Q9C007 (Q9C007_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Voltage-gated sodium channel alpha subunit splice variant SCN3A-s EMBL AAK00218.1

Gene names

Name:

SCN3A EMBL AAK00218.1

Organism

Homo sapiens (Human) EMBL AAK00218.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1951 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003809.
Sequence similarities	Belongs to the sodium channel family. RuleBase RU003809

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Sodium
Molecular function	Ion channel Sodium channel RuleBase RU003809 Voltage-gated channel RuleBase RU003809
Gene Ontology (GO)
Biological_process	sodium ion transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	voltage-gated sodium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated sodium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9C007 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 99AD4C032CE124AB	FASTA	1,951	221,520
	10 20 30 40 50 60 MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK PNSDLEAGKN 70 80 90 100 110 120 LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVMNKGKAIF RFSATSALYI LTPLNPVRKI 130 140 150 160 170 180 AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 190 200 210 220 230 240 EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 250 260 270 280 290 300 IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD 310 320 330 340 350 360 SNGTFVNVTM STFNWKDYIG DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 370 380 390 400 410 420 YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 430 440 450 460 470 480 AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGVGGLGE 490 500 510 520 530 540 LLESSSEASK LSSKGAKEWR NRRKKRRQRE HLEGNNKGER DSFPKSESED SVKRSSFLFS 550 560 570 580 590 600 MDGNRLTSDK KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 610 620 630 640 650 660 FEDSESRRDS LFVPHRHGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS SGRQRAVSIA 670 680 690 700 710 720 SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV KHLVNLIVMD PFVDLAITIC 730 740 750 760 770 780 IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG 790 800 810 820 830 840 IIVSLSLMEL GLSNVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL 850 860 870 880 890 900 AIIVFIFAVV GMQLFGKSYK ECVCKINDDC TLPRWHMNDF FHSFLIVFRV LCGEWIETMW 910 920 930 940 950 960 DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG 970 980 990 1000 1010 1020 RMQKGIDYVK NKMRECFQKA FFRKPKVIEI HEGNKIDSCM SNNTGIEISK ELNYLRDGNG 1030 1040 1050 1060 1070 1080 TTSGVGTGSS VEKYVIDEND YMSFINNPSL TVTVPIAVGE SDFENLNTEE FSSESELEES 1090 1100 1110 1120 1130 1140 KEKLNATSSS EGSTVDVVLP REGEQAETEP EEDFKPEACF TEGCIKKFPF CQVSTEEGKG 1150 1160 1170 1180 1190 1200 KIWWNLRKTC YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY 1210 1220 1230 1240 1250 1260 IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA IKSLRTLRAL 1270 1280 1290 1300 1310 1320 RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNMTT 1330 1340 1350 1360 1370 1380 GNMFDISDVN NLSDCQALGK QARWKNVKVN FDNVGAGYLA LLQVATFKGW MDIMYAAVDS 1390 1400 1410 1420 1430 1440 RDVKLQPVYE ENLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ 1450 1460 1470 1480 1490 1500 KKYYNAMKKL GSKKPQKPIP RPANKFQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD 1510 1520 1530 1540 1550 1560 QGKYMTLVLS RINLVFIVLF TGEFVLKLVS LRHYYFTIGW NIFDFVVVIL SIVGMFLAEM 1570 1580 1590 1600 1610 1620 IEKYSVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY 1630 1640 1650 1660 1670 1680 AIFGMSNFAY VKKEAGIDDM FNFETFGNSM ICLFQITTSA GWDGLLAPIL NSAPPDCDPD 1690 1700 1710 1720 1730 1740 TIHPGSSVKG DRGDPSVGIF FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD 1750 1760 1770 1780 1790 1800 FEMFYEVWEK FDPDATQFIE FSKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC 1810 1820 1830 1840 1850 1860 LDILFAFTKR VLCESGEMDA LRIQMEDRFM ASNPSKVSYE PITTTLKRKQ EEVSAAIIQR 1870 1880 1890 1900 1910 1920 NFRCYLLKQR LKNISSNYNK EAIKGRIDLP IKQDMIIDKL NGNSTPEKTD GSSSTTSPPS 1930 1940 1950 YDSVTKPDKE KFEKDKPEKE SKGKEVRENQ K

References

[1]	"Cloning of cDNA for human voltage-gated sodium channel alpha subunit, SCN3A." Jeong S.-Y., Goto J., Kanazawa I. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF225986 mRNA. Translation: AAK00218.1.
IPI	IPI00218522.
RefSeq	NP_001075145.1. NM_001081676.1.
UniGene	Hs.435274.
3D structure databases
HSSP	HSSP built from PDB template 1BYY based on UniProtKB P04775.
ProteinModelPortal	Q9C007.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9C007.
PTM databases
PhosphoSite	Q9C007.
Proteomic databases
PRIDE	Q9C007.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6328.
KEGG	hsa:6328.
Organism-specific databases
CTD	6328.
PharmGKB	PA35005.
Phylogenomic databases
HOGENOM	HOG000231755.
HOVERGEN	HBG053100.
KO	K04836.
Gene expression databases
ArrayExpress	Q9C007.
Family and domain databases
InterPro	IPR024583. DUF3451. IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. [Graphical view]
Pfam	PF11933. DUF3451. 1 hit. PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL.
SMART	SM00015. IQ. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6328.
NextBio	24562.

Entry information

Entry name

Q9C007_HUMAN

Accession

Primary (citable) accession number: Q9C007

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	March 6, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.