##gff-version 3
Q9C004	UniProtKB	Chain	1	299	.	.	.	ID=PRO_0000076905;Note=Protein sprouty homolog 4	
Q9C004	UniProtKB	Domain	166	273	.	.	.	Note=SPR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00572	
Q9C004	UniProtKB	Region	55	79	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q9C004	UniProtKB	Region	92	126	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q9C004	UniProtKB	Region	181	299	.	.	.	Note=Required for interaction with TESK1. Required for colocalization with TESK1 at vesicular spots in the cytoplasm and inhibition of TESK1 kinase activity%2C resulting in inhibition of cell spreading;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15584898;Dbxref=PMID:15584898	
Q9C004	UniProtKB	Compositional bias	92	111	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q9C004	UniProtKB	Modified residue	1	1	.	.	.	Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22223895;Dbxref=PMID:22223895	
Q9C004	UniProtKB	Modified residue	125	125	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163	
Q9C004	UniProtKB	Alternative sequence	97	106	.	.	.	ID=VSP_006219;Note=In isoform C. SSVSSSSSTS->CSATCLPPAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12027893;Dbxref=PMID:12027893	
Q9C004	UniProtKB	Alternative sequence	107	299	.	.	.	ID=VSP_006220;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12027893;Dbxref=PMID:12027893	
Q9C004	UniProtKB	Natural variant	77	77	.	.	.	ID=VAR_069929;Note=In HH17%3B phenotype consistent with Kallmann syndrome. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs774674946,PMID:23643382	
Q9C004	UniProtKB	Natural variant	82	82	.	.	.	ID=VAR_069930;Note=In HH17%3B without anosmia. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs568363732,PMID:23643382	
Q9C004	UniProtKB	Natural variant	154	154	.	.	.	ID=VAR_069931;Note=In HH17%3B phenotype consistent with Kallmann syndrome. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs78310959,PMID:23643382	
Q9C004	UniProtKB	Natural variant	186	186	.	.	.	ID=VAR_069932;Note=In HH17%3B phenotype consistent with Kallmann syndrome. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs148983803,PMID:23643382	
Q9C004	UniProtKB	Natural variant	218	218	.	.	.	ID=VAR_069933;Note=In HH17%3B some patients have a second mutation in another HH-associated gene including DUSP6 and FGFR1. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs139512218,PMID:23643382	
Q9C004	UniProtKB	Natural variant	258	258	.	.	.	ID=VAR_069934;Note=In HH17%3B without anosmia. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs200364529,PMID:23643382	
Q9C004	UniProtKB	Natural variant	281	281	.	.	.	ID=VAR_069935;Note=In HH17%3B without anosmia. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs142439525,PMID:23643382	
Q9C004	UniProtKB	Sequence conflict	102	102	.	.	.	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305