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Protein

Tripartite motif-containing protein 15

Gene

TRIM15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 11942B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: UniProtKB
  • mesodermal cell fate determination Source: ProtInc
  • negative regulation of intracellular transport of viral material Source: UniProtKB
  • negative regulation of viral release from host cell Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of RIG-I signaling pathway Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of type I interferon production Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 15
Alternative name(s):
RING finger protein 93
Zinc finger protein 178
Zinc finger protein B7
Gene namesi
Name:TRIM15
Synonyms:RNF93, ZNF178, ZNFB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16284. TRIM15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38114.

Polymorphism and mutation databases

BioMutaiTRIM15.
DMDMi25009482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Tripartite motif-containing protein 15PRO_0000056218Add
BLAST

Proteomic databases

MaxQBiQ9C019.
PaxDbiQ9C019.
PRIDEiQ9C019.

PTM databases

iPTMnetiQ9C019.
PhosphoSiteiQ9C019.

Expressioni

Gene expression databases

BgeeiQ9C019.
CleanExiHS_TRIM15.
ExpressionAtlasiQ9C019. baseline and differential.
GenevisibleiQ9C019. HS.

Organism-specific databases

HPAiHPA047527.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM151BQ6UXP73EBI-2342111,EBI-8456391
FAM161AQ3B8203EBI-2342111,EBI-719941
RABGEF1Q9UJ413EBI-2342111,EBI-913954

Protein-protein interaction databases

BioGridi124626. 42 interactions.
IntActiQ9C019. 7 interactions.
STRINGi9606.ENSP00000365884.

Structurei

3D structure databases

ProteinModelPortaliQ9C019.
SMRiQ9C019. Positions 3-85, 296-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini276 – 465190B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili126 – 229104Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 11942B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9C019.
KOiK12005.
OMAiCKEDEIP.
PhylomeDBiQ9C019.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C019-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS
60 70 80 90 100
SGKILLCPLC QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF
110 120 130 140 150
LCVFCREGPT HQAHTVGFLD EAIQPYRDRL RSRLEALSTE RDEIEDVKCQ
160 170 180 190 200
EDQKLQVLLT QIESKKHQVE TAFERLQQEL EQQRCLLLAR LRELEQQIWK
210 220 230 240 250
ERDEYITKVS EEVTRLGAQV KELEEKCQQP ASELLQDVRV NQSRCEMKTF
260 270 280 290 300
VSPEAISPDL VKKIRDFHRK ILTLPEMMRM FSENLAHHLE IDSGVITLDP
310 320 330 340 350
QTASRSLVLS EDRKSVRYTR QKKSLPDSPL RFDGLPAVLG FPGFSSGRHR
360 370 380 390 400
WQVDLQLGDG GGCTVGVAGE GVRRKGEMGL SAEDGVWAVI ISHQQCWAST
410 420 430 440 450
SPGTDLPLSE IPRGVRVALD YEAGQVTLHN AQTQEPIFTF TASFSGKVFP
460
FFAVWKKGSC LTLKG
Length:465
Mass (Da):52,113
Last modified:June 1, 2001 - v1
Checksum:i303B8BF8623CB00A
GO
Isoform 2 (identifier: Q9C019-2) [UniParc]FASTAAdd to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     103-115: VFCREGPTHQAHT → TSECRTTDGFGCA
     116-465: Missing.

Show »
Length:115
Mass (Da):12,315
Checksum:i797B6EAA4B95283E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291I → V.3 Publications
Corresponds to variant rs17194460 [ dbSNP | Ensembl ].
VAR_014228
Natural varianti42 – 421A → T.
Corresponds to variant rs17194467 [ dbSNP | Ensembl ].
VAR_052129
Natural varianti84 – 841E → Q.
Corresponds to variant rs17194474 [ dbSNP | Ensembl ].
VAR_052130
Natural varianti235 – 2351L → V.
Corresponds to variant rs34823152 [ dbSNP | Ensembl ].
VAR_052131
Natural varianti324 – 3241S → N.2 Publications
Corresponds to variant rs929156 [ dbSNP | Ensembl ].
VAR_052132

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei103 – 11513VFCRE…HQAHT → TSECRTTDGFGCA in isoform 2. 1 PublicationVSP_005760Add
BLAST
Alternative sequencei116 – 465350Missing in isoform 2. 1 PublicationVSP_005761Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220132 mRNA. Translation: AAG53505.1.
AF220133 mRNA. Translation: AAG53506.1.
U34249 mRNA. Translation: AAD03787.1.
BA000025 Genomic DNA. Translation: BAB63331.1.
AB088089 Genomic DNA. Translation: BAC54922.1.
BX248419, BX005441 Genomic DNA. Translation: CAM26028.1.
BX005441, BX248419 Genomic DNA. Translation: CAM26239.1.
CR759838 Genomic DNA. Translation: CAQ11093.1.
BC038585 mRNA. Translation: AAH38585.1.
CCDSiCCDS4677.1. [Q9C019-1]
RefSeqiNP_150232.2. NM_033229.2. [Q9C019-1]
UniGeneiHs.591789.
Hs.606488.

Genome annotation databases

EnsembliENST00000259930; ENSP00000259930; ENSG00000137384. [Q9C019-1]
ENST00000376688; ENSP00000365878; ENSG00000204610. [Q9C019-2]
ENST00000376694; ENSP00000365884; ENSG00000204610. [Q9C019-1]
ENST00000414873; ENSP00000415480; ENSG00000235259. [Q9C019-1]
ENST00000421984; ENSP00000413961; ENSG00000227147. [Q9C019-1]
ENST00000427091; ENSP00000411683; ENSG00000235960. [Q9C019-1]
ENST00000431059; ENSP00000403221; ENSG00000233599. [Q9C019-1]
ENST00000550400; ENSP00000447500; ENSG00000233599. [Q9C019-2]
ENST00000552676; ENSP00000449686; ENSG00000235905. [Q9C019-2]
ENST00000552836; ENSP00000449617; ENSG00000224145. [Q9C019-2]
GeneIDi89870.
KEGGihsa:89870.
UCSCiuc010jrx.4. human. [Q9C019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220132 mRNA. Translation: AAG53505.1.
AF220133 mRNA. Translation: AAG53506.1.
U34249 mRNA. Translation: AAD03787.1.
BA000025 Genomic DNA. Translation: BAB63331.1.
AB088089 Genomic DNA. Translation: BAC54922.1.
BX248419, BX005441 Genomic DNA. Translation: CAM26028.1.
BX005441, BX248419 Genomic DNA. Translation: CAM26239.1.
CR759838 Genomic DNA. Translation: CAQ11093.1.
BC038585 mRNA. Translation: AAH38585.1.
CCDSiCCDS4677.1. [Q9C019-1]
RefSeqiNP_150232.2. NM_033229.2. [Q9C019-1]
UniGeneiHs.591789.
Hs.606488.

3D structure databases

ProteinModelPortaliQ9C019.
SMRiQ9C019. Positions 3-85, 296-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124626. 42 interactions.
IntActiQ9C019. 7 interactions.
STRINGi9606.ENSP00000365884.

PTM databases

iPTMnetiQ9C019.
PhosphoSiteiQ9C019.

Polymorphism and mutation databases

BioMutaiTRIM15.
DMDMi25009482.

Proteomic databases

MaxQBiQ9C019.
PaxDbiQ9C019.
PRIDEiQ9C019.

Protocols and materials databases

DNASUi89870.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259930; ENSP00000259930; ENSG00000137384. [Q9C019-1]
ENST00000376688; ENSP00000365878; ENSG00000204610. [Q9C019-2]
ENST00000376694; ENSP00000365884; ENSG00000204610. [Q9C019-1]
ENST00000414873; ENSP00000415480; ENSG00000235259. [Q9C019-1]
ENST00000421984; ENSP00000413961; ENSG00000227147. [Q9C019-1]
ENST00000427091; ENSP00000411683; ENSG00000235960. [Q9C019-1]
ENST00000431059; ENSP00000403221; ENSG00000233599. [Q9C019-1]
ENST00000550400; ENSP00000447500; ENSG00000233599. [Q9C019-2]
ENST00000552676; ENSP00000449686; ENSG00000235905. [Q9C019-2]
ENST00000552836; ENSP00000449617; ENSG00000224145. [Q9C019-2]
GeneIDi89870.
KEGGihsa:89870.
UCSCiuc010jrx.4. human. [Q9C019-1]

Organism-specific databases

CTDi89870.
GeneCardsiTRIM15.
HGNCiHGNC:16284. TRIM15.
HPAiHPA047527.
neXtProtiNX_Q9C019.
PharmGKBiPA38114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9C019.
KOiK12005.
OMAiCKEDEIP.
PhylomeDBiQ9C019.
TreeFamiTF342569.

Miscellaneous databases

ChiTaRSiTRIM15. human.
GeneWikiiTRIM15.
GenomeRNAii89870.
PROiQ9C019.

Gene expression databases

BgeeiQ9C019.
CleanExiHS_TRIM15.
ExpressionAtlasiQ9C019. baseline and differential.
GenevisibleiQ9C019. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-29.
  2. "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection."
    Goei V.L., Parimoo S., Capossela A., Chu T.W., Gruen J.R.
    Am. J. Hum. Genet. 54:244-251(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-29.
  3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
    Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-29.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-324.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-324.
    Tissue: Colon.

Entry informationi

Entry nameiTRI15_HUMAN
AccessioniPrimary (citable) accession number: Q9C019
Secondary accession number(s): A2BEC9
, O95604, Q8IUX9, Q9C018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.