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Q9C098

- DCLK3_HUMAN

UniProt

Q9C098 - DCLK3_HUMAN

Protein

Serine/threonine-protein kinase DCLK3

Gene

DCLK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei385 – 3851ATPPROSITE-ProRule annotation
    Active sitei477 – 4771Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi362 – 3709ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9C098.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase DCLK3 (EC:2.7.11.1)
    Alternative name(s):
    Doublecortin domain-containing protein 3C
    Doublecortin-like and CAM kinase-like 3
    Doublecortin-like kinase 3
    Gene namesi
    Name:DCLK3
    Synonyms:DCAMKL3, DCDC3C, KIAA1765
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19005. DCLK3.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162383403.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 648648Serine/threonine-protein kinase DCLK3PRO_0000252254Add
    BLAST

    Proteomic databases

    PaxDbiQ9C098.
    PRIDEiQ9C098.

    PTM databases

    PhosphoSiteiQ9C098.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C098.
    BgeeiQ9C098.
    CleanExiHS_DCLK3.
    GenevestigatoriQ9C098.

    Organism-specific databases

    HPAiCAB015207.

    Interactioni

    Protein-protein interaction databases

    BioGridi124530. 1 interaction.
    IntActiQ9C098. 1 interaction.
    STRINGi9606.ENSP00000295943.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C098.
    SMRiQ9C098. Positions 351-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini356 – 613258Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000112176.
    HOVERGENiHBG101914.
    InParanoidiQ9C098.
    KOiK17530.
    OMAiHYETGRV.
    OrthoDBiEOG7M98FQ.
    PhylomeDBiQ9C098.
    TreeFamiTF318770.

    Family and domain databases

    InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24347. PTHR24347. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C098-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG    50
    DHRCGETETP KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW 100
    EPEPSSKPPR EATLEERHAR GEKHLGVEIE KTSGEIIRCE KCKRERELQQ 150
    SLERERLSLG TSELDMGKGP MYDVEKLVRT RSCRRSPEAN PASGEEGWKG 200
    DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA KAKKDLVEVL 250
    PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE 300
    KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA 350
    NVEKHYETGR VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD 400
    SEILIIQSLS HPNIVKLHEV YETDMEIYLI LEYVQGGDLF DAIIESVKFP 450
    EPDAALMIMD LCKALVHMHD KSIVHRDLKP ENLLVQRNED KSTTLKLADF 500
    GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG VILYILLCGF 550
    PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK 600
    RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS 648
    Length:648
    Mass (Da):73,814
    Last modified:October 3, 2006 - v2
    Checksum:i09E37E51920F2A21
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241R → Q.1 Publication
    Corresponds to variant rs56070233 [ dbSNP | Ensembl ].
    VAR_040444
    Natural varianti108 – 1081P → L in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
    VAR_040445
    Natural varianti422 – 4221E → K in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040446
    Natural varianti472 – 4721S → N in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_040447
    Natural varianti554 – 5541R → C in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
    VAR_040448
    Natural varianti570 – 5701G → R in a renal clear cell carcinoma sample; somatic mutation. 1 Publication
    VAR_040449
    Natural varianti596 – 5961V → A in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040450
    Natural varianti633 – 6331E → D.1 Publication
    Corresponds to variant rs35704209 [ dbSNP | Ensembl ].
    VAR_040451

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DA523113 mRNA. No translation available.
    AB051552 mRNA. Translation: BAB21856.1.
    CCDSiCCDS43064.1.
    RefSeqiNP_208382.1. NM_033403.1.
    UniGeneiHs.631907.

    Genome annotation databases

    EnsembliENST00000416516; ENSP00000394484; ENSG00000163673.
    GeneIDi85443.
    KEGGihsa:85443.
    UCSCiuc003cgi.2. human.

    Polymorphism databases

    DMDMi115502142.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DA523113 mRNA. No translation available.
    AB051552 mRNA. Translation: BAB21856.1 .
    CCDSi CCDS43064.1.
    RefSeqi NP_208382.1. NM_033403.1.
    UniGenei Hs.631907.

    3D structure databases

    ProteinModelPortali Q9C098.
    SMRi Q9C098. Positions 351-628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124530. 1 interaction.
    IntActi Q9C098. 1 interaction.
    STRINGi 9606.ENSP00000295943.

    Chemistry

    BindingDBi Q9C098.
    ChEMBLi CHEMBL6123.
    GuidetoPHARMACOLOGYi 2007.

    PTM databases

    PhosphoSitei Q9C098.

    Polymorphism databases

    DMDMi 115502142.

    Proteomic databases

    PaxDbi Q9C098.
    PRIDEi Q9C098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000416516 ; ENSP00000394484 ; ENSG00000163673 .
    GeneIDi 85443.
    KEGGi hsa:85443.
    UCSCi uc003cgi.2. human.

    Organism-specific databases

    CTDi 85443.
    GeneCardsi GC03M036731.
    H-InvDB HIX0003164.
    HGNCi HGNC:19005. DCLK3.
    HPAi CAB015207.
    MIMi 613167. gene.
    neXtProti NX_Q9C098.
    PharmGKBi PA162383403.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000112176.
    HOVERGENi HBG101914.
    InParanoidi Q9C098.
    KOi K17530.
    OMAi HYETGRV.
    OrthoDBi EOG7M98FQ.
    PhylomeDBi Q9C098.
    TreeFami TF318770.

    Enzyme and pathway databases

    SignaLinki Q9C098.

    Miscellaneous databases

    GenomeRNAii 85443.
    NextBioi 76029.
    PROi Q9C098.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C098.
    Bgeei Q9C098.
    CleanExi HS_DCLK3.
    Genevestigatori Q9C098.

    Family and domain databases

    InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24347. PTHR24347. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-105.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-648.
      Tissue: Brain.
    3. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-24; LEU-108; LYS-422; ASN-472; CYS-554; ARG-570; ALA-596 AND ASP-633.

    Entry informationi

    Entry nameiDCLK3_HUMAN
    AccessioniPrimary (citable) accession number: Q9C098
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3