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Protein

Interleukin-2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation
Biological processAdaptive immunityUniRule annotation, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2UniRule annotation
Short name:
IL-2UniRule annotation
Gene namesi
Name:IL2UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500903192221 – 150Interleukin-2UniRule annotationAdd BLAST130

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiQ9C001.

Expressioni

Gene expression databases

BgeeiENSG00000109471.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000226730.

Structurei

3D structure databases

ProteinModelPortaliQ9C001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOVERGENiHBG007496.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
PANTHERiPTHR10078:SF32. PTHR10078:SF32. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00424. INTERLEUKIN_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9C001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS
Length:150
Mass (Da):17,312
Last modified:June 1, 2001 - v1
Checksum:iBF25860F8436ACE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei150Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228636 mRNA. Translation: AAG53575.1.
UniGeneiHs.89679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228636 mRNA. Translation: AAG53575.1.
UniGeneiHs.89679.

3D structure databases

ProteinModelPortaliQ9C001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000226730.

Proteomic databases

PaxDbiQ9C001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOVERGENiHBG007496.

Gene expression databases

BgeeiENSG00000109471.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
PANTHERiPTHR10078:SF32. PTHR10078:SF32. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00424. INTERLEUKIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9C001_HUMAN
AccessioniPrimary (citable) accession number: Q9C001
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.