Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9C001

- Q9C001_HUMAN

UniProt

Q9C001 - Q9C001_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Interleukin-2

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: Ensembl
  2. glycosphingolipid binding Source: Ensembl

GO - Biological processi

  1. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  2. immune response Source: InterPro
  3. negative regulation of heart contraction Source: Ensembl
  4. negative regulation of inflammatory response Source: Ensembl
  5. negative regulation of lymphocyte proliferation Source: Ensembl
  6. negative regulation of protein phosphorylation Source: Ensembl
  7. positive regulation of activated T cell proliferation Source: Ensembl
  8. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  9. positive regulation of dendritic spine development Source: Ensembl
  10. positive regulation of immunoglobulin secretion Source: Ensembl
  11. positive regulation of interferon-gamma production Source: Ensembl
  12. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  13. positive regulation of regulatory T cell differentiation Source: Ensembl
  14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  15. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  16. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  17. regulation of T cell homeostatic proliferation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9C001.
ExpressionAtlasiQ9C001. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ9C001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG007496.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9C001-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS
Length:150
Mass (Da):17,312
Last modified:June 1, 2001 - v1
Checksum:iBF25860F8436ACE5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei150 – 1501Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228636 mRNA. Translation: AAG53575.1.
UniGeneiHs.89679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228636 mRNA. Translation: AAG53575.1 .
UniGenei Hs.89679.

3D structure databases

ProteinModelPortali Q9C001.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG007496.

Gene expression databases

Bgeei Q9C001.
ExpressionAtlasi Q9C001. baseline and differential.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view ]
PANTHERi PTHR11443. PTHR11443. 1 hit.
Pfami PF00715. IL2. 1 hit.
[Graphical view ]
PRINTSi PR00265. INTERLEUKIN2.
ProDomi PD003649. Interleukin-2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00189. IL2. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9C001_HUMAN
AccessioniPrimary (citable) accession number: Q9C001
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.