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Protein

Normal mucosa of esophagus-specific gene 1 protein

Gene

NMES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Normal mucosa of esophagus-specific gene 1 protein
Alternative name(s):
Protein FOAP-11
Gene namesi
Name:NMES1
Synonyms:C15orf48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29898. C15orf48.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672265.

Polymorphism and mutation databases

BioMutaiNMES1.
DMDMi23396774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Normal mucosa of esophagus-specific gene 1 proteinPRO_0000118823Add
BLAST

Proteomic databases

MaxQBiQ9C002.
PaxDbiQ9C002.
PeptideAtlasiQ9C002.
PRIDEiQ9C002.
TopDownProteomicsiQ9C002.

PTM databases

iPTMnetiQ9C002.
PhosphoSiteiQ9C002.

Expressioni

Tissue specificityi

Expressed mainly in stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. Down-regulated in esophageal squamous cell carcinoma.

Gene expression databases

BgeeiQ9C002.
CleanExiHS_C15orf48.
ExpressionAtlasiQ9C002. baseline and differential.
GenevisibleiQ9C002. HS.

Organism-specific databases

HPAiHPA012943.

Interactioni

Protein-protein interaction databases

BioGridi124071. 2 interactions.
IntActiQ9C002. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9C002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J1F7. Eukaryota.
ENOG410YXE9. LUCA.
GeneTreeiENSGT00390000009277.
HOGENOMiHOG000261679.
HOVERGENiHBG052639.
InParanoidiQ9C002.
OMAiQWKPVET.
OrthoDBiEOG73BVGK.
PhylomeDBiQ9C002.
TreeFamiTF106383.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFQLLMKR KELIPLVVFM TVAAGGASSF AVYSLWKTDV ILDRKKNPEP
60 70 80
WETVDPTVPQ KLITINQQWK PIEELQNVQR VTK
Length:83
Mass (Da):9,617
Last modified:June 1, 2001 - v1
Checksum:i21884FE8A009C039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228422 mRNA. Translation: AAK00708.1.
AB026707 mRNA. Translation: BAB61021.1.
BC021173 mRNA. Translation: AAH21173.1.
CCDSiCCDS10124.1.
RefSeqiNP_115789.1. NM_032413.3.
NP_922946.1. NM_197955.2.
UniGeneiHs.112242.

Genome annotation databases

EnsembliENST00000344300; ENSP00000341610; ENSG00000166920.
ENST00000396650; ENSP00000379887; ENSG00000166920.
GeneIDi84419.
KEGGihsa:84419.
UCSCiuc001zvg.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228422 mRNA. Translation: AAK00708.1.
AB026707 mRNA. Translation: BAB61021.1.
BC021173 mRNA. Translation: AAH21173.1.
CCDSiCCDS10124.1.
RefSeqiNP_115789.1. NM_032413.3.
NP_922946.1. NM_197955.2.
UniGeneiHs.112242.

3D structure databases

ProteinModelPortaliQ9C002.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124071. 2 interactions.
IntActiQ9C002. 2 interactions.

PTM databases

iPTMnetiQ9C002.
PhosphoSiteiQ9C002.

Polymorphism and mutation databases

BioMutaiNMES1.
DMDMi23396774.

Proteomic databases

MaxQBiQ9C002.
PaxDbiQ9C002.
PeptideAtlasiQ9C002.
PRIDEiQ9C002.
TopDownProteomicsiQ9C002.

Protocols and materials databases

DNASUi84419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344300; ENSP00000341610; ENSG00000166920.
ENST00000396650; ENSP00000379887; ENSG00000166920.
GeneIDi84419.
KEGGihsa:84419.
UCSCiuc001zvg.5. human.

Organism-specific databases

CTDi84419.
GeneCardsiC15orf48.
HGNCiHGNC:29898. C15orf48.
HPAiHPA012943.
MIMi608409. gene.
neXtProtiNX_Q9C002.
PharmGKBiPA142672265.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1F7. Eukaryota.
ENOG410YXE9. LUCA.
GeneTreeiENSGT00390000009277.
HOGENOMiHOG000261679.
HOVERGENiHBG052639.
InParanoidiQ9C002.
OMAiQWKPVET.
OrthoDBiEOG73BVGK.
PhylomeDBiQ9C002.
TreeFamiTF106383.

Miscellaneous databases

GenomeRNAii84419.
PROiQ9C002.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C002.
CleanExiHS_C15orf48.
ExpressionAtlasiQ9C002. baseline and differential.
GenevisibleiQ9C002. HS.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma."
    Zhou J., Wang H., Lu A., Hu G., Luo A., Ding F., Zhang J., Wang X., Wu M., Liu Z.
    Int. J. Cancer 101:311-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Homo sapiens mRNA for FOAP-11 protein, complete cds."
    Fujii Y., Takayama K., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguhci A.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Macrophage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiNMES1_HUMAN
AccessioniPrimary (citable) accession number: Q9C002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.