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Protein

Ropporin-1B

Gene

ROPN1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB

GO - Biological processi

  • acrosome reaction Source: UniProtKB
  • cytokinesis Source: UniProtKB
  • fusion of sperm to egg plasma membrane Source: UniProtKB
  • Rho protein signal transduction Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
  • spermatogenesis Source: UniProtKB
  • sperm motility Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ropporin-1B
Alternative name(s):
Rhophilin-associated protein 1B
Gene namesi
Name:ROPN1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31927. ROPN1B.

Subcellular locationi


    Note: In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • motile cilium Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi18 – 181L → A: Abolishes interaction with AKAP3. 1 Publication

Organism-specific databases

PharmGKBiPA142671053.

Polymorphism and mutation databases

BioMutaiROPN1B.
DMDMi74717806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ropporin-1BPRO_0000307393Add
BLAST

Proteomic databases

PaxDbiQ9BZX4.
PRIDEiQ9BZX4.

Expressioni

Gene expression databases

BgeeiQ9BZX4.
CleanExiHS_ROPN1B.
ExpressionAtlasiQ9BZX4. baseline and differential.
GenevisibleiQ9BZX4. HS.

Organism-specific databases

HPAiHPA052530.

Interactioni

Subunit structurei

Homodimer. Interacts with RHPN1. May interact with SPA17 (By similarity). Interacts with AKAP3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP3O759692EBI-9033148,EBI-9033101

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB

Protein-protein interaction databases

BioGridi127418. 1 interaction.
IntActiQ9BZX4. 1 interaction.
STRINGi9606.ENSP00000251776.

Structurei

3D structure databases

ProteinModelPortaliQ9BZX4.
SMRiQ9BZX4. Positions 10-46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4938RIIaAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2124Interaction with RHPN1By similarity

Domaini

The RIIa domain mediates interaction with AKAP3.

Sequence similaritiesi

Belongs to the ropporin family.Curated
Contains 1 RIIa domain.Curated

Phylogenomic databases

eggNOGiENOG410IFDW. Eukaryota.
ENOG410ZIXI. LUCA.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ9BZX4.
OMAiSDHDGGP.
OrthoDBiEOG70ZZP6.
PhylomeDBiQ9BZX4.
TreeFamiTF105421.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQTDKPTCI PPELPKMLKE FAKAAIRAQP QDLIQWGADY FEALSRGETP
60 70 80 90 100
PVRERSERVA LCNWAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP
110 120 130 140 150
TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN
160 170 180 190 200
GGLPRIPFST FQFLYTYIAE VDGEICASHV SRMLNYIEQE VIGPDGLITV
210
NDFTQNPRVW LE
Length:212
Mass (Da):23,964
Last modified:June 1, 2001 - v1
Checksum:i2867946D20C637AE
GO
Isoform 2 (identifier: Q9BZX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:120
Mass (Da):13,587
Checksum:i23DB964953F16CDF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_028745Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231410 mRNA. Translation: AAG59586.1.
CH471052 Genomic DNA. Translation: EAW79382.1.
CH471052 Genomic DNA. Translation: EAW79383.1.
BC015413 mRNA. Translation: AAH15413.1.
BC141849 mRNA. Translation: AAI41850.1.
CCDSiCCDS33841.1. [Q9BZX4-1]
RefSeqiNP_001012337.1. NM_001012337.2. [Q9BZX4-1]
NP_001295242.1. NM_001308313.1. [Q9BZX4-1]
XP_005247195.1. XM_005247138.3. [Q9BZX4-2]
XP_006713576.1. XM_006713513.2. [Q9BZX4-1]
UniGeneiHs.663128.

Genome annotation databases

EnsembliENST00000251776; ENSP00000251776; ENSG00000114547. [Q9BZX4-1]
ENST00000505382; ENSP00000421662; ENSG00000114547. [Q9BZX4-2]
ENST00000511082; ENSP00000424447; ENSG00000114547. [Q9BZX4-2]
ENST00000514116; ENSP00000426271; ENSG00000114547. [Q9BZX4-1]
GeneIDi152015.
KEGGihsa:152015.
UCSCiuc003eih.4. human. [Q9BZX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231410 mRNA. Translation: AAG59586.1.
CH471052 Genomic DNA. Translation: EAW79382.1.
CH471052 Genomic DNA. Translation: EAW79383.1.
BC015413 mRNA. Translation: AAH15413.1.
BC141849 mRNA. Translation: AAI41850.1.
CCDSiCCDS33841.1. [Q9BZX4-1]
RefSeqiNP_001012337.1. NM_001012337.2. [Q9BZX4-1]
NP_001295242.1. NM_001308313.1. [Q9BZX4-1]
XP_005247195.1. XM_005247138.3. [Q9BZX4-2]
XP_006713576.1. XM_006713513.2. [Q9BZX4-1]
UniGeneiHs.663128.

3D structure databases

ProteinModelPortaliQ9BZX4.
SMRiQ9BZX4. Positions 10-46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127418. 1 interaction.
IntActiQ9BZX4. 1 interaction.
STRINGi9606.ENSP00000251776.

Polymorphism and mutation databases

BioMutaiROPN1B.
DMDMi74717806.

Proteomic databases

PaxDbiQ9BZX4.
PRIDEiQ9BZX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251776; ENSP00000251776; ENSG00000114547. [Q9BZX4-1]
ENST00000505382; ENSP00000421662; ENSG00000114547. [Q9BZX4-2]
ENST00000511082; ENSP00000424447; ENSG00000114547. [Q9BZX4-2]
ENST00000514116; ENSP00000426271; ENSG00000114547. [Q9BZX4-1]
GeneIDi152015.
KEGGihsa:152015.
UCSCiuc003eih.4. human. [Q9BZX4-1]

Organism-specific databases

CTDi152015.
GeneCardsiROPN1B.
HGNCiHGNC:31927. ROPN1B.
HPAiHPA052530.
MIMi611757. gene.
neXtProtiNX_Q9BZX4.
PharmGKBiPA142671053.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFDW. Eukaryota.
ENOG410ZIXI. LUCA.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ9BZX4.
OMAiSDHDGGP.
OrthoDBiEOG70ZZP6.
PhylomeDBiQ9BZX4.
TreeFamiTF105421.

Miscellaneous databases

GenomeRNAii152015.
PROiQ9BZX4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZX4.
CleanExiHS_ROPN1B.
ExpressionAtlasiQ9BZX4. baseline and differential.
GenevisibleiQ9BZX4. HS.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA."
    Carr D.W., Fujita A., Stentz C.L., Liberty G.A., Olson G.E., Narumiya S.
    J. Biol. Chem. 276:17332-17338(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH AKAP3, MUTAGENESIS OF LEU-18.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland.

Entry informationi

Entry nameiROP1B_HUMAN
AccessioniPrimary (citable) accession number: Q9BZX4
Secondary accession number(s): D3DNA6, Q96BM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.