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Protein

Protein FAM117A

Gene

FAM117A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121104-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM117A
Alternative name(s):
C/EBP-induced protein
Gene namesi
Name:FAM117A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24179. FAM117A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi81558.
OpenTargetsiENSG00000121104.
PharmGKBiPA145008393.

Polymorphism and mutation databases

BioMutaiFAM117A.
DMDMi74733494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002649881 – 453Protein FAM117AAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei299PhosphothreonineCombined sources1
Modified residuei319PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei413PhosphoserineBy similarity1
Modified residuei428PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C073.
MaxQBiQ9C073.
PaxDbiQ9C073.
PeptideAtlasiQ9C073.
PRIDEiQ9C073.

PTM databases

iPTMnetiQ9C073.
PhosphoSitePlusiQ9C073.

Expressioni

Gene expression databases

BgeeiENSG00000121104.
CleanExiHS_FAM117A.
ExpressionAtlasiQ9C073. baseline and differential.
GenevisibleiQ9C073. HS.

Organism-specific databases

HPAiHPA022531.

Interactioni

Protein-protein interaction databases

BioGridi123522. 3 interactors.
IntActiQ9C073. 2 interactors.
STRINGi9606.ENSP00000240364.

Structurei

3D structure databases

ProteinModelPortaliQ9C073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 175Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi402 – 444Pro-richAdd BLAST43

Sequence similaritiesi

Belongs to the FAM117 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00390000005655.
HOGENOMiHOG000252927.
HOVERGENiHBG079782.
InParanoidiQ9C073.
OMAiPPQSGSC.
OrthoDBiEOG091G0B78.
PhylomeDBiQ9C073.
TreeFamiTF333159.

Family and domain databases

InterProiIPR026642. Glcci1/FAM117.
[Graphical view]
PANTHERiPTHR14972. PTHR14972. 1 hit.
PfamiPF15388. FAM117. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C073-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAAAGGRG GGAWGPGRGG AGGLRRGCSP PAPAGSPRAG LQPLRATIPF
60 70 80 90 100
QLQQPHQRRD GGGRAASVPC SVAPEKSVCR PQPLQVRRTF SLDTILSSYL
110 120 130 140 150
LGQWPRDADG AFTCCTNDKA TQTPLSWQEL EGERASSCAH KRSASWGSTD
160 170 180 190 200
HRKEISKLKQ QLQRTKLSRS GKEKERGSPL LGDHAVRGAL RASPPSFPSG
210 220 230 240 250
SPVLRLSPCL HRSLEGLNQE LEEVFVKEQG EEELLRILDI PDGHRAPAPP
260 270 280 290 300
QSGSCDHPLL LLEPGNLASS PSMSLASPQP CGLASHEEHR GAAEELASTP
310 320 330 340 350
NDKASSPGHP AFLEDGSPSP VLAFAASPRP NHSYIFKREP PEGCEKVRVF
360 370 380 390 400
EEATSPGPDL AFLTSCPDKN KVHFNPTGSA FCPVNLMKPL FPGMGFIFRN
410 420 430 440 450
CPSNPGSPLP PASPRPPPRK DPEASKASPL PFEPWQRTPP SEEPVLFQSS

LMV
Length:453
Mass (Da):48,319
Last modified:June 1, 2001 - v1
Checksum:i93B83B4E293BBC7E
GO
Isoform 2 (identifier: Q9C073-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-272: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):19,436
Checksum:iBDE1115CA65EBA3D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561291 – 272Missing in isoform 2. 1 PublicationAdd BLAST272

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123073 mRNA. Translation: AAK01477.1.
AK302376 mRNA. Translation: BAH13689.1.
AC015795 Genomic DNA. No translation available.
BC037572 mRNA. Translation: AAH37572.1.
BC065199 mRNA. Translation: AAH65199.1.
CCDSiCCDS11553.1. [Q9C073-1]
RefSeqiNP_110429.1. NM_030802.3. [Q9C073-1]
UniGeneiHs.514308.

Genome annotation databases

EnsembliENST00000240364; ENSP00000240364; ENSG00000121104. [Q9C073-1]
ENST00000513602; ENSP00000465808; ENSG00000121104. [Q9C073-2]
GeneIDi81558.
KEGGihsa:81558.
UCSCiuc002ipk.4. human. [Q9C073-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123073 mRNA. Translation: AAK01477.1.
AK302376 mRNA. Translation: BAH13689.1.
AC015795 Genomic DNA. No translation available.
BC037572 mRNA. Translation: AAH37572.1.
BC065199 mRNA. Translation: AAH65199.1.
CCDSiCCDS11553.1. [Q9C073-1]
RefSeqiNP_110429.1. NM_030802.3. [Q9C073-1]
UniGeneiHs.514308.

3D structure databases

ProteinModelPortaliQ9C073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123522. 3 interactors.
IntActiQ9C073. 2 interactors.
STRINGi9606.ENSP00000240364.

PTM databases

iPTMnetiQ9C073.
PhosphoSitePlusiQ9C073.

Polymorphism and mutation databases

BioMutaiFAM117A.
DMDMi74733494.

Proteomic databases

EPDiQ9C073.
MaxQBiQ9C073.
PaxDbiQ9C073.
PeptideAtlasiQ9C073.
PRIDEiQ9C073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240364; ENSP00000240364; ENSG00000121104. [Q9C073-1]
ENST00000513602; ENSP00000465808; ENSG00000121104. [Q9C073-2]
GeneIDi81558.
KEGGihsa:81558.
UCSCiuc002ipk.4. human. [Q9C073-1]

Organism-specific databases

CTDi81558.
DisGeNETi81558.
GeneCardsiFAM117A.
HGNCiHGNC:24179. FAM117A.
HPAiHPA022531.
neXtProtiNX_Q9C073.
OpenTargetsiENSG00000121104.
PharmGKBiPA145008393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00390000005655.
HOGENOMiHOG000252927.
HOVERGENiHBG079782.
InParanoidiQ9C073.
OMAiPPQSGSC.
OrthoDBiEOG091G0B78.
PhylomeDBiQ9C073.
TreeFamiTF333159.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121104-MONOMER.

Miscellaneous databases

GenomeRNAii81558.
PROiQ9C073.

Gene expression databases

BgeeiENSG00000121104.
CleanExiHS_FAM117A.
ExpressionAtlasiQ9C073. baseline and differential.
GenevisibleiQ9C073. HS.

Family and domain databases

InterProiIPR026642. Glcci1/FAM117.
[Graphical view]
PANTHERiPTHR14972. PTHR14972. 1 hit.
PfamiPF15388. FAM117. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF117A_HUMAN
AccessioniPrimary (citable) accession number: Q9C073
Secondary accession number(s): B7Z7Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.