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Q9C009 (FOXQ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein Q1
Alternative name(s):
HNF-3/forkhead-like protein 1
Short name=HFH-1
Hepatocyte nuclear factor 3 forkhead homolog 1
Gene names
Name:FOXQ1
Synonyms:HFH1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in hair follicle differentiation By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed predominantly in the stomach, trachea, bladder and salivary gland. Ref.1

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhair follicle morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

tissue development

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Forkhead box protein Q1
PRO_0000091890

Regions

DNA binding119 – 21496Fork-head
Compositional bias13 – 10391Ala/Gly-rich
Compositional bias221 – 397177Pro-rich

Natural variations

Natural variant601T → P. Ref.1 Ref.3
Corresponds to variant rs9502889 [ dbSNP | Ensembl ].
VAR_031606
Natural variant611Q → P. Ref.1 Ref.3
Corresponds to variant rs9502890 [ dbSNP | Ensembl ].
VAR_031607

Experimental info

Sequence conflict49 – 524NSPA → KPS in AAF75586. Ref.2
Sequence conflict3861S → L in AAF75586. Ref.2
Sequence conflict3951P → S in AAF75586. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9C009 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 0709E0A6A0AE2174

FASTA40341,526
        10         20         30         40         50         60 
MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS PAAGGGARDT 

        70         80         90        100        110        120 
QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA GGAGSGEGAR SKPYTRRPKP 

       130        140        150        160        170        180 
PYSYIALIAM AIRDSAGGRL TLAEINEYLM GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV 

       190        200        210        220        230        240 
LRDPSRPWGK DNYWMLNPNS EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP 

       250        260        270        280        290        300 
PAPAAPASPR MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA 

       310        320        330        340        350        360 
PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL APLPAAAPAK 

       370        380        390        400 
PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET LLA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the human forkhead gene FOXQ1."
Bieller A., Pasche B., Frank S., Glaeser B., Kunz J., Witt K., Zoll B.
DNA Cell Biol. 20:555-561(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, VARIANTS PRO-60 AND PRO-61.
[2]"The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice."
Hong H.-K., Noveroske J.K., Headon D.J., Liu T., Sy M.S., Justice M.J., Chakravarti A.
Genesis 29:163-171(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-60 AND PRO-61.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF225950 Genomic DNA. Translation: AAK00639.1.
AF153341 Genomic DNA. Translation: AAF75586.1.
BC053850 mRNA. Translation: AAH53850.1.
CCDSCCDS4471.1.
RefSeqNP_150285.3. NM_033260.3.
UniGeneHs.591352.

3D structure databases

ProteinModelPortalQ9C009.
SMRQ9C009. Positions 124-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125147. 1 interaction.
IntActQ9C009. 1 interaction.
MINTMINT-6610604.
STRING9606.ENSP00000296839.

PTM databases

PhosphoSiteQ9C009.

Polymorphism databases

DMDM143811391.

Proteomic databases

MaxQBQ9C009.
PaxDbQ9C009.
PRIDEQ9C009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296839; ENSP00000296839; ENSG00000164379.
GeneID94234.
KEGGhsa:94234.
UCSCuc003mtl.4. human.

Organism-specific databases

CTD94234.
GeneCardsGC06P001312.
H-InvDBHIX0025221.
HGNCHGNC:20951. FOXQ1.
MIM612788. gene.
neXtProtNX_Q9C009.
PharmGKBPA134924898.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000112634.
HOVERGENHBG051658.
InParanoidQ9C009.
KOK09410.
OMAPAKPFRG.
OrthoDBEOG708W0T.
PhylomeDBQ9C009.
TreeFamTF316127.

Enzyme and pathway databases

SignaLinkQ9C009.

Gene expression databases

BgeeQ9C009.
CleanExHS_FOXQ1.
GenevestigatorQ9C009.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi94234.
NextBio78472.
PROQ9C009.
SOURCESearch...

Entry information

Entry nameFOXQ1_HUMAN
AccessionPrimary (citable) accession number: Q9C009
Secondary accession number(s): Q9NS06
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM