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Protein

INO80 complex subunit B

Gene

INO80B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces growth and cell cycle arrests at the G1 phase of the cell cycle.1 Publication
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri305 – 336HIT-typeAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5689603 UCH proteinases
R-HSA-5696394 DNA Damage Recognition in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
INO80 complex subunit B
Alternative name(s):
High mobility group AT-hook 1-like 4
IES2 homolog
Short name:
hIes2
PAP-1-associated protein 1
Short name:
PAPA-1
Zinc finger HIT domain-containing protein 4
Gene namesi
Name:INO80B
Synonyms:HMGA1L4, PAPA1, ZNHIT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115274.14
HGNCiHGNC:13324 INO80B
MIMi616456 gene
neXtProtiNX_Q9C086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83444
OpenTargetsiENSG00000115274
PharmGKBiPA162392117

Polymorphism and mutation databases

BioMutaiINO80B
DMDMi229462939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735541 – 356INO80 complex subunit BAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C086
MaxQBiQ9C086
PaxDbiQ9C086
PeptideAtlasiQ9C086
PRIDEiQ9C086

PTM databases

iPTMnetiQ9C086
PhosphoSitePlusiQ9C086

Expressioni

Gene expression databases

BgeeiENSG00000115274
CleanExiHS_INO80B
ExpressionAtlasiQ9C086 baseline and differential
GenevisibleiQ9C086 HS

Organism-specific databases

HPAiHPA042717

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with RP9.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123646, 102 interactors
CORUMiQ9C086
IntActiQ9C086, 79 interactors
MINTiQ9C086
STRINGi9606.ENSP00000233331

Structurei

3D structure databases

ProteinModelPortaliQ9C086
SMRiQ9C086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili213 – 245Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 50Lys-richAdd BLAST14
Compositional biasi145 – 149Poly-Glu5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri305 – 336HIT-typeAdd BLAST32

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IWBA Eukaryota
ENOG411078Z LUCA
GeneTreeiENSGT00390000001754
HOVERGENiHBG082450
InParanoidiQ9C086
KOiK11666
OrthoDBiEOG091G0FOR
PhylomeDBiQ9C086
TreeFamiTF105373

Family and domain databases

InterProiView protein in InterPro
IPR029523 INO80B/Ies2
IPR006880 INO80B_C
IPR007529 Znf_HIT
PANTHERiPTHR21561 PTHR21561, 1 hit
PfamiView protein in Pfam
PF04795 PAPA-1, 1 hit
PF04438 zf-HIT, 1 hit
SMARTiView protein in SMART
SM01406 PAPA-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLWRRGST SGAMEAPEPG EALELSLAGA HGHGVHKKKH KKHKKKHKKK
60 70 80 90 100
HHQEEDAGPT QPSPAKPQLK LKIKLGGQVL GTKSVPTFTV IPEGPRSPSP
110 120 130 140 150
LMVVDNEEEP MEGVPLEQYR AWLDEDSNLS PSPLRDLSGG LGGQEEEEEQ
160 170 180 190 200
RWLDALEKGE LDDNGDLKKE INERLLTARQ RALLQKARSQ PSPMLPLPVA
210 220 230 240 250
EGCPPPALTE EMLLKREERA RKRRLQAARR AEEHKNQTIE RLTKTAATSG
260 270 280 290 300
RGGRGGARGE RRGGRAAAPA PMVRYCSGAQ GSTLSFPPGV PAPTAVSQRP
310 320 330 340 350
SPSGPPPRCS VPGCPHPRRY ACSRTGQALC SLQCYRINLQ MRLGGPEGPG

SPLLAT
Length:356
Mass (Da):38,637
Last modified:May 5, 2009 - v2
Checksum:i235C836556B5F91F
GO

Sequence cautioni

The sequence BAB21111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → G in BAB21111 (PubMed:15556297).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055083152W → G. Corresponds to variant dbSNP:rs1054209Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005041 Genomic DNA No translation available.
BC050666 mRNA Translation: AAH50666.2
BC064425 mRNA Translation: AAH64425.2
AB054538 mRNA Translation: BAB21111.1 Different initiation.
CCDSiCCDS1942.2
RefSeqiNP_112578.2, NM_031288.3
UniGeneiHs.410786

Genome annotation databases

EnsembliENST00000233331; ENSP00000233331; ENSG00000115274
GeneIDi83444
KEGGihsa:83444
UCSCiuc002slg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIN80B_HUMAN
AccessioniPrimary (citable) accession number: Q9C086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 5, 2009
Last modified: February 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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