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Protein

Interleukin-2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation
Biological processAdaptive immunityUniRule annotation, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2UniRule annotation
Short name:
IL-2UniRule annotation
Gene namesi
Name:IL2UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500903192221 – 150Interleukin-2UniRule annotationAdd BLAST130

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PRIDEiQ9C001

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9C001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 96Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the IL-2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
HOVERGENiHBG007496

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9C001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS
Length:150
Mass (Da):17,312
Last modified:June 1, 2001 - v1
Checksum:iBF25860F8436ACE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei150Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228636 mRNA Translation: AAG53575.1
UniGeneiHs.89679

Similar proteinsi

Entry informationi

Entry nameiQ9C001_HUMAN
AccessioniPrimary (citable) accession number: Q9C001
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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