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Protein

Protein dpy-30 homolog

Gene

DPY30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.3 Publications

GO - Molecular functioni

  • histone-lysine N-methyltransferase activity Source: Reactome
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • chromatin silencing at telomere Source: GO_Central
  • endosomal transport Source: UniProtKB
  • histone H3-K4 methylation Source: UniProtKB
  • regulation of megakaryocyte differentiation Source: Reactome
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214841. PKMTs methylate histone lysines.
R-HSA-8936459. RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
SIGNORiQ9C005.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dpy-30 homolog
Alternative name(s):
Dpy-30-like protein
Short name:
Dpy-30L
Gene namesi
Name:DPY30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000162961.13.
HGNCiHGNC:24590. DPY30.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84661.
OpenTargetsiENSG00000162961.
PharmGKBiPA162384063.

Polymorphism and mutation databases

BioMutaiDPY30.
DMDMi14916555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146831 – 99Protein dpy-30 homologAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei35N6-acetyllysine; alternateCombined sources1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9C005.
MaxQBiQ9C005.
PaxDbiQ9C005.
PeptideAtlasiQ9C005.
PRIDEiQ9C005.
TopDownProteomicsiQ9C005.

PTM databases

iPTMnetiQ9C005.
PhosphoSitePlusiQ9C005.

Expressioni

Gene expression databases

BgeeiENSG00000162961.
CleanExiHS_DPY30.
GenevisibleiQ9C005. HS.

Organism-specific databases

HPAiHPA043761.

Interactioni

Subunit structurei

Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct. Interacts with ARFGEF1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.By similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi124181. 60 interactors.
CORUMiQ9C005.
DIPiDIP-34476N.
IntActiQ9C005. 66 interactors.
MINTiMINT-1447664.
STRINGi9606.ENSP00000295066.

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi31 – 34Combined sources4
Helixi48 – 50Combined sources3
Helixi53 – 58Combined sources6
Turni59 – 61Combined sources3
Helixi62 – 75Combined sources14
Helixi80 – 91Combined sources12
Helixi92 – 95Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G36X-ray1.20A/B/C/D45-99[»]
4RIQX-ray2.23A/B/D/E/G/H/J/K/M/N/P/Q/S/T/V/Z45-99[»]
4RT4X-ray2.00A/B/C/D41-99[»]
4RTAX-ray2.12A/B1-99[»]
ProteinModelPortaliQ9C005.
SMRiQ9C005.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9C005.

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-30 family.Curated

Phylogenomic databases

eggNOGiKOG4109. Eukaryota.
ENOG41123UZ. LUCA.
GeneTreeiENSGT00390000008808.
HOGENOMiHOG000006847.
HOVERGENiHBG051402.
InParanoidiQ9C005.
KOiK14965.
OMAiENPHAEY.
OrthoDBiEOG091G1311.
PhylomeDBiQ9C005.

Family and domain databases

InterProiView protein in InterPro
IPR007858. Dpy-30_motif.
PfamiView protein in Pfam
PF05186. Dpy-30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9C005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEQMLEGQ TQVAENPHSE YGLTDNVERI VENEKINAEK SSKQKVDLQS
60 70 80 90
LPTRAYLDQT VVPILLQGLA VLAKERPPNP IEFLASYLLK NKAQFEDRN
Length:99
Mass (Da):11,250
Last modified:June 1, 2001 - v1
Checksum:i5356AC515B9C2ADB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226998 mRNA. Translation: AAK00640.1.
CH471053 Genomic DNA. Translation: EAX00463.1.
CH471053 Genomic DNA. Translation: EAX00466.1.
BC015970 mRNA. Translation: AAH15970.1.
CCDSiCCDS1777.1.
RefSeqiNP_001308138.1. NM_001321209.1.
NP_115963.1. NM_032574.3.
UniGeneiHs.531788.
Hs.679657.

Genome annotation databases

EnsembliENST00000295066; ENSP00000295066; ENSG00000162961.
ENST00000342166; ENSP00000345837; ENSG00000162961.
GeneIDi84661.
KEGGihsa:84661.
UCSCiuc002roa.2. human.

Similar proteinsi

Entry informationi

Entry nameiDPY30_HUMAN
AccessioniPrimary (citable) accession number: Q9C005
Secondary accession number(s): D6W578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families