTETA WTIIQHNGSD LTRVRNTNPE
660 670 680 690 700
NPYAGFFEYV ASMEQLQATI NRAEHCEQEF TYYCKKSRLV NKQDGTPLSW
710 720 730 740 750
WVGRTNETQT YWGGSSPDLQ KCTCGLEGNC IDSQYYCNCD ADRNEWTNDT
760 770 780 790 800
GLLAYKEHLP VTKIVITDTG RLHSEAAYKL GPLLCQGDRS FWNSASFDTE
810 820 830 840 850
ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGIADFI RIELRSPTVV
860 870 880 890 900
TFSFDVGNGP FEISVQSPTH FNDNQWHHVR VERNMKEASL QVDQLTPKTQ
910 920 930 940 950
PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGM TLDLEERAQV
960 970 980 990 1000
TPEVQPGCRG HCSSYGKLCR NGGKCRERPI GFFCDCTFSA YTGPFCSNEI
1010 1020 1030 1040 1050
SAYFGSGSSV IYNFQENYLL SKNSSSHAAS FHGDMKLSRE MIKFSFRTTR
1060 1070 1080 1090 1100
TPSLLLFVSS FYKEYLSVII AKNGSLQIRY KLNKYQEPDV VNFDFKNMAD
1110 1120 1130 1140 1150
GQLHHIMINR EEGVVFIEID DNRRRQVHLS SGTEFSAVKS LVLGRILEHS
1160 1170 1180 1190 1200
DVDQDTALAG AQGFTGCLSA VQLSHVAPLK AALHPSHPDP VTVTGHVTES
1210 1220 1230 1240 1250
SCMAQPGTDA TSRERTHSFA DHSGTIDDRE PLANAIKSDS AVIGGLIAVV
1260 1270 1280 1290 1300
IFILLCITAI AVRIYQQKRL YKRSEAKRSE NVDSAEAVLK SELNIQNAVN

ENQKEYFF
Length:1,308
Mass (Da):145,274
Last modified:October 14, 2008 - v3
Checksum:iC135FD64184E82B1
GO
Isoform 2 (identifier: Q9C0A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MGSVTGAVLKTLLLLSTQNWNRVEAGNS → MWN
     310-357: Missing.

Show »
Length:1,235
Mass (Da):137,495
Checksum:i97955649BF1D90D1
GO

Sequence cautioni

The sequence BAB21854 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441L → R in BAC55271 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti276 – 2761L → V.
Corresponds to variant rs34251012 [ dbSNP | Ensembl ].
VAR_061371
Natural varianti513 – 5131Q → H.
Corresponds to variant rs6564343 [ dbSNP | Ensembl ].
VAR_050268
Natural varianti786 – 7861Q → R.2 Publications
Corresponds to variant rs12933808 [ dbSNP | Ensembl ].
VAR_061372
Natural varianti1155 – 11551D → E.2 Publications
Corresponds to variant rs7202925 [ dbSNP | Ensembl ].
VAR_050269
Natural varianti1300 – 13001N → S.
Corresponds to variant rs34198820 [ dbSNP | Ensembl ].
VAR_050270

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MGSVT…EAGNS → MWN in isoform 2. 1 PublicationVSP_044464Add
BLAST
Alternative sequencei310 – 35748Missing in isoform 2. 1 PublicationVSP_044465Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100093 mRNA. Translation: BAC55271.1.
AB051550 mRNA. Translation: BAB21854.2. Different initiation.
AC010528 Genomic DNA. No translation available.
AC106741 Genomic DNA. No translation available.
CCDSiCCDS10924.2. [Q9C0A0-2]
CCDS73915.1. [Q9C0A0-1]
RefSeqiNP_207837.2. NM_033401.4. [Q9C0A0-1]
NP_620481.2. NM_138994.4. [Q9C0A0-2]
UniGeneiHs.461389.

Genome annotation databases

EnsembliENST00000478060; ENSP00000418741; ENSG00000152910. [Q9C0A0-2]
ENST00000611870; ENSP00000479811; ENSG00000152910. [Q9C0A0-1]
GeneIDi85445.
KEGGihsa:85445.
UCSCiuc010chb.2. human. [Q9C0A0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100093 mRNA. Translation: BAC55271.1.
AB051550 mRNA. Translation: BAB21854.2. Different initiation.
AC010528 Genomic DNA. No translation available.
AC106741 Genomic DNA. No translation available.
CCDSiCCDS10924.2. [Q9C0A0-2]
CCDS73915.1. [Q9C0A0-1]
RefSeqiNP_207837.2. NM_033401.4. [Q9C0A0-1]
NP_620481.2. NM_138994.4. [Q9C0A0-2]
UniGeneiHs.461389.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NXQX-ray2.10D/E/F1301-1308[»]
ProteinModelPortaliQ9C0A0.
SMRiQ9C0A0. Positions 56-587, 793-1178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124532. 6 interactions.
DIPiDIP-31652N.
IntActiQ9C0A0. 4 interactions.
MINTiMINT-241176.
STRINGi9606.ENSP00000418741.

PTM databases

iPTMnetiQ9C0A0.
PhosphoSiteiQ9C0A0.

Polymorphism and mutation databases

BioMutaiCNTNAP4.
DMDMi209572753.

Proteomic databases

MaxQBiQ9C0A0.
PaxDbiQ9C0A0.
PeptideAtlasiQ9C0A0.
PRIDEiQ9C0A0.

Protocols and materials databases

DNASUi85445.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000478060; ENSP00000418741; ENSG00000152910. [Q9C0A0-2]
ENST00000611870; ENSP00000479811; ENSG00000152910. [Q9C0A0-1]
GeneIDi85445.
KEGGihsa:85445.
UCSCiuc010chb.2. human. [Q9C0A0-1]

Organism-specific databases

CTDi85445.
GeneCardsiCNTNAP4.
HGNCiHGNC:18747. CNTNAP4.
HPAiHPA031859.
HPA057342.
MIMi610518. gene.
neXtProtiNX_Q9C0A0.
PharmGKBiPA134874662.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ9C0A0.
PhylomeDBiQ9C0A0.
TreeFamiTF321823.

Miscellaneous databases

GeneWikiiCNTNAP4.
GenomeRNAii85445.
PROiQ9C0A0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152910.
CleanExiHS_CNTNAP4.
ExpressionAtlasiQ9C0A0. baseline and differential.
GenevisibleiQ9C0A0. HS.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028875. CASPR4.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF659. PTHR10127:SF659. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTP4_HUMAN
AccessioniPrimary (citable) accession number: Q9C0A0
Secondary accession number(s): E9PFZ6, Q86YZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.