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Q9C030

- TRIM6_HUMAN

UniProt

Q9C030 - TRIM6_HUMAN

Protein

Tripartite motif-containing protein 6

Gene

TRIM6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein trimerization Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 6
    Alternative name(s):
    RING finger protein 89
    Gene namesi
    Name:TRIM6
    Synonyms:RNF89
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16277. TRIM6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38110.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Tripartite motif-containing protein 6PRO_0000056202Add
    BLAST

    Proteomic databases

    MaxQBiQ9C030.
    PaxDbiQ9C030.
    PRIDEiQ9C030.

    PTM databases

    PhosphoSiteiQ9C030.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C030.
    BgeeiQ9C030.
    GenevestigatoriQ9C030.

    Organism-specific databases

    HPAiHPA052690.
    HPA060514.

    Interactioni

    Subunit structurei

    Homomultimer.1 Publication

    Protein-protein interaction databases

    BioGridi125596. 6 interactions.
    MINTiMINT-6631743.
    STRINGi9606.ENSP00000369440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C030.
    SMRiQ9C030. Positions 5-78, 97-131, 275-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini282 – 488207B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili134 – 248115Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG259921.
    HOGENOMiHOG000234134.
    HOVERGENiHBG001357.
    KOiK11999.
    OMAiNHEYRAY.
    OrthoDBiEOG7RJPR6.
    PhylomeDBiQ9C030.
    TreeFamiTF342569.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C030-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ    50
    EGERSCPVCQ TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH 100
    GEKLQLFCQE DGKVICWLCE RSQEHRGHHT FLVEEVAQEY QEKFQESLKK 150
    LKNEEQEAEK LTAFIREKKT SWKNQMEPER CRIQTEFNQL RNILDRVEQR 200
    ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR CQGSTMELLQ 250
    DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW 300
    VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF 350
    SSGKHYWEVD VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG 400
    YWVIGLQHNH EYRAYEDSSP SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT 450
    NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP MTLRRPSS 488
    Length:488
    Mass (Da):56,400
    Last modified:June 1, 2001 - v1
    Checksum:iF6AEC6BF578E9E72
    GO
    Isoform 2 (identifier: Q9C030-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MCGSERILQAGNILEIRVGQAGARRVATM

    Show »
    Length:516
    Mass (Da):59,353
    Checksum:i728D531A6FC6BABD
    GO
    Isoform 3 (identifier: Q9C030-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-175: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:313
    Mass (Da):36,400
    Checksum:iBC1F6158D0815F6A
    GO

    Sequence cautioni

    The sequence BAB17050.1 differs from that shown. Reason: Chimeric cDNA. The in vivo relevance of this transcript of the TRIM34 (AC Q9BYJ4) and TRIM6 genes that codes for a chimeric protein of 842 residues is uncertain.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 692LR → FG in BAB17050. (PubMed:11013086)Curated
    Sequence conflicti184 – 1841Q → K in AAH47564. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541E → K.
    Corresponds to variant rs57856328 [ dbSNP | Ensembl ].
    VAR_061823

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 175175Missing in isoform 3. 1 PublicationVSP_046924Add
    BLAST
    Alternative sequencei1 – 11M → MCGSERILQAGNILEIRVGQ AGARRVATM in isoform 2. 3 PublicationsVSP_012087

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220030 mRNA. Translation: AAG53484.1.
    AK027664 mRNA. Translation: BAB55276.1.
    AK290172 mRNA. Translation: BAF82861.1.
    AK293295 mRNA. Translation: BAG56816.1.
    AK298301 mRNA. Translation: BAG60556.1.
    AK316178 mRNA. Translation: BAH14549.1.
    AK316289 mRNA. Translation: BAH14660.1.
    AC015691 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68783.1.
    CH471064 Genomic DNA. Translation: EAW68785.1.
    BC047564 mRNA. Translation: AAH47564.1.
    AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
    CCDSiCCDS31389.1. [Q9C030-2]
    CCDS31390.1. [Q9C030-1]
    CCDS55738.1. [Q9C030-3]
    RefSeqiNP_001003818.1. NM_001003818.2. [Q9C030-2]
    NP_001185573.1. NM_001198644.1. [Q9C030-3]
    NP_001185574.1. NM_001198645.1. [Q9C030-3]
    NP_477514.1. NM_058166.4. [Q9C030-1]
    UniGeneiHs.729048.

    Genome annotation databases

    EnsembliENST00000278302; ENSP00000278302; ENSG00000121236. [Q9C030-1]
    ENST00000380097; ENSP00000369440; ENSG00000121236. [Q9C030-2]
    ENST00000445329; ENSP00000399215; ENSG00000121236. [Q9C030-3]
    ENST00000506134; ENSP00000421079; ENSG00000121236. [Q9C030-3]
    ENST00000507320; ENSP00000427704; ENSG00000121236. [Q9C030-3]
    ENST00000515022; ENSP00000421802; ENSG00000121236. [Q9C030-3]
    GeneIDi117854.
    KEGGihsa:117854.
    UCSCiuc001mbc.2. human. [Q9C030-1]
    uc001mbd.3. human. [Q9C030-2]

    Polymorphism databases

    DMDMi25009488.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220030 mRNA. Translation: AAG53484.1 .
    AK027664 mRNA. Translation: BAB55276.1 .
    AK290172 mRNA. Translation: BAF82861.1 .
    AK293295 mRNA. Translation: BAG56816.1 .
    AK298301 mRNA. Translation: BAG60556.1 .
    AK316178 mRNA. Translation: BAH14549.1 .
    AK316289 mRNA. Translation: BAH14660.1 .
    AC015691 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68783.1 .
    CH471064 Genomic DNA. Translation: EAW68785.1 .
    BC047564 mRNA. Translation: AAH47564.1 .
    AB039903 mRNA. Translation: BAB17050.1 . Sequence problems.
    CCDSi CCDS31389.1. [Q9C030-2 ]
    CCDS31390.1. [Q9C030-1 ]
    CCDS55738.1. [Q9C030-3 ]
    RefSeqi NP_001003818.1. NM_001003818.2. [Q9C030-2 ]
    NP_001185573.1. NM_001198644.1. [Q9C030-3 ]
    NP_001185574.1. NM_001198645.1. [Q9C030-3 ]
    NP_477514.1. NM_058166.4. [Q9C030-1 ]
    UniGenei Hs.729048.

    3D structure databases

    ProteinModelPortali Q9C030.
    SMRi Q9C030. Positions 5-78, 97-131, 275-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125596. 6 interactions.
    MINTi MINT-6631743.
    STRINGi 9606.ENSP00000369440.

    PTM databases

    PhosphoSitei Q9C030.

    Polymorphism databases

    DMDMi 25009488.

    Proteomic databases

    MaxQBi Q9C030.
    PaxDbi Q9C030.
    PRIDEi Q9C030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278302 ; ENSP00000278302 ; ENSG00000121236 . [Q9C030-1 ]
    ENST00000380097 ; ENSP00000369440 ; ENSG00000121236 . [Q9C030-2 ]
    ENST00000445329 ; ENSP00000399215 ; ENSG00000121236 . [Q9C030-3 ]
    ENST00000506134 ; ENSP00000421079 ; ENSG00000121236 . [Q9C030-3 ]
    ENST00000507320 ; ENSP00000427704 ; ENSG00000121236 . [Q9C030-3 ]
    ENST00000515022 ; ENSP00000421802 ; ENSG00000121236 . [Q9C030-3 ]
    GeneIDi 117854.
    KEGGi hsa:117854.
    UCSCi uc001mbc.2. human. [Q9C030-1 ]
    uc001mbd.3. human. [Q9C030-2 ]

    Organism-specific databases

    CTDi 117854.
    GeneCardsi GC11P005617.
    HGNCi HGNC:16277. TRIM6.
    HPAi HPA052690.
    HPA060514.
    MIMi 607564. gene.
    neXtProti NX_Q9C030.
    PharmGKBi PA38110.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259921.
    HOGENOMi HOG000234134.
    HOVERGENi HBG001357.
    KOi K11999.
    OMAi NHEYRAY.
    OrthoDBi EOG7RJPR6.
    PhylomeDBi Q9C030.
    TreeFami TF342569.

    Miscellaneous databases

    ChiTaRSi TRIM6. human.
    GeneWikii TRIM6.
    GenomeRNAii 117854.
    NextBioi 80243.
    PROi Q9C030.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C030.
    Bgeei Q9C030.
    Genevestigatori Q9C030.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Astrocyte, Fetal kidney, Kidney, Placenta and Thalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    6. "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem."
      Orimo A., Tominaga N., Yoshimura K., Yamauchi Y., Nomura M., Sato M., Nogi Y., Suzuki M., Suzuki H., Ikeda K., Inoue S., Muramatsu M.
      Genomics 69:143-149(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-300 (ISOFORM 2).

    Entry informationi

    Entry nameiTRIM6_HUMAN
    AccessioniPrimary (citable) accession number: Q9C030
    Secondary accession number(s): A8K2A7
    , B4DDQ5, Q86WZ8, Q9HCR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3