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Protein

Normal mucosa of esophagus-specific gene 1 protein

Gene

NMES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Normal mucosa of esophagus-specific gene 1 protein
Alternative name(s):
Protein FOAP-11
Gene namesi
Name:NMES1
Synonyms:C15orf48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29898. C15orf48.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex IV Source: GO_Central
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84419.
OpenTargetsiENSG00000166920.
PharmGKBiPA142672265.

Polymorphism and mutation databases

BioMutaiNMES1.
DMDMi23396774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188231 – 83Normal mucosa of esophagus-specific gene 1 proteinAdd BLAST83

Proteomic databases

MaxQBiQ9C002.
PaxDbiQ9C002.
PeptideAtlasiQ9C002.
PRIDEiQ9C002.
TopDownProteomicsiQ9C002.

PTM databases

iPTMnetiQ9C002.
PhosphoSitePlusiQ9C002.

Expressioni

Tissue specificityi

Expressed mainly in stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. Down-regulated in esophageal squamous cell carcinoma.

Gene expression databases

BgeeiENSG00000166920.
CleanExiHS_C15orf48.
ExpressionAtlasiQ9C002. baseline and differential.
GenevisibleiQ9C002. HS.

Organism-specific databases

HPAiHPA012677.
HPA012943.

Interactioni

Protein-protein interaction databases

BioGridi124071. 120 interactors.
IntActiQ9C002. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9C002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J1F7. Eukaryota.
ENOG410YXE9. LUCA.
GeneTreeiENSGT00390000009277.
HOGENOMiHOG000261679.
HOVERGENiHBG052639.
InParanoidiQ9C002.
OMAiQWKPVET.
PhylomeDBiQ9C002.
TreeFamiTF106383.

Family and domain databases

InterProiView protein in InterPro
IPR010530. B12D.
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiView protein in Pfam
PF06522. B12D. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9C002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFQLLMKR KELIPLVVFM TVAAGGASSF AVYSLWKTDV ILDRKKNPEP
60 70 80
WETVDPTVPQ KLITINQQWK PIEELQNVQR VTK
Length:83
Mass (Da):9,617
Last modified:June 1, 2001 - v1
Checksum:i21884FE8A009C039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228422 mRNA. Translation: AAK00708.1.
AB026707 mRNA. Translation: BAB61021.1.
BC021173 mRNA. Translation: AAH21173.1.
CCDSiCCDS10124.1.
RefSeqiNP_115789.1. NM_032413.3.
NP_922946.1. NM_197955.2.
UniGeneiHs.112242.

Genome annotation databases

EnsembliENST00000344300; ENSP00000341610; ENSG00000166920.
ENST00000396650; ENSP00000379887; ENSG00000166920.
GeneIDi84419.
KEGGihsa:84419.
UCSCiuc001zvg.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228422 mRNA. Translation: AAK00708.1.
AB026707 mRNA. Translation: BAB61021.1.
BC021173 mRNA. Translation: AAH21173.1.
CCDSiCCDS10124.1.
RefSeqiNP_115789.1. NM_032413.3.
NP_922946.1. NM_197955.2.
UniGeneiHs.112242.

3D structure databases

ProteinModelPortaliQ9C002.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124071. 120 interactors.
IntActiQ9C002. 2 interactors.

PTM databases

iPTMnetiQ9C002.
PhosphoSitePlusiQ9C002.

Polymorphism and mutation databases

BioMutaiNMES1.
DMDMi23396774.

Proteomic databases

MaxQBiQ9C002.
PaxDbiQ9C002.
PeptideAtlasiQ9C002.
PRIDEiQ9C002.
TopDownProteomicsiQ9C002.

Protocols and materials databases

DNASUi84419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344300; ENSP00000341610; ENSG00000166920.
ENST00000396650; ENSP00000379887; ENSG00000166920.
GeneIDi84419.
KEGGihsa:84419.
UCSCiuc001zvg.5. human.

Organism-specific databases

CTDi84419.
DisGeNETi84419.
GeneCardsiC15orf48.
MIR147B.
HGNCiHGNC:29898. C15orf48.
HPAiHPA012677.
HPA012943.
MIMi608409. gene.
neXtProtiNX_Q9C002.
OpenTargetsiENSG00000166920.
PharmGKBiPA142672265.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1F7. Eukaryota.
ENOG410YXE9. LUCA.
GeneTreeiENSGT00390000009277.
HOGENOMiHOG000261679.
HOVERGENiHBG052639.
InParanoidiQ9C002.
OMAiQWKPVET.
PhylomeDBiQ9C002.
TreeFamiTF106383.

Miscellaneous databases

GenomeRNAii84419.
PROiPR:Q9C002.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166920.
CleanExiHS_C15orf48.
ExpressionAtlasiQ9C002. baseline and differential.
GenevisibleiQ9C002. HS.

Family and domain databases

InterProiView protein in InterPro
IPR010530. B12D.
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiView protein in Pfam
PF06522. B12D. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNMES1_HUMAN
AccessioniPrimary (citable) accession number: Q9C002
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: March 15, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.