Q9C001 (Q9C001_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Interleukin-2 EMBL AAG53575.1
Organism	Homo sapiens (Human) EMBL AAG53575.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	150 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro negative regulation of heart contraction Inferred from electronic annotation. Source: Compara negative regulation of inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of lymphocyte proliferation Inferred from electronic annotation. Source: Compara negative regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of activated T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of dendritic spine development Inferred from electronic annotation. Source: Compara positive regulation of immunoglobulin secretion Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of isotype switching to IgG isotypes Inferred from electronic annotation. Source: Compara positive regulation of regulatory T cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat5 protein Inferred from electronic annotation. Source: Compara protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of T cell homeostatic proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: Compara glycosphingolipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	150	1	EMBL AAG53575.1

Sequences

	Sequence		Length	Mass (Da)
	Q9C001 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: BF25860F8436ACE5	FASTA	150	17,312
	10 20 30 40 50 60 MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML 70 80 90 100 110 120 TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE 130 140 150 TTFMCEYADE TATIVEFLNR WITFCQSIIS

References

[1]	"Allelic selection of human IL-2 gene." Matesanz F., Delgado C., Fresno M., Alcina A. Eur. J. Immunol. 30:3516-3521(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF228636 mRNA. Translation: AAG53575.1.
IPI	IPI00003099.
UniGene	Hs.89679.
3D structure databases
HSSP	HSSP built from PDB template 1IRL based on UniProtKB P60568.
ProteinModelPortal	Q9C001.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9C001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG007496.
Gene expression databases
ArrayExpress	Q9C001.
Bgee	Q9C001.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000779. Interleukin-2. [Graphical view]
PANTHER	PTHR11443. PTHR11443. 1 hit.
Pfam	PF00715. IL2. 1 hit. [Graphical view]
PRINTS	PR00265. INTERLEUKIN2.
ProDom	PD003649. Interleukin-2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00189. IL2. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00424. INTERLEUKIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9C001_HUMAN

Accession

Primary (citable) accession number: Q9C001

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.