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Q9C004

- SPY4_HUMAN

UniProt

Q9C004 - SPY4_HUMAN

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Protein

Protein sprouty homolog 4

Gene

SPRY4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.1 Publication

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. negative regulation of MAP kinase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

SignaLinkiQ9C004.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 4
Short name:
Spry-4
Gene namesi
Name:SPRY4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:15533. SPRY4.

Subcellular locationi

Cytoplasm 1 Publication. Cell projectionruffle membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: HPA
  3. focal adhesion Source: UniProtKB
  4. Golgi apparatus Source: HPA
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 17 with or without anosmia (HH17) [MIM:615266]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).1 Publication
Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in SPRY4 also have a heterozygous mutation in another HH-associated gene including DUSP6 and FGFR1 (PubMed:23643382).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771T → M in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_069929
Natural varianti82 – 821D → N in HH17; without anosmia. 1 Publication
VAR_069930
Natural varianti154 – 1541K → R in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs78310959 [ dbSNP | Ensembl ].
VAR_069931
Natural varianti186 – 1861C → Y in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs148983803 [ dbSNP | Ensembl ].
VAR_069932
Natural varianti218 – 2181S → Y in HH17; rare variant associated with susceptibility to disease; some patients have a second mutation in another HH-associated gene including DUSP6 and FGFR1. 1 Publication
Corresponds to variant rs139512218 [ dbSNP | Ensembl ].
VAR_069933
Natural varianti258 – 2581V → M in HH17; without anosmia. 1 Publication
Corresponds to variant rs200364529 [ dbSNP | Ensembl ].
VAR_069934
Natural varianti281 – 2811V → I in HH17; without anosmia. 1 Publication
Corresponds to variant rs142439525 [ dbSNP | Ensembl ].
VAR_069935

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

MIMi615266. phenotype.
Orphaneti478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
363494. Testicular non seminomatous germ cell tumor.
PharmGKBiPA37975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Protein sprouty homolog 4PRO_0000076905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei125 – 1251Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9C004.
PaxDbiQ9C004.
PRIDEiQ9C004.

PTM databases

PhosphoSiteiQ9C004.

Expressioni

Gene expression databases

BgeeiQ9C004.
CleanExiHS_SPRY4.
ExpressionAtlasiQ9C004. baseline and differential.
GenevestigatoriQ9C004.

Organism-specific databases

HPAiCAB008086.
HPA055471.

Interactioni

Subunit structurei

Interacts with the C-terminus of TESK1. Interacts with RAF1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CBLP226819EBI-354861,EBI-518228
TESK1Q155694EBI-354861,EBI-354852
ZDHHC17Q8IUH52EBI-354861,EBI-524753

Protein-protein interaction databases

BioGridi123599. 6 interactions.
IntActiQ9C004. 3 interactions.
MINTiMINT-6538953.
STRINGi9606.ENSP00000344967.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BUNX-ray2.00A46-58[»]
ProteinModelPortaliQ9C004.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9C004.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 273108SPRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 10711Poly-SerAdd
BLAST
Compositional biasi159 – 283125Cys-richAdd
BLAST

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG68509.
GeneTreeiENSGT00390000003535.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiQ9C004.
KOiK17385.
OrthoDBiEOG7G4QDV.
PhylomeDBiQ9C004.
TreeFamiTF325070.

Family and domain databases

InterProiIPR007875. Sprouty.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9C004-1) [UniParc]FASTAAdd to Basket

Also known as: Sprouty-4A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPPIPQSAP LTPNSVMVQP LLDSRMSHSR LQHPLTILPI DQVKTSHVEN
60 70 80 90 100
DYIDNPSLAL TTGPKRTRGG APELAPTPAR CDQDVTHHWI SFSGRPSSVS
110 120 130 140 150
SSSSTSSDQR LLDHMAPPPV ADQASPRAVR IQPKVVHCQP LDLKGPAVPP
160 170 180 190 200
ELDKHFLLCE ACGKCKCKEC ASPRTLPSCW VCNQECLCSA QTLVNYGTCM
210 220 230 240 250
CLVQGIFYHC TNEDDEGSCA DHPCSCSRSN CCARWSFMGA LSVVLPCLLC
260 270 280 290
YLPATGCVKL AQRGYDRLRR PGCRCKHTNS VICKAASGDA KTSRPDKPF
Length:299
Mass (Da):32,541
Last modified:July 11, 2001 - v2
Checksum:i105F6F1BE9F7B6C3
GO
Isoform C (identifier: Q9C004-2) [UniParc]FASTAAdd to Basket

Also known as: Sprouty-4C

The sequence of this isoform differs from the canonical sequence as follows:
     97-106: SSVSSSSSTS → CSATCLPPAA
     107-299: Missing.

Note: No experimental confirmation available.

