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Q9C037 (TRIM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 4
Alternative name(s):
RING finger protein 87
Gene names
Name:TRIM4
Synonyms:RNF87
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein trimerization

Inferred from direct assay PubMed 17156811. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 17156811Ref.1. Source: UniProtKB

plasma membrane

Inferred from direct assay. Source: HPA

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q9C037-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q9C037-2)

The sequence of this isoform differs from the canonical sequence as follows:
     132-157: Missing.
Isoform Gamma (identifier: Q9C037-3)

The sequence of this isoform differs from the canonical sequence as follows:
     132-157: Missing.
     307-320: VAVNLAEDTAHPKL → ATKIKTQKQNRHNM
     321-500: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Tripartite motif-containing protein 4
PRO_0000056200

Regions

Domain288 – 500213B30.2/SPRY
Zinc finger12 – 5342RING-type
Zinc finger82 – 12342B box-type
Coiled coil212 – 25342 Potential

Natural variations

Alternative sequence132 – 15726Missing in isoform Beta and isoform Gamma.
VSP_010197
Alternative sequence307 – 32014VAVNL…AHPKL → ATKIKTQKQNRHNM in isoform Gamma.
VSP_010198
Alternative sequence321 – 500180Missing in isoform Gamma.
VSP_010199
Natural variant3671P → S.
Corresponds to variant rs35432946 [ dbSNP | Ensembl ].
VAR_046715
Natural variant4741S → C.
Corresponds to variant rs33998596 [ dbSNP | Ensembl ].
VAR_046716

Experimental info

Sequence conflict1541F → S in AAG53477. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 427D7F3DBF53A72C

FASTA50057,461
        10         20         30         40         50         60 
MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA 

        70         80         90        100        110        120 
LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM 

       130        140        150        160        170        180 
APIDEAFESY RTGNFDIHVD EWKRRLIRLL LYHFKQEEKL LKSQRNLVAK MKKVMHLQDV 

       190        200        210        220        230        240 
EVKNATQWKD KIKSQRMRIS TEFSKLHNFL VEEEDLFLQR LNKEEEETKK KLNENTLKLN 

       250        260        270        280        290        300 
QTIASLKKLI LEVGEKSQAP TLELLQNPKE VLTRSEIQDV NYSLEAVKVK TVCQIPLMKE 

       310        320        330        340        350        360 
MLKRFQVAVN LAEDTAHPKL VFSQEGRYVK NTASASSWPV FSSAWNYFAG WRNPQKTAFV 

       370        380        390        400        410        420 
ERFQHLPCVL GKNVFTSGKH YWEVESRDSL EVAVGVCRED VMGITDRSKM SPDVGIWAIY 

       430        440        450        460        470        480 
WSAAGYWPLI GFPGTPTQQE PALHRVGVYL DRGTGNVSFY SAVDGVHLHT FSCSSVSRLR 

       490        500 
PFFWLSPLAS LVIPPVTDRK 

« Hide

Isoform Beta [UniParc].

Checksum: B8C2FB94B2E2183E
Show »

FASTA47454,151
Isoform Gamma [UniParc].

Checksum: 3E5F09926DD4A824
Show »

FASTA29434,194

References

« Hide 'large scale' references
[1]"The tripartite motif family identifies cell compartments."
Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A.
EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA).
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF220023 mRNA. Translation: AAG53477.1.
AF220024 mRNA. Translation: AAG53478.1.
AC011904 Genomic DNA. Translation: AAS07396.1.
AC011904 Genomic DNA. Translation: AAS07398.1.
AC011904 Genomic DNA. Translation: AAS07397.1.
CH236956 Genomic DNA. Translation: EAL23864.1.
CH471091 Genomic DNA. Translation: EAW76625.1.
CH471091 Genomic DNA. Translation: EAW76626.1.
CH236956 Genomic DNA. Translation: EAL23865.1.
BC011763 mRNA. Translation: AAH11763.1.
BC025949 mRNA. Translation: AAH25949.1.
RefSeqNP_148977.2. NM_033017.3.
NP_149082.1. NM_033091.2.
UniGeneHs.50749.

3D structure databases

ProteinModelPortalQ9C037.
SMRQ9C037. Positions 6-123, 307-483.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124585. 6 interactions.
IntActQ9C037. 2 interactions.

PTM databases

PhosphoSiteQ9C037.

Polymorphism databases

DMDM209572691.

Proteomic databases

PaxDbQ9C037.
PRIDEQ9C037.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000349062; ENSP00000275736; ENSG00000146833. [Q9C037-2]
ENST00000354241; ENSP00000346186; ENSG00000146833. [Q9C037-3]
ENST00000355947; ENSP00000348216; ENSG00000146833. [Q9C037-1]
GeneID89122.
KEGGhsa:89122.
UCSCuc003usd.3. human. [Q9C037-1]
uc003use.3. human. [Q9C037-2]
uc003usf.3. human. [Q9C037-3]

Organism-specific databases

CTD89122.
GeneCardsGC07M099474.
HGNCHGNC:16275. TRIM4.
HPAHPA019356.
HPA029461.
neXtProtNX_Q9C037.
PharmGKBPA38108.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322533.
HOGENOMHOG000234133.
HOVERGENHBG001357.
InParanoidQ9C037.
KOK11998.
OMAWEVERRD.
PhylomeDBQ9C037.
TreeFamTF338674.

Gene expression databases

ArrayExpressQ9C037.
BgeeQ9C037.
CleanExHS_TRIM4.
GenevestigatorQ9C037.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi89122.
NextBio76224.
PROQ9C037.

Entry information

Entry nameTRIM4_HUMAN
AccessionPrimary (citable) accession number: Q9C037
Secondary accession number(s): A4D298 expand/collapse secondary AC list , Q75MK1, Q96F06, Q9C036
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM