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Q9C004

- SPY4_HUMAN

UniProt

Q9C004 - SPY4_HUMAN

Protein

Protein sprouty homolog 4

Gene

SPRY4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (11 Jul 2001)
      Previous versions | rss
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    Functioni

    Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. negative regulation of MAP kinase activity Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Enzyme and pathway databases

    SignaLinkiQ9C004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein sprouty homolog 4
    Short name:
    Spry-4
    Gene namesi
    Name:SPRY4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:15533. SPRY4.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell projectionruffle membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. ruffle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hypogonadotropic hypogonadism 17 with or without anosmia (HH17) [MIM:615266]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).1 Publication
    Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in SPRY4 also have a heterozygous mutation in another HH-associated gene including DUSP6 and FGFR1 (PubMed:23643382).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771T → M in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
    VAR_069929
    Natural varianti82 – 821D → N in HH17; without anosmia. 1 Publication
    VAR_069930
    Natural varianti154 – 1541K → R in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs78310959 [ dbSNP | Ensembl ].
    VAR_069931
    Natural varianti186 – 1861C → Y in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs148983803 [ dbSNP | Ensembl ].
    VAR_069932
    Natural varianti218 – 2181S → Y in HH17; rare variant associated with susceptibility to disease; some patients have a second mutation in another HH-associated gene including DUSP6 and FGFR1. 1 Publication
    Corresponds to variant rs139512218 [ dbSNP | Ensembl ].
    VAR_069933
    Natural varianti258 – 2581V → M in HH17; without anosmia. 1 Publication
    Corresponds to variant rs200364529 [ dbSNP | Ensembl ].
    VAR_069934
    Natural varianti281 – 2811V → I in HH17; without anosmia. 1 Publication
    Corresponds to variant rs142439525 [ dbSNP | Ensembl ].
    VAR_069935

    Keywords - Diseasei

    Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

    Organism-specific databases

    MIMi615266. phenotype.
    Orphaneti478. Kallmann syndrome.
    432. Normosmic congenital hypogonadotropic hypogonadism.
    363494. Testicular non seminomatous germ cell tumor.
    842. Testicular seminomatous germ cell tumor.
    PharmGKBiPA37975.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Protein sprouty homolog 4PRO_0000076905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei125 – 1251Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9C004.
    PaxDbiQ9C004.
    PRIDEiQ9C004.

    PTM databases

    PhosphoSiteiQ9C004.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C004.
    BgeeiQ9C004.
    CleanExiHS_SPRY4.
    GenevestigatoriQ9C004.

    Organism-specific databases

    HPAiCAB008086.
    HPA055471.

    Interactioni

    Subunit structurei

    Interacts with the C-terminus of TESK1. Interacts with RAF1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CBLP226819EBI-354861,EBI-518228
    TESK1Q155694EBI-354861,EBI-354852
    ZDHHC17Q8IUH52EBI-354861,EBI-524753

    Protein-protein interaction databases

    BioGridi123599. 6 interactions.
    IntActiQ9C004. 3 interactions.
    MINTiMINT-6538953.
    STRINGi9606.ENSP00000344967.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BUNX-ray2.00A46-58[»]
    ProteinModelPortaliQ9C004.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9C004.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini166 – 273108SPRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi97 – 10711Poly-SerAdd
    BLAST
    Compositional biasi159 – 283125Cys-richAdd
    BLAST

    Domaini

    The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

    Sequence similaritiesi

    Belongs to the sprouty family.Curated
    Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG68509.
    HOGENOMiHOG000233079.
    HOVERGENiHBG003544.
    InParanoidiQ9C004.
    KOiK17385.
    OrthoDBiEOG7G4QDV.
    PhylomeDBiQ9C004.
    TreeFamiTF325070.

