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Protein

Tripartite motif-containing protein 7

Gene

TRIM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 8254RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 16642B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 7
Alternative name(s):
Glycogenin-interacting protein
RING finger protein 90
Gene namesi
Name:TRIM7
Synonyms:GNIP, RNF90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16278. TRIM7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38398.

Polymorphism and mutation databases

BioMutaiTRIM7.
DMDMi38605728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Tripartite motif-containing protein 7PRO_0000056204Add
BLAST

Proteomic databases

EPDiQ9C029.
MaxQBiQ9C029.
PaxDbiQ9C029.
PRIDEiQ9C029.
TopDownProteomicsiQ9C029-2. [Q9C029-2]

PTM databases

PhosphoSiteiQ9C029.

Expressioni

Tissue specificityi

Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart.1 Publication

Gene expression databases

BgeeiQ9C029.
CleanExiHS_TRIM7.
GenevisibleiQ9C029. HS.

Organism-specific databases

HPAiHPA039213.

Interactioni

Subunit structurei

Forms homodimers and heterodimers. Interacts with GYG and DES.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-2813981,EBI-747107

Protein-protein interaction databases

BioGridi123579. 11 interactions.
IntActiQ9C029. 14 interactions.
STRINGi9606.ENSP00000274773.

Structurei

3D structure databases

ProteinModelPortaliQ9C029.
SMRiQ9C029. Positions 23-99, 130-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini324 – 511188B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili166 – 26398Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1289Poly-Ala

Domaini

The B30.2 domain mediates interaction with GYG. The coiled-coil region mediates homodimerization and heterodimerization.

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 8254RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 16642B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOVERGENiHBG001357.
InParanoidiQ9C029.
KOiK12000.
OMAiCRACIGR.
OrthoDBiEOG761BTK.
PhylomeDBiQ9C029.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR020457. Znf_B-box_chordata.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01406. BBOXZNFINGER.
PR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C029-2) [UniParc]FASTAAdd to basket

Also known as: GNIP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVGPRTGP GTGAEALALA AELQGEATCS ICLELFREPV SVECGHSFCR
60 70 80 90 100
ACIGRCWERP GAGSVGAATR APPFPLPCPQ CREPARPSQL RPNRQLAAVA
110 120 130 140 150
TLLRRFSLPA AAPGEHGSQA AAARAAAARC GQHGEPFKLY CQDDGRAICV
160 170 180 190 200
VCDRAREHRE HAVLPLDEAV QEAKELLESR LRVLKKELED CEVFRSTEKK
210 220 230 240 250
ESKELLKQMA AEQEKVGAEF QALRAFLVEQ EGRLLGRLEE LSREVAQKQN
260 270 280 290 300
ENLAQLGVEI TQLSKLSSQI QETAQKPDLD FLQEFKSTLS RCSNVPGPKP
310 320 330 340 350
TTVSSEMKNK VWNVSLKTFV LKGMLKKFKE DLRGELEKEE KVELTLDPDT
360 370 380 390 400
ANPRLILSLD LKGVRLGERA QDLPNHPCRF DTNTRVLASC GFSSGRHHWE
410 420 430 440 450
VEVGSKDGWA FGVARESVRR KGLTPFTPEE GVWALQLNGG QYWAVTSPER
460 470 480 490 500
SPLSCGHLSR VRVALDLEVG AVSFYAVEDM RHLYTFRVNF QERVFPLFSV
510
CSTGTYLRIW P
Length:511
Mass (Da):56,631
Last modified:November 28, 2003 - v2
Checksum:i05C37C837A462597
GO
Isoform 2 (identifier: Q9C029-3) [UniParc]FASTAAdd to basket

Also known as: GNIP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:303
Mass (Da):34,213
Checksum:iEE42B77E99C93883
GO
Isoform 3 (identifier: Q9C029-4) [UniParc]FASTAAdd to basket

Also known as: GNIP3

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.
     183-206: VLKKELEDCEVFRSTEKKESKELL → MTQATGQMLCLHVQVPLQLLLLGQ

Show »
Length:329
Mass (Da):37,088
Checksum:i307859A40C440AC6
GO
Isoform 4 (identifier: Q9C029-1) [UniParc]FASTAAdd to basket

Also known as: TRIM7

The sequence of this isoform differs from the canonical sequence as follows:
     207-221: KQMAAEQEKVGAEFQ → VSQAPAGPPWDITEA
     222-511: Missing.

Show »
Length:221
Mass (Da):23,700
Checksum:i7DB1D43D798BA92B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181A → S.
Corresponds to variant rs3857300 [ dbSNP | Ensembl ].
VAR_017399
Natural varianti73 – 731P → S.
Corresponds to variant rs2770946 [ dbSNP | Ensembl ].
VAR_017400
Natural varianti95 – 951Q → E.1 Publication
Corresponds to variant rs2770945 [ dbSNP | Ensembl ].
VAR_017401
Natural varianti258 – 2581V → A.
Corresponds to variant rs416574 [ dbSNP | Ensembl ].
VAR_052125
Natural varianti363 – 3631G → S.
Corresponds to variant rs254460 [ dbSNP | Ensembl ].
VAR_052126

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 208208Missing in isoform 2. 1 PublicationVSP_009020Add
BLAST
Alternative sequencei1 – 182182Missing in isoform 3. 1 PublicationVSP_009018Add
BLAST
Alternative sequencei183 – 20624VLKKE…SKELL → MTQATGQMLCLHVQVPLQLL LLGQ in isoform 3. 1 PublicationVSP_009019Add
BLAST
Alternative sequencei207 – 22115KQMAA…GAEFQ → VSQAPAGPPWDITEA in isoform 4. 2 PublicationsVSP_009021Add
BLAST
Alternative sequencei222 – 511290Missing in isoform 4. 2 PublicationsVSP_009022Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220032 mRNA. Translation: AAG53486.1.
AF396651 mRNA. Translation: AAK85377.1.
AF396652 mRNA. Translation: AAK85378.1.
AF396653 mRNA. Translation: AAK85379.1.
AF396654 mRNA. Translation: AAK85380.1.
AF396655 mRNA. Translation: AAK85381.1.
CH471165 Genomic DNA. Translation: EAW53718.1.
CH471165 Genomic DNA. Translation: EAW53716.1.
CH471165 Genomic DNA. Translation: EAW53717.1.
CH471165 Genomic DNA. Translation: EAW53719.1.
BC011567 mRNA. Translation: AAH11567.1.
BC080553 mRNA. Translation: AAH80553.1.
BC132863 mRNA. Translation: AAI32864.1.
BC132867 mRNA. Translation: AAI32868.1.
CCDSiCCDS43414.1. [Q9C029-4]
CCDS4462.1. [Q9C029-2]
CCDS4463.1. [Q9C029-3]
CCDS4464.1. [Q9C029-1]
RefSeqiNP_203128.1. NM_033342.3. [Q9C029-1]
NP_976038.1. NM_203293.2. [Q9C029-2]
NP_976039.1. NM_203294.1. [Q9C029-3]
NP_976040.1. NM_203295.1. [Q9C029-3]
NP_976041.1. NM_203296.1. [Q9C029-3]
NP_976042.1. NM_203297.1. [Q9C029-4]
UniGeneiHs.487412.

Genome annotation databases

EnsembliENST00000274773; ENSP00000274773; ENSG00000146054. [Q9C029-2]
ENST00000334421; ENSP00000334666; ENSG00000146054. [Q9C029-1]
ENST00000393315; ENSP00000376991; ENSG00000146054. [Q9C029-3]
ENST00000393319; ENSP00000376994; ENSG00000146054. [Q9C029-4]
ENST00000422067; ENSP00000391458; ENSG00000146054. [Q9C029-3]
GeneIDi81786.
KEGGihsa:81786.
UCSCiuc003mmv.2. human. [Q9C029-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220032 mRNA. Translation: AAG53486.1.
AF396651 mRNA. Translation: AAK85377.1.
AF396652 mRNA. Translation: AAK85378.1.
AF396653 mRNA. Translation: AAK85379.1.
AF396654 mRNA. Translation: AAK85380.1.
AF396655 mRNA. Translation: AAK85381.1.
CH471165 Genomic DNA. Translation: EAW53718.1.
CH471165 Genomic DNA. Translation: EAW53716.1.
CH471165 Genomic DNA. Translation: EAW53717.1.
CH471165 Genomic DNA. Translation: EAW53719.1.
BC011567 mRNA. Translation: AAH11567.1.
BC080553 mRNA. Translation: AAH80553.1.
BC132863 mRNA. Translation: AAI32864.1.
BC132867 mRNA. Translation: AAI32868.1.
CCDSiCCDS43414.1. [Q9C029-4]
CCDS4462.1. [Q9C029-2]
CCDS4463.1. [Q9C029-3]
CCDS4464.1. [Q9C029-1]
RefSeqiNP_203128.1. NM_033342.3. [Q9C029-1]
NP_976038.1. NM_203293.2. [Q9C029-2]
NP_976039.1. NM_203294.1. [Q9C029-3]
NP_976040.1. NM_203295.1. [Q9C029-3]
NP_976041.1. NM_203296.1. [Q9C029-3]
NP_976042.1. NM_203297.1. [Q9C029-4]
UniGeneiHs.487412.

3D structure databases

ProteinModelPortaliQ9C029.
SMRiQ9C029. Positions 23-99, 130-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123579. 11 interactions.
IntActiQ9C029. 14 interactions.
STRINGi9606.ENSP00000274773.

PTM databases

PhosphoSiteiQ9C029.

Polymorphism and mutation databases

BioMutaiTRIM7.
DMDMi38605728.

Proteomic databases

EPDiQ9C029.
MaxQBiQ9C029.
PaxDbiQ9C029.
PRIDEiQ9C029.
TopDownProteomicsiQ9C029-2. [Q9C029-2]

Protocols and materials databases

DNASUi81786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274773; ENSP00000274773; ENSG00000146054. [Q9C029-2]
ENST00000334421; ENSP00000334666; ENSG00000146054. [Q9C029-1]
ENST00000393315; ENSP00000376991; ENSG00000146054. [Q9C029-3]
ENST00000393319; ENSP00000376994; ENSG00000146054. [Q9C029-4]
ENST00000422067; ENSP00000391458; ENSG00000146054. [Q9C029-3]
GeneIDi81786.
KEGGihsa:81786.
UCSCiuc003mmv.2. human. [Q9C029-2]

Organism-specific databases

CTDi81786.
GeneCardsiTRIM7.
HGNCiHGNC:16278. TRIM7.
HPAiHPA039213.
MIMi609315. gene.
neXtProtiNX_Q9C029.
PharmGKBiPA38398.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOVERGENiHBG001357.
InParanoidiQ9C029.
KOiK12000.
OMAiCRACIGR.
OrthoDBiEOG761BTK.
PhylomeDBiQ9C029.
TreeFamiTF342569.

Miscellaneous databases

GenomeRNAii81786.
NextBioi72071.
PROiQ9C029.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C029.
CleanExiHS_TRIM7.
GenevisibleiQ9C029. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR020457. Znf_B-box_chordata.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01406. BBOXZNFINGER.
PR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  2. "GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis."
    Skurat A.V., Dietrich A.D., Zhai L., Roach P.J.
    J. Biol. Chem. 277:19331-19338(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), INTERACTION WITH GYG.
    Tissue: Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT GLU-95.
    Tissue: Lung and Salivary gland.
  5. "Structure-function analysis of GNIP, the glycogenin-interacting protein."
    Zhai L., Dietrich A., Skurat A.V., Roach P.J.
    Arch. Biochem. Biophys. 421:236-242(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GYG, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTRIM7_HUMAN
AccessioniPrimary (citable) accession number: Q9C029
Secondary accession number(s): A2RUE4
, D3DWR7, Q969F5, Q96F67, Q96J89, Q96J90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 28, 2003
Last modified: April 13, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.