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Q9C098

- DCLK3_HUMAN

UniProt

Q9C098 - DCLK3_HUMAN

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Protein

Serine/threonine-protein kinase DCLK3

Gene

DCLK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei385 – 3851ATPPROSITE-ProRule annotation
Active sitei477 – 4771Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi362 – 3709ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9C098.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK3 (EC:2.7.11.1)
Alternative name(s):
Doublecortin domain-containing protein 3C
Doublecortin-like and CAM kinase-like 3
Doublecortin-like kinase 3
Gene namesi
Name:DCLK3
Synonyms:DCAMKL3, DCDC3C, KIAA1765
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19005. DCLK3.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Serine/threonine-protein kinase DCLK3PRO_0000252254Add
BLAST

Proteomic databases

PaxDbiQ9C098.
PRIDEiQ9C098.

PTM databases

PhosphoSiteiQ9C098.

Expressioni

Gene expression databases

BgeeiQ9C098.
CleanExiHS_DCLK3.
ExpressionAtlasiQ9C098. baseline.
GenevestigatoriQ9C098.

Organism-specific databases

HPAiCAB015207.

Interactioni

Protein-protein interaction databases

BioGridi124530. 1 interaction.
IntActiQ9C098. 1 interaction.
STRINGi9606.ENSP00000295943.

Structurei

3D structure databases

ProteinModelPortaliQ9C098.
SMRiQ9C098. Positions 324-614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini356 – 613258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119185.
HOGENOMiHOG000112176.
HOVERGENiHBG101914.
InParanoidiQ9C098.
KOiK17530.
OMAiHYETGRV.
OrthoDBiEOG7M98FQ.
PhylomeDBiQ9C098.
TreeFamiTF318770.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C098-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG
60 70 80 90 100
DHRCGETETP KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW
110 120 130 140 150
EPEPSSKPPR EATLEERHAR GEKHLGVEIE KTSGEIIRCE KCKRERELQQ
160 170 180 190 200
SLERERLSLG TSELDMGKGP MYDVEKLVRT RSCRRSPEAN PASGEEGWKG
210 220 230 240 250
DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA KAKKDLVEVL
260 270 280 290 300
PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE
310 320 330 340 350
KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA
360 370 380 390 400
NVEKHYETGR VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD
410 420 430 440 450
SEILIIQSLS HPNIVKLHEV YETDMEIYLI LEYVQGGDLF DAIIESVKFP
460 470 480 490 500
EPDAALMIMD LCKALVHMHD KSIVHRDLKP ENLLVQRNED KSTTLKLADF
510 520 530 540 550
GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG VILYILLCGF
560 570 580 590 600
PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK
610 620 630 640
RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS
Length:648
Mass (Da):73,814
Last modified:October 3, 2006 - v2
Checksum:i09E37E51920F2A21
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241R → Q.1 Publication
Corresponds to variant rs56070233 [ dbSNP | Ensembl ].
VAR_040444
Natural varianti108 – 1081P → L in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
VAR_040445
Natural varianti422 – 4221E → K in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040446
Natural varianti472 – 4721S → N in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_040447
Natural varianti554 – 5541R → C in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
VAR_040448
Natural varianti570 – 5701G → R in a renal clear cell carcinoma sample; somatic mutation. 1 Publication
VAR_040449
Natural varianti596 – 5961V → A in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040450
Natural varianti633 – 6331E → D.1 Publication
Corresponds to variant rs35704209 [ dbSNP | Ensembl ].
VAR_040451

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DA523113 mRNA. No translation available.
AB051552 mRNA. Translation: BAB21856.1.
CCDSiCCDS43064.1.
RefSeqiNP_208382.1. NM_033403.1.
UniGeneiHs.631907.

Genome annotation databases

EnsembliENST00000416516; ENSP00000394484; ENSG00000163673.
GeneIDi85443.
KEGGihsa:85443.
UCSCiuc003cgi.2. human.

Polymorphism databases

DMDMi115502142.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DA523113 mRNA. No translation available.
AB051552 mRNA. Translation: BAB21856.1 .
CCDSi CCDS43064.1.
RefSeqi NP_208382.1. NM_033403.1.
UniGenei Hs.631907.

3D structure databases

ProteinModelPortali Q9C098.
SMRi Q9C098. Positions 324-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124530. 1 interaction.
IntActi Q9C098. 1 interaction.
STRINGi 9606.ENSP00000295943.

Chemistry

BindingDBi Q9C098.
ChEMBLi CHEMBL6123.
GuidetoPHARMACOLOGYi 2007.

PTM databases

PhosphoSitei Q9C098.

Polymorphism databases

DMDMi 115502142.

Proteomic databases

PaxDbi Q9C098.
PRIDEi Q9C098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000416516 ; ENSP00000394484 ; ENSG00000163673 .
GeneIDi 85443.
KEGGi hsa:85443.
UCSCi uc003cgi.2. human.

Organism-specific databases

CTDi 85443.
GeneCardsi GC03M036731.
H-InvDB HIX0003164.
HGNCi HGNC:19005. DCLK3.
HPAi CAB015207.
MIMi 613167. gene.
neXtProti NX_Q9C098.
PharmGKBi PA162383403.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119185.
HOGENOMi HOG000112176.
HOVERGENi HBG101914.
InParanoidi Q9C098.
KOi K17530.
OMAi HYETGRV.
OrthoDBi EOG7M98FQ.
PhylomeDBi Q9C098.
TreeFami TF318770.

Enzyme and pathway databases

SignaLinki Q9C098.

Miscellaneous databases

GenomeRNAii 85443.
NextBioi 76029.
PROi Q9C098.
SOURCEi Search...

Gene expression databases

Bgeei Q9C098.
CleanExi HS_DCLK3.
ExpressionAtlasi Q9C098. baseline.
Genevestigatori Q9C098.

Family and domain databases

InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-105.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-648.
    Tissue: Brain.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-24; LEU-108; LYS-422; ASN-472; CYS-554; ARG-570; ALA-596 AND ASP-633.

Entry informationi

Entry nameiDCLK3_HUMAN
AccessioniPrimary (citable) accession number: Q9C098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3