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Q9C037

- TRIM4_HUMAN

UniProt

Q9C037 - TRIM4_HUMAN

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Protein
Tripartite motif-containing protein 4
Gene
TRIM4, RNF87
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 5342RING-type
Add
BLAST
Zinc fingeri82 – 12342B box-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein trimerization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 4
Alternative name(s):
RING finger protein 87
Gene namesi
Name:TRIM4
Synonyms:RNF87
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:16275. TRIM4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. plasma membrane Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Tripartite motif-containing protein 4
PRO_0000056200Add
BLAST

Proteomic databases

MaxQBiQ9C037.
PaxDbiQ9C037.
PRIDEiQ9C037.

PTM databases

PhosphoSiteiQ9C037.

Expressioni

Gene expression databases

ArrayExpressiQ9C037.
BgeeiQ9C037.
CleanExiHS_TRIM4.
GenevestigatoriQ9C037.

Organism-specific databases

HPAiHPA019356.
HPA029461.

Interactioni

Protein-protein interaction databases

BioGridi124585. 6 interactions.
IntActiQ9C037. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9C037.
SMRiQ9C037. Positions 6-52, 85-123, 307-483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 500213B30.2/SPRY
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili212 – 25342 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.
Contains 1 B30.2/SPRY domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG322533.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9C037.
KOiK11998.
OMAiWEVERRD.
PhylomeDBiQ9C037.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q9C037-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP    50
ECRHPSAPAA LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED 100
DQRPVCLVCR ESQEHQTHAM APIDEAFESY RTGNFDIHVD EWKRRLIRLL 150
LYHFKQEEKL LKSQRNLVAK MKKVMHLQDV EVKNATQWKD KIKSQRMRIS 200
TEFSKLHNFL VEEEDLFLQR LNKEEEETKK KLNENTLKLN QTIASLKKLI 250
LEVGEKSQAP TLELLQNPKE VLTRSEIQDV NYSLEAVKVK TVCQIPLMKE 300
MLKRFQVAVN LAEDTAHPKL VFSQEGRYVK NTASASSWPV FSSAWNYFAG 350
WRNPQKTAFV ERFQHLPCVL GKNVFTSGKH YWEVESRDSL EVAVGVCRED 400
VMGITDRSKM SPDVGIWAIY WSAAGYWPLI GFPGTPTQQE PALHRVGVYL 450
DRGTGNVSFY SAVDGVHLHT FSCSSVSRLR PFFWLSPLAS LVIPPVTDRK 500
Length:500
Mass (Da):57,461
Last modified:October 14, 2008 - v2
Checksum:i427D7F3DBF53A72C
GO
Isoform Beta (identifier: Q9C037-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-157: Missing.

Show »
Length:474
Mass (Da):54,151
Checksum:iB8C2FB94B2E2183E
GO
Isoform Gamma (identifier: Q9C037-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-157: Missing.
     307-320: VAVNLAEDTAHPKL → ATKIKTQKQNRHNM
     321-500: Missing.

Show »
Length:294
Mass (Da):34,194
Checksum:i3E5F09926DD4A824
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti367 – 3671P → S.
Corresponds to variant rs35432946 [ dbSNP | Ensembl ].
VAR_046715
Natural varianti474 – 4741S → C.
Corresponds to variant rs33998596 [ dbSNP | Ensembl ].
VAR_046716

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei132 – 15726Missing in isoform Beta and isoform Gamma.
VSP_010197Add
BLAST
Alternative sequencei307 – 32014VAVNL…AHPKL → ATKIKTQKQNRHNM in isoform Gamma.
VSP_010198Add
BLAST
Alternative sequencei321 – 500180Missing in isoform Gamma.
VSP_010199Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541F → S in AAG53477. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220023 mRNA. Translation: AAG53477.1.
AF220024 mRNA. Translation: AAG53478.1.
AC011904 Genomic DNA. Translation: AAS07396.1.
AC011904 Genomic DNA. Translation: AAS07398.1.
AC011904 Genomic DNA. Translation: AAS07397.1.
CH236956 Genomic DNA. Translation: EAL23864.1.
CH471091 Genomic DNA. Translation: EAW76625.1.
CH471091 Genomic DNA. Translation: EAW76626.1.
CH236956 Genomic DNA. Translation: EAL23865.1.
BC011763 mRNA. Translation: AAH11763.1.
BC025949 mRNA. Translation: AAH25949.1.
CCDSiCCDS5678.1. [Q9C037-2]
CCDS5679.1. [Q9C037-1]
RefSeqiNP_148977.2. NM_033017.3. [Q9C037-1]
NP_149082.1. NM_033091.2. [Q9C037-2]
UniGeneiHs.50749.

Genome annotation databases

EnsembliENST00000349062; ENSP00000275736; ENSG00000146833. [Q9C037-2]
ENST00000354241; ENSP00000346186; ENSG00000146833. [Q9C037-3]
ENST00000355947; ENSP00000348216; ENSG00000146833. [Q9C037-1]
GeneIDi89122.
KEGGihsa:89122.
UCSCiuc003usd.3. human. [Q9C037-1]
uc003use.3. human. [Q9C037-2]
uc003usf.3. human. [Q9C037-3]

Polymorphism databases

DMDMi209572691.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220023 mRNA. Translation: AAG53477.1 .
AF220024 mRNA. Translation: AAG53478.1 .
AC011904 Genomic DNA. Translation: AAS07396.1 .
AC011904 Genomic DNA. Translation: AAS07398.1 .
AC011904 Genomic DNA. Translation: AAS07397.1 .
CH236956 Genomic DNA. Translation: EAL23864.1 .
CH471091 Genomic DNA. Translation: EAW76625.1 .
CH471091 Genomic DNA. Translation: EAW76626.1 .
CH236956 Genomic DNA. Translation: EAL23865.1 .
BC011763 mRNA. Translation: AAH11763.1 .
BC025949 mRNA. Translation: AAH25949.1 .
CCDSi CCDS5678.1. [Q9C037-2 ]
CCDS5679.1. [Q9C037-1 ]
RefSeqi NP_148977.2. NM_033017.3. [Q9C037-1 ]
NP_149082.1. NM_033091.2. [Q9C037-2 ]
UniGenei Hs.50749.

3D structure databases

ProteinModelPortali Q9C037.
SMRi Q9C037. Positions 6-52, 85-123, 307-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124585. 6 interactions.
IntActi Q9C037. 2 interactions.

PTM databases

PhosphoSitei Q9C037.

Polymorphism databases

DMDMi 209572691.

Proteomic databases

MaxQBi Q9C037.
PaxDbi Q9C037.
PRIDEi Q9C037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000349062 ; ENSP00000275736 ; ENSG00000146833 . [Q9C037-2 ]
ENST00000354241 ; ENSP00000346186 ; ENSG00000146833 . [Q9C037-3 ]
ENST00000355947 ; ENSP00000348216 ; ENSG00000146833 . [Q9C037-1 ]
GeneIDi 89122.
KEGGi hsa:89122.
UCSCi uc003usd.3. human. [Q9C037-1 ]
uc003use.3. human. [Q9C037-2 ]
uc003usf.3. human. [Q9C037-3 ]

Organism-specific databases

CTDi 89122.
GeneCardsi GC07M099474.
HGNCi HGNC:16275. TRIM4.
HPAi HPA019356.
HPA029461.
neXtProti NX_Q9C037.
PharmGKBi PA38108.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322533.
HOGENOMi HOG000234133.
HOVERGENi HBG001357.
InParanoidi Q9C037.
KOi K11998.
OMAi WEVERRD.
PhylomeDBi Q9C037.
TreeFami TF338674.

Miscellaneous databases

GenomeRNAii 89122.
NextBioi 76224.
PROi Q9C037.

Gene expression databases

ArrayExpressi Q9C037.
Bgeei Q9C037.
CleanExi HS_TRIM4.
Genevestigatori Q9C037.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA).
    Tissue: Melanoma.

Entry informationi

Entry nameiTRIM4_HUMAN
AccessioniPrimary (citable) accession number: Q9C037
Secondary accession number(s): A4D298
, Q75MK1, Q96F06, Q9C036
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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