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Protein

Keratin, type I cytoskeletal 23

Gene

KRT23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108244-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name:
CK-23
Keratin-23
Short name:
K23
Gene namesi
Name:KRT23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6438. KRT23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi25984.
OpenTargetsiENSG00000108244.
ENSG00000263309.
PharmGKBiPA134914537.

Polymorphism and mutation databases

BioMutaiKRT23.
DMDMi143811410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636771 – 422Keratin, type I cytoskeletal 23Add BLAST422

Proteomic databases

PaxDbiQ9C075.
PeptideAtlasiQ9C075.
PRIDEiQ9C075.

PTM databases

iPTMnetiQ9C075.
PhosphoSitePlusiQ9C075.
SwissPalmiQ9C075.

Expressioni

Gene expression databases

BgeeiENSG00000108244.
CleanExiHS_KRT23.
ExpressionAtlasiQ9C075. baseline and differential.
GenevisibleiQ9C075. HS.

Organism-specific databases

HPAiCAB017091.
HPA012050.
HPA016959.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Protein-protein interaction databases

BioGridi117467. 1 interactor.
IntActiQ9C075. 1 interactor.
STRINGi9606.ENSP00000209718.

Structurei

3D structure databases

ProteinModelPortaliQ9C075.
SMRiQ9C075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 71HeadAdd BLAST71
Regioni72 – 378RodAdd BLAST307
Regioni72 – 107Coil 1AAdd BLAST36
Regioni108 – 125Linker 1Add BLAST18
Regioni126 – 217Coil 1BAdd BLAST92
Regioni218 – 240Linker 12Add BLAST23
Regioni241 – 378Coil 2Add BLAST138
Regioni379 – 422Rod-like helical tailAdd BLAST44

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK9C. Eukaryota.
ENOG4111DWD. LUCA.
GeneTreeiENSGT00760000119046.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9C075.
KOiK07604.
OMAiDTWYKEQ.
OrthoDBiEOG091G087I.
PhylomeDBiQ9C075.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C075-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSGHSFSQT PSASFHGAGG GWGRPRSFPR APTVHGGAGG ARISLSFTTR
60 70 80 90 100
SCPPPGGSWG SGRSSPLLGG NGKATMQNLN DRLASYLEKV RALEEANMKL
110 120 130 140 150
ESRILKWHQQ RDPGSKKDYS QYEENITHLQ EQIVDGKMTN AQIILLIDNA
160 170 180 190 200
RMAVDDFNLK YENEHSFKKD LEIEVEGLRR TLDNLTIVTT DLEQEVEGMR
210 220 230 240 250
KELILMKKHH EQEMEKHHVP SDFNVNVKVD TGPREDLIKV LEDMRQEYEL
260 270 280 290 300
IIKKKHRDLD TWYKEQSAAM SQEAASPATV QSRQGDIHEL KRTFQALEID
310 320 330 340 350
LQTQYSTKSA LENMLSETQS RYSCKLQDMQ EIISHYEEEL TQLRHELERQ
360 370 380 390 400
NNEYQVLLGI KTHLEKEITT YRRLLEGESE GTREESKSSM KVSATPKIKA
410 420
ITQETINGRL VLCQVNEIQK HA
Length:422
Mass (Da):48,131
Last modified:April 3, 2007 - v2
Checksum:iA43876CCBA9CBE7D
GO
Isoform 2 (identifier: Q9C075-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):33,341
Checksum:i66974FC5BAB7C436
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137K → N in AAK00050 (PubMed:11135429).Curated1
Sequence conflicti208K → E in BAA92054 (PubMed:14702039).Curated1
Sequence conflicti216K → E in BAA92054 (PubMed:14702039).Curated1
Sequence conflicti322Y → N in AAK00050 (PubMed:11135429).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031608303T → A.1 PublicationCorresponds to variant rs9257dbSNPEnsembl.1
Natural variantiVAR_049785393S → F.Corresponds to variant rs17856805dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556621 – 137Missing in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102848 mRNA. Translation: AAK00050.1.
AK002047 mRNA. Translation: BAA92054.1.
AK289449 mRNA. Translation: BAF82138.1.
AK302109 mRNA. Translation: BAH13628.1.
AC004231 Genomic DNA. No translation available.
CCDSiCCDS11380.1. [Q9C075-1]
CCDS62182.1. [Q9C075-2]
RefSeqiNP_001269362.1. NM_001282433.1. [Q9C075-2]
NP_056330.3. NM_015515.4. [Q9C075-1]
XP_005257257.1. XM_005257200.4. [Q9C075-2]
XP_011522897.1. XM_011524595.1. [Q9C075-2]
UniGeneiHs.9029.

