ID DCLK3_HUMAN Reviewed; 648 AA. AC Q9C098; DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 03-OCT-2006, sequence version 2. DT 27-MAR-2024, entry version 156. DE RecName: Full=Serine/threonine-protein kinase DCLK3; DE EC=2.7.11.1; DE AltName: Full=Doublecortin domain-containing protein 3C; DE AltName: Full=Doublecortin-like and CAM kinase-like 3; DE AltName: Full=Doublecortin-like kinase 3; GN Name=DCLK3; Synonyms=DCAMKL3, DCDC3C, KIAA1765; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-105. RC TISSUE=Brain; RX PubMed=11214970; DOI=10.1093/dnares/7.6.347; RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XIX. The RT complete sequences of 100 new cDNA clones from brain which code for large RT proteins in vitro."; RL DNA Res. 7:347-355(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-648. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP VARIANTS [LARGE SCALE ANALYSIS] GLN-24; LEU-108; LYS-422; ASN-472; CYS-554; RP ARG-570; ALA-596 AND ASP-633. RX PubMed=17344846; DOI=10.1038/nature05610; RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., RA Futreal P.A., Stratton M.R.; RT "Patterns of somatic mutation in human cancer genomes."; RL Nature 446:153-158(2007). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; CC EC=2.7.11.1; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr CC protein kinase family. CaMK subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DA523113; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AB051552; BAB21856.1; -; mRNA. DR CCDS; CCDS43064.1; -. DR RefSeq; NP_208382.1; NM_033403.1. DR RefSeq; XP_011532469.1; XM_011534167.2. DR AlphaFoldDB; Q9C098; -. DR SMR; Q9C098; -. DR BioGRID; 124530; 4. DR IntAct; Q9C098; 8. DR STRING; 9606.ENSP00000394484; -. DR BindingDB; Q9C098; -. DR ChEMBL; CHEMBL6123; -. DR DrugBank; DB12010; Fostamatinib. DR DrugCentral; Q9C098; -. DR iPTMnet; Q9C098; -. DR PhosphoSitePlus; Q9C098; -. DR BioMuta; DCLK3; -. DR DMDM; 115502142; -. DR CPTAC; CPTAC-2832; -. DR CPTAC; CPTAC-2833; -. DR jPOST; Q9C098; -. DR MassIVE; Q9C098; -. DR MaxQB; Q9C098; -. DR PaxDb; 9606-ENSP00000394484; -. DR PeptideAtlas; Q9C098; -. DR ProteomicsDB; 79972; -. DR Antibodypedia; 28151; 116 antibodies from 30 providers. DR DNASU; 85443; -. DR Ensembl; ENST00000416516.2; ENSP00000394484.2; ENSG00000163673.8. DR GeneID; 85443; -. DR KEGG; hsa:85443; -. DR UCSC; uc003cgi.2; human. DR AGR; HGNC:19005; -. DR CTD; 85443; -. DR DisGeNET; 85443; -. DR GeneCards; DCLK3; -. DR HGNC; HGNC:19005; DCLK3. DR HPA; ENSG00000163673; Tissue enhanced (brain, testis). DR MIM; 613167; gene. DR neXtProt; NX_Q9C098; -. DR OpenTargets; ENSG00000163673; -. DR PharmGKB; PA162383403; -. DR VEuPathDB; HostDB:ENSG00000163673; -. DR eggNOG; KOG0032; Eukaryota. DR GeneTree; ENSGT00940000159476; -. DR HOGENOM; CLU_000288_94_2_1; -. DR InParanoid; Q9C098; -. DR OMA; GHHCGET; -. DR OrthoDB; 2956627at2759; -. DR PhylomeDB; Q9C098; -. DR TreeFam; TF318770; -. DR PathwayCommons; Q9C098; -. DR SignaLink; Q9C098; -. DR BioGRID-ORCS; 85443; 15 hits in 1178 CRISPR screens. DR GenomeRNAi; 85443; -. DR Pharos; Q9C098; Tchem. DR PRO; PR:Q9C098; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q9C098; Protein. DR Bgee; ENSG00000163673; Expressed in sural nerve and 98 other cell types or tissues. DR ExpressionAtlas; Q9C098; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central. DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR CDD; cd14185; STKc_DCKL3; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1. DR PANTHER; PTHR24347:SF427; SERINE_THREONINE-PROTEIN KINASE DCLK3; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. DR Genevisible; Q9C098; HS. PE 2: Evidence at transcript level; KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; KW Reference proteome; Serine/threonine-protein kinase; Transferase. FT CHAIN 1..648 FT /note="Serine/threonine-protein kinase DCLK3" FT /id="PRO_0000252254" FT DOMAIN 356..613 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT REGION 86..127 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 150..345 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 628..648 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 169..183 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 197..340 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 477 FT /note="Proton acceptor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, FT ECO:0000255|PROSITE-ProRule:PRU10027" FT BINDING 362..370 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 385 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT VARIANT 24 FT /note="R -> Q (in dbSNP:rs56070233)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040444" FT VARIANT 108 FT /note="P -> L (in a breast infiltrating ductal carcinoma FT sample; somatic mutation)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040445" FT VARIANT 422 FT /note="E -> K (in a colorectal adenocarcinoma sample; FT somatic mutation; dbSNP:rs373605259)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040446" FT VARIANT 472 FT /note="S -> N (in a lung large cell carcinoma sample; FT somatic mutation)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040447" FT VARIANT 554 FT /note="R -> C (in a lung squamous cell carcinoma sample; FT somatic mutation; dbSNP:rs374711533)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040448" FT VARIANT 570 FT /note="G -> R (in a renal clear cell carcinoma sample; FT somatic mutation)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040449" FT VARIANT 596 FT /note="V -> A (in a colorectal adenocarcinoma sample; FT somatic mutation)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040450" FT VARIANT 633 FT /note="E -> D (in dbSNP:rs35704209)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_040451" SQ SEQUENCE 648 AA; 73814 MW; 09E37E51920F2A21 CRC64; MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG DHRCGETETP KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW EPEPSSKPPR EATLEERHAR GEKHLGVEIE KTSGEIIRCE KCKRERELQQ SLERERLSLG TSELDMGKGP MYDVEKLVRT RSCRRSPEAN PASGEEGWKG DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA KAKKDLVEVL PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA NVEKHYETGR VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD SEILIIQSLS HPNIVKLHEV YETDMEIYLI LEYVQGGDLF DAIIESVKFP EPDAALMIMD LCKALVHMHD KSIVHRDLKP ENLLVQRNED KSTTLKLADF GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG VILYILLCGF PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS //