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Q9C075 (K1C23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name=CK-23
Keratin-23
Short name=K23
Gene names
Name:KRT23
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins By similarity.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Keratin, type I cytoskeletal 23
PRO_0000063677

Regions

Region1 – 7171Head
Region72 – 378307Rod
Region72 – 10736Coil 1A
Region108 – 12518Linker 1
Region126 – 21792Coil 1B
Region218 – 24023Linker 12
Region241 – 378138Coil 2
Region379 – 42244Rod-like helical tail

Natural variations

Natural variant3031T → A. Ref.2
Corresponds to variant rs9257 [ dbSNP | Ensembl ].
VAR_031608
Natural variant3931S → F.
Corresponds to variant rs17856805 [ dbSNP | Ensembl ].
VAR_049785

Experimental info

Sequence conflict1371K → N in AAK00050. Ref.1
Sequence conflict2081K → E in BAA92054. Ref.2
Sequence conflict2161K → E in BAA92054. Ref.2
Sequence conflict3221Y → N in AAK00050. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9C075 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: A43876CCBA9CBE7D

FASTA42248,131
        10         20         30         40         50         60 
MNSGHSFSQT PSASFHGAGG GWGRPRSFPR APTVHGGAGG ARISLSFTTR SCPPPGGSWG 

        70         80         90        100        110        120 
SGRSSPLLGG NGKATMQNLN DRLASYLEKV RALEEANMKL ESRILKWHQQ RDPGSKKDYS 

       130        140        150        160        170        180 
QYEENITHLQ EQIVDGKMTN AQIILLIDNA RMAVDDFNLK YENEHSFKKD LEIEVEGLRR 

       190        200        210        220        230        240 
TLDNLTIVTT DLEQEVEGMR KELILMKKHH EQEMEKHHVP SDFNVNVKVD TGPREDLIKV 

       250        260        270        280        290        300 
LEDMRQEYEL IIKKKHRDLD TWYKEQSAAM SQEAASPATV QSRQGDIHEL KRTFQALEID 

       310        320        330        340        350        360 
LQTQYSTKSA LENMLSETQS RYSCKLQDMQ EIISHYEEEL TQLRHELERQ NNEYQVLLGI 

       370        380        390        400        410        420 
KTHLEKEITT YRRLLEGESE GTREESKSSM KVSATPKIKA ITQETINGRL VLCQVNEIQK 


HA 

« Hide

References

« Hide 'large scale' references
[1]"Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells."
Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I.
Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-303.
Tissue: Placenta and Urinary bladder.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF102848 mRNA. Translation: AAK00050.1.
AK002047 mRNA. Translation: BAA92054.1.
AK289449 mRNA. Translation: BAF82138.1.
CCDSCCDS11380.1.
RefSeqNP_056330.3. NM_015515.4.
UniGeneHs.9029.

3D structure databases

ProteinModelPortalQ9C075.
SMRQ9C075. Positions 289-377.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117467. 2 interactions.
IntActQ9C075. 1 interaction.

PTM databases

PhosphoSiteQ9C075.

Polymorphism databases

DMDM143811410.

Proteomic databases

MaxQBQ9C075.
PaxDbQ9C075.
PRIDEQ9C075.

Protocols and materials databases

DNASU25984.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000209718; ENSP00000209718; ENSG00000108244.
ENST00000574480; ENSP00000459021; ENSG00000263309.
GeneID25984.
KEGGhsa:25984.
UCSCuc002hvm.1. human.

Organism-specific databases

CTD25984.
GeneCardsGC17M039078.
HGNCHGNC:6438. KRT23.
HPACAB017091.
HPA012050.
HPA016959.
MIM606194. gene.
neXtProtNX_Q9C075.
PharmGKBPA134914537.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145955.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidQ9C075.
KOK07604.
OMAKAITQES.
PhylomeDBQ9C075.
TreeFamTF332742.

Gene expression databases

ArrayExpressQ9C075.
BgeeQ9C075.
CleanExHS_KRT23.
GenevestigatorQ9C075.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKRT23. human.
GeneWikiKRT23.
GenomeRNAi25984.
NextBio47672.
PROQ9C075.
SOURCESearch...

Entry information

Entry nameK1C23_HUMAN
AccessionPrimary (citable) accession number: Q9C075
Secondary accession number(s): A8K084, Q9NUR6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM