Q9BZZ2 (SN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sialoadhesin

Alternative name(s):
Sialic acid-binding Ig-like lectin 1
Short name=Siglec-1
CD_antigen=CD169

Gene names

Name:	SIGLEC1
Synonyms:	SN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1709 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid By similarity. Binds to SPN/CD43 on T-cells By similarity. May play a role in hemopoiesis.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue specificity	Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
Sequence similarities	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 16 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Cell adhesion Endocytosis
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Lectin
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Non-traceable author statement Ref.1. Source: UniProtKB cell-matrix adhesion Non-traceable author statement Ref.1. Source: UniProtKB endocytosis Inferred from electronic annotation. Source: UniProtKB-KW inflammatory response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	carbohydrate binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9BZZ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BZZ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS

Isoform 3 (identifier: Q9BZZ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 1709	1690	Sialoadhesin		PRO_0000014968
Regions
	Topological domain	20 – 1641	1622	Extracellular Potential
	Transmembrane	1642 – 1662	21	Helical; Potential
	Topological domain	1663 – 1709	47	Cytoplasmic Potential
	Domain	20 – 136	117	Ig-like V-type
	Domain	139 – 233	95	Ig-like C2-type 1
	Domain	238 – 320	83	Ig-like C2-type 2
	Domain	326 – 405	80	Ig-like C2-type 3
	Domain	411 – 507	97	Ig-like C2-type 4
	Domain	511 – 593	83	Ig-like C2-type 5
	Domain	601 – 705	105	Ig-like C2-type 6
	Domain	708 – 785	78	Ig-like C2-type 7
	Domain	799 – 894	96	Ig-like C2-type 8
	Domain	898 – 977	80	Ig-like C2-type 9
	Domain	984 – 1083	100	Ig-like C2-type 10
	Domain	1085 – 1165	81	Ig-like C2-type 11
	Domain	1176 – 1248	73	Ig-like C2-type 12
	Domain	1259 – 1341	83	Ig-like C2-type 13
	Domain	1350 – 1442	93	Ig-like C2-type 14
	Domain	1445 – 1528	84	Ig-like C2-type 15
	Domain	1536 – 1631	96	Ig-like C2-type 16
	Region	122 – 126	5	Sialic acid binding By similarity
Sites
	Binding site	63	1	Sialic acid By similarity
	Binding site	116	1	Sialic acid By similarity
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Glycosylation	339	1	N-linked (GlcNAc...) Potential
	Glycosylation	499	1	N-linked (GlcNAc...) Potential
	Glycosylation	697	1	N-linked (GlcNAc...) Potential
	Glycosylation	726	1	N-linked (GlcNAc...) Potential
	Glycosylation	730	1	N-linked (GlcNAc...) Potential
	Glycosylation	741	1	N-linked (GlcNAc...) Potential
	Glycosylation	886	1	N-linked (GlcNAc...) Potential
	Glycosylation	1104	1	N-linked (GlcNAc...) Potential
	Glycosylation	1138	1	N-linked (GlcNAc...) Potential
	Glycosylation	1251	1	N-linked (GlcNAc...) Potential
	Glycosylation	1462	1	N-linked (GlcNAc...) Potential
	Glycosylation	1476	1	N-linked (GlcNAc...) Potential
	Disulfide bond	36 ↔ 166		By similarity
	Disulfide bond	41 ↔ 98		By similarity
	Disulfide bond	160 ↔ 217		By similarity
	Disulfide bond	262 ↔ 305		By similarity
	Disulfide bond	346 ↔ 390		By similarity
	Disulfide bond	433 ↔ 491		By similarity
	Disulfide bond	531 ↔ 575		By similarity
	Disulfide bond	624 ↔ 689		By similarity
	Disulfide bond	729 ↔ 774		By similarity
	Disulfide bond	817 ↔ 876		By similarity
	Disulfide bond	916 ↔ 960		By similarity
	Disulfide bond	1005 ↔ 1067		By similarity
	Disulfide bond	1107 ↔ 1149		By similarity
	Disulfide bond	1193 ↔ 1241		By similarity
	Disulfide bond	1281 ↔ 1324		By similarity
	Disulfide bond	1367 ↔ 1425		By similarity
	Disulfide bond	1465 ↔ 1511		By similarity
	Disulfide bond	1554 ↔ 1613		By similarity
Natural variations
	Alternative sequence	1632 – 1709	78	ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2.		VSP_002571
	Alternative sequence	1666 – 1709	44	RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3.		VSP_002572
	Natural variant	141	1	V → L. Corresponds to variant rs35953127 [ dbSNP | Ensembl ].		VAR_049943
	Natural variant	221	1	V → M. Corresponds to variant rs6037651 [ dbSNP | Ensembl ].		VAR_024502
	Natural variant	239	1	K → R. Corresponds to variant rs625372 [ dbSNP | Ensembl ].		VAR_014136
	Natural variant	464	1	R → H. Corresponds to variant rs34924243 [ dbSNP | Ensembl ].		VAR_049944
	Natural variant	919	1	H → P. Corresponds to variant rs709012 [ dbSNP | Ensembl ].		VAR_014137
	Natural variant	974	1	A → V. Corresponds to variant rs3746638 [ dbSNP | Ensembl ].		VAR_021926
	Natural variant	1335	1	S → Y. Corresponds to variant rs3746636 [ dbSNP | Ensembl ].		VAR_021927
	Natural variant	1487	1	R → W. Corresponds to variant rs16988873 [ dbSNP | Ensembl ].		VAR_049945
	Natural variant	1519	1	A → P. Corresponds to variant rs2853217 [ dbSNP | Ensembl ].		VAR_014138
Experimental info
	Sequence conflict	1349	1	A → T in AAK00757. Ref.1
	Sequence conflict	1519	1	A → V in BAB15749. Ref.3
	Sequence conflict	1519	1	A → V in BAB15769. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 18, 2001. Version 2. Checksum: 587C7CCA0B789A6D	FASTA	1,709	182,624
	10 20 30 40 50 60 MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY 70 80 90 100 110 120 YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS 130 140 150 160 170 180 EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP 190 200 210 220 230 240 ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG 250 260 270 280 290 300 VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 310 320 330 340 350 360 GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW 370 380 390 400 410 420 YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF 430 440 450 460 470 480 LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD 490 500 510 520 530 540 LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD 550 560 570 580 590 600 ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 610 620 630 640 650 660 PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS 670 680 690 700 710 720 PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ 730 740 750 760 770 780 EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA 790 800 810 820 830 840 GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL 850 860 870 880 890 900 GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 910 920 930 940 950 960 SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC 970 980 990 1000 1010 1020 QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG 1030 1040 1050 1060 1070 1080 DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA 1090 1100 1110 1120 1130 1140 DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT 1150 1160 1170 1180 1190 1200 VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 1210 1220 1230 1240 1250 1260 AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG 1270 1280 1290 1300 1310 1320 VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG 1330 1340 1350 1360 1370 1380 AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS 1390 1400 1410 1420 1430 1440 HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL 1450 1460 1470 1480 1490 1500 QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 1510 1520 1530 1540 1550 1560 VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP 1570 1580 1590 1600 1610 1620 LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG 1630 1640 1650 1660 1670 1680 SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV 1690 1700 EMAFQKETTQ LIDPDAATCE TSTCAPPLG
	Isoform 2 [UniParc]. Checksum: 460B32A6B1577C4F	FASTA	1,649	175,727
	10 20 30 40 50 60 MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY 70 80 90 100 110 120 YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS 130 140 150 160 170 180 EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP 190 200 210 220 230 240 ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG 250 260 270 280 290 300 VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 310 320 330 340 350 360 GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW 370 380 390 400 410 420 YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF 430 440 450 460 470 480 LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD 490 500 510 520 530 540 LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD 550 560 570 580 590 600 ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 610 620 630 640 650 660 PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS 670 680 690 700 710 720 PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ 730 740 750 760 770 780 EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA 790 800 810 820 830 840 GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL 850 860 870 880 890 900 GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 910 920 930 940 950 960 SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC 970 980 990 1000 1010 1020 QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG 1030 1040 1050 1060 1070 1080 DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA 1090 1100 1110 1120 1130 1140 DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT 1150 1160 1170 1180 1190 1200 VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 1210 1220 1230 1240 1250 1260 AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG 1270 1280 1290 1300 1310 1320 VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG 1330 1340 1350 1360 1370 1380 AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS 1390 1400 1410 1420 1430 1440 HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL 1450 1460 1470 1480 1490 1500 QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 1510 1520 1530 1540 1550 1560 VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP 1570 1580 1590 1600 1610 1620 LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG 1630 1640 SASTSTYFGV RGEGRGLHLP GHSAQKPSS
	Isoform 3 [UniParc]. Checksum: CB39EDDAB09606E6	FASTA	1,701	181,733
	10 20 30 40 50 60 MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY 70 80 90 100 110 120 YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS 130 140 150 160 170 180 EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP 190 200 210 220 230 240 ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG 250 260 270 280 290 300 VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 310 320 330 340 350 360 GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW 370 380 390 400 410 420 YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF 430 440 450 460 470 480 LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD 490 500 510 520 530 540 LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD 550 560 570 580 590 600 ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 610 620 630 640 650 660 PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS 670 680 690 700 710 720 PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ 730 740 750 760 770 780 EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA 790 800 810 820 830 840 GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL 850 860 870 880 890 900 GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 910 920 930 940 950 960 SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC 970 980 990 1000 1010 1020 QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG 1030 1040 1050 1060 1070 1080 DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA 1090 1100 1110 1120 1130 1140 DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT 1150 1160 1170 1180 1190 1200 VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 1210 1220 1230 1240 1250 1260 AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG 1270 1280 1290 1300 1310 1320 VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG 1330 1340 1350 1360 1370 1380 AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS 1390 1400 1410 1420 1430 1440 HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL 1450 1460 1470 1480 1490 1500 QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 1510 1520 1530 1540 1550 1560 VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP 1570 1580 1590 1600 1610 1620 LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG 1630 1640 1650 1660 1670 1680 SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWSSLIL MQPHVRPQPV 1690 1700 PHPWADQWCC LPSGGESGQN L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations." Hartnell A., Steel J., Turley H., Jones M., Jackson D.G., Crocker P.R. Blood 97:288-296(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION. Tissue: Monocyte.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
[3]	"Characterization of long cDNA clones from human adult spleen." Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O. DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 733-1709 (ISOFORMS 1 AND 2). Tissue: Spleen.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1539-1709 (ISOFORM 3). Tissue: Thymus.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF230073 mRNA. Translation: AAK00757.1. AL109804 Genomic DNA. Translation: CAC17543.1. AL109804 Genomic DNA. Translation: CAC17542.1. AK024459 mRNA. Translation: BAB15749.1. AK024462 mRNA. Translation: BAB15752.1. AK024479 mRNA. Translation: BAB15769.1. AK057560 mRNA. Translation: BAB71527.1.
IPI	IPI00011961. IPI00219698. IPI00219699.
RefSeq	NP_075556.1. NM_023068.3.
UniGene	Hs.31869.
3D structure databases
ProteinModelPortal	Q9BZZ2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341141.
PTM databases
PhosphoSite	Q9BZZ2.
Polymorphism databases
DMDM	18202745.
Proteomic databases
PaxDb	Q9BZZ2.
PRIDE	Q9BZZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000202578; ENSP00000202578; ENSG00000088827. ENST00000344754; ENSP00000341141; ENSG00000088827.
GeneID	6614.
KEGG	hsa:6614.
UCSC	uc002wiz.4. human. uc002wja.3. human.
Organism-specific databases
CTD	6614.
GeneCards	GC20M003667.
H-InvDB	HIX0203038.
HGNC	HGNC:11127. SIGLEC1.
HPA	HPA053457.
MIM	600751. gene.
neXtProt	NX_Q9BZZ2.
PharmGKB	PA35976.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252328.
HOGENOM	HOG000154365.
HOVERGEN	HBG003550.
InParanoid	Q9BZZ2.
KO	K06548.
OMA	CTVDSRP.
OrthoDB	EOG4ZKJKC.
Gene expression databases
Bgee	Q9BZZ2.
CleanEx	HS_SIGLEC1.
Genevestigator	Q9BZZ2.
GermOnline	ENSG00000088827. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 17 hits.
InterPro	IPR013162. CD80_C2-set. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF08205. C2-set_2. 1 hit. PF07679. I-set. 2 hits. PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 8 hits. SM00408. IGc2. 5 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 14 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6614.
NextBio	25753.
SOURCE	Search...

Entry information

Entry name

SN_HUMAN

Accession

Primary (citable) accession number: Q9BZZ2
Secondary accession number(s): Q96DL4 , Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	October 18, 2001
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.