Q9C075 (K1C23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cytoskeletal 23

Alternative name(s):
Cytokeratin-23
Short name=CK-23
Keratin-23
Short name=K23

Gene names

Name:

KRT23

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins By similarity.
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Keratin, type I cytoskeletal 23		PRO_0000063677
Regions
	Region	1 – 71	71	Head
	Region	72 – 378	307	Rod
	Region	72 – 107	36	Coil 1A
	Region	108 – 125	18	Linker 1
	Region	126 – 217	92	Coil 1B
	Region	218 – 240	23	Linker 12
	Region	241 – 378	138	Coil 2
	Region	379 – 422	44	Rod-like helical tail
Natural variations
	Natural variant	303	1	T → A. Ref.2 Corresponds to variant rs9257 [ dbSNP | Ensembl ].		VAR_031608
	Natural variant	393	1	S → F. Corresponds to variant rs17856805 [ dbSNP | Ensembl ].		VAR_049785
Experimental info
	Sequence conflict	137	1	K → N in AAK00050. Ref.1
	Sequence conflict	208	1	K → E in BAA92054. Ref.2
	Sequence conflict	216	1	K → E in BAA92054. Ref.2
	Sequence conflict	322	1	Y → N in AAK00050. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9C075 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: A43876CCBA9CBE7D	FASTA	422	48,131
	10 20 30 40 50 60 MNSGHSFSQT PSASFHGAGG GWGRPRSFPR APTVHGGAGG ARISLSFTTR SCPPPGGSWG 70 80 90 100 110 120 SGRSSPLLGG NGKATMQNLN DRLASYLEKV RALEEANMKL ESRILKWHQQ RDPGSKKDYS 130 140 150 160 170 180 QYEENITHLQ EQIVDGKMTN AQIILLIDNA RMAVDDFNLK YENEHSFKKD LEIEVEGLRR 190 200 210 220 230 240 TLDNLTIVTT DLEQEVEGMR KELILMKKHH EQEMEKHHVP SDFNVNVKVD TGPREDLIKV 250 260 270 280 290 300 LEDMRQEYEL IIKKKHRDLD TWYKEQSAAM SQEAASPATV QSRQGDIHEL KRTFQALEID 310 320 330 340 350 360 LQTQYSTKSA LENMLSETQS RYSCKLQDMQ EIISHYEEEL TQLRHELERQ NNEYQVLLGI 370 380 390 400 410 420 KTHLEKEITT YRRLLEGESE GTREESKSSM KVSATPKIKA ITQETINGRL VLCQVNEIQK HA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells." Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I. Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-303. Tissue: Placenta and Urinary bladder.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF102848 mRNA. Translation: AAK00050.1. AK002047 mRNA. Translation: BAA92054.1. AK289449 mRNA. Translation: BAF82138.1.
IPI	IPI00304458.
RefSeq	NP_056330.3. NM_015515.3.
UniGene	Hs.9029.
3D structure databases
ProteinModelPortal	Q9C075.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9C075. 1 interaction.
PTM databases
PhosphoSite	Q9C075.
Polymorphism databases
DMDM	143811410.
Proteomic databases
PaxDb	Q9C075.
PRIDE	Q9C075.
Protocols and materials databases
DNASU	25984.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000209718; ENSP00000209718; ENSG00000108244. ENST00000574480; ENSP00000459021; ENSG00000263309.
GeneID	25984.
KEGG	hsa:25984.
UCSC	uc002hvm.1. human.
Organism-specific databases
CTD	25984.
GeneCards	GC17M039078.
HGNC	HGNC:6438. KRT23.
HPA	CAB017091. HPA012050. HPA016959.
MIM	606194. gene.
neXtProt	NX_Q9C075.
PharmGKB	PA134914537.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG145955.
HOGENOM	HOG000230975.
HOVERGEN	HBG013015.
InParanoid	Q9C075.
KO	K07604.
OMA	LILMKKH.
OrthoDB	EOG4001JS.
PhylomeDB	Q9C075.
Gene expression databases
ArrayExpress	Q9C075.
Bgee	Q9C075.
CleanEx	HS_KRT23.
Genevestigator	Q9C075.
GermOnline	ENSG00000108244. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KRT23. human.
GenomeRNAi	25984.
NextBio	47672.
SOURCE	Search...

Entry information

Entry name

K1C23_HUMAN

Accession

Primary (citable) accession number: Q9C075
Secondary accession number(s): A8K084, Q9NUR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.