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Q9C075

- K1C23_HUMAN

UniProt

Q9C075 - K1C23_HUMAN

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Protein

Keratin, type I cytoskeletal 23

Gene

KRT23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name:
CK-23
Keratin-23
Short name:
K23
Gene namesi
Name:KRT23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6438. KRT23.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Keratin, type I cytoskeletal 23PRO_0000063677Add
BLAST

Proteomic databases

MaxQBiQ9C075.
PaxDbiQ9C075.
PRIDEiQ9C075.

PTM databases

PhosphoSiteiQ9C075.

Expressioni

Gene expression databases

BgeeiQ9C075.
CleanExiHS_KRT23.
ExpressionAtlasiQ9C075. baseline and differential.
GenevestigatoriQ9C075.

Organism-specific databases

HPAiCAB017091.
HPA012050.
HPA016959.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Protein-protein interaction databases

BioGridi117467. 2 interactions.
IntActiQ9C075. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9C075.
SMRiQ9C075. Positions 289-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7171HeadAdd
BLAST
Regioni72 – 378307RodAdd
BLAST
Regioni72 – 10736Coil 1AAdd
BLAST
Regioni108 – 12518Linker 1Add
BLAST
Regioni126 – 21792Coil 1BAdd
BLAST
Regioni218 – 24023Linker 12Add
BLAST
Regioni241 – 378138Coil 2Add
BLAST
Regioni379 – 42244Rod-like helical tailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG145955.
GeneTreeiENSGT00760000119046.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9C075.
KOiK07604.
OMAiKAITQES.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ9C075.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C075-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSGHSFSQT PSASFHGAGG GWGRPRSFPR APTVHGGAGG ARISLSFTTR
60 70 80 90 100
SCPPPGGSWG SGRSSPLLGG NGKATMQNLN DRLASYLEKV RALEEANMKL
110 120 130 140 150
ESRILKWHQQ RDPGSKKDYS QYEENITHLQ EQIVDGKMTN AQIILLIDNA
160 170 180 190 200
RMAVDDFNLK YENEHSFKKD LEIEVEGLRR TLDNLTIVTT DLEQEVEGMR
210 220 230 240 250
KELILMKKHH EQEMEKHHVP SDFNVNVKVD TGPREDLIKV LEDMRQEYEL
260 270 280 290 300
IIKKKHRDLD TWYKEQSAAM SQEAASPATV QSRQGDIHEL KRTFQALEID
310 320 330 340 350
LQTQYSTKSA LENMLSETQS RYSCKLQDMQ EIISHYEEEL TQLRHELERQ
360 370 380 390 400
NNEYQVLLGI KTHLEKEITT YRRLLEGESE GTREESKSSM KVSATPKIKA
410 420
ITQETINGRL VLCQVNEIQK HA
Length:422
Mass (Da):48,131
Last modified:April 3, 2007 - v2
Checksum:iA43876CCBA9CBE7D
GO
Isoform 2 (identifier: Q9C075-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.

Show »
Length:285
Mass (Da):33,341
Checksum:i66974FC5BAB7C436
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371K → N in AAK00050. (PubMed:11135429)Curated
Sequence conflicti208 – 2081K → E in BAA92054. (PubMed:14702039)Curated
Sequence conflicti216 – 2161K → E in BAA92054. (PubMed:14702039)Curated
Sequence conflicti322 – 3221Y → N in AAK00050. (PubMed:11135429)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti303 – 3031T → A.1 Publication
Corresponds to variant rs9257 [ dbSNP | Ensembl ].
VAR_031608
Natural varianti393 – 3931S → F.
Corresponds to variant rs17856805 [ dbSNP | Ensembl ].
VAR_049785

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 137137Missing in isoform 2. 1 PublicationVSP_055662Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102848 mRNA. Translation: AAK00050.1.
AK002047 mRNA. Translation: BAA92054.1.
AK289449 mRNA. Translation: BAF82138.1.
AK302109 mRNA. Translation: BAH13628.1.
AC004231 Genomic DNA. No translation available.
CCDSiCCDS11380.1. [Q9C075-1]
CCDS62182.1. [Q9C075-2]
RefSeqiNP_001269362.1. NM_001282433.1. [Q9C075-2]
NP_056330.3. NM_015515.4. [Q9C075-1]
XP_005257257.1. XM_005257200.2. [Q9C075-2]
XP_005277848.1. XM_005277791.2. [Q9C075-2]
UniGeneiHs.9029.

Genome annotation databases

EnsembliENST00000209718; ENSP00000209718; ENSG00000108244. [Q9C075-1]
ENST00000436344; ENSP00000414056; ENSG00000108244. [Q9C075-2]
ENST00000571258; ENSP00000460637; ENSG00000263309. [Q9C075-2]
ENST00000574480; ENSP00000459021; ENSG00000263309. [Q9C075-1]
GeneIDi25984.
KEGGihsa:25984.
UCSCiuc002hvm.1. human. [Q9C075-1]

Polymorphism databases

DMDMi143811410.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102848 mRNA. Translation: AAK00050.1 .
AK002047 mRNA. Translation: BAA92054.1 .
AK289449 mRNA. Translation: BAF82138.1 .
AK302109 mRNA. Translation: BAH13628.1 .
AC004231 Genomic DNA. No translation available.
CCDSi CCDS11380.1. [Q9C075-1 ]
CCDS62182.1. [Q9C075-2 ]
RefSeqi NP_001269362.1. NM_001282433.1. [Q9C075-2 ]
NP_056330.3. NM_015515.4. [Q9C075-1 ]
XP_005257257.1. XM_005257200.2. [Q9C075-2 ]
XP_005277848.1. XM_005277791.2. [Q9C075-2 ]
UniGenei Hs.9029.

3D structure databases

ProteinModelPortali Q9C075.
SMRi Q9C075. Positions 289-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117467. 2 interactions.
IntActi Q9C075. 1 interaction.

PTM databases

PhosphoSitei Q9C075.

Polymorphism databases

DMDMi 143811410.

Proteomic databases

MaxQBi Q9C075.
PaxDbi Q9C075.
PRIDEi Q9C075.

Protocols and materials databases

DNASUi 25984.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000209718 ; ENSP00000209718 ; ENSG00000108244 . [Q9C075-1 ]
ENST00000436344 ; ENSP00000414056 ; ENSG00000108244 . [Q9C075-2 ]
ENST00000571258 ; ENSP00000460637 ; ENSG00000263309 . [Q9C075-2 ]
ENST00000574480 ; ENSP00000459021 ; ENSG00000263309 . [Q9C075-1 ]
GeneIDi 25984.
KEGGi hsa:25984.
UCSCi uc002hvm.1. human. [Q9C075-1 ]

Organism-specific databases

CTDi 25984.
GeneCardsi GC17M039078.
HGNCi HGNC:6438. KRT23.
HPAi CAB017091.
HPA012050.
HPA016959.
MIMi 606194. gene.
neXtProti NX_Q9C075.
PharmGKBi PA134914537.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145955.
GeneTreei ENSGT00760000119046.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi Q9C075.
KOi K07604.
OMAi KAITQES.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q9C075.
TreeFami TF332742.

Miscellaneous databases

ChiTaRSi KRT23. human.
GeneWikii KRT23.
GenomeRNAii 25984.
NextBioi 35480241.
PROi Q9C075.
SOURCEi Search...

Gene expression databases

Bgeei Q9C075.
CleanExi HS_KRT23.
ExpressionAtlasi Q9C075. baseline and differential.
Genevestigatori Q9C075.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells."
    Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I.
    Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-303.
    Tissue: Placenta, Testis and Urinary bladder.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiK1C23_HUMAN
AccessioniPrimary (citable) accession number: Q9C075
Secondary accession number(s): A8K084
, B7Z7J2, I3L3Q6, Q9NUR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3