Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TRIM31

Gene

TRIM31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri90 – 131B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral transcription Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of viral release from host cell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137397-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM31 (EC:6.3.2.-)
Alternative name(s):
Tripartite motif-containing protein 31
Gene namesi
Name:TRIM31
Synonyms:C6orf13, RNF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16289. TRIM31.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Mitochondrion 1 Publication

  • Note: Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi11074.
OpenTargetsiENSG00000204616.
ENSG00000223531.
ENSG00000224168.
ENSG00000225130.
PharmGKBiPA38117.

Polymorphism and mutation databases

BioMutaiTRIM31.
DMDMi68068082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562451 – 425E3 ubiquitin-protein ligase TRIM31Add BLAST425

Post-translational modificationi

Auto-ubiquitinated (in vitro).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9BZY9.
PeptideAtlasiQ9BZY9.
PRIDEiQ9BZY9.

PTM databases

iPTMnetiQ9BZY9.
PhosphoSitePlusiQ9BZY9.

Expressioni

Tissue specificityi

Up-regulated in gastric adenocarcinomas.1 Publication

Gene expression databases

BgeeiENSG00000137397.
ExpressionAtlasiQ9BZY9. baseline and differential.
GenevisibleiQ9BZY9. HS.

Organism-specific databases

HPAiHPA046400.

Interactioni

Subunit structurei

Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA1P433554EBI-747544,EBI-740978

Protein-protein interaction databases

BioGridi116257. 21 interactors.
IntActiQ9BZY9. 11 interactors.
STRINGi9606.ENSP00000365924.

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni17 – 19Combined sources3
Beta strandi24 – 28Combined sources5
Beta strandi32 – 35Combined sources4
Helixi37 – 46Combined sources10
Beta strandi54 – 56Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YSJNMR-A1-56[»]
2YSLNMR-A1-66[»]
ProteinModelPortaliQ9BZY9.
SMRiQ9BZY9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZY9.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili126 – 162Sequence analysisAdd BLAST37
Coiled coili270 – 307Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri90 – 131B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00860000133752.
HOVERGENiHBG083771.
InParanoidiQ9BZY9.
KOiK12011.
OMAiYFCEQDG.
OrthoDBiEOG091G07DI.
PhylomeDBiQ9BZY9.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR020457. Znf_B-box_chordata.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01406. BBOXZNFINGER.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q9BZY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF
60 70 80 90 100
FKCPLCKTSV RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE
110 120 130 140 150
MFHYFCEDDG KFLCFVCRES KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ
160 170 180 190 200
QKEKETVQVK AQGVHRVDVF TDQVEHEKQR ILTEFELLHQ VLEEEKNFLL
210 220 230 240 250
SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN MPPRQLLEDI
260 270 280 290 300
KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD
310 320 330 340 350
RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP
360 370 380 390 400
NHHSSAPSHS LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL
410 420
SEELHAALSE WLTAIRAWFC EVPSS
Length:425
Mass (Da):48,244
Last modified:June 21, 2005 - v2
Checksum:i8CCC0D07F2DBB52D
GO
Isoform Beta (identifier: Q9BZY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-267: DIKVVLCRSEEFQFLNPTP → NWRKNSVKQNQDTTPSQGA
     268-425: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:267
Mass (Da):30,831
Checksum:iA5B06E3F28E451AB
GO

Sequence cautioni

The sequence AAH16866 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37 – 38LK → PQ in AAG50165 (PubMed:11331580).Curated2
Sequence conflicti37 – 38LK → PQ in AAG50166 (PubMed:11331580).Curated2
Sequence conflicti37 – 38LK → PQ in CAA69165 (Ref. 6) Curated2
Sequence conflicti62 – 63KN → RD in AAG50165 (PubMed:11331580).Curated2
Sequence conflicti62 – 63KN → RD in AAG50166 (PubMed:11331580).Curated2
Sequence conflicti62 – 63KN → RD in CAA69165 (Ref. 6) Curated2
Sequence conflicti109D → G in BAD96449 (Ref. 3) Curated1
Sequence conflicti219 – 236ASTEP…VDSLK → EIPLMPTVERSQEARCYP in CAA69165 (Ref. 6) CuratedAdd BLAST18

