Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9C030 (TRIM6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 6
Alternative name(s):
RING finger protein 89
Gene names
Name:TRIM6
Synonyms:RNF89
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homomultimer Probable. Ref.1

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence BAB17050.1 differs from that shown. Reason: Chimeric cDNA. The biological existence and relevance of this transcript product of both TRIM34 (AC Q9BYJ4) and TRIM6 genes and coding for a chimeric protein of 842 residues is uncertain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein trimerization

Inferred from direct assay PubMed 17156811. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 17156811. Source: UniProtKB

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9C030-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9C030-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCGSERILQAGNILEIRVGQAGARRVATM
Isoform 3 (identifier: Q9C030-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Tripartite motif-containing protein 6
PRO_0000056202

Regions

Domain282 – 488207B30.2/SPRY
Zinc finger15 – 6046RING-type
Zinc finger92 – 13342B box-type
Coiled coil134 – 248115 Potential

Natural variations

Alternative sequence1 – 175175Missing in isoform 3.
VSP_046924
Alternative sequence11M → MCGSERILQAGNILEIRVGQ AGARRVATM in isoform 2.
VSP_012087
Natural variant1541E → K.
Corresponds to variant rs57856328 [ dbSNP | Ensembl ].
VAR_061823

Experimental info

Sequence conflict68 – 692LR → FG in BAB17050. Ref.6
Sequence conflict1841Q → K in AAH47564. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F6AEC6BF578E9E72

FASTA48856,400
        10         20         30         40         50         60 
MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ EGERSCPVCQ 

        70         80         90        100        110        120 
TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH GEKLQLFCQE DGKVICWLCE 

       130        140        150        160        170        180 
RSQEHRGHHT FLVEEVAQEY QEKFQESLKK LKNEEQEAEK LTAFIREKKT SWKNQMEPER 

       190        200        210        220        230        240 
CRIQTEFNQL RNILDRVEQR ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR 

       250        260        270        280        290        300 
CQGSTMELLQ DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW 

       310        320        330        340        350        360 
VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF SSGKHYWEVD 

       370        380        390        400        410        420 
VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG YWVIGLQHNH EYRAYEDSSP 

       430        440        450        460        470        480 
SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP 


MTLRRPSS 

« Hide

Isoform 2 [UniParc].

Checksum: 728D531A6FC6BABD
Show »

FASTA51659,353
Isoform 3 [UniParc].

Checksum: BC1F6158D0815F6A
Show »

FASTA31336,400

References

« Hide 'large scale' references
[1]"The tripartite motif family identifies cell compartments."
Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A.
EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Astrocyte, Fetal kidney, Kidney, Placenta and Thalamus.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[6]"Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem."
Orimo A., Tominaga N., Yoshimura K., Yamauchi Y., Nomura M., Sato M., Nogi Y., Suzuki M., Suzuki H., Ikeda K., Inoue S., Muramatsu M.
Genomics 69:143-149(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-300 (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF220030 mRNA. Translation: AAG53484.1.
AK027664 mRNA. Translation: BAB55276.1.
AK290172 mRNA. Translation: BAF82861.1.
AK293295 mRNA. Translation: BAG56816.1.
AK298301 mRNA. Translation: BAG60556.1.
AK316178 mRNA. Translation: BAH14549.1.
AK316289 mRNA. Translation: BAH14660.1.
AC015691 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68783.1.
CH471064 Genomic DNA. Translation: EAW68785.1.
BC047564 mRNA. Translation: AAH47564.1.
AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
RefSeqNP_001003818.1. NM_001003818.2.
NP_001185573.1. NM_001198644.1.
NP_001185574.1. NM_001198645.1.
NP_477514.1. NM_058166.4.
XP_005252840.1. XM_005252783.1.
XP_005252841.1. XM_005252784.1.
UniGeneHs.729048.

3D structure databases

ProteinModelPortalQ9C030.
SMRQ9C030. Positions 5-78, 97-131, 275-486.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125596. 6 interactions.
MINTMINT-6631743.
STRING9606.ENSP00000369440.

PTM databases

PhosphoSiteQ9C030.

Polymorphism databases

DMDM25009488.

Proteomic databases

PaxDbQ9C030.
PRIDEQ9C030.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278302; ENSP00000278302; ENSG00000121236. [Q9C030-1]
ENST00000380097; ENSP00000369440; ENSG00000121236. [Q9C030-2]
ENST00000445329; ENSP00000399215; ENSG00000121236. [Q9C030-3]
ENST00000506134; ENSP00000421079; ENSG00000121236. [Q9C030-3]
ENST00000507320; ENSP00000427704; ENSG00000121236. [Q9C030-3]
ENST00000515022; ENSP00000421802; ENSG00000121236. [Q9C030-3]
GeneID117854.
KEGGhsa:117854.
UCSCuc001mbc.2. human. [Q9C030-1]
uc001mbd.3. human. [Q9C030-2]

Organism-specific databases

CTD117854.
GeneCardsGC11P005617.
HGNCHGNC:16277. TRIM6.
HPAHPA052690.
HPA060514.
MIM607564. gene.
neXtProtNX_Q9C030.
PharmGKBPA38110.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259921.
HOGENOMHOG000234134.
HOVERGENHBG001357.
KOK11999.
OMANHEYRAY.
OrthoDBEOG7RJPR6.
TreeFamTF342569.

Gene expression databases

ArrayExpressQ9C030.
BgeeQ9C030.
GenevestigatorQ9C030.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRIM6. human.
GeneWikiTRIM6.
GenomeRNAi117854.
NextBio80243.
PROQ9C030.
SOURCESearch...

Entry information

Entry nameTRIM6_HUMAN
AccessionPrimary (citable) accession number: Q9C030
Secondary accession number(s): A8K2A7 expand/collapse secondary AC list , B4DDQ5, Q86WZ8, Q9HCR1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: March 19, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM