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Protein

Tripartite motif-containing protein 6

Gene

TRIM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein trimerization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 6
Alternative name(s):
RING finger protein 89
Gene namesi
Name:TRIM6
Synonyms:RNF89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:16277. TRIM6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38110.

Polymorphism and mutation databases

BioMutaiTRIM6.
DMDMi25009488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Tripartite motif-containing protein 6PRO_0000056202Add
BLAST

Proteomic databases

MaxQBiQ9C030.
PaxDbiQ9C030.
PRIDEiQ9C030.

PTM databases

PhosphoSiteiQ9C030.

Expressioni

Gene expression databases

BgeeiQ9C030.
ExpressionAtlasiQ9C030. baseline and differential.
GenevestigatoriQ9C030.

Organism-specific databases

HPAiHPA052690.
HPA060514.

Interactioni

Subunit structurei

Homomultimer.1 Publication

Protein-protein interaction databases

BioGridi125596. 9 interactions.
MINTiMINT-6631743.
STRINGi9606.ENSP00000369440.

Structurei

3D structure databases

ProteinModelPortaliQ9C030.
SMRiQ9C030. Positions 5-78, 97-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 488207B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili134 – 248115Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG259921.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9C030.
KOiK11999.
OMAiNHEYRAY.
OrthoDBiEOG7RJPR6.
PhylomeDBiQ9C030.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C030-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ
60 70 80 90 100
EGERSCPVCQ TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH
110 120 130 140 150
GEKLQLFCQE DGKVICWLCE RSQEHRGHHT FLVEEVAQEY QEKFQESLKK
160 170 180 190 200
LKNEEQEAEK LTAFIREKKT SWKNQMEPER CRIQTEFNQL RNILDRVEQR
210 220 230 240 250
ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR CQGSTMELLQ
260 270 280 290 300
DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW
310 320 330 340 350
VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF
360 370 380 390 400
SSGKHYWEVD VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG
410 420 430 440 450
YWVIGLQHNH EYRAYEDSSP SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT
460 470 480
NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP MTLRRPSS
Length:488
Mass (Da):56,400
Last modified:June 1, 2001 - v1
Checksum:iF6AEC6BF578E9E72
GO
Isoform 2 (identifier: Q9C030-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCGSERILQAGNILEIRVGQAGARRVATM

Show »
Length:516
Mass (Da):59,353
Checksum:i728D531A6FC6BABD
GO
Isoform 3 (identifier: Q9C030-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: No experimental confirmation available.

Show »
Length:313
Mass (Da):36,400
Checksum:iBC1F6158D0815F6A
GO

Sequence cautioni

The sequence BAB17050.1 differs from that shown.Chimeric cDNA. The in vivo relevance of this transcript of the TRIM34 (AC Q9BYJ4) and TRIM6 genes that codes for a chimeric protein of 842 residues is uncertain.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 692LR → FG in BAB17050 (PubMed:11013086).Curated
Sequence conflicti184 – 1841Q → K in AAH47564 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541E → K.
Corresponds to variant rs57856328 [ dbSNP | Ensembl ].
VAR_061823

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 175175Missing in isoform 3. 1 PublicationVSP_046924Add
BLAST
Alternative sequencei1 – 11M → MCGSERILQAGNILEIRVGQ AGARRVATM in isoform 2. 3 PublicationsVSP_012087

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220030 mRNA. Translation: AAG53484.1.
AK027664 mRNA. Translation: BAB55276.1.
AK290172 mRNA. Translation: BAF82861.1.
AK293295 mRNA. Translation: BAG56816.1.
AK298301 mRNA. Translation: BAG60556.1.
AK316178 mRNA. Translation: BAH14549.1.
AK316289 mRNA. Translation: BAH14660.1.
AC015691 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68783.1.
CH471064 Genomic DNA. Translation: EAW68785.1.
BC047564 mRNA. Translation: AAH47564.1.
AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
CCDSiCCDS31389.1. [Q9C030-2]
CCDS31390.1. [Q9C030-1]
CCDS55738.1. [Q9C030-3]
RefSeqiNP_001003818.1. NM_001003818.2. [Q9C030-2]
NP_001185573.1. NM_001198644.1. [Q9C030-3]
NP_001185574.1. NM_001198645.1. [Q9C030-3]
NP_477514.1. NM_058166.4. [Q9C030-1]
UniGeneiHs.729048.

Genome annotation databases

EnsembliENST00000278302; ENSP00000278302; ENSG00000121236. [Q9C030-1]
ENST00000380097; ENSP00000369440; ENSG00000121236. [Q9C030-2]
ENST00000445329; ENSP00000399215; ENSG00000121236. [Q9C030-3]
ENST00000506134; ENSP00000421079; ENSG00000121236. [Q9C030-3]
ENST00000507320; ENSP00000427704; ENSG00000121236. [Q9C030-3]
ENST00000515022; ENSP00000421802; ENSG00000121236. [Q9C030-3]
GeneIDi117854.
KEGGihsa:117854.
UCSCiuc001mbc.2. human. [Q9C030-1]
uc001mbd.3. human. [Q9C030-2]

Polymorphism and mutation databases

BioMutaiTRIM6.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220030 mRNA. Translation: AAG53484.1.
AK027664 mRNA. Translation: BAB55276.1.
AK290172 mRNA. Translation: BAF82861.1.
AK293295 mRNA. Translation: BAG56816.1.
AK298301 mRNA. Translation: BAG60556.1.
AK316178 mRNA. Translation: BAH14549.1.
AK316289 mRNA. Translation: BAH14660.1.
AC015691 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68783.1.
CH471064 Genomic DNA. Translation: EAW68785.1.
BC047564 mRNA. Translation: AAH47564.1.
AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
CCDSiCCDS31389.1. [Q9C030-2]
CCDS31390.1. [Q9C030-1]
CCDS55738.1. [Q9C030-3]
RefSeqiNP_001003818.1. NM_001003818.2. [Q9C030-2]
NP_001185573.1. NM_001198644.1. [Q9C030-3]
NP_001185574.1. NM_001198645.1. [Q9C030-3]
NP_477514.1. NM_058166.4. [Q9C030-1]
UniGeneiHs.729048.

3D structure databases

ProteinModelPortaliQ9C030.
SMRiQ9C030. Positions 5-78, 97-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125596. 9 interactions.
MINTiMINT-6631743.
STRINGi9606.ENSP00000369440.

PTM databases

PhosphoSiteiQ9C030.

Polymorphism and mutation databases

BioMutaiTRIM6.
DMDMi25009488.

Proteomic databases

MaxQBiQ9C030.
PaxDbiQ9C030.
PRIDEiQ9C030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278302; ENSP00000278302; ENSG00000121236. [Q9C030-1]
ENST00000380097; ENSP00000369440; ENSG00000121236. [Q9C030-2]
ENST00000445329; ENSP00000399215; ENSG00000121236. [Q9C030-3]
ENST00000506134; ENSP00000421079; ENSG00000121236. [Q9C030-3]
ENST00000507320; ENSP00000427704; ENSG00000121236. [Q9C030-3]
ENST00000515022; ENSP00000421802; ENSG00000121236. [Q9C030-3]
GeneIDi117854.
KEGGihsa:117854.
UCSCiuc001mbc.2. human. [Q9C030-1]
uc001mbd.3. human. [Q9C030-2]

Organism-specific databases

CTDi117854.
GeneCardsiGC11P005617.
HGNCiHGNC:16277. TRIM6.
HPAiHPA052690.
HPA060514.
MIMi607564. gene.
neXtProtiNX_Q9C030.
PharmGKBiPA38110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG259921.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9C030.
KOiK11999.
OMAiNHEYRAY.
OrthoDBiEOG7RJPR6.
PhylomeDBiQ9C030.
TreeFamiTF342569.

Enzyme and pathway databases

ReactomeiREACT_25078. Interferon gamma signaling.

Miscellaneous databases

GeneWikiiTRIM6.
GenomeRNAii117854.
NextBioi80243.
PROiQ9C030.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C030.
ExpressionAtlasiQ9C030. baseline and differential.
GenevestigatoriQ9C030.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Astrocyte, Fetal kidney, Kidney, Placenta and Thalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  6. "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem."
    Orimo A., Tominaga N., Yoshimura K., Yamauchi Y., Nomura M., Sato M., Nogi Y., Suzuki M., Suzuki H., Ikeda K., Inoue S., Muramatsu M.
    Genomics 69:143-149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-300 (ISOFORM 2).

Entry informationi

Entry nameiTRIM6_HUMAN
AccessioniPrimary (citable) accession number: Q9C030
Secondary accession number(s): A8K2A7
, B4DDQ5, Q86WZ8, Q9HCR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.