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Reviewed, UniProtKB/Swiss-Prot Q9C098 (DCLK3_HUMAN)

Last modified June 16, 2009. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Serine/threonine-protein kinase DCLK3
    EC=2.7.11.1
Alternative name(s):
    Doublecortin-like and CAM kinase-like 3
      Short name=Doublecortin-like kinase 3
Gene names
Name: DCLK3
Synonyms: DCAMKL3, DCDC3C, KIAA1765
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

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Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
Gene Ontology (GO)
   Biological processprotein amino acid phosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Serine/threonine-protein kinase DCLK3
PRO_0000252254

Regions

Domain356 – 613258Protein kinase
Nucleotide binding362 – 3709ATP By similarity

Sites

Active site4771Proton acceptor By similarity
Binding site3851ATP By similarity

Natural variations

Natural variant241R → Q Ref.3
VAR_040444
Natural variant1081P → L in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.3
VAR_040445
Natural variant4221E → K in a colorectal adenocarcinoma sample; somatic mutation. Ref.3
VAR_040446
Natural variant4721S → N in a lung large cell carcinoma sample; somatic mutation. Ref.3
VAR_040447
Natural variant5541R → C in a lung squamous cell carcinoma sample; somatic mutation. Ref.3
VAR_040448
Natural variant5701G → R in a renal clear cell carcinoma sample; somatic mutation. Ref.3
VAR_040449
Natural variant5961V → A in a colorectal adenocarcinoma sample; somatic mutation. Ref.3
VAR_040450
Natural variant6331E → D Ref.3
VAR_040451

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Sequences

Sequence LengthMass (Da)Tools
Q9C098-1 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 09E37E51920F2A21

FASTA64873,814
        10         20         30         40         50         60 
MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG DHRCGETETP 

        70         80         90        100        110        120 
KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW EPEPSSKPPR EATLEERHAR 

       130        140        150        160        170        180 
GEKHLGVEIE KTSGEIIRCE KCKRERELQQ SLERERLSLG TSELDMGKGP MYDVEKLVRT 

       190        200        210        220        230        240 
RSCRRSPEAN PASGEEGWKG DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA 

       250        260        270        280        290        300 
KAKKDLVEVL PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE 

       310        320        330        340        350        360 
KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA NVEKHYETGR 

       370        380        390        400        410        420 
VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD SEILIIQSLS HPNIVKLHEV 

       430        440        450        460        470        480 
YETDMEIYLI LEYVQGGDLF DAIIESVKFP EPDAALMIMD LCKALVHMHD KSIVHRDLKP 

       490        500        510        520        530        540 
ENLLVQRNED KSTTLKLADF GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG 

       550        560        570        580        590        600 
VILYILLCGF PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK 

       610        620        630        640 
RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS

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References

[1]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed: 11214970] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-105.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-648.
Tissue: Brain.
[3]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-24; LEU-108; LYS-422; ASN-472; CYS-554; ARG-570; ALA-596 AND ASP-633.

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Cross-references

Sequence databases

DA523113 mRNA. No translation available.
AB051552 mRNA. Translation: BAB21856.1.
IPIIPI00852660.
RefSeqNP_208382.1.
UniGeneHs.631907

3D structure databases

HSSPHSSP built from PDB template 1NY3 based on UniProtKB P49137.
ModBaseSearch...

PTM databases

PhosphoSiteQ9C098.

Proteomic databases

PRIDEQ9C098.

Genome annotation databases

EnsemblENSG00000163673. Homo sapiens. [Contig view]
GeneID85443.
KEGGhsa:85443.

Organism-specific databases

GeneCardsGC03M036731.
HGNCHGNC:19005. DCLK3.
HPACAB015207.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9C098.
OMAQ9C098. RRSPEAN.

Enzyme and pathway databases

BRENDA2.7.11.1. 247.

Gene expression databases

ArrayExpressQ9C098.
BgeeQ9C098.
CleanExHS_DCLK3.
GermOnlineENSG00000163673. Homo sapiens.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio76029.

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Entry information

Entry nameDCLK3_HUMAN
AccessionPrimary (citable) accession number: Q9C098
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 16, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents