Reviewed, UniProtKB/Swiss-Prot Q9C002 (NMES1_HUMAN)

Names and origin

Protein names

Recommended name:
    Normal mucosa of esophagus-specific gene 1 protein
Alternative name(s):
    Protein FOAP-11

Gene names

Name:	NMES1
Synonyms:	C15orf48

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus. Ref.1
Tissue specificity	Expressed mainly in stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. Down-regulated in esophageal squamous cell carcinoma.
Sequence similarities	Belongs to the complex I NDUFA4 subunit family.

Ontologies

Keywords
Cellular component	Nucleus
Gene Ontology (GO)
Cellular component	nucleus Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 83	83	Normal mucosa of esophagus-specific gene 1 protein		PRO_0000118823

Sequences

	Sequence		Length	Mass (Da)
	Q9C002-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 21884FE8A009C039	FASTA	83	9,617
	10 20 30 40 50 60 MSFFQLLMKR KELIPLVVFM TVAAGGASSF AVYSLWKTDV ILDRKKNPEP WETVDPTVPQ 70 80 KLITINQQWK PIEELQNVQR VTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma." Zhou J., Wang H., Lu A., Hu G., Luo A., Ding F., Zhang J., Wang X., Wu M., Liu Z. Int. J. Cancer 101:311-316(2002) [PubMed: 12209954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]	"Homo sapiens mRNA for FOAP-11 protein, complete cds." Fujii Y., Takayama K., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguhci A. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Macrophage.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF228422 mRNA. Translation: AAK00708.1. AB026707 mRNA. Translation: BAB61021.1. BC021173 mRNA. Translation: AAH21173.1.
IPI	IPI00031772.
RefSeq	NP_115789.1. NP_922946.1.
UniGene	Hs.112242
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9C002.
Proteomic databases
PRIDE	Q9C002.
Genome annotation databases
Ensembl	ENSG00000166920. Homo sapiens. [Contig view]
GeneID	84419.
KEGG	hsa:84419.
Organism-specific databases
GeneCards	GC15P043511.
H-InvDB	HIX0012210.
HGNC	HGNC:29898. C15orf48.
MIM	608409. gene.
PharmGKB	PA142672265.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9C002.
HOVERGEN	Q9C002.
OMA	Q9C002. IDRKRNP.
Gene expression databases
ArrayExpress	Q9C002.
Bgee	Q9C002.
CleanEx	HS_C15orf48.
GermOnline	ENSG00000166920. Homo sapiens.
Family and domain databases
InterPro	IPR019550. NADH_Ub_cplx-1_asub_su-4. [Graphical view]
Pfam	PF10526. NADH_ub_rd_NUML. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74160.
SOURCE	Search...

Entry information

Entry name

NMES1_HUMAN

Accession

Primary (citable) accession number: Q9C002

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)