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Q9C037

- TRIM4_HUMAN

UniProt

Q9C037 - TRIM4_HUMAN

Protein

Tripartite motif-containing protein 4

Gene

TRIM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 5342RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri82 – 12342B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein trimerization Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 4
    Alternative name(s):
    RING finger protein 87
    Gene namesi
    Name:TRIM4
    Synonyms:RNF87
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16275. TRIM4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. plasma membrane Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38108.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Tripartite motif-containing protein 4PRO_0000056200Add
    BLAST

    Proteomic databases

    MaxQBiQ9C037.
    PaxDbiQ9C037.
    PRIDEiQ9C037.

    PTM databases

    PhosphoSiteiQ9C037.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C037.
    BgeeiQ9C037.
    CleanExiHS_TRIM4.
    GenevestigatoriQ9C037.

    Organism-specific databases

    HPAiHPA019356.
    HPA029461.

    Interactioni

    Protein-protein interaction databases

    BioGridi124585. 6 interactions.
    IntActiQ9C037. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C037.
    SMRiQ9C037. Positions 6-52, 85-123, 307-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini288 – 500213B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili212 – 25342Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 5342RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri82 – 12342B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG322533.
    HOGENOMiHOG000234133.
    HOVERGENiHBG001357.
    InParanoidiQ9C037.
    KOiK11998.
    OMAiWEVERRD.
    PhylomeDBiQ9C037.
    TreeFamiTF338674.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: Q9C037-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP    50
    ECRHPSAPAA LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED 100
    DQRPVCLVCR ESQEHQTHAM APIDEAFESY RTGNFDIHVD EWKRRLIRLL 150
    LYHFKQEEKL LKSQRNLVAK MKKVMHLQDV EVKNATQWKD KIKSQRMRIS 200
    TEFSKLHNFL VEEEDLFLQR LNKEEEETKK KLNENTLKLN QTIASLKKLI 250
    LEVGEKSQAP TLELLQNPKE VLTRSEIQDV NYSLEAVKVK TVCQIPLMKE 300
    MLKRFQVAVN LAEDTAHPKL VFSQEGRYVK NTASASSWPV FSSAWNYFAG 350
    WRNPQKTAFV ERFQHLPCVL GKNVFTSGKH YWEVESRDSL EVAVGVCRED 400
    VMGITDRSKM SPDVGIWAIY WSAAGYWPLI GFPGTPTQQE PALHRVGVYL 450
    DRGTGNVSFY SAVDGVHLHT FSCSSVSRLR PFFWLSPLAS LVIPPVTDRK 500
    Length:500
    Mass (Da):57,461
    Last modified:October 14, 2008 - v2
    Checksum:i427D7F3DBF53A72C
    GO
    Isoform Beta (identifier: Q9C037-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-157: Missing.

    Show »
    Length:474
    Mass (Da):54,151
    Checksum:iB8C2FB94B2E2183E
    GO
    Isoform Gamma (identifier: Q9C037-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-157: Missing.
         307-320: VAVNLAEDTAHPKL → ATKIKTQKQNRHNM
         321-500: Missing.

    Show »
    Length:294
    Mass (Da):34,194
    Checksum:i3E5F09926DD4A824
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541F → S in AAG53477. (PubMed:11331580)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti367 – 3671P → S.
    Corresponds to variant rs35432946 [ dbSNP | Ensembl ].
    VAR_046715
    Natural varianti474 – 4741S → C.
    Corresponds to variant rs33998596 [ dbSNP | Ensembl ].
    VAR_046716

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei132 – 15726Missing in isoform Beta and isoform Gamma. 2 PublicationsVSP_010197Add
    BLAST
    Alternative sequencei307 – 32014VAVNL…AHPKL → ATKIKTQKQNRHNM in isoform Gamma. 1 PublicationVSP_010198Add
    BLAST
    Alternative sequencei321 – 500180Missing in isoform Gamma. 1 PublicationVSP_010199Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220023 mRNA. Translation: AAG53477.1.
    AF220024 mRNA. Translation: AAG53478.1.
    AC011904 Genomic DNA. Translation: AAS07396.1.
    AC011904 Genomic DNA. Translation: AAS07398.1.
    AC011904 Genomic DNA. Translation: AAS07397.1.
    CH236956 Genomic DNA. Translation: EAL23864.1.
    CH471091 Genomic DNA. Translation: EAW76625.1.
    CH471091 Genomic DNA. Translation: EAW76626.1.
    CH236956 Genomic DNA. Translation: EAL23865.1.
    BC011763 mRNA. Translation: AAH11763.1.
    BC025949 mRNA. Translation: AAH25949.1.
    CCDSiCCDS5678.1. [Q9C037-2]
    CCDS5679.1. [Q9C037-1]
    RefSeqiNP_148977.2. NM_033017.3. [Q9C037-1]
    NP_149082.1. NM_033091.2. [Q9C037-2]
    UniGeneiHs.50749.

    Genome annotation databases

    EnsembliENST00000349062; ENSP00000275736; ENSG00000146833. [Q9C037-2]
    ENST00000354241; ENSP00000346186; ENSG00000146833. [Q9C037-3]
    ENST00000355947; ENSP00000348216; ENSG00000146833. [Q9C037-1]
    GeneIDi89122.
    KEGGihsa:89122.
    UCSCiuc003usd.3. human. [Q9C037-1]
    uc003use.3. human. [Q9C037-2]
    uc003usf.3. human. [Q9C037-3]

    Polymorphism databases

    DMDMi209572691.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220023 mRNA. Translation: AAG53477.1 .
    AF220024 mRNA. Translation: AAG53478.1 .
    AC011904 Genomic DNA. Translation: AAS07396.1 .
    AC011904 Genomic DNA. Translation: AAS07398.1 .
    AC011904 Genomic DNA. Translation: AAS07397.1 .
    CH236956 Genomic DNA. Translation: EAL23864.1 .
    CH471091 Genomic DNA. Translation: EAW76625.1 .
    CH471091 Genomic DNA. Translation: EAW76626.1 .
    CH236956 Genomic DNA. Translation: EAL23865.1 .
    BC011763 mRNA. Translation: AAH11763.1 .
    BC025949 mRNA. Translation: AAH25949.1 .
    CCDSi CCDS5678.1. [Q9C037-2 ]
    CCDS5679.1. [Q9C037-1 ]
    RefSeqi NP_148977.2. NM_033017.3. [Q9C037-1 ]
    NP_149082.1. NM_033091.2. [Q9C037-2 ]
    UniGenei Hs.50749.

    3D structure databases

    ProteinModelPortali Q9C037.
    SMRi Q9C037. Positions 6-52, 85-123, 307-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124585. 6 interactions.
    IntActi Q9C037. 2 interactions.

    PTM databases

    PhosphoSitei Q9C037.

    Polymorphism databases

    DMDMi 209572691.

    Proteomic databases

    MaxQBi Q9C037.
    PaxDbi Q9C037.
    PRIDEi Q9C037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349062 ; ENSP00000275736 ; ENSG00000146833 . [Q9C037-2 ]
    ENST00000354241 ; ENSP00000346186 ; ENSG00000146833 . [Q9C037-3 ]
    ENST00000355947 ; ENSP00000348216 ; ENSG00000146833 . [Q9C037-1 ]
    GeneIDi 89122.
    KEGGi hsa:89122.
    UCSCi uc003usd.3. human. [Q9C037-1 ]
    uc003use.3. human. [Q9C037-2 ]
    uc003usf.3. human. [Q9C037-3 ]

    Organism-specific databases

    CTDi 89122.
    GeneCardsi GC07M099474.
    HGNCi HGNC:16275. TRIM4.
    HPAi HPA019356.
    HPA029461.
    neXtProti NX_Q9C037.
    PharmGKBi PA38108.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322533.
    HOGENOMi HOG000234133.
    HOVERGENi HBG001357.
    InParanoidi Q9C037.
    KOi K11998.
    OMAi WEVERRD.
    PhylomeDBi Q9C037.
    TreeFami TF338674.

    Miscellaneous databases

    GenomeRNAii 89122.
    NextBioi 76224.
    PROi Q9C037.

    Gene expression databases

    ArrayExpressi Q9C037.
    Bgeei Q9C037.
    CleanExi HS_TRIM4.
    Genevestigatori Q9C037.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA).
      Tissue: Melanoma.

    Entry informationi

    Entry nameiTRIM4_HUMAN
    AccessioniPrimary (citable) accession number: Q9C037
    Secondary accession number(s): A4D298
    , Q75MK1, Q96F06, Q9C036
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3