##gff-version 3 Q9C000 UniProtKB Chain 1 1473 . . . ID=PRO_0000096710;Note=NACHT%2C LRR and PYD domains-containing protein 1 Q9C000 UniProtKB Chain 1 1212 . . . ID=PRO_0000452851;Note=NACHT%2C LRR and PYD domains-containing protein 1%2C N-terminus;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Chain 1213 1473 . . . ID=PRO_0000452852;Note=NACHT%2C LRR and PYD domains-containing protein 1%2C C-terminus;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Domain 1 92 . . . Note=Pyrin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00061 Q9C000 UniProtKB Domain 328 637 . . . Note=NACHT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136 Q9C000 UniProtKB Repeat 809 830 . . . Note=LRR 1 Q9C000 UniProtKB Repeat 838 858 . . . Note=LRR 2 Q9C000 UniProtKB Repeat 866 887 . . . Note=LRR 3 Q9C000 UniProtKB Repeat 895 915 . . . Note=LRR 4 Q9C000 UniProtKB Repeat 923 944 . . . Note=LRR 5 Q9C000 UniProtKB Repeat 950 973 . . . Note=LRR 6 Q9C000 UniProtKB Domain 1079 1364 . . . Note=FIIND;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01174 Q9C000 UniProtKB Domain 1374 1463 . . . Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046 Q9C000 UniProtKB Region 90 113 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9C000 UniProtKB Region 160 254 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9C000 UniProtKB Region 991 1017 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9C000 UniProtKB Region 1079 1212 . . . Note=ZU5;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22087307;Dbxref=PMID:22087307 Q9C000 UniProtKB Region 1213 1364 . . . Note=UPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22087307;Dbxref=PMID:22087307 Q9C000 UniProtKB Motif 111 117 . . . Note=ZAKalpha motif 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Motif 177 183 . . . Note=ZAKalpha motif 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Compositional bias 160 187 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9C000 UniProtKB Compositional bias 215 231 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9C000 UniProtKB Compositional bias 997 1015 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9C000 UniProtKB Binding site 334 341 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136 Q9C000 UniProtKB Site 130 131 . . . Note=(Microbial infection) Cleavage%3B by human rhinovirus 14 (HRV-14) Protease 3C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:33093214,ECO:0000269|PubMed:33410748;Dbxref=PMID:33093214,PMID:33410748 Q9C000 UniProtKB Site 333 334 . . . Note=(Microbial infection) Cleavage%3B by coronavirus SARS-CoV-2 proteinase nsp5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35594856;Dbxref=PMID:35594856 Q9C000 UniProtKB Site 1212 1213 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01174,ECO:0000269|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Modified residue 93 93 . . . Note=Phosphoserine%3B by MAPK11 and MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 99 99 . . . Note=Phosphoserine%3B by MAPK11 and MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 101 101 . . . Note=Phosphoserine%3B by MAPK11 and MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 107 107 . . . Note=Phosphoserine%3B by MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 112 112 . . . Note=Phosphothreonine%3B by MAPK11%2C MAPK14 and MAP3K20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 113 113 . . . Note=Phosphoserine%3B by MAP3K20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 114 114 . . . Note=Phosphothreonine%3B by MAP3K20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 129 129 . . . Note=Phosphothreonine%3B by MAP3K20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 132 132 . . . Note=Phosphoserine%3B by MAP3K20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 163 163 . . . Note=Phosphoserine%3B by MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 168 168 . . . Note=Phosphoserine%3B by MAPK11 and MAPk14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 170 170 . . . Note=Phosphoserine%3B by MAPK11 and MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 173 173 . . . Note=Phosphoserine%3B by MAPK11;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 178 178 . . . Note=Phosphothreonine%3B by MAPK11;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 179 179 . . . Note=Phosphoserine%3B by MAPK11 and MAP3K20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Modified residue 180 180 . . . Note=Phosphothreonine%3B by MAPK11 and MAP3K20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Alternative sequence 958 987 . . . ID=VSP_004326;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11113115;Dbxref=PMID:11113115 Q9C000 UniProtKB Alternative sequence 1044 1044 . . . ID=VSP_053803;Note=In isoform 5. A->AGKSH;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q9C000 UniProtKB Alternative sequence 1262 1305 . . . ID=VSP_004327;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:11076957,ECO:0000303|PubMed:11113115,ECO:0000303|PubMed:11250163,ECO:0000303|PubMed:11270363;Dbxref=PMID:10231032,PMID:11076957,PMID:11113115,PMID:11250163,PMID:11270363 Q9C000 UniProtKB Alternative sequence 1354 1371 . . . ID=VSP_053804;Note=In isoform 5. DLMPATTLIPPARIAVPS->RNTSQPWNLRCNRDARRY;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q9C000 UniProtKB Alternative sequence 1372 1473 . . . ID=VSP_053805;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q9C000 UniProtKB Natural variant 54 54 . . . ID=VAR_078798;Note=In MSPC%3B increased NLRP1-inflammasome complex assembly%3B altered protein folding. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27662089;Dbxref=dbSNP:rs1057519492,PMID:27662089 Q9C000 UniProtKB Natural variant 66 66 . . . ID=VAR_078799;Note=In MSPC%3B increased NLRP1-inflammasome complex assembly%3B altered protein folding. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27662089;Dbxref=dbSNP:rs1057519493,PMID:27662089 Q9C000 UniProtKB Natural variant 77 77 . . . ID=VAR_069901;Note=In MSPC%3B destabilization of the N-terminal fragment. M->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23349227,ECO:0000269|PubMed:33093214;Dbxref=dbSNP:rs397514692,PMID:23349227,PMID:33093214 Q9C000 UniProtKB Natural variant 155 155 . . . ID=VAR_033239;Note=Risk factor for VAMAS1. L->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11270363,ECO:0000269|PubMed:17377159;Dbxref=dbSNP:rs12150220,PMID:11270363,PMID:17377159 Q9C000 UniProtKB Natural variant 246 246 . . . ID=VAR_024238;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11270363;Dbxref=dbSNP:rs11651595,PMID:11270363 Q9C000 UniProtKB Natural variant 404 404 . . . ID=VAR_021886;Note=R->Q;Dbxref=dbSNP:rs3744718 Q9C000 UniProtKB Natural variant 726 726 . . . ID=VAR_078800;Note=In AIADK%3B uncertain significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27965258;Dbxref=dbSNP:rs776245016,PMID:27965258 Q9C000 UniProtKB Natural variant 755 755 . . . ID=VAR_083844;Note=In JRRP%3B gain-of-function variant resulting in spontaneous inflammasome activation%3B increased NLRP1-inflammasome complex assembly. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31484767;Dbxref=PMID:31484767 Q9C000 UniProtKB Natural variant 787 843 . . . ID=VAR_078801;Note=In MSPC%3B increased NLRP1-inflammasome complex assembly. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27662089;Dbxref=PMID:27662089 Q9C000 UniProtKB Natural variant 878 878 . . . ID=VAR_033240;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11270363;Dbxref=dbSNP:rs11657747,PMID:11270363 Q9C000 UniProtKB Natural variant 1059 1059 . . . ID=VAR_024239;Note=V->M;Dbxref=dbSNP:rs2301582 Q9C000 UniProtKB Natural variant 1069 1069 . . . ID=VAR_033241;Note=H->Y;Dbxref=dbSNP:rs9907167 Q9C000 UniProtKB Natural variant 1119 1119 . . . ID=VAR_033242;Note=No effect on autocatalytic processing%2C nor on IL1B release. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11270363,ECO:0000269|PubMed:22665479;Dbxref=dbSNP:rs35596958,PMID:11270363,PMID:22665479 Q9C000 UniProtKB Natural variant 1184 1184 . . . ID=VAR_033243;Note=Increased autocatalytic processing and IL1B release. M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11270363,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:22665479;Dbxref=dbSNP:rs11651270,PMID:11270363,PMID:17974005,PMID:22665479 Q9C000 UniProtKB Natural variant 1214 1214 . . . ID=VAR_078802;Note=In AIADK%3B decreased interaction with DPP9%2C leading to increased inflammasome activity. P->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27965258,ECO:0000269|PubMed:30291141,ECO:0000269|PubMed:33731932;Dbxref=dbSNP:rs1057524876,PMID:27965258,PMID:30291141,PMID:33731932 Q9C000 UniProtKB Natural variant 1241 1241 . . . ID=VAR_033244;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11270363;Dbxref=dbSNP:rs11653832,PMID:11270363 Q9C000 UniProtKB Natural variant 1366 1366 . . . ID=VAR_020437;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11270363;Dbxref=dbSNP:rs2137722,PMID:11270363 Q9C000 UniProtKB Mutagenesis 76 76 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 85 85 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 87 87 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 110 110 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 130 130 . . . Note=Inhibits cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 130 130 . . . Note=Inhibits cleavage by Protease 3C from Coxsackievirus B3 and HRV-14. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33410748;Dbxref=PMID:33410748 Q9C000 UniProtKB Mutagenesis 139 139 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 158 158 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 171 171 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 178 180 . . . Note=In 3A mutant%3B abolished activation of the NLRP1 inflammasome in response to UV-B irradiation and ribosome collisions. TST->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35857590;Dbxref=PMID:35857590 Q9C000 UniProtKB Mutagenesis 191 191 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 199 199 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 205 205 . . . Note=No effect on cleavage by HRV-14 Protease 3C. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33093214;Dbxref=PMID:33093214 Q9C000 UniProtKB Mutagenesis 333 333 . . . Note=Abolished cleavage by the 3C-like proteinase nsp5 from human coronavirus SARS-CoV-2. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35594856;Dbxref=PMID:35594856 Q9C000 UniProtKB Mutagenesis 339 340 . . . Note=Loss of ATP binding. GK->EA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15212762;Dbxref=PMID:15212762 Q9C000 UniProtKB Mutagenesis 340 340 . . . Note=No effect. K->L%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11076957;Dbxref=PMID:11076957 Q9C000 UniProtKB Mutagenesis 1168 1168 . . . Note=Complete loss of autocatalytic processing and of IL1B release. Autocatalytic processing cannot be restored by treatment with hydroxylamine. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Mutagenesis 1186 1186 . . . Note=Complete loss of autocatalytic processing and of IL1B release. Autocatalytic processing can be restored by treatment with hydroxylamine. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Mutagenesis 1193 1194 . . . Note=Reduced autocatalytic processing and reduced interaction with DPP9. LL->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33731932;Dbxref=PMID:33731932 Q9C000 UniProtKB Mutagenesis 1211 1211 . . . Note=Partial loss of autocatalytic processing and of IL1B release. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Mutagenesis 1212 1212 . . . Note=Complete loss of autocatalytic processing and of IL1B release. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22665479,ECO:0000269|PubMed:33093214;Dbxref=PMID:22665479,PMID:33093214 Q9C000 UniProtKB Mutagenesis 1213 1213 . . . Note=Complete loss of autocatalytic processing and of IL1B release. Autocatalytic processing cannot be restored by treatment with hydroxylamine. Abolished interaction with DPP9. Loss of activation by dsRNA or positive-strand RNA virus. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22087307,ECO:0000269|PubMed:22665479,ECO:0000269|PubMed:31525884,ECO:0000269|PubMed:32051255,ECO:0000269|PubMed:33243852,ECO:0000269|PubMed:33731932;Dbxref=PMID:22087307,PMID:22665479,PMID:31525884,PMID:32051255,PMID:33243852,PMID:33731932 Q9C000 UniProtKB Mutagenesis 1213 1213 . . . Note=Complete loss of autocatalytic processing%2C which can be restored by treatment with hydroxylamine. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Mutagenesis 1214 1214 . . . Note=Partial loss of autocatalytic processing (50%25) and of IL1B release (50%25). P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Mutagenesis 1240 1240 . . . Note=Slightly reduced formation of an inflammasome filament together with PYCARD/ASC. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1249 1249 . . . Note=Complete loss of autocatalytic processing and IL1B release. Autocatalytic processing cannot be restored by treatment with hydroxylamine. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665479;Dbxref=PMID:22665479 Q9C000 UniProtKB Mutagenesis 1260 1261 . . . Note=Slightly reduced formation of an inflammasome filament together with PYCARD/ASC. RK->DD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1276 1276 . . . Note=Abolished ability to form the NLRP1 inflammasome. H->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33731932;Dbxref=PMID:33731932 Q9C000 UniProtKB Mutagenesis 1277 1277 . . . Note=Abolished ability to form the NLRP1 inflammasome. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33731932;Dbxref=PMID:33731932 Q9C000 UniProtKB Mutagenesis 1278 1279 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. PP->AG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1278 1278 . . . Note=Impaired ability to form the NLRP1 inflammasome. P->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33731929;Dbxref=PMID:33731929 Q9C000 UniProtKB Mutagenesis 1281 1281 . . . Note=Impaired ability to form the NLRP1 inflammasome. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33731929;Dbxref=PMID:33731929 Q9C000 UniProtKB Mutagenesis 1320 1320 . . . Note=Slightly reduced formation of an inflammasome filament together with PYCARD/ASC. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1322 1322 . . . Note=Abolished ability to form the NLRP1 inflammasome. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33731932;Dbxref=PMID:33731932 Q9C000 UniProtKB Mutagenesis 1383 1383 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1386 1386 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1387 1387 . . . Note=Does not affect formation of an inflammasome filament together with PYCARD/ASC. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1388 1388 . . . Note=Does not affect formation of an inflammasome filament together with PYCARD/ASC. Q->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1392 1392 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1392 1392 . . . Note=Impaired ability to induce programmed cell death. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420033;Dbxref=PMID:33420033 Q9C000 UniProtKB Mutagenesis 1395 1395 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1397 1397 . . . Note=Impaired ability to induce programmed cell death. Abolished formation of an inflammasome filament together with PYCARD/ASC. E->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:33420028,ECO:0000269|PubMed:33420033;Dbxref=PMID:33420028,PMID:33420033 Q9C000 UniProtKB Mutagenesis 1401 1401 . . . Note=Impaired ability to induce programmed cell death. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420033;Dbxref=PMID:33420033 Q9C000 UniProtKB Mutagenesis 1402 1402 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. K->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1402 1402 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1404 1404 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1406 1406 . . . Note=Does not affect formation of an inflammasome filament together with PYCARD/ASC. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1410 1410 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1411 1411 . . . Note=Impaired ability to induce programmed cell death. Abolished formation of an inflammasome filament together with PYCARD/ASC. E->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:33420028,ECO:0000269|PubMed:33420033;Dbxref=PMID:33420028,PMID:33420033 Q9C000 UniProtKB Mutagenesis 1413 1413 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1414 1414 . . . Note=Impaired ability to induce programmed cell death. Abolished formation of an inflammasome filament together with PYCARD/ASC. E->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:33420028,ECO:0000269|PubMed:33420033;Dbxref=PMID:33420028,PMID:33420033 Q9C000 UniProtKB Mutagenesis 1415 1415 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1420 1420 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. N->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1422 1422 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1427 1427 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1427 1427 . . . Note=Impaired ability to induce programmed cell death. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420033;Dbxref=PMID:33420033 Q9C000 UniProtKB Mutagenesis 1428 1428 . . . Note=Does not affect formation of an inflammasome filament together with PYCARD/ASC. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1434 1434 . . . Note=Does not affect formation of an inflammasome filament together with PYCARD/ASC. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1437 1437 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1445 1445 . . . Note=Abolished inflammasome filament formation. Impaired ability to induce programmed cell death%2C but retains CAPS1 processing. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420033;Dbxref=PMID:33420033 Q9C000 UniProtKB Mutagenesis 1449 1449 . . . Note=Does not affect formation of an inflammasome filament together with PYCARD/ASC. K->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1450 1450 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1451 1451 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1454 1454 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1454 1454 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. H->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1457 1457 . . . Note=Does not affect ability to induce programmed cell death. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420033;Dbxref=PMID:33420033 Q9C000 UniProtKB Mutagenesis 1458 1458 . . . Note=Abolished formation of an inflammasome filament together with PYCARD/ASC. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420028;Dbxref=PMID:33420028 Q9C000 UniProtKB Mutagenesis 1460 1460 . . . Note=Does not affect ability to induce programmed cell death. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33420033;Dbxref=PMID:33420033 Q9C000 UniProtKB Mutagenesis 1461 1461 . . . Note=Does not affect formation of an inflammasome filament together with PYCARD/ASC. E->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:33420028,ECO:0000269|PubMed:33420033;Dbxref=PMID:33420028,PMID:33420033 Q9C000 UniProtKB Sequence conflict 287 287 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9C000 UniProtKB Sequence conflict 782 782 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9C000 UniProtKB Sequence conflict 995 995 . . . Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9C000 UniProtKB Helix 9 15 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1PN5 Q9C000 UniProtKB Helix 18 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1PN5 Q9C000 UniProtKB Helix 50 60 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1PN5 Q9C000 UniProtKB Helix 63 77 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1PN5 Q9C000 UniProtKB Helix 80 85 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1PN5 Q9C000 UniProtKB Beta strand 88 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1PN5 Q9C000 UniProtKB Beta strand 286 288 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 300 306 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 314 316 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 322 324 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 328 333 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Turn 340 342 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 343 353 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Turn 358 360 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 362 366 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 369 374 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 380 387 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 389 391 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 395 399 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 402 404 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 405 408 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 412 415 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 422 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 436 444 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 447 451 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 453 457 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 459 461 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Turn 464 466 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 474 478 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 483 491 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 497 509 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 511 516 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 520 535 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 547 558 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 559 561 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 566 580 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 588 593 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 598 607 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 609 611 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 614 617 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 619 622 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 624 639 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 656 659 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Turn 660 662 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Turn 665 667 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 669 676 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 682 689 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 698 701 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 703 709 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 716 723 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Turn 728 732 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 733 735 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 748 759 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 760 763 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 766 770 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Beta strand 783 787 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 794 804 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 807 809 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Y3S Q9C000 UniProtKB Beta strand 812 814 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Helix 822 833 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 840 843 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Helix 851 862 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 869 871 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Helix 878 889 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 898 900 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Helix 908 910 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Helix 911 920 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 926 928 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 931 933 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Helix 935 946 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 955 957 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 961 963 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WGE Q9C000 UniProtKB Helix 965 977 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 982 984 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IM6 Q9C000 UniProtKB Beta strand 1089 1092 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Turn 1093 1096 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1097 1102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1104 1106 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Turn 1111 1113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1116 1118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1123 1129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Helix 1132 1138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Turn 1142 1144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1145 1147 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1152 1156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1163 1166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1174 1176 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1179 1181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1184 1188 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1191 1195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1198 1200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1218 1220 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1223 1225 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1234 1236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1241 1253 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Helix 1257 1269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1289 1294 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1305 1308 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1314 1316 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1320 1327 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1333 1338 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Turn 1339 1341 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Beta strand 1344 1349 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X6C Q9C000 UniProtKB Helix 1381 1384 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Helix 1386 1392 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Helix 1396 1403 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Turn 1405 1407 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Helix 1410 1417 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Beta strand 1419 1421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Helix 1422 1433 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Helix 1438 1451 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP Q9C000 UniProtKB Helix 1453 1462 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4IFP