    Family and domain databases

    InterProiIPR007875. Sprouty.
    [Graphical view]
    PfamiPF05210. Sprouty. 1 hit.
    [Graphical view]
    PROSITEiPS51227. SPR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9C004-1) [UniParc]FASTAAdd to Basket

    Also known as: Sprouty-4A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPPIPQSAP LTPNSVMVQP LLDSRMSHSR LQHPLTILPI DQVKTSHVEN    50
    DYIDNPSLAL TTGPKRTRGG APELAPTPAR CDQDVTHHWI SFSGRPSSVS 100
    SSSSTSSDQR LLDHMAPPPV ADQASPRAVR IQPKVVHCQP LDLKGPAVPP 150
    ELDKHFLLCE ACGKCKCKEC ASPRTLPSCW VCNQECLCSA QTLVNYGTCM 200
    CLVQGIFYHC TNEDDEGSCA DHPCSCSRSN CCARWSFMGA LSVVLPCLLC 250
    YLPATGCVKL AQRGYDRLRR PGCRCKHTNS VICKAASGDA KTSRPDKPF 299
    Length:299
    Mass (Da):32,541
    Last modified:July 11, 2001 - v2
    Checksum:i105F6F1BE9F7B6C3
    GO
    Isoform C (identifier: Q9C004-2) [UniParc]FASTAAdd to Basket

    Also known as: Sprouty-4C

    The sequence of this isoform differs from the canonical sequence as follows:
         97-106: SSVSSSSSTS → CSATCLPPAA
         107-299: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:106
    Mass (Da):11,482
    Checksum:i6158571E3477A598
    GO

    Sequence cautioni

    The sequence AAK00652.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021S → N in AAI25097. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771T → M in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
    VAR_069929
    Natural varianti82 – 821D → N in HH17; without anosmia. 1 Publication
    VAR_069930
    Natural varianti154 – 1541K → R in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs78310959 [ dbSNP | Ensembl ].
    VAR_069931
    Natural varianti186 – 1861C → Y in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs148983803 [ dbSNP | Ensembl ].
    VAR_069932
    Natural varianti218 – 2181S → Y in HH17; rare variant associated with susceptibility to disease; some patients have a second mutation in another HH-associated gene including DUSP6 and FGFR1. 1 Publication
    Corresponds to variant rs139512218 [ dbSNP | Ensembl ].
    VAR_069933
    Natural varianti258 – 2581V → M in HH17; without anosmia. 1 Publication
    Corresponds to variant rs200364529 [ dbSNP | Ensembl ].
    VAR_069934
    Natural varianti281 – 2811V → I in HH17; without anosmia. 1 Publication
    Corresponds to variant rs142439525 [ dbSNP | Ensembl ].
    VAR_069935

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei97 – 10610SSVSSSSSTS → CSATCLPPAA in isoform C. 1 PublicationVSP_006219
    Alternative sequencei107 – 299193Missing in isoform C. 1 PublicationVSP_006220Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227516 mRNA. Translation: AAK00652.1. Different initiation.
    AF227517 mRNA. Translation: AAK00653.1.
    AY538661 Genomic DNA. Translation: AAS46253.1.
    AK096464 mRNA. Translation: BAC04798.1.
    AC091825 Genomic DNA. No translation available.
    BC125095 mRNA. Translation: AAI25096.1.
    BC125096 mRNA. Translation: AAI25097.1.
    CCDSiCCDS47296.1. [Q9C004-1]
    RefSeqiNP_001120968.1. NM_001127496.1. [Q9C004-1]
    NP_112226.2. NM_030964.3.
    XP_005268576.1. XM_005268519.2. [Q9C004-1]
    UniGeneiHs.323308.

    Genome annotation databases

    EnsembliENST00000344120; ENSP00000344967; ENSG00000187678.
    ENST00000434127; ENSP00000399468; ENSG00000187678. [Q9C004-1]
    GeneIDi81848.
    KEGGihsa:81848.
    UCSCiuc003lml.2. human. [Q9C004-1]

    Polymorphism databases

    DMDMi14916719.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227516 mRNA. Translation: AAK00652.1 . Different initiation.
    AF227517 mRNA. Translation: AAK00653.1 .
    AY538661 Genomic DNA. Translation: AAS46253.1 .
    AK096464 mRNA. Translation: BAC04798.1 .
    AC091825 Genomic DNA. No translation available.
    BC125095 mRNA. Translation: AAI25096.1 .
    BC125096 mRNA. Translation: AAI25097.1 .
    CCDSi CCDS47296.1. [Q9C004-1 ]
    RefSeqi NP_001120968.1. NM_001127496.1. [Q9C004-1 ]
    NP_112226.2. NM_030964.3.
    XP_005268576.1. XM_005268519.2. [Q9C004-1 ]
    UniGenei Hs.323308.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BUN X-ray 2.00 A 46-58 [» ]
    ProteinModelPortali Q9C004.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123599. 6 interactions.
    IntActi Q9C004. 3 interactions.
    MINTi MINT-6538953.
    STRINGi 9606.ENSP00000344967.

    PTM databases

    PhosphoSitei Q9C004.

    Polymorphism databases

    DMDMi 14916719.

    Proteomic databases

    MaxQBi Q9C004.
    PaxDbi Q9C004.
    PRIDEi Q9C004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344120 ; ENSP00000344967 ; ENSG00000187678 .
    ENST00000434127 ; ENSP00000399468 ; ENSG00000187678 . [Q9C004-1 ]
    GeneIDi 81848.
    KEGGi hsa:81848.
    UCSCi uc003lml.2. human. [Q9C004-1 ]

    Organism-specific databases

    CTDi 81848.
    GeneCardsi GC05M141670.
    HGNCi HGNC:15533. SPRY4.
    HPAi CAB008086.
    HPA055471.
    MIMi 607984. gene.
    615266. phenotype.
    neXtProti NX_Q9C004.
    Orphaneti 478. Kallmann syndrome.
    432. Normosmic congenital hypogonadotropic hypogonadism.
    363494. Testicular non seminomatous germ cell tumor.
    842. Testicular seminomatous germ cell tumor.
    PharmGKBi PA37975.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68509.
    HOGENOMi HOG000233079.
    HOVERGENi HBG003544.
    InParanoidi Q9C004.
    KOi K17385.
    OrthoDBi EOG7G4QDV.
    PhylomeDBi Q9C004.
    TreeFami TF325070.

    Enzyme and pathway databases

    SignaLinki Q9C004.

    Miscellaneous databases

    ChiTaRSi SPRY4. human.
    EvolutionaryTracei Q9C004.
    GeneWikii SPRY4.
    GenomeRNAii 81848.
    NextBioi 72154.
    PROi Q9C004.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C004.
    Bgeei Q9C004.
    CleanExi HS_SPRY4.
    Genevestigatori Q9C004.

    Family and domain databases

    InterProi IPR007875. Sprouty.
    [Graphical view ]
    Pfami PF05210. Sprouty. 1 hit.
    [Graphical view ]
    PROSITEi PS51227. SPR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND C), CHARACTERIZATION, SUBCELLULAR LOCATION, INTERACTION WITH TESK1.
      Tissue: Umbilical artery.
    2. "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis."
      Ding W., Bellusci S., Shi W., Warburton D.
      Am. J. Physiol. 287:L52-L59(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Brain.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    6. "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1."
      Sasaki A., Taketomi T., Kato R., Saeki K., Nonami A., Sasaki M., Kuriyama M., Saito N., Shibuya M., Yoshimura A.
      Nat. Cell Biol. 5:427-432(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RAF1.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: VARIANTS HH17 MET-77; ASN-82; ARG-154; TYR-186; TYR-218; MET-258 AND ILE-281.

    Entry informationi

    Entry nameiSPY4_HUMAN
    AccessioniPrimary (citable) accession number: Q9C004
    Secondary accession number(s): A4FVB2
    , A4FVB3, Q6QIX2, Q9C003
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: July 11, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3