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Q9BZZ2 (SN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sialoadhesin
Alternative name(s):
Sialic acid-binding Ig-like lectin 1
Short name=Siglec-1
CD_antigen=CD169
Gene names
Name:SIGLEC1
Synonyms:SN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1709 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid By similarity. Binds to SPN/CD43 on T-cells By similarity. May play a role in hemopoiesis.

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Isoform 2: Secreted.

Tissue specificity

Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Sequence similarities

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Contains 16 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9BZZ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BZZ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS
Isoform 3 (identifier: Q9BZZ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 17091690Sialoadhesin
PRO_0000014968

Regions

Topological domain20 – 16411622Extracellular Potential
Transmembrane1642 – 166221Helical; Potential
Topological domain1663 – 170947Cytoplasmic Potential
Domain20 – 136117Ig-like V-type
Domain139 – 23395Ig-like C2-type 1
Domain238 – 32083Ig-like C2-type 2
Domain326 – 40580Ig-like C2-type 3
Domain411 – 50797Ig-like C2-type 4
Domain511 – 59383Ig-like C2-type 5
Domain601 – 705105Ig-like C2-type 6
Domain708 – 78578Ig-like C2-type 7
Domain799 – 89496Ig-like C2-type 8
Domain898 – 97780Ig-like C2-type 9
Domain984 – 1083100Ig-like C2-type 10
Domain1085 – 116581Ig-like C2-type 11
Domain1176 – 124873Ig-like C2-type 12
Domain1259 – 134183Ig-like C2-type 13
Domain1350 – 144293Ig-like C2-type 14
Domain1445 – 152884Ig-like C2-type 15
Domain1536 – 163196Ig-like C2-type 16
Region122 – 1265Sialic acid binding By similarity

Sites

Binding site631Sialic acid By similarity
Binding site1161Sialic acid By similarity

Amino acid modifications

Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation3391N-linked (GlcNAc...) Potential
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation6971N-linked (GlcNAc...) Potential
Glycosylation7261N-linked (GlcNAc...) Potential
Glycosylation7301N-linked (GlcNAc...) Potential
Glycosylation7411N-linked (GlcNAc...) Potential
Glycosylation8861N-linked (GlcNAc...) Potential
Glycosylation11041N-linked (GlcNAc...) Potential
Glycosylation11381N-linked (GlcNAc...) Potential
Glycosylation12511N-linked (GlcNAc...) Potential
Glycosylation14621N-linked (GlcNAc...) Potential
Glycosylation14761N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 166 By similarity
Disulfide bond41 ↔ 98 By similarity
Disulfide bond160 ↔ 217 By similarity
Disulfide bond262 ↔ 305 By similarity
Disulfide bond346 ↔ 390 By similarity
Disulfide bond433 ↔ 491 By similarity
Disulfide bond531 ↔ 575 By similarity
Disulfide bond624 ↔ 689 By similarity
Disulfide bond729 ↔ 774 By similarity
Disulfide bond817 ↔ 876 By similarity
Disulfide bond916 ↔ 960 By similarity
Disulfide bond1005 ↔ 1067 By similarity
Disulfide bond1107 ↔ 1149 By similarity
Disulfide bond1193 ↔ 1241 By similarity
Disulfide bond1281 ↔ 1324 By similarity
Disulfide bond1367 ↔ 1425 By similarity
Disulfide bond1465 ↔ 1511 By similarity
Disulfide bond1554 ↔ 1613 By similarity

Natural variations

Alternative sequence1632 – 170978ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2.
VSP_002571
Alternative sequence1666 – 170944RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3.
VSP_002572
Natural variant1411V → L.
Corresponds to variant rs35953127 [ dbSNP | Ensembl ].
VAR_049943
Natural variant2211V → M.
Corresponds to variant rs6037651 [ dbSNP | Ensembl ].
VAR_024502
Natural variant2391K → R.
Corresponds to variant rs625372 [ dbSNP | Ensembl ].
VAR_014136
Natural variant4641R → H.
Corresponds to variant rs34924243 [ dbSNP | Ensembl ].
VAR_049944
Natural variant9191H → P.
Corresponds to variant rs709012 [ dbSNP | Ensembl ].
VAR_014137
Natural variant9741A → V.
Corresponds to variant rs3746638 [ dbSNP | Ensembl ].
VAR_021926
Natural variant13351S → Y.
Corresponds to variant rs3746636 [ dbSNP | Ensembl ].
VAR_021927
Natural variant14871R → W.
Corresponds to variant rs16988873 [ dbSNP | Ensembl ].
VAR_049945
Natural variant15191A → P.
Corresponds to variant rs2853217 [ dbSNP | Ensembl ].
VAR_014138

