Q9C037 (TRIM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 4

Alternative name(s):
RING finger protein 87

Gene names

Name:	TRIM4
Synonyms:	RNF87

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein trimerization Inferred from direct assay PubMed 17156811. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay PubMed 17156811Ref.1. Source: UniProtKB plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: Q9C037-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q9C037-2)

The sequence of this isoform differs from the canonical sequence as follows:
     132-157: Missing.

Isoform Gamma (identifier: Q9C037-3)

The sequence of this isoform differs from the canonical sequence as follows:
     132-157: Missing.
     307-320: VAVNLAEDTAHPKL → ATKIKTQKQNRHNM
     321-500: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Tripartite motif-containing protein 4		PRO_0000056200
Regions
	Domain	288 – 500	213	B30.2/SPRY
	Zinc finger	12 – 53	42	RING-type
	Zinc finger	82 – 123	42	B box-type
	Coiled coil	212 – 253	42	Potential
Natural variations
	Alternative sequence	132 – 157	26	Missing in isoform Beta and isoform Gamma.		VSP_010197
	Alternative sequence	307 – 320	14	VAVNL…AHPKL → ATKIKTQKQNRHNM in isoform Gamma.		VSP_010198
	Alternative sequence	321 – 500	180	Missing in isoform Gamma.		VSP_010199
	Natural variant	367	1	P → S. Corresponds to variant rs35432946 [ dbSNP | Ensembl ].		VAR_046715
	Natural variant	474	1	S → C. Corresponds to variant rs33998596 [ dbSNP | Ensembl ].		VAR_046716
Experimental info
	Sequence conflict	154	1	F → S in AAG53477. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 427D7F3DBF53A72C	FASTA	500	57,461
	10 20 30 40 50 60 MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA 70 80 90 100 110 120 LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM 130 140 150 160 170 180 APIDEAFESY RTGNFDIHVD EWKRRLIRLL LYHFKQEEKL LKSQRNLVAK MKKVMHLQDV 190 200 210 220 230 240 EVKNATQWKD KIKSQRMRIS TEFSKLHNFL VEEEDLFLQR LNKEEEETKK KLNENTLKLN 250 260 270 280 290 300 QTIASLKKLI LEVGEKSQAP TLELLQNPKE VLTRSEIQDV NYSLEAVKVK TVCQIPLMKE 310 320 330 340 350 360 MLKRFQVAVN LAEDTAHPKL VFSQEGRYVK NTASASSWPV FSSAWNYFAG WRNPQKTAFV 370 380 390 400 410 420 ERFQHLPCVL GKNVFTSGKH YWEVESRDSL EVAVGVCRED VMGITDRSKM SPDVGIWAIY 430 440 450 460 470 480 WSAAGYWPLI GFPGTPTQQE PALHRVGVYL DRGTGNVSFY SAVDGVHLHT FSCSSVSRLR 490 500 PFFWLSPLAS LVIPPVTDRK
	Isoform Beta [UniParc]. Checksum: B8C2FB94B2E2183E	FASTA	474	54,151
	10 20 30 40 50 60 MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA 70 80 90 100 110 120 LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM 130 140 150 160 170 180 APIDEAFESY REKLLKSQRN LVAKMKKVMH LQDVEVKNAT QWKDKIKSQR MRISTEFSKL 190 200 210 220 230 240 HNFLVEEEDL FLQRLNKEEE ETKKKLNENT LKLNQTIASL KKLILEVGEK SQAPTLELLQ 250 260 270 280 290 300 NPKEVLTRSE IQDVNYSLEA VKVKTVCQIP LMKEMLKRFQ VAVNLAEDTA HPKLVFSQEG 310 320 330 340 350 360 RYVKNTASAS SWPVFSSAWN YFAGWRNPQK TAFVERFQHL PCVLGKNVFT SGKHYWEVES 370 380 390 400 410 420 RDSLEVAVGV CREDVMGITD RSKMSPDVGI WAIYWSAAGY WPLIGFPGTP TQQEPALHRV 430 440 450 460 470 GVYLDRGTGN VSFYSAVDGV HLHTFSCSSV SRLRPFFWLS PLASLVIPPV TDRK
	Isoform Gamma [UniParc]. Checksum: 3E5F09926DD4A824	FASTA	294	34,194
	10 20 30 40 50 60 MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA 70 80 90 100 110 120 LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM 130 140 150 160 170 180 APIDEAFESY REKLLKSQRN LVAKMKKVMH LQDVEVKNAT QWKDKIKSQR MRISTEFSKL 190 200 210 220 230 240 HNFLVEEEDL FLQRLNKEEE ETKKKLNENT LKLNQTIASL KKLILEVGEK SQAPTLELLQ 250 260 270 280 290 NPKEVLTRSE IQDVNYSLEA VKVKTVCQIP LMKEMLKRFQ ATKIKTQKQN RHNM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The tripartite motif family identifies cell compartments." Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA). Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF220023 mRNA. Translation: AAG53477.1. AF220024 mRNA. Translation: AAG53478.1. AC011904 Genomic DNA. Translation: AAS07396.1. AC011904 Genomic DNA. Translation: AAS07398.1. AC011904 Genomic DNA. Translation: AAS07397.1. CH236956 Genomic DNA. Translation: EAL23864.1. CH471091 Genomic DNA. Translation: EAW76625.1. CH471091 Genomic DNA. Translation: EAW76626.1. CH236956 Genomic DNA. Translation: EAL23865.1. BC011763 mRNA. Translation: AAH11763.1. BC025949 mRNA. Translation: AAH25949.1.
IPI	IPI00011551. IPI00030371. IPI00410582.
RefSeq	NP_148977.2. NM_033017.3. NP_149082.1. NM_033091.2.
UniGene	Hs.50749.
3D structure databases
ProteinModelPortal	Q9C037.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9C037. 2 interactions.
PTM databases
PhosphoSite	Q9C037.
Polymorphism databases
DMDM	209572691.
Proteomic databases
PaxDb	Q9C037.
PRIDE	Q9C037.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349062; ENSP00000275736; ENSG00000146833. ENST00000354241; ENSP00000346186; ENSG00000146833. ENST00000355947; ENSP00000348216; ENSG00000146833.
GeneID	89122.
KEGG	hsa:89122.
UCSC	uc003usd.3. human. uc003use.3. human. uc003usf.3. human.
Organism-specific databases
CTD	89122.
GeneCards	GC07M099474.
HGNC	HGNC:16275. TRIM4.
HPA	HPA019356. HPA029461.
neXtProt	NX_Q9C037.
PharmGKB	PA38108.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322533.
HOGENOM	HOG000234133.
HOVERGEN	HBG001357.
InParanoid	Q9C037.
KO	K11998.
OMA	ECRHPSA.
PhylomeDB	Q9C037.
Gene expression databases
ArrayExpress	Q9C037.
Bgee	Q9C037.
CleanEx	HS_TRIM4.
Genevestigator	Q9C037.
GermOnline	ENSG00000146833. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00336. BBOX. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	89122.
NextBio	76224.

Entry information

Entry name

TRIM4_HUMAN

Accession

Primary (citable) accession number: Q9C037
Secondary accession number(s): A4D298 , Q75MK1, Q96F06, Q9C036

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.