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Q9C009

- FOXQ1_HUMAN

UniProt

Q9C009 - FOXQ1_HUMAN

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Protein

Forkhead box protein Q1

Gene
FOXQ1, HFH1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in hair follicle differentiation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi119 – 21496Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. double-stranded DNA binding Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome

GO - Biological processi

  1. hair follicle morphogenesis Source: Ensembl
  2. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  3. pattern specification process Source: RefGenome
  4. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. tissue development Source: RefGenome
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ9C009.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein Q1
Alternative name(s):
HNF-3/forkhead-like protein 1
Short name:
HFH-1
Hepatocyte nuclear factor 3 forkhead homolog 1
Gene namesi
Name:FOXQ1
Synonyms:HFH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20951. FOXQ1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Forkhead box protein Q1PRO_0000091890Add
BLAST

Proteomic databases

MaxQBiQ9C009.
PaxDbiQ9C009.
PRIDEiQ9C009.

PTM databases

PhosphoSiteiQ9C009.

Expressioni

Tissue specificityi

Expressed predominantly in the stomach, trachea, bladder and salivary gland.1 Publication

Gene expression databases

BgeeiQ9C009.
CleanExiHS_FOXQ1.
GenevestigatoriQ9C009.

Interactioni

Protein-protein interaction databases

BioGridi125147. 1 interaction.
IntActiQ9C009. 1 interaction.
MINTiMINT-6610604.
STRINGi9606.ENSP00000296839.

Structurei

3D structure databases

ProteinModelPortaliQ9C009.
SMRiQ9C009. Positions 124-198.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 10391Ala/Gly-richAdd
BLAST
Compositional biasi221 – 397177Pro-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000112634.
HOVERGENiHBG051658.
InParanoidiQ9C009.
KOiK09410.
OMAiPAKPFRG.
OrthoDBiEOG708W0T.
PhylomeDBiQ9C009.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C009-1 [UniParc]FASTAAdd to Basket

« Hide

MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS    50
PAAGGGARDT QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA 100
GGAGSGEGAR SKPYTRRPKP PYSYIALIAM AIRDSAGGRL TLAEINEYLM 150
GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV LRDPSRPWGK DNYWMLNPNS 200
EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP PAPAAPASPR 250
MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA 300
PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL 350
APLPAAAPAK PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET 400
LLA 403
Length:403
Mass (Da):41,526
Last modified:April 3, 2007 - v2
Checksum:i0709E0A6A0AE2174
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601T → P.2 Publications
Corresponds to variant rs9502889 [ dbSNP | Ensembl ].
VAR_031606
Natural varianti61 – 611Q → P.2 Publications
Corresponds to variant rs9502890 [ dbSNP | Ensembl ].
VAR_031607

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 524NSPA → KPS in AAF75586. 1 Publication
Sequence conflicti386 – 3861S → L in AAF75586. 1 Publication
Sequence conflicti395 – 3951P → S in AAF75586. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF225950 Genomic DNA. Translation: AAK00639.1.
AF153341 Genomic DNA. Translation: AAF75586.1.
BC053850 mRNA. Translation: AAH53850.1.
CCDSiCCDS4471.1.
RefSeqiNP_150285.3. NM_033260.3.
UniGeneiHs.591352.

Genome annotation databases

EnsembliENST00000296839; ENSP00000296839; ENSG00000164379.
GeneIDi94234.
KEGGihsa:94234.
UCSCiuc003mtl.4. human.

Polymorphism databases

DMDMi143811391.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF225950 Genomic DNA. Translation: AAK00639.1 .
AF153341 Genomic DNA. Translation: AAF75586.1 .
BC053850 mRNA. Translation: AAH53850.1 .
CCDSi CCDS4471.1.
RefSeqi NP_150285.3. NM_033260.3.
UniGenei Hs.591352.

3D structure databases

ProteinModelPortali Q9C009.
SMRi Q9C009. Positions 124-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125147. 1 interaction.
IntActi Q9C009. 1 interaction.
MINTi MINT-6610604.
STRINGi 9606.ENSP00000296839.

PTM databases

PhosphoSitei Q9C009.

Polymorphism databases

DMDMi 143811391.

Proteomic databases

MaxQBi Q9C009.
PaxDbi Q9C009.
PRIDEi Q9C009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296839 ; ENSP00000296839 ; ENSG00000164379 .
GeneIDi 94234.
KEGGi hsa:94234.
UCSCi uc003mtl.4. human.

Organism-specific databases

CTDi 94234.
GeneCardsi GC06P001312.
H-InvDB HIX0025221.
HGNCi HGNC:20951. FOXQ1.
MIMi 612788. gene.
neXtProti NX_Q9C009.
PharmGKBi PA134924898.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000112634.
HOVERGENi HBG051658.
InParanoidi Q9C009.
KOi K09410.
OMAi PAKPFRG.
OrthoDBi EOG708W0T.
PhylomeDBi Q9C009.
TreeFami TF316127.

Enzyme and pathway databases

SignaLinki Q9C009.

Miscellaneous databases

GenomeRNAii 94234.
NextBioi 78472.
PROi Q9C009.
SOURCEi Search...

Gene expression databases

Bgeei Q9C009.
CleanExi HS_FOXQ1.
Genevestigatori Q9C009.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the human forkhead gene FOXQ1."
    Bieller A., Pasche B., Frank S., Glaeser B., Kunz J., Witt K., Zoll B.
    DNA Cell Biol. 20:555-561(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, VARIANTS PRO-60 AND PRO-61.
  2. "The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice."
    Hong H.-K., Noveroske J.K., Headon D.J., Liu T., Sy M.S., Justice M.J., Chakravarti A.
    Genesis 29:163-171(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-60 AND PRO-61.
    Tissue: Lung.

Entry informationi

Entry nameiFOXQ1_HUMAN
AccessioniPrimary (citable) accession number: Q9C009
Secondary accession number(s): Q9NS06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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