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Protein

cAMP-dependent protein kinase inhibitor beta

Gene

PKIB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei23 – 231Important for inhibitionBy similarity
Sitei26 – 261Important for inhibitionBy similarity
Sitei27 – 271Important for inhibitionBy similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cAMP-dependent protein kinase activity Source: GO_Central
  • positive regulation of telomerase activity Source: BHF-UCL
  • positive regulation of telomere capping Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor beta
Short name:
PKI-beta
Gene namesi
Name:PKIB
Synonyms:PRKACN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9018. PKIB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33350.

Polymorphism and mutation databases

BioMutaiPKIB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878cAMP-dependent protein kinase inhibitor betaPRO_0000154538Add
BLAST

Proteomic databases

EPDiQ9C010.
MaxQBiQ9C010.
PaxDbiQ9C010.
PRIDEiQ9C010.

PTM databases

iPTMnetiQ9C010.
PhosphoSiteiQ9C010.

Expressioni

Gene expression databases

BgeeiQ9C010.
CleanExiHS_PKIB.
ExpressionAtlasiQ9C010. baseline and differential.
GenevisibleiQ9C010. HS.

Organism-specific databases

HPAiHPA030156.

Interactioni

Protein-protein interaction databases

BioGridi111557. 4 interactions.
IntActiQ9C010. 2 interactions.
STRINGi9606.ENSP00000346227.

Structurei

3D structure databases

ProteinModelPortaliQ9C010.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410JF7B. Eukaryota.
ENOG410Y067. LUCA.
GeneTreeiENSGT00530000064264.
HOGENOMiHOG000059641.
HOVERGENiHBG003541.
InParanoidiQ9C010.
OrthoDBiEOG7JHM8S.
PhylomeDBiQ9C010.
TreeFamiTF330809.

Family and domain databases

InterProiIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamiPF02827. PKI. 1 hit.
[Graphical view]
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C010-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE
60 70
ALSVKEDAKE KDEKTTQDQL EKPQNEEK
Length:78
Mass (Da):8,468
Last modified:June 1, 2001 - v1
Checksum:iCA4AE267B9ECCD81
GO
Isoform 2 (identifier: Q9C010-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSHQDVAM

Note: Gene prediction based on EST data.
Show »
Length:85
Mass (Da):9,237
Checksum:iA05D93A815C69A40
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MSHQDVAM in isoform 2. CuratedVSP_046922

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225513 mRNA. Translation: AAK00638.1.
AK315151 mRNA. Translation: BAG37599.1.
AF087873 mRNA. Translation: AAM10501.1.
AL512283 Genomic DNA. No translation available.
AL513481 Genomic DNA. No translation available.
Z99129 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48171.1.
BC036011 mRNA. Translation: AAH36011.1.
BC093027 mRNA. Translation: AAH93027.1.
CCDSiCCDS5126.1. [Q9C010-1]
CCDS59033.1. [Q9C010-2]
RefSeqiNP_001257322.1. NM_001270393.1. [Q9C010-1]
NP_001257323.1. NM_001270394.1. [Q9C010-2]
NP_001257324.1. NM_001270395.1. [Q9C010-2]
NP_115860.1. NM_032471.5. [Q9C010-1]
NP_861459.1. NM_181794.2. [Q9C010-1]
NP_861460.1. NM_181795.2. [Q9C010-1]
XP_011534232.1. XM_011535930.1. [Q9C010-2]
XP_011534233.1. XM_011535931.1. [Q9C010-2]
XP_011534234.1. XM_011535932.1. [Q9C010-2]
XP_011534235.1. XM_011535933.1. [Q9C010-2]
XP_011534236.1. XM_011535934.1. [Q9C010-2]
XP_011534237.1. XM_011535935.1. [Q9C010-1]
XP_011534238.1. XM_011535936.1. [Q9C010-1]
XP_011534239.1. XM_011535937.1. [Q9C010-1]
UniGeneiHs.741340.
Hs.744965.

Genome annotation databases

EnsembliENST00000258014; ENSP00000258014; ENSG00000135549. [Q9C010-2]
ENST00000354275; ENSP00000346227; ENSG00000135549. [Q9C010-1]
ENST00000368448; ENSP00000357433; ENSG00000135549. [Q9C010-1]
ENST00000368452; ENSP00000357437; ENSG00000135549. [Q9C010-1]
ENST00000392490; ENSP00000376280; ENSG00000135549. [Q9C010-1]
ENST00000392491; ENSP00000376281; ENSG00000135549. [Q9C010-1]
ENST00000615438; ENSP00000480824; ENSG00000135549. [Q9C010-2]
GeneIDi5570.
KEGGihsa:5570.
UCSCiuc003pyz.4. human. [Q9C010-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225513 mRNA. Translation: AAK00638.1.
AK315151 mRNA. Translation: BAG37599.1.
AF087873 mRNA. Translation: AAM10501.1.
AL512283 Genomic DNA. No translation available.
AL513481 Genomic DNA. No translation available.
Z99129 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48171.1.
BC036011 mRNA. Translation: AAH36011.1.
BC093027 mRNA. Translation: AAH93027.1.
CCDSiCCDS5126.1. [Q9C010-1]
CCDS59033.1. [Q9C010-2]
RefSeqiNP_001257322.1. NM_001270393.1. [Q9C010-1]
NP_001257323.1. NM_001270394.1. [Q9C010-2]
NP_001257324.1. NM_001270395.1. [Q9C010-2]
NP_115860.1. NM_032471.5. [Q9C010-1]
NP_861459.1. NM_181794.2. [Q9C010-1]
NP_861460.1. NM_181795.2. [Q9C010-1]
XP_011534232.1. XM_011535930.1. [Q9C010-2]
XP_011534233.1. XM_011535931.1. [Q9C010-2]
XP_011534234.1. XM_011535932.1. [Q9C010-2]
XP_011534235.1. XM_011535933.1. [Q9C010-2]
XP_011534236.1. XM_011535934.1. [Q9C010-2]
XP_011534237.1. XM_011535935.1. [Q9C010-1]
XP_011534238.1. XM_011535936.1. [Q9C010-1]
XP_011534239.1. XM_011535937.1. [Q9C010-1]
UniGeneiHs.741340.
Hs.744965.

3D structure databases

ProteinModelPortaliQ9C010.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111557. 4 interactions.
IntActiQ9C010. 2 interactions.
STRINGi9606.ENSP00000346227.

PTM databases

iPTMnetiQ9C010.
PhosphoSiteiQ9C010.

Polymorphism and mutation databases

BioMutaiPKIB.

Proteomic databases

EPDiQ9C010.
MaxQBiQ9C010.
PaxDbiQ9C010.
PRIDEiQ9C010.

Protocols and materials databases

DNASUi5570.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258014; ENSP00000258014; ENSG00000135549. [Q9C010-2]
ENST00000354275; ENSP00000346227; ENSG00000135549. [Q9C010-1]
ENST00000368448; ENSP00000357433; ENSG00000135549. [Q9C010-1]
ENST00000368452; ENSP00000357437; ENSG00000135549. [Q9C010-1]
ENST00000392490; ENSP00000376280; ENSG00000135549. [Q9C010-1]
ENST00000392491; ENSP00000376281; ENSG00000135549. [Q9C010-1]
ENST00000615438; ENSP00000480824; ENSG00000135549. [Q9C010-2]
GeneIDi5570.
KEGGihsa:5570.
UCSCiuc003pyz.4. human. [Q9C010-1]

Organism-specific databases

CTDi5570.
GeneCardsiPKIB.
HGNCiHGNC:9018. PKIB.
HPAiHPA030156.
MIMi606914. gene.
neXtProtiNX_Q9C010.
PharmGKBiPA33350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JF7B. Eukaryota.
ENOG410Y067. LUCA.
GeneTreeiENSGT00530000064264.
HOGENOMiHOG000059641.
HOVERGENiHBG003541.
InParanoidiQ9C010.
OrthoDBiEOG7JHM8S.
PhylomeDBiQ9C010.
TreeFamiTF330809.

Miscellaneous databases

ChiTaRSiPKIB. human.
GeneWikiiPKIB.
GenomeRNAii5570.
NextBioi21588.
PROiQ9C010.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C010.
CleanExiHS_PKIB.
ExpressionAtlasiQ9C010. baseline and differential.
GenevisibleiQ9C010. HS.

Family and domain databases

InterProiIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamiPF02827. PKI. 1 hit.
[Graphical view]
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA."
    Zheng L., Yu L., Tu Q., Zhang M., He H., Chen W., Gao J., Yu J., Wu Q., Zhao S.
    Biochem. J. 349:403-407(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Subthalamic nucleus.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiIPKB_HUMAN
AccessioniPrimary (citable) accession number: Q9C010
Secondary accession number(s): B2RCK2, Q567T9, Q5T0Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.