Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9C075

- K1C23_HUMAN

UniProt

Q9C075 - K1C23_HUMAN

Protein

Keratin, type I cytoskeletal 23

Gene

KRT23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cytoskeletal 23
    Alternative name(s):
    Cytokeratin-23
    Short name:
    CK-23
    Keratin-23
    Short name:
    K23
    Gene namesi
    Name:KRT23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6438. KRT23.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Keratin, type I cytoskeletal 23PRO_0000063677Add
    BLAST

    Proteomic databases

    MaxQBiQ9C075.
    PaxDbiQ9C075.
    PRIDEiQ9C075.

    PTM databases

    PhosphoSiteiQ9C075.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C075.
    BgeeiQ9C075.
    CleanExiHS_KRT23.
    GenevestigatoriQ9C075.

    Organism-specific databases

    HPAiCAB017091.
    HPA012050.
    HPA016959.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.By similarity

    Protein-protein interaction databases

    BioGridi117467. 2 interactions.
    IntActiQ9C075. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C075.
    SMRiQ9C075. Positions 289-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7171HeadAdd
    BLAST
    Regioni72 – 378307RodAdd
    BLAST
    Regioni72 – 10736Coil 1AAdd
    BLAST
    Regioni108 – 12518Linker 1Add
    BLAST
    Regioni126 – 21792Coil 1BAdd
    BLAST
    Regioni218 – 24023Linker 12Add
    BLAST
    Regioni241 – 378138Coil 2Add
    BLAST
    Regioni379 – 42244Rod-like helical tailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG145955.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ9C075.
    KOiK07604.
    OMAiKAITQES.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ9C075.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C075-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSGHSFSQT PSASFHGAGG GWGRPRSFPR APTVHGGAGG ARISLSFTTR    50
    SCPPPGGSWG SGRSSPLLGG NGKATMQNLN DRLASYLEKV RALEEANMKL 100
    ESRILKWHQQ RDPGSKKDYS QYEENITHLQ EQIVDGKMTN AQIILLIDNA 150
    RMAVDDFNLK YENEHSFKKD LEIEVEGLRR TLDNLTIVTT DLEQEVEGMR 200
    KELILMKKHH EQEMEKHHVP SDFNVNVKVD TGPREDLIKV LEDMRQEYEL 250
    IIKKKHRDLD TWYKEQSAAM SQEAASPATV QSRQGDIHEL KRTFQALEID 300
    LQTQYSTKSA LENMLSETQS RYSCKLQDMQ EIISHYEEEL TQLRHELERQ 350
    NNEYQVLLGI KTHLEKEITT YRRLLEGESE GTREESKSSM KVSATPKIKA 400
    ITQETINGRL VLCQVNEIQK HA 422
    Length:422
    Mass (Da):48,131
    Last modified:April 3, 2007 - v2
    Checksum:iA43876CCBA9CBE7D
    GO
    Isoform 2 (identifier: Q9C075-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-137: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:285
    Mass (Da):33,341
    Checksum:i66974FC5BAB7C436
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371K → N in AAK00050. (PubMed:11135429)Curated
    Sequence conflicti208 – 2081K → E in BAA92054. (PubMed:14702039)Curated
    Sequence conflicti216 – 2161K → E in BAA92054. (PubMed:14702039)Curated
    Sequence conflicti322 – 3221Y → N in AAK00050. (PubMed:11135429)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031T → A.1 Publication
    Corresponds to variant rs9257 [ dbSNP | Ensembl ].
    VAR_031608
    Natural varianti393 – 3931S → F.
    Corresponds to variant rs17856805 [ dbSNP | Ensembl ].
    VAR_049785

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 137137Missing in isoform 2. 1 PublicationVSP_055662Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102848 mRNA. Translation: AAK00050.1.
    AK002047 mRNA. Translation: BAA92054.1.
    AK289449 mRNA. Translation: BAF82138.1.
    AK302109 mRNA. Translation: BAH13628.1.
    AC004231 Genomic DNA. No translation available.
    CCDSiCCDS11380.1.
    RefSeqiNP_056330.3. NM_015515.4.
    UniGeneiHs.9029.

    Genome annotation databases

    EnsembliENST00000209718; ENSP00000209718; ENSG00000108244. [Q9C075-1]
    ENST00000436344; ENSP00000414056; ENSG00000108244. [Q9C075-2]
    ENST00000571258; ENSP00000460637; ENSG00000263309. [Q9C075-2]
    ENST00000574480; ENSP00000459021; ENSG00000263309. [Q9C075-1]
    GeneIDi25984.
    KEGGihsa:25984.
    UCSCiuc002hvm.1. human.

    Polymorphism databases

    DMDMi143811410.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102848 mRNA. Translation: AAK00050.1 .
    AK002047 mRNA. Translation: BAA92054.1 .
    AK289449 mRNA. Translation: BAF82138.1 .
    AK302109 mRNA. Translation: BAH13628.1 .
    AC004231 Genomic DNA. No translation available.
    CCDSi CCDS11380.1.
    RefSeqi NP_056330.3. NM_015515.4.
    UniGenei Hs.9029.

    3D structure databases

    ProteinModelPortali Q9C075.
    SMRi Q9C075. Positions 289-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117467. 2 interactions.
    IntActi Q9C075. 1 interaction.

    PTM databases

    PhosphoSitei Q9C075.

    Polymorphism databases

    DMDMi 143811410.

    Proteomic databases

    MaxQBi Q9C075.
    PaxDbi Q9C075.
    PRIDEi Q9C075.

    Protocols and materials databases

    DNASUi 25984.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000209718 ; ENSP00000209718 ; ENSG00000108244 . [Q9C075-1 ]
    ENST00000436344 ; ENSP00000414056 ; ENSG00000108244 . [Q9C075-2 ]
    ENST00000571258 ; ENSP00000460637 ; ENSG00000263309 . [Q9C075-2 ]
    ENST00000574480 ; ENSP00000459021 ; ENSG00000263309 . [Q9C075-1 ]
    GeneIDi 25984.
    KEGGi hsa:25984.
    UCSCi uc002hvm.1. human.

    Organism-specific databases

    CTDi 25984.
    GeneCardsi GC17M039078.
    HGNCi HGNC:6438. KRT23.
    HPAi CAB017091.
    HPA012050.
    HPA016959.
    MIMi 606194. gene.
    neXtProti NX_Q9C075.
    PharmGKBi PA134914537.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145955.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q9C075.
    KOi K07604.
    OMAi KAITQES.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q9C075.
    TreeFami TF332742.

    Miscellaneous databases

    ChiTaRSi KRT23. human.
    GeneWikii KRT23.
    GenomeRNAii 25984.
    NextBioi 47672.
    PROi Q9C075.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C075.
    Bgeei Q9C075.
    CleanExi HS_KRT23.
    Genevestigatori Q9C075.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells."
      Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I.
      Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-303.
      Tissue: Placenta, Testis and Urinary bladder.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiK1C23_HUMAN
    AccessioniPrimary (citable) accession number: Q9C075
    Secondary accession number(s): A8K084
    , B7Z7J2, I3L3Q6, Q9NUR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3