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05213917P → R.Corresponds to variant rs36063651dbSNPEnsembl.1
Natural variantiVAR_022728118R → C.1 PublicationCorresponds to variant rs3734838dbSNPEnsembl.1
Natural variantiVAR_022729232V → I.1 PublicationCorresponds to variant rs2523989dbSNPEnsembl.1
Natural variantiVAR_052140235L → P.Corresponds to variant rs35775852dbSNPEnsembl.1
Natural variantiVAR_019962421E → K.3 PublicationsCorresponds to variant rs1116221dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005764249 – 267DIKVV…LNPTP → NWRKNSVKQNQDTTPSQGA in isoform Beta. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_005765268 – 425Missing in isoform Beta. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230386 mRNA. Translation: AAG50165.1.
AF230387 mRNA. Translation: AAG50166.1.
BT006675 mRNA. Translation: AAP35321.1.
AK222729 mRNA. Translation: BAD96449.1.
AL671859 Genomic DNA. Translation: CAI17583.1.
AL669914 Genomic DNA. Translation: CAI18183.1.
BX322644 Genomic DNA. Translation: CAI18447.1.
CR753815 Genomic DNA. Translation: CAP58476.1.
BC016866 mRNA. Translation: AAH16866.1. Different initiation.
BC017017 mRNA. Translation: AAH17017.1.
Y07828 mRNA. Translation: CAA69165.1.
CCDSiCCDS34374.1. [Q9BZY9-1]
RefSeqiNP_008959.3. NM_007028.4. [Q9BZY9-1]
UniGeneiHs.493275.

Genome annotation databases

EnsembliENST00000357569; ENSP00000350182; ENSG00000137397.
ENST00000376734; ENSP00000365924; ENSG00000204616. [Q9BZY9-1]
ENST00000433864; ENSP00000390551; ENSG00000233573.
ENST00000445679; ENSP00000409501; ENSG00000224168. [Q9BZY9-1]
ENST00000449412; ENSP00000398677; ENSG00000223531. [Q9BZY9-1]
ENST00000453266; ENSP00000391685; ENSG00000225130. [Q9BZY9-1]
ENST00000551027; ENSP00000446675; ENSG00000137397.
GeneIDi11074.
KEGGihsa:11074.
UCSCiuc003npg.2. human. [Q9BZY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230386 mRNA. Translation: AAG50165.1.
AF230387 mRNA. Translation: AAG50166.1.
BT006675 mRNA. Translation: AAP35321.1.
AK222729 mRNA. Translation: BAD96449.1.
AL671859 Genomic DNA. Translation: CAI17583.1.
AL669914 Genomic DNA. Translation: CAI18183.1.
BX322644 Genomic DNA. Translation: CAI18447.1.
CR753815 Genomic DNA. Translation: CAP58476.1.
BC016866 mRNA. Translation: AAH16866.1. Different initiation.
BC017017 mRNA. Translation: AAH17017.1.
Y07828 mRNA. Translation: CAA69165.1.
CCDSiCCDS34374.1. [Q9BZY9-1]
RefSeqiNP_008959.3. NM_007028.4. [Q9BZY9-1]
UniGeneiHs.493275.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YSJNMR-A1-56[»]
2YSLNMR-A1-66[»]
ProteinModelPortaliQ9BZY9.
SMRiQ9BZY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116257. 21 interactors.
IntActiQ9BZY9. 11 interactors.
STRINGi9606.ENSP00000365924.

PTM databases

iPTMnetiQ9BZY9.
PhosphoSitePlusiQ9BZY9.

Polymorphism and mutation databases

BioMutaiTRIM31.
DMDMi68068082.

Proteomic databases

PaxDbiQ9BZY9.
PeptideAtlasiQ9BZY9.
PRIDEiQ9BZY9.

Protocols and materials databases

DNASUi11074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357569; ENSP00000350182; ENSG00000137397.
ENST00000376734; ENSP00000365924; ENSG00000204616. [Q9BZY9-1]
ENST00000433864; ENSP00000390551; ENSG00000233573.
ENST00000445679; ENSP00000409501; ENSG00000224168. [Q9BZY9-1]
ENST00000449412; ENSP00000398677; ENSG00000223531. [Q9BZY9-1]
ENST00000453266; ENSP00000391685; ENSG00000225130. [Q9BZY9-1]
ENST00000551027; ENSP00000446675; ENSG00000137397.
GeneIDi11074.
KEGGihsa:11074.
UCSCiuc003npg.2. human. [Q9BZY9-1]

Organism-specific databases

CTDi11074.
DisGeNETi11074.
GeneCardsiTRIM31.
H-InvDBHIX0005686.
HIX0166392.
HGNCiHGNC:16289. TRIM31.
HPAiHPA046400.
MIMi609316. gene.
neXtProtiNX_Q9BZY9.
OpenTargetsiENSG00000204616.
ENSG00000223531.
ENSG00000224168.
ENSG00000225130.
PharmGKBiPA38117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00860000133752.
HOVERGENiHBG083771.
InParanoidiQ9BZY9.
KOiK12011.
OMAiYFCEQDG.
OrthoDBiEOG091G07DI.
PhylomeDBiQ9BZY9.
TreeFamiTF338674.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000137397-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiQ9BZY9.
GeneWikiiTRIM31.
GenomeRNAii11074.
PROiQ9BZY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137397.
ExpressionAtlasiQ9BZY9. baseline and differential.
GenevisibleiQ9BZY9. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR020457. Znf_B-box_chordata.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01406. BBOXZNFINGER.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI31_HUMAN
AccessioniPrimary (citable) accession number: Q9BZY9
Secondary accession number(s): A6NLX6
, A9R9Q4, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.