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Q9C009

- FOXQ1_HUMAN

UniProt

Q9C009 - FOXQ1_HUMAN

Protein

Forkhead box protein Q1

Gene

FOXQ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Plays a role in hair follicle differentiation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi119 – 21496Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. hair follicle morphogenesis Source: Ensembl
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ9C009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein Q1
    Alternative name(s):
    HNF-3/forkhead-like protein 1
    Short name:
    HFH-1
    Hepatocyte nuclear factor 3 forkhead homolog 1
    Gene namesi
    Name:FOXQ1
    Synonyms:HFH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20951. FOXQ1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134924898.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Forkhead box protein Q1PRO_0000091890Add
    BLAST

    Proteomic databases

    MaxQBiQ9C009.
    PaxDbiQ9C009.
    PRIDEiQ9C009.

    PTM databases

    PhosphoSiteiQ9C009.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the stomach, trachea, bladder and salivary gland.1 Publication

    Gene expression databases

    BgeeiQ9C009.
    CleanExiHS_FOXQ1.
    GenevestigatoriQ9C009.

    Interactioni

    Protein-protein interaction databases

    BioGridi125147. 1 interaction.
    IntActiQ9C009. 1 interaction.
    MINTiMINT-6610604.
    STRINGi9606.ENSP00000296839.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C009.
    SMRiQ9C009. Positions 124-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi13 – 10391Ala/Gly-richAdd
    BLAST
    Compositional biasi221 – 397177Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000112634.
    HOVERGENiHBG051658.
    InParanoidiQ9C009.
    KOiK09410.
    OMAiPAKPFRG.
    OrthoDBiEOG708W0T.
    PhylomeDBiQ9C009.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C009-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS    50
    PAAGGGARDT QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA 100
    GGAGSGEGAR SKPYTRRPKP PYSYIALIAM AIRDSAGGRL TLAEINEYLM 150
    GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV LRDPSRPWGK DNYWMLNPNS 200
    EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP PAPAAPASPR 250
    MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA 300
    PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL 350
    APLPAAAPAK PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET 400
    LLA 403
    Length:403
    Mass (Da):41,526
    Last modified:April 3, 2007 - v2
    Checksum:i0709E0A6A0AE2174
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 524NSPA → KPS in AAF75586. (PubMed:11309849)Curated
    Sequence conflicti386 – 3861S → L in AAF75586. (PubMed:11309849)Curated
    Sequence conflicti395 – 3951P → S in AAF75586. (PubMed:11309849)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601T → P.2 Publications
    Corresponds to variant rs9502889 [ dbSNP | Ensembl ].
    VAR_031606
    Natural varianti61 – 611Q → P.2 Publications
    Corresponds to variant rs9502890 [ dbSNP | Ensembl ].
    VAR_031607

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF225950 Genomic DNA. Translation: AAK00639.1.
    AF153341 Genomic DNA. Translation: AAF75586.1.
    BC053850 mRNA. Translation: AAH53850.1.
    CCDSiCCDS4471.1.
    RefSeqiNP_150285.3. NM_033260.3.
    UniGeneiHs.591352.

    Genome annotation databases

    EnsembliENST00000296839; ENSP00000296839; ENSG00000164379.
    GeneIDi94234.
    KEGGihsa:94234.
    UCSCiuc003mtl.4. human.

    Polymorphism databases

    DMDMi143811391.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF225950 Genomic DNA. Translation: AAK00639.1 .
    AF153341 Genomic DNA. Translation: AAF75586.1 .
    BC053850 mRNA. Translation: AAH53850.1 .
    CCDSi CCDS4471.1.
    RefSeqi NP_150285.3. NM_033260.3.
    UniGenei Hs.591352.

    3D structure databases

    ProteinModelPortali Q9C009.
    SMRi Q9C009. Positions 124-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125147. 1 interaction.
    IntActi Q9C009. 1 interaction.
    MINTi MINT-6610604.
    STRINGi 9606.ENSP00000296839.

    PTM databases

    PhosphoSitei Q9C009.

    Polymorphism databases

    DMDMi 143811391.

    Proteomic databases

    MaxQBi Q9C009.
    PaxDbi Q9C009.
    PRIDEi Q9C009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296839 ; ENSP00000296839 ; ENSG00000164379 .
    GeneIDi 94234.
    KEGGi hsa:94234.
    UCSCi uc003mtl.4. human.

    Organism-specific databases

    CTDi 94234.
    GeneCardsi GC06P001312.
    H-InvDB HIX0025221.
    HGNCi HGNC:20951. FOXQ1.
    MIMi 612788. gene.
    neXtProti NX_Q9C009.
    PharmGKBi PA134924898.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000112634.
    HOVERGENi HBG051658.
    InParanoidi Q9C009.
    KOi K09410.
    OMAi PAKPFRG.
    OrthoDBi EOG708W0T.
    PhylomeDBi Q9C009.
    TreeFami TF316127.

    Enzyme and pathway databases

    SignaLinki Q9C009.

    Miscellaneous databases

    GenomeRNAii 94234.
    NextBioi 78472.
    PROi Q9C009.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9C009.
    CleanExi HS_FOXQ1.
    Genevestigatori Q9C009.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the human forkhead gene FOXQ1."
      Bieller A., Pasche B., Frank S., Glaeser B., Kunz J., Witt K., Zoll B.
      DNA Cell Biol. 20:555-561(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, VARIANTS PRO-60 AND PRO-61.
    2. "The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice."
      Hong H.-K., Noveroske J.K., Headon D.J., Liu T., Sy M.S., Justice M.J., Chakravarti A.
      Genesis 29:163-171(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-60 AND PRO-61.
      Tissue: Lung.

    Entry informationi

    Entry nameiFOXQ1_HUMAN
    AccessioniPrimary (citable) accession number: Q9C009
    Secondary accession number(s): Q9NS06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3