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Q9BZW8

- CD244_HUMAN

UniProt

Q9BZW8 - CD244_HUMAN

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Protein

Natural killer cell receptor 2B4

Gene
CD244, 2B4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. leukocyte migration Source: Reactome
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
SignaLinkiQ9BZW8.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural killer cell receptor 2B4
Alternative name(s):
NK cell activation-inducing ligand
Short name:
NAIL
NK cell type I receptor protein 2B4
Short name:
NKR2B4
Short name:
h2B4
SLAM family member 4
Short name:
SLAMF4
Signaling lymphocytic activation molecule 4
CD_antigen: CD244
Gene namesi
Name:CD244
Synonyms:2B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18171. CD244.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 229208Extracellular Reviewed predictionAdd
BLAST
Transmembranei230 – 25021Helical; Reviewed predictionAdd
BLAST
Topological domaini251 – 370120Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21212 PublicationsAdd
BLAST
Chaini22 – 370349Natural killer cell receptor 2B4PRO_0000014668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication
Glycosylationi77 – 771N-linked (GlcNAc...)1 Publication
Glycosylationi89 – 891N-linked (GlcNAc...)1 Publication
Disulfide bondi157 ↔ 199 Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9BZW8.
PRIDEiQ9BZW8.

PTM databases

PhosphoSiteiQ9BZW8.

Expressioni

Tissue specificityi

Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.1 Publication

Gene expression databases

BgeeiQ9BZW8.
CleanExiHS_CD244.
GenevestigatoriQ9BZW8.

Organism-specific databases

HPAiHPA010628.

Interactioni

Subunit structurei

Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CD48P093262EBI-1580565,EBI-714770

Protein-protein interaction databases

BioGridi119709. 2 interactions.
IntActiQ9BZW8. 4 interactions.
MINTiMINT-3371787.
STRINGi9606.ENSP00000357013.

Structurei

3D structure databases

ProteinModelPortaliQ9BZW8.
SMRiQ9BZW8. Positions 22-126.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 127106Ig-like 1Add
BLAST
Domaini131 – 21585Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46473.
HOVERGENiHBG050850.
InParanoidiQ9BZW8.
KOiK06582.
OMAiHTYTCNV.
OrthoDBiEOG7QVM45.
PhylomeDBiQ9BZW8.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR024304. NK_rcpt_2B4.
IPR024303. NK_rcpt_2B4_Ig_dom.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERiPTHR12080. PTHR12080. 1 hit.
PTHR12080:SF3. PTHR12080:SF3. 1 hit.
PfamiPF11465. Receptor_2B4. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BZW8-1) [UniParc]FASTAAdd to Basket

Also known as: H2B4-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLGQVVTLIL LLLLKVYQGK GCQGSADHVV SISGVPLQLQ PNSIQTKVDS    50
IAWKKLLPSQ NGFHHILKWE NGSLPSNTSN DRFSFIVKNL SLLIKAAQQQ 100
DSGLYCLEVT SISGKVQTAT FQVFVFESLL PDKVEKPRLQ GQGKILDRGR 150
CQVALSCLVS RDGNVSYAWY RGSKLIQTAG NLTYLDEEVD INGTHTYTCN 200
VSNPVSWESH TLNLTQDCQN AHQEFRFWPF LVIIVILSAL FLGTLACFCV 250
WRRKRKEKQS ETSPKEFLTI YEDVKDLKTR RNHEQEQTFP GGGSTIYSMI 300
QSQSSAPTSQ EPAYTLYSLI QPSRKSGSRK RNHSPSFNST IYEVIGKSQP 350
KAQNPARLSR KELENFDVYS 370
Length:370
Mass (Da):41,616
Last modified:May 24, 2004 - v2
Checksum:i959FF8DBB0BACC87
GO
Isoform 2 (identifier: Q9BZW8-2) [UniParc]FASTAAdd to Basket

Also known as: H2B4-A

The sequence of this isoform differs from the canonical sequence as follows:
     127-131: Missing.

Note: Binds to CD48 with a sronger affinity than isoform 1, and interactions induces greater cytotoxicity and intracellular calcium release.

Show »
Length:365
Mass (Da):41,077
Checksum:i7DEDD0EBF2E19322
GO
Isoform 3 (identifier: Q9BZW8-3) [UniParc]FASTAAdd to Basket

Also known as: H2B4

The sequence of this isoform differs from the canonical sequence as follows:
     127-131: Missing.
     326-334: SGSRKRNHS → GDRFYSFSG
     335-370: Missing.

Note: No experimental confirmation available.

Show »
Length:329
Mass (Da):36,987
Checksum:i639FE10EA76F074E
GO
Isoform 4 (identifier: Q9BZW8-4) [UniParc]FASTAAdd to Basket

Also known as: H2B4b

The sequence of this isoform differs from the canonical sequence as follows:
     128-224: Missing.