Experimental info

Sequence conflict13491A → T in AAK00757. Ref.1
Sequence conflict15191A → V in BAB15749. Ref.3
Sequence conflict15191A → V in BAB15769. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 18, 2001. Version 2.
Checksum: 587C7CCA0B789A6D

FASTA1,709182,624
        10         20         30         40         50         60 
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY 

        70         80         90        100        110        120 
YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS 

       130        140        150        160        170        180 
EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP 

       190        200        210        220        230        240 
ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG 

       250        260        270        280        290        300 
VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 

       310        320        330        340        350        360 
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW 

       370        380        390        400        410        420 
YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF 

       430        440        450        460        470        480 
LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD 

       490        500        510        520        530        540 
LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD 

       550        560        570        580        590        600 
ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 

       610        620        630        640        650        660 
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS 

       670        680        690        700        710        720 
PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ 

       730        740        750        760        770        780 
EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA 

       790        800        810        820        830        840 
GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL 

       850        860        870        880        890        900 
GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 

       910        920        930        940        950        960 
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC 

       970        980        990       1000       1010       1020 
QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG 

      1030       1040       1050       1060       1070       1080 
DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA 

      1090       1100       1110       1120       1130       1140 
DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT 

      1150       1160       1170       1180       1190       1200 
VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 

      1210       1220       1230       1240       1250       1260 
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG 

      1270       1280       1290       1300       1310       1320 
VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG 

      1330       1340       1350       1360       1370       1380 
AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS 

      1390       1400       1410       1420       1430       1440 
HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL 

      1450       1460       1470       1480       1490       1500 
QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 

      1510       1520       1530       1540       1550       1560 
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP 

      1570       1580       1590       1600       1610       1620 
LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG 

      1630       1640       1650       1660       1670       1680 
SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV 

      1690       1700 
EMAFQKETTQ LIDPDAATCE TSTCAPPLG 

« Hide

Isoform 2 [UniParc].

Checksum: 460B32A6B1577C4F
Show »

FASTA1,649175,727
Isoform 3 [UniParc].

Checksum: CB39EDDAB09606E6
Show »

FASTA1,701181,733

References

« Hide 'large scale' references
[1]"Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations."
Hartnell A., Steel J., Turley H., Jones M., Jackson D.G., Crocker P.R.
Blood 97:288-296(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
Tissue: Monocyte.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
[3]"Characterization of long cDNA clones from human adult spleen."
Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 733-1709 (ISOFORMS 1 AND 2).
Tissue: Spleen.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1539-1709 (ISOFORM 3).
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF230073 mRNA. Translation: AAK00757.1.
AL109804 Genomic DNA. Translation: CAC17543.1.
AL109804 Genomic DNA. Translation: CAC17542.1.
AK024459 mRNA. Translation: BAB15749.1.
AK024462 mRNA. Translation: BAB15752.1.
AK024479 mRNA. Translation: BAB15769.1.
AK057560 mRNA. Translation: BAB71527.1.
RefSeqNP_075556.1. NM_023068.3.
UniGeneHs.31869.

3D structure databases

ProteinModelPortalQ9BZZ2.
SMRQ9BZZ2. Positions 20-1633.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000341141.

PTM databases

PhosphoSiteQ9BZZ2.

Polymorphism databases

DMDM18202745.

Proteomic databases

PaxDbQ9BZZ2.
PRIDEQ9BZZ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000202578; ENSP00000202578; ENSG00000088827. [Q9BZZ2-3]
ENST00000344754; ENSP00000341141; ENSG00000088827. [Q9BZZ2-1]
GeneID6614.
KEGGhsa:6614.
UCSCuc002wiz.4. human. [Q9BZZ2-3]
uc002wja.3. human. [Q9BZZ2-1]

Organism-specific databases

CTD6614.
GeneCardsGC20M003667.
H-InvDBHIX0203038.
HGNCHGNC:11127. SIGLEC1.
HPAHPA053457.
MIM600751. gene.
neXtProtNX_Q9BZZ2.
PharmGKBPA35976.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG252328.
HOGENOMHOG000154365.
HOVERGENHBG003550.
InParanoidQ9BZZ2.
KOK06548.
OMACTVDSRP.
OrthoDBEOG77T13N.
PhylomeDBQ9BZZ2.
TreeFamTF334827.

Gene expression databases

BgeeQ9BZZ2.
CleanExHS_SIGLEC1.
GenevestigatorQ9BZZ2.

Family and domain databases

Gene3D2.60.40.10. 17 hits.
InterProIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 8 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 14 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6614.
NextBio25753.
PROQ9BZZ2.
SOURCESearch...

Entry information

Entry nameSN_HUMAN
AccessionPrimary (citable) accession number: Q9BZZ2
Secondary accession number(s): Q96DL4 expand/collapse secondary AC list , Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries