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Protein

Ropporin-1B

Gene

ROPN1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB

GO - Biological processi

  • acrosome reaction Source: UniProtKB
  • cilium organization Source: UniProtKB
  • cytokinesis Source: UniProtKB
  • flagellated sperm motility Source: UniProtKB
  • fusion of sperm to egg plasma membrane Source: UniProtKB
  • protein localization to cilium Source: UniProtKB
  • regulation of protein phosphorylation Source: UniProtKB
  • Rho protein signal transduction Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
  • spermatogenesis Source: UniProtKB
  • sperm capacitation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Ropporin-1B
Alternative name(s):
Rhophilin-associated protein 1B
Gene namesi
Name:ROPN1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114547.9.
HGNCiHGNC:31927. ROPN1B.

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18L → A: Abolishes interaction with AKAP3. 1 Publication1

Organism-specific databases

DisGeNETi152015.
OpenTargetsiENSG00000114547.
PharmGKBiPA142671053.

Polymorphism and mutation databases

BioMutaiROPN1B.
DMDMi74717806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073931 – 212Ropporin-1BAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BZX4.
PeptideAtlasiQ9BZX4.
PRIDEiQ9BZX4.

PTM databases

PhosphoSitePlusiQ9BZX4.

Expressioni

Gene expression databases

BgeeiENSG00000114547.
CleanExiHS_ROPN1B.
ExpressionAtlasiQ9BZX4. baseline and differential.
GenevisibleiQ9BZX4. HS.

Organism-specific databases

HPAiHPA052530.

Interactioni

Subunit structurei

Homodimer. Interacts with RHPN1. May interact with SPA17 (By similarity). Interacts with AKAP3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP3O759692EBI-9033148,EBI-9033101

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB

Protein-protein interaction databases

BioGridi127418. 1 interactor.
IntActiQ9BZX4. 1 interactor.
STRINGi9606.ENSP00000251776.

Structurei

3D structure databases

ProteinModelPortaliQ9BZX4.
SMRiQ9BZX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 49RIIaAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 212Interaction with RHPN1By similarity4

Domaini

The RIIa domain mediates interaction with AKAP3.

Sequence similaritiesi

Belongs to the ropporin family.Curated

Phylogenomic databases

eggNOGiENOG410IFDW. Eukaryota.
ENOG410ZIXI. LUCA.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ9BZX4.
OMAiSDHDGGP.
OrthoDBiEOG091G0LKF.
PhylomeDBiQ9BZX4.
TreeFamiTF105421.

Family and domain databases

InterProiView protein in InterPro
IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQTDKPTCI PPELPKMLKE FAKAAIRAQP QDLIQWGADY FEALSRGETP
60 70 80 90 100
PVRERSERVA LCNWAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP
110 120 130 140 150
TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN
160 170 180 190 200
GGLPRIPFST FQFLYTYIAE VDGEICASHV SRMLNYIEQE VIGPDGLITV
210
NDFTQNPRVW LE
Length:212
Mass (Da):23,964
Last modified:June 1, 2001 - v1
Checksum:i2867946D20C637AE
GO
Isoform 2 (identifier: Q9BZX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:120
Mass (Da):13,587
Checksum:i23DB964953F16CDF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0287451 – 92Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231410 mRNA. Translation: AAG59586.1.
CH471052 Genomic DNA. Translation: EAW79382.1.
CH471052 Genomic DNA. Translation: EAW79383.1.
BC015413 mRNA. Translation: AAH15413.1.
BC141849 mRNA. Translation: AAI41850.1.
CCDSiCCDS33841.1. [Q9BZX4-1]
RefSeqiNP_001012337.1. NM_001012337.2. [Q9BZX4-1]
NP_001295242.1. NM_001308313.1. [Q9BZX4-1]
XP_005247195.1. XM_005247138.3. [Q9BZX4-2]
XP_006713576.1. XM_006713513.3. [Q9BZX4-1]
UniGeneiHs.663128.

Genome annotation databases

EnsembliENST00000251776; ENSP00000251776; ENSG00000114547. [Q9BZX4-1]
ENST00000505382; ENSP00000421662; ENSG00000114547. [Q9BZX4-2]
ENST00000511082; ENSP00000424447; ENSG00000114547. [Q9BZX4-2]
ENST00000514116; ENSP00000426271; ENSG00000114547. [Q9BZX4-1]
GeneIDi152015.
KEGGihsa:152015.
UCSCiuc003eih.4. human. [Q9BZX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiROP1B_HUMAN
AccessioniPrimary (citable) accession number: Q9BZX4
Secondary accession number(s): D3DNA6, Q96BM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families