Genome annotation databases

EnsembliENST00000209718; ENSP00000209718; ENSG00000108244. [Q9C075-1]
ENST00000436344; ENSP00000414056; ENSG00000108244. [Q9C075-2]
ENST00000571258; ENSP00000460637; ENSG00000263309. [Q9C075-2]
ENST00000574480; ENSP00000459021; ENSG00000263309. [Q9C075-1]
GeneIDi25984.
KEGGihsa:25984.
UCSCiuc002hvm.3. human. [Q9C075-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102848 mRNA. Translation: AAK00050.1.
AK002047 mRNA. Translation: BAA92054.1.
AK289449 mRNA. Translation: BAF82138.1.
AK302109 mRNA. Translation: BAH13628.1.
AC004231 Genomic DNA. No translation available.
CCDSiCCDS11380.1. [Q9C075-1]
CCDS62182.1. [Q9C075-2]
RefSeqiNP_001269362.1. NM_001282433.1. [Q9C075-2]
NP_056330.3. NM_015515.4. [Q9C075-1]
XP_005257257.1. XM_005257200.4. [Q9C075-2]
XP_011522897.1. XM_011524595.1. [Q9C075-2]
UniGeneiHs.9029.

3D structure databases

ProteinModelPortaliQ9C075.
SMRiQ9C075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117467. 1 interactor.
IntActiQ9C075. 1 interactor.
STRINGi9606.ENSP00000209718.

PTM databases

iPTMnetiQ9C075.
PhosphoSitePlusiQ9C075.
SwissPalmiQ9C075.

Polymorphism and mutation databases

BioMutaiKRT23.
DMDMi143811410.

Proteomic databases

PaxDbiQ9C075.
PeptideAtlasiQ9C075.
PRIDEiQ9C075.

Protocols and materials databases

DNASUi25984.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000209718; ENSP00000209718; ENSG00000108244. [Q9C075-1]
ENST00000436344; ENSP00000414056; ENSG00000108244. [Q9C075-2]
ENST00000571258; ENSP00000460637; ENSG00000263309. [Q9C075-2]
ENST00000574480; ENSP00000459021; ENSG00000263309. [Q9C075-1]
GeneIDi25984.
KEGGihsa:25984.
UCSCiuc002hvm.3. human. [Q9C075-1]

Organism-specific databases

CTDi25984.
DisGeNETi25984.
GeneCardsiKRT23.
HGNCiHGNC:6438. KRT23.
HPAiCAB017091.
HPA012050.
HPA016959.
MIMi606194. gene.
neXtProtiNX_Q9C075.
OpenTargetsiENSG00000108244.
ENSG00000263309.
PharmGKBiPA134914537.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK9C. Eukaryota.
ENOG4111DWD. LUCA.
GeneTreeiENSGT00760000119046.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9C075.
KOiK07604.
OMAiDTWYKEQ.
OrthoDBiEOG091G087I.
PhylomeDBiQ9C075.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108244-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiKRT23. human.
GeneWikiiKRT23.
GenomeRNAii25984.
PROiQ9C075.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108244.
CleanExiHS_KRT23.
ExpressionAtlasiQ9C075. baseline and differential.
GenevisibleiQ9C075. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C23_HUMAN
AccessioniPrimary (citable) accession number: Q9C075
Secondary accession number(s): A8K084
, B7Z7J2, I3L3Q6, Q9NUR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.