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Q9BZZ2

- SN_HUMAN

UniProt

Q9BZZ2 - SN_HUMAN

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Protein
Sialoadhesin
Gene
SIGLEC1, SN
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid By similarity. Binds to SPN/CD43 on T-cells By similarity. May play a role in hemopoiesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631Sialic acid By similarity
Binding sitei116 – 1161Sialic acid By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell-matrix adhesion Source: UniProtKB
  2. endocytosis Source: UniProtKB-KW
  3. inflammatory response Source: UniProtKB
  4. positive regulation of T cell apoptotic process Source: Ensembl
  5. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  6. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Endocytosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Sialoadhesin
Alternative name(s):
Sialic acid-binding Ig-like lectin 1
Short name:
Siglec-1
CD_antigen: CD169
Gene namesi
Name:SIGLEC1
Synonyms:SN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11127. SIGLEC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 16411622Extracellular Reviewed prediction
Add
BLAST
Transmembranei1642 – 166221Helical; Reviewed prediction
Add
BLAST
Topological domaini1663 – 170947Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 17091690Sialoadhesin
PRO_0000014968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 166 By similarity
Disulfide bondi41 ↔ 98 By similarity
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi160 ↔ 217 By similarity
Disulfide bondi262 ↔ 305 By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi346 ↔ 390 By similarity
Disulfide bondi433 ↔ 491 By similarity
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi531 ↔ 575 By similarity
Disulfide bondi624 ↔ 689 By similarity
Glycosylationi697 – 6971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi726 – 7261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi729 ↔ 774 By similarity
Glycosylationi730 – 7301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi741 – 7411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi817 ↔ 876 By similarity
Glycosylationi886 – 8861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi916 ↔ 960 By similarity
Disulfide bondi1005 ↔ 1067 By similarity
Glycosylationi1104 – 11041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1107 ↔ 1149 By similarity
Glycosylationi1138 – 11381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1193 ↔ 1241 By similarity
Glycosylationi1251 – 12511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1281 ↔ 1324 By similarity
Disulfide bondi1367 ↔ 1425 By similarity
Glycosylationi1462 – 14621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1465 ↔ 1511 By similarity
Glycosylationi1476 – 14761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1554 ↔ 1613 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BZZ2.
PRIDEiQ9BZZ2.

PTM databases

PhosphoSiteiQ9BZZ2.

Expressioni

Tissue specificityi

Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Gene expression databases

BgeeiQ9BZZ2.
CleanExiHS_SIGLEC1.
GenevestigatoriQ9BZZ2.

Organism-specific databases

HPAiHPA053457.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341141.

Structurei

3D structure databases

ProteinModelPortaliQ9BZZ2.
SMRiQ9BZZ2. Positions 20-219, 237-1633.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 136117Ig-like V-type
Add
BLAST
Domaini139 – 23395Ig-like C2-type 1
Add
BLAST
Domaini238 – 32083Ig-like C2-type 2
Add
BLAST
Domaini326 – 40580Ig-like C2-type 3
Add
BLAST
Domaini411 – 50797Ig-like C2-type 4
Add
BLAST
Domaini511 – 59383Ig-like C2-type 5
Add
BLAST
Domaini601 – 705105Ig-like C2-type 6
Add
BLAST
Domaini708 – 78578Ig-like C2-type 7
Add
BLAST
Domaini799 – 89496Ig-like C2-type 8
Add
BLAST
Domaini898 – 97780Ig-like C2-type 9
Add
BLAST
Domaini984 – 1083100Ig-like C2-type 10
Add
BLAST
Domaini1085 – 116581Ig-like C2-type 11
Add
BLAST
Domaini1176 – 124873Ig-like C2-type 12
Add
BLAST
Domaini1259 – 134183Ig-like C2-type 13
Add
BLAST
Domaini1350 – 144293Ig-like C2-type 14
Add
BLAST
Domaini1445 – 152884Ig-like C2-type 15
Add
BLAST
Domaini1536 – 163196Ig-like C2-type 16
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 1265Sialic acid binding By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG252328.
HOGENOMiHOG000154365.
HOVERGENiHBG003550.
InParanoidiQ9BZZ2.
KOiK06548.
OMAiCTVDSRP.
OrthoDBiEOG77T13N.
PhylomeDBiQ9BZZ2.
TreeFamiTF334827.

Family and domain databases

Gene3Di2.60.40.10. 17 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 8 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9BZZ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE     50
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL 100
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL 150
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE 200
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR 250
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 300
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN 350
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER 400
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH 450
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA 500
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA 550
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 600
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG 650
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST 700
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL 750
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK 800
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF 850
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 900
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI 950
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL 1000
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL 1050
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG 1100
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG 1150
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 1200
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA 1250
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW 1300
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV 1350
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG 1400
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE 1450
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 1500
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG 1550
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI 1600
EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV 1650
GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE 1700
TSTCAPPLG 1709
Length:1,709
Mass (Da):182,624
Last modified:October 18, 2001 - v2
Checksum:i587C7CCA0B789A6D
GO
Isoform 2 (identifier: Q9BZZ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS

Show »
Length:1,649
Mass (Da):175,727
Checksum:i460B32A6B1577C4F
GO
Isoform 3 (identifier: Q9BZZ2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL

Note: No experimental confirmation available.

Show »
Length:1,701
Mass (Da):181,733
Checksum:iCB39EDDAB09606E6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411V → L.
Corresponds to variant rs35953127 [ dbSNP | Ensembl ].
VAR_049943
Natural varianti221 – 2211V → M.
Corresponds to variant rs6037651 [ dbSNP | Ensembl ].
VAR_024502
Natural varianti239 – 2391K → R.
Corresponds to variant rs625372 [ dbSNP | Ensembl ].
VAR_014136
Natural varianti464 – 4641R → H.
Corresponds to variant rs34924243 [ dbSNP | Ensembl ].
VAR_049944
Natural varianti919 – 9191H → P.
Corresponds to variant rs709012 [ dbSNP | Ensembl ].
VAR_014137
Natural varianti974 – 9741A → V.
Corresponds to variant rs3746638 [ dbSNP | Ensembl ].
VAR_021926
Natural varianti1335 – 13351S → Y.
Corresponds to variant rs3746636 [ dbSNP | Ensembl ].
VAR_021927
Natural varianti1487 – 14871R → W.
Corresponds to variant rs16988873 [ dbSNP | Ensembl ].
VAR_049945
Natural varianti1519 – 15191A → P.
Corresponds to variant rs2853217 [ dbSNP | Ensembl ].
VAR_014138

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1632 – 170978ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2.
VSP_002571Add
BLAST
Alternative sequencei1666 – 170944RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3.
VSP_002572Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1349 – 13491A → T in AAK00757. 1 Publication
Sequence conflicti1519 – 15191A → V in BAB15749. 1 Publication
Sequence conflicti1519 – 15191A → V in BAB15769. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230073 mRNA. Translation: AAK00757.1.
AL109804 Genomic DNA. Translation: CAC17543.1.
AL109804 Genomic DNA. Translation: CAC17542.1.
AK024459 mRNA. Translation: BAB15749.1.
AK024462 mRNA. Translation: BAB15752.1.
AK024479 mRNA. Translation: BAB15769.1.
AK057560 mRNA. Translation: BAB71527.1.
CCDSiCCDS13060.1. [Q9BZZ2-1]
RefSeqiNP_075556.1. NM_023068.3. [Q9BZZ2-1]
XP_006723673.1. XM_006723610.1. [Q9BZZ2-1]
XP_006723674.1. XM_006723611.1. [Q9BZZ2-3]
UniGeneiHs.31869.

Genome annotation databases

EnsembliENST00000202578; ENSP00000202578; ENSG00000088827. [Q9BZZ2-3]
ENST00000344754; ENSP00000341141; ENSG00000088827. [Q9BZZ2-1]
GeneIDi6614.
KEGGihsa:6614.
UCSCiuc002wiz.4. human. [Q9BZZ2-3]
uc002wja.3. human. [Q9BZZ2-1]

Polymorphism databases

DMDMi18202745.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230073 mRNA. Translation: AAK00757.1 .
AL109804 Genomic DNA. Translation: CAC17543.1 .
AL109804 Genomic DNA. Translation: CAC17542.1 .
AK024459 mRNA. Translation: BAB15749.1 .
AK024462 mRNA. Translation: BAB15752.1 .
AK024479 mRNA. Translation: BAB15769.1 .
AK057560 mRNA. Translation: BAB71527.1 .
CCDSi CCDS13060.1. [Q9BZZ2-1 ]
RefSeqi NP_075556.1. NM_023068.3. [Q9BZZ2-1 ]
XP_006723673.1. XM_006723610.1. [Q9BZZ2-1 ]
XP_006723674.1. XM_006723611.1. [Q9BZZ2-3 ]
UniGenei Hs.31869.

3D structure databases

ProteinModelPortali Q9BZZ2.
SMRi Q9BZZ2. Positions 20-219, 237-1633.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000341141.

PTM databases

PhosphoSitei Q9BZZ2.

Polymorphism databases

DMDMi 18202745.

Proteomic databases

PaxDbi Q9BZZ2.
PRIDEi Q9BZZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000202578 ; ENSP00000202578 ; ENSG00000088827 . [Q9BZZ2-3 ]
ENST00000344754 ; ENSP00000341141 ; ENSG00000088827 . [Q9BZZ2-1 ]
GeneIDi 6614.
KEGGi hsa:6614.
UCSCi uc002wiz.4. human. [Q9BZZ2-3 ]
uc002wja.3. human. [Q9BZZ2-1 ]

Organism-specific databases

CTDi 6614.
GeneCardsi GC20M003667.
H-InvDB HIX0203038.
HGNCi HGNC:11127. SIGLEC1.
HPAi HPA053457.
MIMi 600751. gene.
neXtProti NX_Q9BZZ2.
PharmGKBi PA35976.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252328.
HOGENOMi HOG000154365.
HOVERGENi HBG003550.
InParanoidi Q9BZZ2.
KOi K06548.
OMAi CTVDSRP.
OrthoDBi EOG77T13N.
PhylomeDBi Q9BZZ2.
TreeFami TF334827.

Miscellaneous databases

GenomeRNAii 6614.
NextBioi 25753.
PROi Q9BZZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9BZZ2.
CleanExi HS_SIGLEC1.
Genevestigatori Q9BZZ2.

Family and domain databases

Gene3Di 2.60.40.10. 17 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 8 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations."
    Hartnell A., Steel J., Turley H., Jones M., Jackson D.G., Crocker P.R.
    Blood 97:288-296(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Monocyte.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
  3. "Characterization of long cDNA clones from human adult spleen."
    Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
    DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 733-1709 (ISOFORMS 1 AND 2).
    Tissue: Spleen.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1539-1709 (ISOFORM 3).
    Tissue: Thymus.

Entry informationi

Entry nameiSN_HUMAN
AccessioniPrimary (citable) accession number: Q9BZZ2
Secondary accession number(s): Q96DL4
, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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