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Protein

GREB1-like protein

Gene

GREB1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GREB1-like protein
Gene namesi
Name:GREB1L
Synonyms:C18orf6, KIAA1772
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:31042. GREB1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1843 – 186220HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165429012.

Polymorphism and mutation databases

BioMutaiGREB1L.
DMDMi172046226.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19231923GREB1-like proteinPRO_0000320946Add
BLAST

Proteomic databases

MaxQBiQ9C091.
PaxDbiQ9C091.
PRIDEiQ9C091.

PTM databases

iPTMnetiQ9C091.
PhosphoSiteiQ9C091.

Expressioni

Gene expression databases

BgeeiQ9C091.
CleanExiHS_KIAA1772.
ExpressionAtlasiQ9C091. baseline and differential.
GenevisibleiQ9C091. HS.

Organism-specific databases

HPAiHPA041647.
HPA044218.

Interactioni

Protein-protein interaction databases

BioGridi123059. 4 interactions.
STRINGi9606.ENSP00000412060.

Structurei

3D structure databases

ProteinModelPortaliQ9C091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1121 – 120686Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the GREB1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9T. Eukaryota.
ENOG410Z1PN. LUCA.
GeneTreeiENSGT00390000008041.
HOGENOMiHOG000090251.
HOVERGENiHBG107963.
InParanoidiQ9C091.
OMAiMMDDSCV.
OrthoDBiEOG76X5Z7.
PhylomeDBiQ9C091.
TreeFamiTF329531.

Family and domain databases

InterProiIPR028422. GREB1.
IPR024840. GREB1-like.
[Graphical view]
PANTHERiPTHR15720. PTHR15720. 1 hit.
PTHR15720:SF12. PTHR15720:SF12. 1 hit.
PfamiPF15782. GREB1. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C091-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNSYAGQLK SARFEEALHN SIEASLRCSS VVPRPIFSQL YLDPDQHPFS
60 70 80 90 100
SADVKPKVED LDKDLVNRYT QNGSLDFSNN LTVNEMEDDE DDEEMSDSNS
110 120 130 140 150
PPIPYSQKPA PEGSCTTDGF CQAGKDLRLV SLCMEQIDIP AGFLLVGAKS
160 170 180 190 200
PNLPEHILVC AVDKRFLPDD HGKNALLGFS GNCIGCGERG FRYFTEFSNH
210 220 230 240 250
INLKLTTQPK KQKHLKYYLV RSSQGVLSKG PLICWKECRS RQSSASCHSI
260 270 280 290 300
KPSSSVSSTV TPENGTTNGY KSGFTQTDAA NGNSSHGGKG SASSSTPAHT
310 320 330 340 350
GNYSLSPRPS YASGDQATMF ISGPPKKRHR GWYPGSPLPQ PGLVVPVPTV
360 370 380 390 400
RPLSRTEPLL SAPVPQTPLT GILQPRPIPA GETVIVPENL LSNSGVRPVI
410 420 430 440 450
LIGYGTLPYF YGNVGDIVVS PLLVNCYKIP QLENKDLEKL GLTGSQFLSV
460 470 480 490 500
ENMILLTIQY LVRLGPDQVP LREEFEQIML KAMQEFTLRE RALQIGAQCV
510 520 530 540 550
PVSPGQLPWL ARLIASVSQD LVHVVVTQNS LAEGISETLR TLSEMRHYQR
560 570 580 590 600
LPDYVVVICA SKIRGNEFCV VVLGQHQSRA LAESMLTTSE FLKEISYELI
610 620 630 640 650
TGKVSFLASH FKTTSLGDDL DKLLEKMQQR RGDSVVTPFD GDLNECVSPQ
660 670 680 690 700
EAAAMIPTQN LDLDNETFHI YQPQLTVARK LLSQVCAIAD SGSQSLDLGH
710 720 730 740 750
FSKVDFIIIV PRSEVLVQQT LQRIRQSGVL VDLGLEENGT AHQRAEKYVV
760 770 780 790 800
RLDNEIQTKF EVFMRRVKQN PYTLFVLVHD NSHVELTSVI SGSLSHSEPS
810 820 830 840 850
HGLADRVINC REVLEAFNLL VLQVSSFPYT LQTQQSRISS SNEVHWIQLD
860 870 880 890 900
TGEDVGCEEK LYFGLSEYSK SLQWGITSPL LRCDETFEKM VNTLLERYPR
910 920 930 940 950
LHSMVVRCYL LIQQYSEALM ALTTMASLRD HSTPETLSIM DDLISSPGKN
960 970 980 990 1000
KSGRGHMLII RVPSVQLAML AKERLQEVRD KLGLQYRFEI ILGNPATELS
1010 1020 1030 1040 1050
VATHFVARLK SWRGNEPEEW IPRTYQDLDG LPCIVILTGK DPLGETFPRS
1060 1070 1080 1090 1100
LKYCDLRLID SSYLTRTALE QEVGLACCYV SKEVIRGPTV ALDLSGKEQE
1110 1120 1130 1140 1150
RAAVSENDSD ELLIDLERPQ SNSSAVTGTS GSIMENGVSS SSTADKSQKQ
1160 1170 1180 1190 1200
SLTPSFQSPA TSLGLDEGVS ASSAGAGAGE TLKQECDSLG PQMASSTTSK
1210 1220 1230 1240 1250
PSSSSSGPRT LPWPGQPIRG CRGPQAALPP VVILSKAAYS LLGSQKSGKL
1260 1270 1280 1290 1300
PSSSSLLPHA DVAWVSSLRP LLNKDMSSEE QSLYYRQWTL ARQHHADYSN
1310 1320 1330 1340 1350
QLDPASGTRN FHPRRLLLTG PPQVGKTGSY LQFLRILFRM LIRLLEVDVY
1360 1370 1380 1390 1400
DEEEINTDHN ESSEVSQSEG EPWPDIESFS KMPFDVSVHD PKYSLMSLVY
1410 1420 1430 1440 1450
TEKLAGVKQE VIKESKVEEP RKRETVSIML TKYAAYNTFH HCEQCRQYMD
1460 1470 1480 1490 1500
FTSASQMSDS TLHAFTFSSS MLGEEVQLYF IIPKSKESHF VFSKQGKHLE
1510 1520 1530 1540 1550
SMRLPLVSDK NLNAVKSPIF TPSSGRHEHG LLNLFHAMEG ISHLHLLVVK
1560 1570 1580 1590 1600
EYEMPLYRKY WPNHIMLVLP GMFNNAGVGA ARFLIKELSY HNLELERNRL
1610 1620 1630 1640 1650
EELGIKRQCV WPFIVMMDDS CVLWNIHSVQ EPSSQPMEVG VSSKNVSLKT
1660 1670 1680 1690 1700
VLQHIEATPK IVHYAILGIQ KWSSKLTSQS LKAPFSRCHV HDFILLNTDL
1710 1720 1730 1740 1750
TQNVQYDFNR YFCEDADFNL RTNSSGLLIC RFNNFSLMKK HVQVGGQRDF
1760 1770 1780 1790 1800
IIKPKIMVSE SLAPILPLQY ICAPDSEHTL LAAPAQFLLE KFLQHASYKL
1810 1820 1830 1840 1850
FPKAIHNFRS PVLAIDCYLN IGPEVAICYI SSRPHSSNVN CEGVFFSGLL
1860 1870 1880 1890 1900
LYLCDSFVGA DLKKFKFLKG ATLCVICQDR SSLRQTIVRL ELEDEWQFRL
1910 1920
RDEFQTANSS DDKPLYFLTG RHV
Length:1,923
Mass (Da):214,354
Last modified:February 26, 2008 - v2
Checksum:iAE5EDD696A23DAFD
GO
Isoform 3 (identifier: Q9C091-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-574: Missing.

Note: No experimental confirmation available.
Show »
Length:1,814
Mass (Da):202,111
Checksum:i63E178E74148B56E
GO
Isoform 4 (identifier: Q9C091-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     729-747: VLVDLGLEENGTAHQRAEK → SSPGSHIAFSYVLFISCNL
     748-1923: Missing.

Note: No experimental confirmation available.
Show »
Length:747
Mass (Da):81,844
Checksum:iAF21625DAEA0433D
GO

Sequence cautioni

The sequence AAI25018.1 differs from that shown. Reason: Frameshift at position 591. Curated
The sequence BAB14666.1 differs from that shown. Reason: Frameshift at position 675. Curated
The sequence BAB14666.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAB21863.1 differs from that shown.Probable cloning artifact. Spurious priming from an intronic poly-A tract.Curated
The sequence BAB21863.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541S → F in AAI25018 (PubMed:15489334).Curated
Sequence conflicti257 – 2571S → V in AAI25018 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei466 – 574109Missing in isoform 3. 1 PublicationVSP_031762Add
BLAST
Alternative sequencei729 – 74719VLVDL…QRAEK → SSPGSHIAFSYVLFISCNL in isoform 4. 1 PublicationVSP_031764Add
BLAST
Alternative sequencei748 – 19231176Missing in isoform 4. 1 PublicationVSP_031765Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023749 mRNA. Translation: BAB14666.1. Sequence problems.
AK309723 mRNA. No translation available.
AC011774 Genomic DNA. No translation available.
AC015878 Genomic DNA. No translation available.
BC125017 mRNA. Translation: AAI25018.1. Frameshift.
AB051559 mRNA. Translation: BAB21863.1. Sequence problems.
CCDSiCCDS45836.1. [Q9C091-1]
RefSeqiNP_001136438.1. NM_001142966.1. [Q9C091-1]
UniGeneiHs.149020.

Genome annotation databases

EnsembliENST00000269218; ENSP00000269218; ENSG00000141449. [Q9C091-3]
ENST00000424526; ENSP00000412060; ENSG00000141449. [Q9C091-1]
ENST00000580732; ENSP00000464162; ENSG00000141449. [Q9C091-1]
GeneIDi80000.
KEGGihsa:80000.
UCSCiuc010xam.2. human. [Q9C091-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023749 mRNA. Translation: BAB14666.1. Sequence problems.
AK309723 mRNA. No translation available.
AC011774 Genomic DNA. No translation available.
AC015878 Genomic DNA. No translation available.
BC125017 mRNA. Translation: AAI25018.1. Frameshift.
AB051559 mRNA. Translation: BAB21863.1. Sequence problems.
CCDSiCCDS45836.1. [Q9C091-1]
RefSeqiNP_001136438.1. NM_001142966.1. [Q9C091-1]
UniGeneiHs.149020.

3D structure databases

ProteinModelPortaliQ9C091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123059. 4 interactions.
STRINGi9606.ENSP00000412060.

PTM databases

iPTMnetiQ9C091.
PhosphoSiteiQ9C091.

Polymorphism and mutation databases

BioMutaiGREB1L.
DMDMi172046226.

Proteomic databases

MaxQBiQ9C091.
PaxDbiQ9C091.
PRIDEiQ9C091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269218; ENSP00000269218; ENSG00000141449. [Q9C091-3]
ENST00000424526; ENSP00000412060; ENSG00000141449. [Q9C091-1]
ENST00000580732; ENSP00000464162; ENSG00000141449. [Q9C091-1]
GeneIDi80000.
KEGGihsa:80000.
UCSCiuc010xam.2. human. [Q9C091-1]

Organism-specific databases

CTDi80000.
GeneCardsiGREB1L.
H-InvDBHIX0014356.
HGNCiHGNC:31042. GREB1L.
HPAiHPA041647.
HPA044218.
neXtProtiNX_Q9C091.
PharmGKBiPA165429012.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9T. Eukaryota.
ENOG410Z1PN. LUCA.
GeneTreeiENSGT00390000008041.
HOGENOMiHOG000090251.
HOVERGENiHBG107963.
InParanoidiQ9C091.
OMAiMMDDSCV.
OrthoDBiEOG76X5Z7.
PhylomeDBiQ9C091.
TreeFamiTF329531.

Miscellaneous databases

ChiTaRSiGREB1L. human.
GenomeRNAii80000.
NextBioi70071.
PROiQ9C091.

Gene expression databases

BgeeiQ9C091.
CleanExiHS_KIAA1772.
ExpressionAtlasiQ9C091. baseline and differential.
GenevisibleiQ9C091. HS.

Family and domain databases

InterProiIPR028422. GREB1.
IPR024840. GREB1-like.
[Graphical view]
PANTHERiPTHR15720. PTHR15720. 1 hit.
PTHR15720:SF12. PTHR15720:SF12. 1 hit.
PfamiPF15782. GREB1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Placenta and Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1102 (ISOFORM 3).
  4. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-728 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiGRB1L_HUMAN
AccessioniPrimary (citable) accession number: Q9C091
Secondary accession number(s): A4QN17, Q9H8F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 16, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.