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Q9BZZ2

- SN_HUMAN

UniProt

Q9BZZ2 - SN_HUMAN

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Protein

Sialoadhesin

Gene

SIGLEC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631Sialic acidBy similarity
Binding sitei116 – 1161Sialic acidBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB

GO - Biological processi

  1. cell-matrix adhesion Source: UniProtKB
  2. endocytosis Source: UniProtKB-KW
  3. inflammatory response Source: UniProtKB
  4. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  5. positive regulation of T cell apoptotic process Source: Ensembl
  6. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Endocytosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Sialoadhesin
Alternative name(s):
Sialic acid-binding Ig-like lectin 1
Short name:
Siglec-1
CD_antigen: CD169
Gene namesi
Name:SIGLEC1
Synonyms:SN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11127. SIGLEC1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 17091690SialoadhesinPRO_0000014968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 166PROSITE-ProRule annotation
Disulfide bondi41 ↔ 98PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi160 ↔ 217PROSITE-ProRule annotation
Disulfide bondi262 ↔ 305PROSITE-ProRule annotation
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi346 ↔ 390PROSITE-ProRule annotation
Disulfide bondi433 ↔ 491PROSITE-ProRule annotation
Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi531 ↔ 575PROSITE-ProRule annotation
Disulfide bondi624 ↔ 689PROSITE-ProRule annotation
Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi729 ↔ 774PROSITE-ProRule annotation
Glycosylationi730 – 7301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi817 ↔ 876PROSITE-ProRule annotation
Glycosylationi886 – 8861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi916 ↔ 960PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1067PROSITE-ProRule annotation
Glycosylationi1104 – 11041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1107 ↔ 1149PROSITE-ProRule annotation
Glycosylationi1138 – 11381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1193 ↔ 1241PROSITE-ProRule annotation
Glycosylationi1251 – 12511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1281 ↔ 1324PROSITE-ProRule annotation
Disulfide bondi1367 ↔ 1425PROSITE-ProRule annotation
Glycosylationi1462 – 14621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1465 ↔ 1511PROSITE-ProRule annotation
Glycosylationi1476 – 14761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1554 ↔ 1613PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BZZ2.
PRIDEiQ9BZZ2.

PTM databases

PhosphoSiteiQ9BZZ2.

Expressioni

Tissue specificityi

Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Gene expression databases

BgeeiQ9BZZ2.
CleanExiHS_SIGLEC1.
GenevestigatoriQ9BZZ2.

Organism-specific databases

HPAiHPA053457.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341141.

Structurei

3D structure databases

ProteinModelPortaliQ9BZZ2.
SMRiQ9BZZ2. Positions 20-1633.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 16411622ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1663 – 170947CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1642 – 166221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 136117Ig-like V-typeAdd
BLAST
Domaini139 – 23395Ig-like C2-type 1Add
BLAST
Domaini238 – 32083Ig-like C2-type 2Add
BLAST
Domaini326 – 40580Ig-like C2-type 3Add
BLAST
Domaini411 – 50797Ig-like C2-type 4Add
BLAST
Domaini511 – 59383Ig-like C2-type 5Add
BLAST
Domaini601 – 705105Ig-like C2-type 6Add
BLAST
Domaini708 – 78578Ig-like C2-type 7Add
BLAST
Domaini799 – 89496Ig-like C2-type 8Add
BLAST
Domaini898 – 97780Ig-like C2-type 9Add
BLAST
Domaini984 – 1083100Ig-like C2-type 10Add
BLAST
Domaini1085 – 116581Ig-like C2-type 11Add
BLAST
Domaini1176 – 124873Ig-like C2-type 12Add
BLAST
Domaini1259 – 134183Ig-like C2-type 13Add
BLAST
Domaini1350 – 144293Ig-like C2-type 14Add
BLAST
Domaini1445 – 152884Ig-like C2-type 15Add
BLAST
Domaini1536 – 163196Ig-like C2-type 16Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 1265Sialic acid bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG252328.
GeneTreeiENSGT00750000117572.
HOGENOMiHOG000154365.
HOVERGENiHBG003550.
InParanoidiQ9BZZ2.
KOiK06548.
OMAiCTVDSRP.
OrthoDBiEOG77T13N.
PhylomeDBiQ9BZZ2.
TreeFamiTF334827.

