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Q9BZZ2

- SN_HUMAN

UniProt

Q9BZZ2 - SN_HUMAN

Protein

Sialoadhesin

Gene

SIGLEC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (18 Oct 2001)
      Previous versions | rss
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    Functioni

    Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid By similarity. Binds to SPN/CD43 on T-cells By similarity. May play a role in hemopoiesis.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631Sialic acidBy similarity
    Binding sitei116 – 1161Sialic acidBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: UniProtKB

    GO - Biological processi

    1. cell-matrix adhesion Source: UniProtKB
    2. endocytosis Source: UniProtKB-KW
    3. inflammatory response Source: UniProtKB
    4. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    5. positive regulation of T cell apoptotic process Source: Ensembl
    6. single organismal cell-cell adhesion Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion, Endocytosis

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialoadhesin
    Alternative name(s):
    Sialic acid-binding Ig-like lectin 1
    Short name:
    Siglec-1
    CD_antigen: CD169
    Gene namesi
    Name:SIGLEC1
    Synonyms:SN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11127. SIGLEC1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35976.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 17091690SialoadhesinPRO_0000014968Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 166PROSITE-ProRule annotation
    Disulfide bondi41 ↔ 98PROSITE-ProRule annotation
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi160 ↔ 217PROSITE-ProRule annotation
    Disulfide bondi262 ↔ 305PROSITE-ProRule annotation
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi346 ↔ 390PROSITE-ProRule annotation
    Disulfide bondi433 ↔ 491PROSITE-ProRule annotation
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi531 ↔ 575PROSITE-ProRule annotation
    Disulfide bondi624 ↔ 689PROSITE-ProRule annotation
    Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi729 ↔ 774PROSITE-ProRule annotation
    Glycosylationi730 – 7301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi817 ↔ 876PROSITE-ProRule annotation
    Glycosylationi886 – 8861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi916 ↔ 960PROSITE-ProRule annotation
    Disulfide bondi1005 ↔ 1067PROSITE-ProRule annotation
    Glycosylationi1104 – 11041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1107 ↔ 1149PROSITE-ProRule annotation
    Glycosylationi1138 – 11381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1193 ↔ 1241PROSITE-ProRule annotation
    Glycosylationi1251 – 12511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1281 ↔ 1324PROSITE-ProRule annotation
    Disulfide bondi1367 ↔ 1425PROSITE-ProRule annotation
    Glycosylationi1462 – 14621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1465 ↔ 1511PROSITE-ProRule annotation
    Glycosylationi1476 – 14761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1554 ↔ 1613PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9BZZ2.
    PRIDEiQ9BZZ2.

    PTM databases

    PhosphoSiteiQ9BZZ2.

    Expressioni

    Tissue specificityi

    Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

    Gene expression databases

    BgeeiQ9BZZ2.
    CleanExiHS_SIGLEC1.
    GenevestigatoriQ9BZZ2.

    Organism-specific databases

    HPAiHPA053457.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341141.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZZ2.
    SMRiQ9BZZ2. Positions 20-219, 237-1633.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 16411622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1663 – 170947CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1642 – 166221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 136117Ig-like V-typeAdd
    BLAST
    Domaini139 – 23395Ig-like C2-type 1Add
    BLAST
    Domaini238 – 32083Ig-like C2-type 2Add
    BLAST
    Domaini326 – 40580Ig-like C2-type 3Add
    BLAST
    Domaini411 – 50797Ig-like C2-type 4Add
    BLAST
    Domaini511 – 59383Ig-like C2-type 5Add
    BLAST
    Domaini601 – 705105Ig-like C2-type 6Add
    BLAST
    Domaini708 – 78578Ig-like C2-type 7Add
    BLAST
    Domaini799 – 89496Ig-like C2-type 8Add
    BLAST
    Domaini898 – 97780Ig-like C2-type 9Add
    BLAST
    Domaini984 – 1083100Ig-like C2-type 10Add
    BLAST
    Domaini1085 – 116581Ig-like C2-type 11Add
    BLAST
    Domaini1176 – 124873Ig-like C2-type 12Add
    BLAST
    Domaini1259 – 134183Ig-like C2-type 13Add
    BLAST
    Domaini1350 – 144293Ig-like C2-type 14Add
    BLAST
    Domaini1445 – 152884Ig-like C2-type 15Add
    BLAST
    Domaini1536 – 163196Ig-like C2-type 16Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni122 – 1265Sialic acid bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG252328.
    HOGENOMiHOG000154365.
    HOVERGENiHBG003550.
    InParanoidiQ9BZZ2.
    KOiK06548.
    OMAiCTVDSRP.
    OrthoDBiEOG77T13N.
    PhylomeDBiQ9BZZ2.
    TreeFamiTF334827.

    Family and domain databases

    Gene3Di2.60.40.10. 17 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07679. I-set. 2 hits.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 8 hits.
    SM00408. IGc2. 5 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 14 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9BZZ2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE     50
    VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL 100
    LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL 150
    LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE 200
    TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR 250
    NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 300
    GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN 350
    EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER 400
    SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH 450
    ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA 500
    TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA 550
    LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 600
    PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG 650
    GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST 700
    SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL 750
    WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK 800
    LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF 850
    QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 900
    SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI 950
    TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL 1000
    GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL 1050
    RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG 1100
    QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG 1150
    VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 1200
    AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA 1250
    NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW 1300
    LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV 1350
    LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG 1400
    HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE 1450
    PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 1500
    VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG 1550
    ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI 1600
    EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV 1650
    GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE 1700
    TSTCAPPLG 1709
    Length:1,709
    Mass (Da):182,624
    Last modified:October 18, 2001 - v2
    Checksum:i587C7CCA0B789A6D
    GO
    Isoform 2 (identifier: Q9BZZ2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS

    Show »
    Length:1,649
    Mass (Da):175,727
    Checksum:i460B32A6B1577C4F
    GO
    Isoform 3 (identifier: Q9BZZ2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL

    Note: No experimental confirmation available.

    Show »
    Length:1,701
    Mass (Da):181,733
    Checksum:iCB39EDDAB09606E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1349 – 13491A → T in AAK00757. (PubMed:11133773)Curated
    Sequence conflicti1519 – 15191A → V in BAB15749. (PubMed:11214971)Curated
    Sequence conflicti1519 – 15191A → V in BAB15769. (PubMed:11214971)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411V → L.
    Corresponds to variant rs35953127 [ dbSNP | Ensembl ].
    VAR_049943
    Natural varianti221 – 2211V → M.
    Corresponds to variant rs6037651 [ dbSNP | Ensembl ].
    VAR_024502
    Natural varianti239 – 2391K → R.
    Corresponds to variant rs625372 [ dbSNP | Ensembl ].
    VAR_014136
    Natural varianti464 – 4641R → H.
    Corresponds to variant rs34924243 [ dbSNP | Ensembl ].
    VAR_049944
    Natural varianti919 – 9191H → P.
    Corresponds to variant rs709012 [ dbSNP | Ensembl ].
    VAR_014137
    Natural varianti974 – 9741A → V.
    Corresponds to variant rs3746638 [ dbSNP | Ensembl ].
    VAR_021926
    Natural varianti1335 – 13351S → Y.
    Corresponds to variant rs3746636 [ dbSNP | Ensembl ].
    VAR_021927
    Natural varianti1487 – 14871R → W.
    Corresponds to variant rs16988873 [ dbSNP | Ensembl ].
    VAR_049945
    Natural varianti1519 – 15191A → P.
    Corresponds to variant rs2853217 [ dbSNP | Ensembl ].
    VAR_014138

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1632 – 170978ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2. 1 PublicationVSP_002571Add
    BLAST
    Alternative sequencei1666 – 170944RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3. 1 PublicationVSP_002572Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF230073 mRNA. Translation: AAK00757.1.
    AL109804 Genomic DNA. Translation: CAC17543.1.
    AL109804 Genomic DNA. Translation: CAC17542.1.
    AK024459 mRNA. Translation: BAB15749.1.
    AK024462 mRNA. Translation: BAB15752.1.
    AK024479 mRNA. Translation: BAB15769.1.
    AK057560 mRNA. Translation: BAB71527.1.
    CCDSiCCDS13060.1. [Q9BZZ2-1]
    RefSeqiNP_075556.1. NM_023068.3. [Q9BZZ2-1]
    XP_006723673.1. XM_006723610.1. [Q9BZZ2-1]
    XP_006723674.1. XM_006723611.1. [Q9BZZ2-3]
    UniGeneiHs.31869.

    Genome annotation databases

    EnsembliENST00000344754; ENSP00000341141; ENSG00000088827. [Q9BZZ2-1]
    GeneIDi6614.
    KEGGihsa:6614.
    UCSCiuc002wiz.4. human. [Q9BZZ2-3]
    uc002wja.3. human. [Q9BZZ2-1]

    Polymorphism databases

    DMDMi18202745.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Siglec-1

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF230073 mRNA. Translation: AAK00757.1 .
    AL109804 Genomic DNA. Translation: CAC17543.1 .
    AL109804 Genomic DNA. Translation: CAC17542.1 .
    AK024459 mRNA. Translation: BAB15749.1 .
    AK024462 mRNA. Translation: BAB15752.1 .
    AK024479 mRNA. Translation: BAB15769.1 .
    AK057560 mRNA. Translation: BAB71527.1 .
    CCDSi CCDS13060.1. [Q9BZZ2-1 ]
    RefSeqi NP_075556.1. NM_023068.3. [Q9BZZ2-1 ]
    XP_006723673.1. XM_006723610.1. [Q9BZZ2-1 ]
    XP_006723674.1. XM_006723611.1. [Q9BZZ2-3 ]
    UniGenei Hs.31869.

    3D structure databases

    ProteinModelPortali Q9BZZ2.
    SMRi Q9BZZ2. Positions 20-219, 237-1633.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341141.

    PTM databases

    PhosphoSitei Q9BZZ2.

    Polymorphism databases

    DMDMi 18202745.

    Proteomic databases

    PaxDbi Q9BZZ2.
    PRIDEi Q9BZZ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344754 ; ENSP00000341141 ; ENSG00000088827 . [Q9BZZ2-1 ]
    GeneIDi 6614.
    KEGGi hsa:6614.
    UCSCi uc002wiz.4. human. [Q9BZZ2-3 ]
    uc002wja.3. human. [Q9BZZ2-1 ]

    Organism-specific databases

    CTDi 6614.
    GeneCardsi GC20M003667.
    H-InvDB HIX0203038.
    HGNCi HGNC:11127. SIGLEC1.
    HPAi HPA053457.
    MIMi 600751. gene.
    neXtProti NX_Q9BZZ2.
    PharmGKBi PA35976.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252328.
    HOGENOMi HOG000154365.
    HOVERGENi HBG003550.
    InParanoidi Q9BZZ2.
    KOi K06548.
    OMAi CTVDSRP.
    OrthoDBi EOG77T13N.
    PhylomeDBi Q9BZZ2.
    TreeFami TF334827.

    Miscellaneous databases

    GenomeRNAii 6614.
    NextBioi 25753.
    PROi Q9BZZ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BZZ2.
    CleanExi HS_SIGLEC1.
    Genevestigatori Q9BZZ2.

    Family and domain databases

    Gene3Di 2.60.40.10. 17 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07679. I-set. 2 hits.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 8 hits.
    SM00408. IGc2. 5 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations."
      Hartnell A., Steel J., Turley H., Jones M., Jackson D.G., Crocker P.R.
      Blood 97:288-296(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
      Tissue: Monocyte.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
    3. "Characterization of long cDNA clones from human adult spleen."
      Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
      DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 733-1709 (ISOFORMS 1 AND 2).
      Tissue: Spleen.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1539-1709 (ISOFORM 3).
      Tissue: Thymus.

    Entry informationi

    Entry nameiSN_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZZ2
    Secondary accession number(s): Q96DL4
    , Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: October 18, 2001
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3