Q9C009 (FOXQ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein Q1

Alternative name(s):
HNF-3/forkhead-like protein 1
Short name=HFH-1
Hepatocyte nuclear factor 3 forkhead homolog 1

Gene names

Name:	FOXQ1
Synonyms:	HFH1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in hair follicle differentiation By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed predominantly in the stomach, trachea, bladder and salivary gland. Ref.1
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic DNA fragmentation Inferred from Biological aspect of Ancestor. Source: RefGenome embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome hair follicle morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome cysteine-type endopeptidase regulator activity involved in apoptotic process Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome estrogen receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome ubiquitin conjugating enzyme binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 403	403	Forkhead box protein Q1		PRO_0000091890
Regions
	DNA binding	119 – 214	96	Fork-head
	Compositional bias	13 – 103	91	Ala/Gly-rich
	Compositional bias	221 – 397	177	Pro-rich
Natural variations
	Natural variant	60	1	T → P. Ref.1 Ref.3 Corresponds to variant rs9502889 [ dbSNP | Ensembl ].		VAR_031606
	Natural variant	61	1	Q → P. Ref.1 Ref.3 Corresponds to variant rs9502890 [ dbSNP | Ensembl ].		VAR_031607
Experimental info
	Sequence conflict	49 – 52	4	NSPA → KPS in AAF75586. Ref.2
	Sequence conflict	386	1	S → L in AAF75586. Ref.2
	Sequence conflict	395	1	P → S in AAF75586. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9C009 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 0709E0A6A0AE2174	FASTA	403	41,526
	10 20 30 40 50 60 MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS PAAGGGARDT 70 80 90 100 110 120 QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA GGAGSGEGAR SKPYTRRPKP 130 140 150 160 170 180 PYSYIALIAM AIRDSAGGRL TLAEINEYLM GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV 190 200 210 220 230 240 LRDPSRPWGK DNYWMLNPNS EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP 250 260 270 280 290 300 PAPAAPASPR MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA 310 320 330 340 350 360 PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL APLPAAAPAK 370 380 390 400 PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET LLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the human forkhead gene FOXQ1." Bieller A., Pasche B., Frank S., Glaeser B., Kunz J., Witt K., Zoll B. DNA Cell Biol. 20:555-561(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, VARIANTS PRO-60 AND PRO-61.
[2]	"The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice." Hong H.-K., Noveroske J.K., Headon D.J., Liu T., Sy M.S., Justice M.J., Chakravarti A. Genesis 29:163-171(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-60 AND PRO-61. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF225950 Genomic DNA. Translation: AAK00639.1. AF153341 Genomic DNA. Translation: AAF75586.1. BC053850 mRNA. Translation: AAH53850.1.
IPI	IPI00018738.
RefSeq	NP_150285.3. NM_033260.3.
UniGene	Hs.591352.
3D structure databases
ProteinModelPortal	Q9C009.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6610604.
STRING	9606.ENSP00000296839.
PTM databases
PhosphoSite	Q9C009.
Polymorphism databases
DMDM	143811391.
Proteomic databases
PaxDb	Q9C009.
PRIDE	Q9C009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296839; ENSP00000296839; ENSG00000164379.
GeneID	94234.
KEGG	hsa:94234.
UCSC	uc003mtl.4. human.
Organism-specific databases
CTD	94234.
GeneCards	GC06P001312.
H-InvDB	HIX0025221.
HGNC	HGNC:20951. FOXQ1.
MIM	612788. gene.
neXtProt	NX_Q9C009.
PharmGKB	PA134924898.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000112634.
HOVERGEN	HBG051658.
InParanoid	Q9C009.
KO	K09410.
OMA	PWGAAPC.
PhylomeDB	Q9C009.
Enzyme and pathway databases
SignaLink	Q9C009.
Gene expression databases
Bgee	Q9C009.
CleanEx	HS_FOXQ1.
Genevestigator	Q9C009.
GermOnline	ENSG00000164379. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	94234.
NextBio	78472.
SOURCE	Search...

Entry information

Entry name

FOXQ1_HUMAN

Accession

Primary (citable) accession number: Q9C009
Secondary accession number(s): Q9NS06

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	April 3, 2007
Last modified:	May 29, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.