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Q9BZW8

- CD244_HUMAN

UniProt

Q9BZW8 - CD244_HUMAN

Protein

Natural killer cell receptor 2B4

Gene

CD244

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. leukocyte migration Source: Reactome
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
    SignaLinkiQ9BZW8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natural killer cell receptor 2B4
    Alternative name(s):
    NK cell activation-inducing ligand
    Short name:
    NAIL
    NK cell type I receptor protein 2B4
    Short name:
    NKR2B4
    Short name:
    h2B4
    SLAM family member 4
    Short name:
    SLAMF4
    Signaling lymphocytic activation molecule 4
    CD_antigen: CD244
    Gene namesi
    Name:CD244
    Synonyms:2B4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18171. CD244.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134905192.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21212 PublicationsAdd
    BLAST
    Chaini22 – 370349Natural killer cell receptor 2B4PRO_0000014668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication
    Glycosylationi77 – 771N-linked (GlcNAc...)1 Publication
    Glycosylationi89 – 891N-linked (GlcNAc...)1 Publication
    Disulfide bondi157 ↔ 199PROSITE-ProRule annotation
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9BZW8.
    PRIDEiQ9BZW8.

    PTM databases

    PhosphoSiteiQ9BZW8.

    Expressioni

    Tissue specificityi

    Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.1 Publication

    Gene expression databases

    BgeeiQ9BZW8.
    CleanExiHS_CD244.
    GenevestigatoriQ9BZW8.

    Organism-specific databases

    HPAiHPA010628.

    Interactioni

    Subunit structurei

    Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CD48P093262EBI-1580565,EBI-714770

    Protein-protein interaction databases

    BioGridi119709. 2 interactions.
    IntActiQ9BZW8. 4 interactions.
    MINTiMINT-3371787.
    STRINGi9606.ENSP00000357013.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZW8.
    SMRiQ9BZW8. Positions 22-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 229208ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 370120CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 127106Ig-like 1Add
    BLAST
    Domaini131 – 21585Ig-like 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46473.
    HOVERGENiHBG050850.
    InParanoidiQ9BZW8.
    KOiK06582.
    OMAiHTYTCNV.
    OrthoDBiEOG7QVM45.
    PhylomeDBiQ9BZW8.
    TreeFamiTF334964.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR024304. NK_rcpt_2B4.
    IPR024303. NK_rcpt_2B4_Ig_dom.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view]
    PANTHERiPTHR12080. PTHR12080. 1 hit.
    PTHR12080:SF3. PTHR12080:SF3. 1 hit.
    PfamiPF11465. Receptor_2B4. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZW8-1) [UniParc]FASTAAdd to Basket

    Also known as: H2B4-B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGQVVTLIL LLLLKVYQGK GCQGSADHVV SISGVPLQLQ PNSIQTKVDS    50
    IAWKKLLPSQ NGFHHILKWE NGSLPSNTSN DRFSFIVKNL SLLIKAAQQQ 100
    DSGLYCLEVT SISGKVQTAT FQVFVFESLL PDKVEKPRLQ GQGKILDRGR 150
    CQVALSCLVS RDGNVSYAWY RGSKLIQTAG NLTYLDEEVD INGTHTYTCN 200
    VSNPVSWESH TLNLTQDCQN AHQEFRFWPF LVIIVILSAL FLGTLACFCV 250
    WRRKRKEKQS ETSPKEFLTI YEDVKDLKTR RNHEQEQTFP GGGSTIYSMI 300
    QSQSSAPTSQ EPAYTLYSLI QPSRKSGSRK RNHSPSFNST IYEVIGKSQP 350
    KAQNPARLSR KELENFDVYS 370
    Length:370
    Mass (Da):41,616
    Last modified:May 24, 2004 - v2
    Checksum:i959FF8DBB0BACC87
    GO
    Isoform 2 (identifier: Q9BZW8-2) [UniParc]FASTAAdd to Basket

    Also known as: H2B4-A

    The sequence of this isoform differs from the canonical sequence as follows:
         127-131: Missing.

    Note: Binds to CD48 with a sronger affinity than isoform 1, and interactions induces greater cytotoxicity and intracellular calcium release.

