ID   FOXQ1_HUMAN             Reviewed;         403 AA.
AC   Q9C009; Q9NS06;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   24-JAN-2024, entry version 178.
DE   RecName: Full=Forkhead box protein Q1;
DE   AltName: Full=HNF-3/forkhead-like protein 1;
DE            Short=HFH-1;
DE   AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 1;
GN   Name=FOXQ1; Synonyms=HFH1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND VARIANTS PRO-60
RP   AND PRO-61.
RX   PubMed=11747606; DOI=10.1089/104454901317094963;
RA   Bieller A., Pasche B., Frank S., Glaeser B., Kunz J., Witt K., Zoll B.;
RT   "Isolation and characterization of the human forkhead gene FOXQ1.";
RL   DNA Cell Biol. 20:555-561(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11309849; DOI=10.1002/gene.1020;
RA   Hong H.-K., Noveroske J.K., Headon D.J., Liu T., Sy M.S., Justice M.J.,
RA   Chakravarti A.;
RT   "The winged helix/forkhead transcription factor Foxq1 regulates
RT   differentiation of hair in satin mice.";
RL   Genesis 29:163-171(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-60 AND PRO-61.
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in hair follicle differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the stomach, trachea,
CC       bladder and salivary gland. {ECO:0000269|PubMed:11747606}.
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DR   EMBL; AF225950; AAK00639.1; -; Genomic_DNA.
DR   EMBL; AF153341; AAF75586.1; -; Genomic_DNA.
DR   EMBL; BC053850; AAH53850.1; -; mRNA.
DR   CCDS; CCDS4471.1; -.
DR   RefSeq; NP_150285.3; NM_033260.3.
DR   AlphaFoldDB; Q9C009; -.
DR   SMR; Q9C009; -.
DR   BioGRID; 125147; 138.
DR   IntAct; Q9C009; 137.
DR   MINT; Q9C009; -.
DR   STRING; 9606.ENSP00000296839; -.
DR   iPTMnet; Q9C009; -.
DR   PhosphoSitePlus; Q9C009; -.
DR   BioMuta; FOXQ1; -.
DR   DMDM; 143811391; -.
DR   jPOST; Q9C009; -.
DR   MassIVE; Q9C009; -.
DR   MaxQB; Q9C009; -.
DR   PaxDb; 9606-ENSP00000296839; -.
DR   PeptideAtlas; Q9C009; -.
DR   ProteomicsDB; 79939; -.
DR   Antibodypedia; 9198; 504 antibodies from 31 providers.
DR   CPTC; Q9C009; 2 antibodies.
DR   DNASU; 94234; -.
DR   Ensembl; ENST00000296839.5; ENSP00000296839.2; ENSG00000164379.7.
DR   GeneID; 94234; -.
DR   KEGG; hsa:94234; -.
DR   MANE-Select; ENST00000296839.5; ENSP00000296839.2; NM_033260.4; NP_150285.3.
DR   UCSC; uc003mtl.5; human.
DR   AGR; HGNC:20951; -.
DR   CTD; 94234; -.
DR   DisGeNET; 94234; -.
DR   GeneCards; FOXQ1; -.
DR   HGNC; HGNC:20951; FOXQ1.
DR   HPA; ENSG00000164379; Tissue enhanced (stomach, urinary bladder).
DR   MIM; 612788; gene.
DR   neXtProt; NX_Q9C009; -.
DR   OpenTargets; ENSG00000164379; -.
DR   PharmGKB; PA134924898; -.
DR   VEuPathDB; HostDB:ENSG00000164379; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000162937; -.
DR   HOGENOM; CLU_055457_0_0_1; -.
DR   InParanoid; Q9C009; -.
DR   OMA; QWGAAPC; -.
DR   OrthoDB; 5385885at2759; -.
DR   PhylomeDB; Q9C009; -.
DR   TreeFam; TF316127; -.
DR   PathwayCommons; Q9C009; -.
DR   SignaLink; Q9C009; -.
DR   SIGNOR; Q9C009; -.
DR   BioGRID-ORCS; 94234; 22 hits in 1177 CRISPR screens.
DR   ChiTaRS; FOXQ1; human.
DR   GenomeRNAi; 94234; -.
DR   Pharos; Q9C009; Tbio.
DR   PRO; PR:Q9C009; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q9C009; Protein.
DR   Bgee; ENSG00000164379; Expressed in parotid gland and 152 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:ARUK-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd20034; FH_FOXQ1-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047518; FH_FOXQ1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR   PANTHER; PTHR11829:SF206; FORKHEAD BOX PROTEIN Q1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   Genevisible; Q9C009; HS.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..403
FT                   /note="Forkhead box protein Q1"
FT                   /id="PRO_0000091890"
FT   DNA_BIND        119..214
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..248
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         60
FT                   /note="T -> P (in dbSNP:rs9502889)"
FT                   /evidence="ECO:0000269|PubMed:11747606,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031606"
FT   VARIANT         61
FT                   /note="Q -> P (in dbSNP:rs9502890)"
FT                   /evidence="ECO:0000269|PubMed:11747606,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031607"
FT   CONFLICT        49..52
FT                   /note="NSPA -> KPS (in Ref. 2; AAF75586)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        386
FT                   /note="S -> L (in Ref. 2; AAF75586)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        395
FT                   /note="P -> S (in Ref. 2; AAF75586)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   403 AA;  41526 MW;  0709E0A6A0AE2174 CRC64;
     MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS PAAGGGARDT
     QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA GGAGSGEGAR SKPYTRRPKP
     PYSYIALIAM AIRDSAGGRL TLAEINEYLM GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV
     LRDPSRPWGK DNYWMLNPNS EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP
     PAPAAPASPR MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA
     PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL APLPAAAPAK
     PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET LLA
//