Family and domain databases

Gene3Di2.60.40.10. 17 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 8 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9BZZ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE
60 70 80 90 100
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL
110 120 130 140 150
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL
160 170 180 190 200
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE
210 220 230 240 250
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR
260 270 280 290 300
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA
310 320 330 340 350
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN
360 370 380 390 400
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER
410 420 430 440 450
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH
460 470 480 490 500
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA
510 520 530 540 550
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA
560 570 580 590 600
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ
610 620 630 640 650
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG
660 670 680 690 700
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST
710 720 730 740 750
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL
760 770 780 790 800
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK
810 820 830 840 850
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF
860 870 880 890 900
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV
910 920 930 940 950
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI
960 970 980 990 1000
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL
1010 1020 1030 1040 1050
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL
1060 1070 1080 1090 1100
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG
1110 1120 1130 1140 1150
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG
1160 1170 1180 1190 1200
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP
1210 1220 1230 1240 1250
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA
1260 1270 1280 1290 1300
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW
1310 1320 1330 1340 1350
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV
1360 1370 1380 1390 1400
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG
1410 1420 1430 1440 1450
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE
1460 1470 1480 1490 1500
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH
1510 1520 1530 1540 1550
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG
1560 1570 1580 1590 1600
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI
1610 1620 1630 1640 1650
EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV
1660 1670 1680 1690 1700
GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE

TSTCAPPLG
Length:1,709
Mass (Da):182,624
Last modified:October 18, 2001 - v2
Checksum:i587C7CCA0B789A6D
GO
Isoform 2 (identifier: Q9BZZ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS

Show »
Length:1,649
Mass (Da):175,727
Checksum:i460B32A6B1577C4F
GO
Isoform 3 (identifier: Q9BZZ2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL

Note: No experimental confirmation available.

Show »
Length:1,701
Mass (Da):181,733
Checksum:iCB39EDDAB09606E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1349 – 13491A → T in AAK00757. (PubMed:11133773)Curated
Sequence conflicti1519 – 15191A → V in BAB15749. (PubMed:11214971)Curated
Sequence conflicti1519 – 15191A → V in BAB15769. (PubMed:11214971)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411V → L.
Corresponds to variant rs35953127 [ dbSNP | Ensembl ].
VAR_049943
Natural varianti221 – 2211V → M.
Corresponds to variant rs6037651 [ dbSNP | Ensembl ].
VAR_024502
Natural varianti239 – 2391K → R.
Corresponds to variant rs625372 [ dbSNP | Ensembl ].
VAR_014136
Natural varianti464 – 4641R → H.
Corresponds to variant rs34924243 [ dbSNP | Ensembl ].
VAR_049944
Natural varianti919 – 9191H → P.
Corresponds to variant rs709012 [ dbSNP | Ensembl ].
VAR_014137
Natural varianti974 – 9741A → V.
Corresponds to variant rs3746638 [ dbSNP | Ensembl ].
VAR_021926
Natural varianti1335 – 13351S → Y.
Corresponds to variant rs3746636 [ dbSNP | Ensembl ].
VAR_021927
Natural varianti1487 – 14871R → W.
Corresponds to variant rs16988873 [ dbSNP | Ensembl ].
VAR_049945
Natural varianti1519 – 15191A → P.
Corresponds to variant rs2853217 [ dbSNP | Ensembl ].
VAR_014138

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1632 – 170978ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2. 1 PublicationVSP_002571Add
BLAST
Alternative sequencei1666 – 170944RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3. 1 PublicationVSP_002572Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230073 mRNA. Translation: AAK00757.1.
AL109804 Genomic DNA. Translation: CAC17543.1.
AL109804 Genomic DNA. Translation: CAC17542.1.
AK024459 mRNA. Translation: BAB15749.1.
AK024462 mRNA. Translation: BAB15752.1.
AK024479 mRNA. Translation: BAB15769.1.
AK057560 mRNA. Translation: BAB71527.1.
CCDSiCCDS13060.1. [Q9BZZ2-1]
RefSeqiNP_075556.1. NM_023068.3. [Q9BZZ2-1]
XP_006723673.1. XM_006723610.1. [Q9BZZ2-1]
XP_006723674.1. XM_006723611.1. [Q9BZZ2-3]
UniGeneiHs.31869.

Genome annotation databases

EnsembliENST00000344754; ENSP00000341141; ENSG00000088827. [Q9BZZ2-1]
GeneIDi6614.
KEGGihsa:6614.
UCSCiuc002wiz.4. human. [Q9BZZ2-3]
uc002wja.3. human. [Q9BZZ2-1]

Polymorphism databases

DMDMi18202745.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230073 mRNA. Translation: AAK00757.1 .
AL109804 Genomic DNA. Translation: CAC17543.1 .
AL109804 Genomic DNA. Translation: CAC17542.1 .
AK024459 mRNA. Translation: BAB15749.1 .
AK024462 mRNA. Translation: BAB15752.1 .
AK024479 mRNA. Translation: BAB15769.1 .
AK057560 mRNA. Translation: BAB71527.1 .
CCDSi CCDS13060.1. [Q9BZZ2-1 ]
RefSeqi NP_075556.1. NM_023068.3. [Q9BZZ2-1 ]
XP_006723673.1. XM_006723610.1. [Q9BZZ2-1 ]
XP_006723674.1. XM_006723611.1. [Q9BZZ2-3 ]
UniGenei Hs.31869.

3D structure databases

ProteinModelPortali Q9BZZ2.
SMRi Q9BZZ2. Positions 20-1633.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000341141.

PTM databases

PhosphoSitei Q9BZZ2.

Polymorphism databases

DMDMi 18202745.

Proteomic databases

PaxDbi Q9BZZ2.
PRIDEi Q9BZZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344754 ; ENSP00000341141 ; ENSG00000088827 . [Q9BZZ2-1 ]
GeneIDi 6614.
KEGGi hsa:6614.
UCSCi uc002wiz.4. human. [Q9BZZ2-3 ]
uc002wja.3. human. [Q9BZZ2-1 ]

Organism-specific databases

CTDi 6614.
GeneCardsi GC20M003667.
H-InvDB HIX0203038.
HGNCi HGNC:11127. SIGLEC1.
HPAi HPA053457.
MIMi 600751. gene.
neXtProti NX_Q9BZZ2.
PharmGKBi PA35976.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252328.
GeneTreei ENSGT00750000117572.
HOGENOMi HOG000154365.
HOVERGENi HBG003550.
InParanoidi Q9BZZ2.
KOi K06548.
OMAi CTVDSRP.
OrthoDBi EOG77T13N.
PhylomeDBi Q9BZZ2.
TreeFami TF334827.

Miscellaneous databases

GenomeRNAii 6614.
NextBioi 25753.
PROi Q9BZZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9BZZ2.
CleanExi HS_SIGLEC1.
Genevestigatori Q9BZZ2.

Family and domain databases

Gene3Di 2.60.40.10. 17 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 8 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations."
    Hartnell A., Steel J., Turley H., Jones M., Jackson D.G., Crocker P.R.
    Blood 97:288-296(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Monocyte.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
  3. "Characterization of long cDNA clones from human adult spleen."
    Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
    DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 733-1709 (ISOFORMS 1 AND 2).
    Tissue: Spleen.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1539-1709 (ISOFORM 3).
    Tissue: Thymus.

Entry informationi

Entry nameiSN_HUMAN
AccessioniPrimary (citable) accession number: Q9BZZ2
Secondary accession number(s): Q96DL4
, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3