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Protein

INO80 complex subunit B

Gene

INO80B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces growth and cell cycle arrests at the G1 phase of the cell cycle.1 Publication
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri305 – 33632HIT-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5696394. DNA Damage Recognition in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
INO80 complex subunit B
Alternative name(s):
High mobility group AT-hook 1-like 4
IES2 homolog
Short name:
hIes2
PAP-1-associated protein 1
Short name:
PAPA-1
Zinc finger HIT domain-containing protein 4
Gene namesi
Name:INO80B
Synonyms:HMGA1L4, PAPA1, ZNHIT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:13324. INO80B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • Ino80 complex Source: UniProtKB
  • nucleolus Source: UniProtKB-SubCell
  • nucleus Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392117.

Polymorphism and mutation databases

BioMutaiINO80B.
DMDMi229462939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356INO80 complex subunit BPRO_0000173554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei99 – 991PhosphoserineBy similarity
Modified residuei127 – 1271PhosphoserineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei132 – 1321PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C086.
MaxQBiQ9C086.
PaxDbiQ9C086.
PRIDEiQ9C086.

PTM databases

iPTMnetiQ9C086.
PhosphoSiteiQ9C086.

Expressioni

Gene expression databases

BgeeiQ9C086.
CleanExiHS_INO80B.
ExpressionAtlasiQ9C086. baseline and differential.
GenevisibleiQ9C086. HS.

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with RP9.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGFBP2P180654EBI-715611,EBI-2504392
PNMA1Q8ND903EBI-715611,EBI-302345
SSX2IPQ9Y2D83EBI-715611,EBI-2212028

Protein-protein interaction databases

BioGridi123646. 23 interactions.
IntActiQ9C086. 25 interactions.
MINTiMINT-1401219.
STRINGi9606.ENSP00000233331.

Structurei

3D structure databases

ProteinModelPortaliQ9C086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili213 – 24533Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 5014Lys-richAdd
BLAST
Compositional biasi145 – 1495Poly-Glu

Sequence similaritiesi

Contains 1 HIT-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri305 – 33632HIT-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IWBA. Eukaryota.
ENOG411078Z. LUCA.
GeneTreeiENSGT00390000001754.
HOVERGENiHBG082450.
InParanoidiQ9C086.
KOiK11666.
PhylomeDBiQ9C086.
TreeFamiTF105373.

Family and domain databases

InterProiIPR029523. INO80B/Ies2.
IPR006880. INO80B_C.
IPR007529. Znf_HIT.
[Graphical view]
PANTHERiPTHR21561. PTHR21561. 1 hit.
PfamiPF04795. PAPA-1. 1 hit.
PF04438. zf-HIT. 1 hit.
[Graphical view]
SMARTiSM01406. PAPA-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLWRRGST SGAMEAPEPG EALELSLAGA HGHGVHKKKH KKHKKKHKKK
60 70 80 90 100
HHQEEDAGPT QPSPAKPQLK LKIKLGGQVL GTKSVPTFTV IPEGPRSPSP
110 120 130 140 150
LMVVDNEEEP MEGVPLEQYR AWLDEDSNLS PSPLRDLSGG LGGQEEEEEQ
160 170 180 190 200
RWLDALEKGE LDDNGDLKKE INERLLTARQ RALLQKARSQ PSPMLPLPVA
210 220 230 240 250
EGCPPPALTE EMLLKREERA RKRRLQAARR AEEHKNQTIE RLTKTAATSG
260 270 280 290 300
RGGRGGARGE RRGGRAAAPA PMVRYCSGAQ GSTLSFPPGV PAPTAVSQRP
310 320 330 340 350
SPSGPPPRCS VPGCPHPRRY ACSRTGQALC SLQCYRINLQ MRLGGPEGPG

SPLLAT
Length:356
Mass (Da):38,637
Last modified:May 5, 2009 - v2
Checksum:i235C836556B5F91F
GO

Sequence cautioni

The sequence BAB21111.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → G in BAB21111 (PubMed:15556297).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521W → G.
Corresponds to variant rs1054209 [ dbSNP | Ensembl ].
VAR_055083

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005041 Genomic DNA. No translation available.
BC050666 mRNA. Translation: AAH50666.2.
BC064425 mRNA. Translation: AAH64425.2.
AB054538 mRNA. Translation: BAB21111.1. Different initiation.
CCDSiCCDS1942.2.
RefSeqiNP_112578.2. NM_031288.3.
UniGeneiHs.410786.

Genome annotation databases

EnsembliENST00000233331; ENSP00000233331; ENSG00000115274.
GeneIDi83444.
KEGGihsa:83444.
UCSCiuc002slg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005041 Genomic DNA. No translation available.
BC050666 mRNA. Translation: AAH50666.2.
BC064425 mRNA. Translation: AAH64425.2.
AB054538 mRNA. Translation: BAB21111.1. Different initiation.
CCDSiCCDS1942.2.
RefSeqiNP_112578.2. NM_031288.3.
UniGeneiHs.410786.

3D structure databases

ProteinModelPortaliQ9C086.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123646. 23 interactions.
IntActiQ9C086. 25 interactions.
MINTiMINT-1401219.
STRINGi9606.ENSP00000233331.

PTM databases

iPTMnetiQ9C086.
PhosphoSiteiQ9C086.

Polymorphism and mutation databases

BioMutaiINO80B.
DMDMi229462939.

Proteomic databases

EPDiQ9C086.
MaxQBiQ9C086.
PaxDbiQ9C086.
PRIDEiQ9C086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233331; ENSP00000233331; ENSG00000115274.
GeneIDi83444.
KEGGihsa:83444.
UCSCiuc002slg.3. human.

Organism-specific databases

CTDi83444.
GeneCardsiINO80B.
HGNCiHGNC:13324. INO80B.
MIMi616456. gene.
neXtProtiNX_Q9C086.
PharmGKBiPA162392117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWBA. Eukaryota.
ENOG411078Z. LUCA.
GeneTreeiENSGT00390000001754.
HOVERGENiHBG082450.
InParanoidiQ9C086.
KOiK11666.
PhylomeDBiQ9C086.
TreeFamiTF105373.

Enzyme and pathway databases

ReactomeiR-HSA-5696394. DNA Damage Recognition in GG-NER.

Miscellaneous databases

ChiTaRSiINO80B. human.
GenomeRNAii83444.
PROiQ9C086.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C086.
CleanExiHS_INO80B.
ExpressionAtlasiQ9C086. baseline and differential.
GenevisibleiQ9C086. HS.

Family and domain databases

InterProiIPR029523. INO80B/Ies2.
IPR006880. INO80B_C.
IPR007529. Znf_HIT.
[Graphical view]
PANTHERiPTHR21561. PTHR21561. 1 hit.
PfamiPF04795. PAPA-1. 1 hit.
PF04438. zf-HIT. 1 hit.
[Graphical view]
SMARTiSM01406. PAPA-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Uterus.
  3. "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase."
    Kuroda T.S., Maita H., Tabata T., Taira T., Kitaura H., Ariga H., Iguchi-Ariga S.M.M.
    Gene 340:83-98(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-356, SUBCELLULAR LOCATION, INTERACTION WITH RP9, FUNCTION.
    Tissue: Colon tumor.
  4. Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
    Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W.
    Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
    Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.
    J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX.

Entry informationi

Entry nameiIN80B_HUMAN
AccessioniPrimary (citable) accession number: Q9C086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.