Show »
Length:106
Mass (Da):11,482
Checksum:i6158571E3477A598
GO

Sequence cautioni

The sequence AAK00652.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021S → N in AAI25097. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771T → M in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_069929
Natural varianti82 – 821D → N in HH17; without anosmia. 1 Publication
VAR_069930
Natural varianti154 – 1541K → R in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs78310959 [ dbSNP | Ensembl ].
VAR_069931
Natural varianti186 – 1861C → Y in HH17; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs148983803 [ dbSNP | Ensembl ].
VAR_069932
Natural varianti218 – 2181S → Y in HH17; rare variant associated with susceptibility to disease; some patients have a second mutation in another HH-associated gene including DUSP6 and FGFR1. 1 Publication
Corresponds to variant rs139512218 [ dbSNP | Ensembl ].
VAR_069933
Natural varianti258 – 2581V → M in HH17; without anosmia. 1 Publication
Corresponds to variant rs200364529 [ dbSNP | Ensembl ].
VAR_069934
Natural varianti281 – 2811V → I in HH17; without anosmia. 1 Publication
Corresponds to variant rs142439525 [ dbSNP | Ensembl ].
VAR_069935

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 10610SSVSSSSSTS → CSATCLPPAA in isoform C. 1 PublicationVSP_006219
Alternative sequencei107 – 299193Missing in isoform C. 1 PublicationVSP_006220Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227516 mRNA. Translation: AAK00652.1. Different initiation.
AF227517 mRNA. Translation: AAK00653.1.
AY538661 Genomic DNA. Translation: AAS46253.1.
AK096464 mRNA. Translation: BAC04798.1.
AC091825 Genomic DNA. No translation available.
BC125095 mRNA. Translation: AAI25096.1.
BC125096 mRNA. Translation: AAI25097.1.
CCDSiCCDS47296.1. [Q9C004-1]
RefSeqiNP_001120968.1. NM_001127496.1. [Q9C004-1]
NP_001280218.1. NM_001293289.1. [Q9C004-1]
NP_001280219.1. NM_001293290.1. [Q9C004-1]
NP_112226.2. NM_030964.3.
XP_005268576.1. XM_005268519.2. [Q9C004-1]
UniGeneiHs.323308.

Genome annotation databases

EnsembliENST00000344120; ENSP00000344967; ENSG00000187678.
ENST00000434127; ENSP00000399468; ENSG00000187678. [Q9C004-1]
GeneIDi81848.
KEGGihsa:81848.
UCSCiuc003lml.2. human. [Q9C004-1]

Polymorphism databases

DMDMi14916719.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227516 mRNA. Translation: AAK00652.1 . Different initiation.
AF227517 mRNA. Translation: AAK00653.1 .
AY538661 Genomic DNA. Translation: AAS46253.1 .
AK096464 mRNA. Translation: BAC04798.1 .
AC091825 Genomic DNA. No translation available.
BC125095 mRNA. Translation: AAI25096.1 .
BC125096 mRNA. Translation: AAI25097.1 .
CCDSi CCDS47296.1. [Q9C004-1 ]
RefSeqi NP_001120968.1. NM_001127496.1. [Q9C004-1 ]
NP_001280218.1. NM_001293289.1. [Q9C004-1 ]
NP_001280219.1. NM_001293290.1. [Q9C004-1 ]
NP_112226.2. NM_030964.3.
XP_005268576.1. XM_005268519.2. [Q9C004-1 ]
UniGenei Hs.323308.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BUN X-ray 2.00 A 46-58 [» ]
ProteinModelPortali Q9C004.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123599. 6 interactions.
IntActi Q9C004. 3 interactions.
MINTi MINT-6538953.
STRINGi 9606.ENSP00000344967.

PTM databases

PhosphoSitei Q9C004.

Polymorphism databases

DMDMi 14916719.

Proteomic databases

MaxQBi Q9C004.
PaxDbi Q9C004.
PRIDEi Q9C004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344120 ; ENSP00000344967 ; ENSG00000187678 .
ENST00000434127 ; ENSP00000399468 ; ENSG00000187678 . [Q9C004-1 ]
GeneIDi 81848.
KEGGi hsa:81848.
UCSCi uc003lml.2. human. [Q9C004-1 ]

Organism-specific databases

CTDi 81848.
GeneCardsi GC05M141670.
HGNCi HGNC:15533. SPRY4.
HPAi CAB008086.
HPA055471.
MIMi 607984. gene.
615266. phenotype.
neXtProti NX_Q9C004.
Orphaneti 478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
363494. Testicular non seminomatous germ cell tumor.
PharmGKBi PA37975.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68509.
GeneTreei ENSGT00390000003535.
HOGENOMi HOG000233079.
HOVERGENi HBG003544.
InParanoidi Q9C004.
KOi K17385.
OrthoDBi EOG7G4QDV.
PhylomeDBi Q9C004.
TreeFami TF325070.

Enzyme and pathway databases

SignaLinki Q9C004.

Miscellaneous databases

ChiTaRSi SPRY4. human.
EvolutionaryTracei Q9C004.
GeneWikii SPRY4.
GenomeRNAii 81848.
NextBioi 72154.
PROi Q9C004.
SOURCEi Search...

Gene expression databases

Bgeei Q9C004.
CleanExi HS_SPRY4.
ExpressionAtlasi Q9C004. baseline and differential.
Genevestigatori Q9C004.

Family and domain databases

InterProi IPR007875. Sprouty.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
[Graphical view ]
PROSITEi PS51227. SPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND C), CHARACTERIZATION, SUBCELLULAR LOCATION, INTERACTION WITH TESK1.
    Tissue: Umbilical artery.
  2. "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis."
    Ding W., Bellusci S., Shi W., Warburton D.
    Am. J. Physiol. 287:L52-L59(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
  6. "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1."
    Sasaki A., Taketomi T., Kato R., Saeki K., Nonami A., Sasaki M., Kuriyama M., Saito N., Shibuya M., Yoshimura A.
    Nat. Cell Biol. 5:427-432(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAF1.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANTS HH17 MET-77; ASN-82; ARG-154; TYR-186; TYR-218; MET-258 AND ILE-281.

Entry informationi

Entry nameiSPY4_HUMAN
AccessioniPrimary (citable) accession number: Q9C004
Secondary accession number(s): A4FVB2
, A4FVB3, Q6QIX2, Q9C003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 11, 2001
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3