Q9C030 (TRIM6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 6

Alternative name(s):
RING finger protein 89

Gene names

Name:	TRIM6
Synonyms:	RNF89

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homomultimer Probable. Ref.1
Sequence similarities	Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.
Sequence caution	The sequence BAB17050.1 differs from that shown. Reason: Chimeric cDNA. The biological existence and relevance of this transcript product of both TRIM34 (AC Q9BYJ4) and TRIM6 genes and coding for a chimeric protein of 842 residues is uncertain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein trimerization Inferred from direct assay PubMed 17156811. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay PubMed 17156811. Source: UniProtKB
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C030-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C030-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCGSERILQAGNILEIRVGQAGARRVATM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Tripartite motif-containing protein 6		PRO_0000056202
Regions
	Domain	282 – 488	207	B30.2/SPRY
	Zinc finger	15 – 60	46	RING-type
	Zinc finger	92 – 133	42	B box-type
	Coiled coil	134 – 248	115	Potential
Natural variations
	Alternative sequence	1	1	M → MCGSERILQAGNILEIRVGQ AGARRVATM in isoform 2.		VSP_012087
	Natural variant	154	1	E → K. Corresponds to variant rs57856328 [ dbSNP | Ensembl ].		VAR_061823
Experimental info
	Sequence conflict	68 – 69	2	LR → FG in BAB17050. Ref.5
	Sequence conflict	184	1	Q → K in AAH47564. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F6AEC6BF578E9E72	FASTA	488	56,400
	10 20 30 40 50 60 MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ EGERSCPVCQ 70 80 90 100 110 120 TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH GEKLQLFCQE DGKVICWLCE 130 140 150 160 170 180 RSQEHRGHHT FLVEEVAQEY QEKFQESLKK LKNEEQEAEK LTAFIREKKT SWKNQMEPER 190 200 210 220 230 240 CRIQTEFNQL RNILDRVEQR ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR 250 260 270 280 290 300 CQGSTMELLQ DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW 310 320 330 340 350 360 VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF SSGKHYWEVD 370 380 390 400 410 420 VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG YWVIGLQHNH EYRAYEDSSP 430 440 450 460 470 480 SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP MTLRRPSS
	Isoform 2 [UniParc]. Checksum: 728D531A6FC6BABD	FASTA	516	59,353
	10 20 30 40 50 60 MCGSERILQA GNILEIRVGQ AGARRVATMT SPVLVDIREE VTCPICLELL TEPLSIDCGH 70 80 90 100 110 120 SFCQACITPN GRESVIGQEG ERSCPVCQTS YQPGNLRPNR HLANIVRRLR EVVLGPGKQL 130 140 150 160 170 180 KAVLCADHGE KLQLFCQEDG KVICWLCERS QEHRGHHTFL VEEVAQEYQE KFQESLKKLK 190 200 210 220 230 240 NEEQEAEKLT AFIREKKTSW KNQMEPERCR IQTEFNQLRN ILDRVEQREL KKLEQEEKKG 250 260 270 280 290 300 LRIIEEAEND LVHQTQSLRE LISDLERRCQ GSTMELLQDV SDVTERSEFW TLRKPEALPT 310 320 330 340 350 360 KLRSMFRAPD LKRMLRVCRE LTDVQSYWVD VTLNPHTANL NLVLAKNRRQ VRFVGAKVSG 370 380 390 400 410 420 PSCLEKHYDC SVLGSQHFSS GKHYWEVDVA KKTAWILGVC SNSLGPTFSF NHFAQNHSAY 430 440 450 460 470 480 SRYQPQSGYW VIGLQHNHEY RAYEDSSPSL LLSMTVPPRR VGVFLDYEAG TVSFYNVTNH 490 500 510 GFPIYTFSKY YFPTTLCPYF NPCNCVIPMT LRRPSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The tripartite motif family identifies cell compartments." Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney and Thalamus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[5]	"Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem." Orimo A., Tominaga N., Yoshimura K., Yamauchi Y., Nomura M., Sato M., Nogi Y., Suzuki M., Suzuki H., Ikeda K., Inoue S., Muramatsu M. Genomics 69:143-149(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-300 (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF220030 mRNA. Translation: AAG53484.1. AK027664 mRNA. Translation: BAB55276.1. AK290172 mRNA. Translation: BAF82861.1. CH471064 Genomic DNA. Translation: EAW68783.1. BC047564 mRNA. Translation: AAH47564.1. AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
IPI	IPI00552150. IPI00940053.
RefSeq	NP_001003818.1. NM_001003818.2. NP_001185573.1. NM_001198644.1. NP_001185574.1. NM_001198645.1. NP_477514.1. NM_058166.4.
UniGene	Hs.729048.
3D structure databases
ProteinModelPortal	Q9C030.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369440.
PTM databases
PhosphoSite	Q9C030.
Polymorphism databases
DMDM	25009488.
Proteomic databases
PaxDb	Q9C030.
PRIDE	Q9C030.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278302; ENSP00000278302; ENSG00000121236. ENST00000380097; ENSP00000369440; ENSG00000121236.
GeneID	117854.
KEGG	hsa:117854.
UCSC	uc001mbc.2. human. uc001mbd.3. human.
Organism-specific databases
CTD	117854.
GeneCards	GC11P005617.
HGNC	HGNC:16277. TRIM6.
MIM	607564. gene.
neXtProt	NX_Q9C030.
PharmGKB	PA38110.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG259921.
HOGENOM	HOG000234134.
HOVERGEN	HBG001357.
KO	K11999.
OMA	CNCVIPM.
OrthoDB	EOG4229JJ.
Gene expression databases
ArrayExpress	Q9C030.
Bgee	Q9C030.
Genevestigator	Q9C030.
GermOnline	ENSG00000121236. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR006574. PRY. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00336. BBOX. 1 hit. SM00589. PRY. 1 hit. SM00184. RING. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRIM6. human.
GenomeRNAi	117854.
NextBio	80243.
SOURCE	Search...

Entry information

Entry name

TRIM6_HUMAN

Accession

Primary (citable) accession number: Q9C030
Secondary accession number(s): A8K2A7, Q86WZ8, Q9HCR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.