Note: No experimental confirmation available.

Show »
Length:273
Mass (Da):30,784
Checksum:i036514F046E2099C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891N → D.
Corresponds to variant rs34846692 [ dbSNP | Ensembl ].
VAR_056036
Natural varianti323 – 3231S → F.
Corresponds to variant rs12064925 [ dbSNP | Ensembl ].
VAR_056037

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 1315Missing in isoform 2 and isoform 3. VSP_010397
Alternative sequencei128 – 22497Missing in isoform 4. VSP_010398Add
BLAST
Alternative sequencei326 – 3349SGSRKRNHS → GDRFYSFSG in isoform 3. VSP_010399
Alternative sequencei335 – 37036Missing in isoform 3. VSP_010400Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1337ESLLPDK → GMAMCPM in AAK50015. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105261 mRNA. Translation: AAD32538.1.
AF117711 mRNA. Translation: AAF28833.1.
AF145782 mRNA. Translation: AAD38951.1.
AF107761 mRNA. Translation: AAD37838.1.
AF242540 mRNA. Translation: AAK00233.1.
AJ245376 mRNA. Translation: CAC00648.1.
AJ245377 mRNA. Translation: CAC00649.1.
AJ245375 mRNA. Translation: CAC00647.1.
AL354714 Genomic DNA. Translation: CAH72353.1.
AL354714 Genomic DNA. Translation: CAH72354.1.
AL354714 Genomic DNA. Translation: CAH72355.1.
CH471121 Genomic DNA. Translation: EAW52691.1.
CH471121 Genomic DNA. Translation: EAW52692.1.
CH471121 Genomic DNA. Translation: EAW52693.1.
BC028073 mRNA. Translation: AAH28073.1.
BC053985 mRNA. Translation: AAH53985.1.
AF363452 mRNA. Translation: AAK50015.1.
CCDSiCCDS1210.1. [Q9BZW8-2]
CCDS53398.1. [Q9BZW8-4]
CCDS53399.1. [Q9BZW8-1]
RefSeqiNP_001160135.1. NM_001166663.1. [Q9BZW8-1]
NP_001160136.1. NM_001166664.1. [Q9BZW8-4]
NP_057466.1. NM_016382.3. [Q9BZW8-2]
UniGeneiHs.157872.

Genome annotation databases

EnsembliENST00000322302; ENSP00000313619; ENSG00000122223. [Q9BZW8-4]
ENST00000368032; ENSP00000357011; ENSG00000122223. [Q9BZW8-3]
ENST00000368033; ENSP00000357012; ENSG00000122223. [Q9BZW8-1]
ENST00000368034; ENSP00000357013; ENSG00000122223. [Q9BZW8-2]
ENST00000492063; ENSP00000432636; ENSG00000122223. [Q9BZW8-3]
GeneIDi51744.
KEGGihsa:51744.
UCSCiuc001fxa.3. human. [Q9BZW8-2]
uc009wtq.3. human. [Q9BZW8-1]
uc009wtr.3. human. [Q9BZW8-4]

Polymorphism databases

DMDMi47605541.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105261 mRNA. Translation: AAD32538.1 .
AF117711 mRNA. Translation: AAF28833.1 .
AF145782 mRNA. Translation: AAD38951.1 .
AF107761 mRNA. Translation: AAD37838.1 .
AF242540 mRNA. Translation: AAK00233.1 .
AJ245376 mRNA. Translation: CAC00648.1 .
AJ245377 mRNA. Translation: CAC00649.1 .
AJ245375 mRNA. Translation: CAC00647.1 .
AL354714 Genomic DNA. Translation: CAH72353.1 .
AL354714 Genomic DNA. Translation: CAH72354.1 .
AL354714 Genomic DNA. Translation: CAH72355.1 .
CH471121 Genomic DNA. Translation: EAW52691.1 .
CH471121 Genomic DNA. Translation: EAW52692.1 .
CH471121 Genomic DNA. Translation: EAW52693.1 .
BC028073 mRNA. Translation: AAH28073.1 .
BC053985 mRNA. Translation: AAH53985.1 .
AF363452 mRNA. Translation: AAK50015.1 .
CCDSi CCDS1210.1. [Q9BZW8-2 ]
CCDS53398.1. [Q9BZW8-4 ]
CCDS53399.1. [Q9BZW8-1 ]
RefSeqi NP_001160135.1. NM_001166663.1. [Q9BZW8-1 ]
NP_001160136.1. NM_001166664.1. [Q9BZW8-4 ]
NP_057466.1. NM_016382.3. [Q9BZW8-2 ]
UniGenei Hs.157872.

3D structure databases

ProteinModelPortali Q9BZW8.
SMRi Q9BZW8. Positions 22-126.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119709. 2 interactions.
IntActi Q9BZW8. 4 interactions.
MINTi MINT-3371787.
STRINGi 9606.ENSP00000357013.

PTM databases

PhosphoSitei Q9BZW8.

Polymorphism databases

DMDMi 47605541.

Proteomic databases

PaxDbi Q9BZW8.
PRIDEi Q9BZW8.

Protocols and materials databases

DNASUi 51744.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322302 ; ENSP00000313619 ; ENSG00000122223 . [Q9BZW8-4 ]
ENST00000368032 ; ENSP00000357011 ; ENSG00000122223 . [Q9BZW8-3 ]
ENST00000368033 ; ENSP00000357012 ; ENSG00000122223 . [Q9BZW8-1 ]
ENST00000368034 ; ENSP00000357013 ; ENSG00000122223 . [Q9BZW8-2 ]
ENST00000492063 ; ENSP00000432636 ; ENSG00000122223 . [Q9BZW8-3 ]
GeneIDi 51744.
KEGGi hsa:51744.
UCSCi uc001fxa.3. human. [Q9BZW8-2 ]
uc009wtq.3. human. [Q9BZW8-1 ]
uc009wtr.3. human. [Q9BZW8-4 ]

Organism-specific databases

CTDi 51744.
GeneCardsi GC01M160799.
HGNCi HGNC:18171. CD244.
HPAi HPA010628.
MIMi 605554. gene.
neXtProti NX_Q9BZW8.
PharmGKBi PA134905192.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46473.
HOVERGENi HBG050850.
InParanoidi Q9BZW8.
KOi K06582.
OMAi HTYTCNV.
OrthoDBi EOG7QVM45.
PhylomeDBi Q9BZW8.
TreeFami TF334964.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.
SignaLinki Q9BZW8.

Miscellaneous databases

GeneWikii CD244.
GenomeRNAii 51744.
NextBioi 55826.
PROi Q9BZW8.
SOURCEi Search...

Gene expression databases

Bgeei Q9BZW8.
CleanExi HS_CD244.
Genevestigatori Q9BZW8.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR024304. NK_rcpt_2B4.
IPR024303. NK_rcpt_2B4_Ig_dom.
IPR015631. SLAM_fam_rcpts.
[Graphical view ]
PANTHERi PTHR12080. PTHR12080. 1 hit.
PTHR12080:SF3. PTHR12080:SF3. 1 hit.
Pfami PF11465. Receptor_2B4. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activating interactions in human NK cell recognition: the role of 2B4-CD48."
    Nakajima H., Cella M., Langen H., Friedlein A., Colonna M.
    Eur. J. Immunol. 29:1676-1683(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH CD48.
  2. "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48."
    Kubin M.Z., Parshley D.L., Din W., Waugh J.Y., Davis-Smith T., Smith C.A., Macduff B.M., Armitage R.J., Chin W., Cassiano L., Borges L., Petersen M., Trinchieri G., Goodwin R.G.
    Eur. J. Immunol. 29:3466-3477(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF N-TERMINUS, TISSUE SPECIFICITY, INTERACTION WITH CD48.
  3. "Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP."
    Tangye S.G., Lazetic S., Woollatt E., Sutherland G.R., Lanier L.L., Phillips J.H.
    J. Immunol. 162:6981-6985(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PHOSPHORYLATION.
  4. "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4."
    Boles K.S., Nakajima H., Colonna M., Chuang S.S., Stepp S.E., Bennett M., Kumar V., Mathew P.A.
    Tissue Antigens 54:27-34(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CD48.
    Tissue: Natural killer cell.
  5. "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript."
    Kumaresan P.R., Mathew P.A.
    Immunogenetics 51:987-992(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells."
    Parolini S., Bottino C., Falco M., Augugliaro R., Giliani S., Franceschini R., Ochs H.D., Wolf H., Bonnefoy J.-Y., Biassoni R., Moretta L., Notarangelo L.D., Moretta A.
    J. Exp. Med. 192:337-346(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    Tissue: Lymphoid tissue.
  7. "Activating NK receptor homolog to the murine 2B4."
    Biassoni R., Falco M.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Lymphoid tissue.
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Blood.
  11. Lennon G.P., Eccleston D.W., Pridgeon C., Pazmany L., Moots R.J.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-133.
  12. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  13. "Functional role of human NK cell receptor 2B4 (CD244) isoforms."
    Mathew S.O., Rao K.K., Kim J.R., Bambard N.D., Mathew P.A.
    Eur. J. Immunol. 39:1632-1641(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  14. "Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein."
    Margraf-Schonfeld S., Bohm C., Watzl C.
    J. Biol. Chem. 286:24142-24149(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-71; ASN-77 AND ASN-89.

Entry informationi

Entry nameiCD244_HUMAN
AccessioniPrimary (citable) accession number: Q9BZW8
Secondary accession number(s): Q5VYI2
, Q5VYI6, Q5VYI7, Q96T47, Q9NQD2, Q9NQD3, Q9Y288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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