    Show »
    Length:365
    Mass (Da):41,077
    Checksum:i7DEDD0EBF2E19322
    GO
    Isoform 3 (identifier: Q9BZW8-3) [UniParc]FASTAAdd to Basket

    Also known as: H2B4

    The sequence of this isoform differs from the canonical sequence as follows:
         127-131: Missing.
         326-334: SGSRKRNHS → GDRFYSFSG
         335-370: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:329
    Mass (Da):36,987
    Checksum:i639FE10EA76F074E
    GO
    Isoform 4 (identifier: Q9BZW8-4) [UniParc]FASTAAdd to Basket

    Also known as: H2B4b

    The sequence of this isoform differs from the canonical sequence as follows:
         128-224: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:273
    Mass (Da):30,784
    Checksum:i036514F046E2099C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1337ESLLPDK → GMAMCPM in AAK50015. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti89 – 891N → D.
    Corresponds to variant rs34846692 [ dbSNP | Ensembl ].
    VAR_056036
    Natural varianti323 – 3231S → F.
    Corresponds to variant rs12064925 [ dbSNP | Ensembl ].
    VAR_056037

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei127 – 1315Missing in isoform 2 and isoform 3. 7 PublicationsVSP_010397
    Alternative sequencei128 – 22497Missing in isoform 4. 1 PublicationVSP_010398Add
    BLAST
    Alternative sequencei326 – 3349SGSRKRNHS → GDRFYSFSG in isoform 3. 1 PublicationVSP_010399
    Alternative sequencei335 – 37036Missing in isoform 3. 1 PublicationVSP_010400Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105261 mRNA. Translation: AAD32538.1.
    AF117711 mRNA. Translation: AAF28833.1.
    AF145782 mRNA. Translation: AAD38951.1.
    AF107761 mRNA. Translation: AAD37838.1.
    AF242540 mRNA. Translation: AAK00233.1.
    AJ245376 mRNA. Translation: CAC00648.1.
    AJ245377 mRNA. Translation: CAC00649.1.
    AJ245375 mRNA. Translation: CAC00647.1.
    AL354714 Genomic DNA. Translation: CAH72353.1.
    AL354714 Genomic DNA. Translation: CAH72354.1.
    AL354714 Genomic DNA. Translation: CAH72355.1.
    CH471121 Genomic DNA. Translation: EAW52691.1.
    CH471121 Genomic DNA. Translation: EAW52692.1.
    CH471121 Genomic DNA. Translation: EAW52693.1.
    BC028073 mRNA. Translation: AAH28073.1.
    BC053985 mRNA. Translation: AAH53985.1.
    AF363452 mRNA. Translation: AAK50015.1.
    CCDSiCCDS1210.1. [Q9BZW8-2]
    CCDS53398.1. [Q9BZW8-4]
    CCDS53399.1. [Q9BZW8-1]
    RefSeqiNP_001160135.1. NM_001166663.1. [Q9BZW8-1]
    NP_001160136.1. NM_001166664.1. [Q9BZW8-4]
    NP_057466.1. NM_016382.3. [Q9BZW8-2]
    UniGeneiHs.157872.

    Genome annotation databases

    EnsembliENST00000322302; ENSP00000313619; ENSG00000122223. [Q9BZW8-4]
    ENST00000368033; ENSP00000357012; ENSG00000122223. [Q9BZW8-1]
    ENST00000368034; ENSP00000357013; ENSG00000122223. [Q9BZW8-2]
    ENST00000492063; ENSP00000432636; ENSG00000122223. [Q9BZW8-3]
    GeneIDi51744.
    KEGGihsa:51744.
    UCSCiuc001fxa.3. human. [Q9BZW8-2]
    uc009wtq.3. human. [Q9BZW8-1]
    uc009wtr.3. human. [Q9BZW8-4]

    Polymorphism databases

    DMDMi47605541.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105261 mRNA. Translation: AAD32538.1 .
    AF117711 mRNA. Translation: AAF28833.1 .
    AF145782 mRNA. Translation: AAD38951.1 .
    AF107761 mRNA. Translation: AAD37838.1 .
    AF242540 mRNA. Translation: AAK00233.1 .
    AJ245376 mRNA. Translation: CAC00648.1 .
    AJ245377 mRNA. Translation: CAC00649.1 .
    AJ245375 mRNA. Translation: CAC00647.1 .
    AL354714 Genomic DNA. Translation: CAH72353.1 .
    AL354714 Genomic DNA. Translation: CAH72354.1 .
    AL354714 Genomic DNA. Translation: CAH72355.1 .
    CH471121 Genomic DNA. Translation: EAW52691.1 .
    CH471121 Genomic DNA. Translation: EAW52692.1 .
    CH471121 Genomic DNA. Translation: EAW52693.1 .
    BC028073 mRNA. Translation: AAH28073.1 .
    BC053985 mRNA. Translation: AAH53985.1 .
    AF363452 mRNA. Translation: AAK50015.1 .
    CCDSi CCDS1210.1. [Q9BZW8-2 ]
    CCDS53398.1. [Q9BZW8-4 ]
    CCDS53399.1. [Q9BZW8-1 ]
    RefSeqi NP_001160135.1. NM_001166663.1. [Q9BZW8-1 ]
    NP_001160136.1. NM_001166664.1. [Q9BZW8-4 ]
    NP_057466.1. NM_016382.3. [Q9BZW8-2 ]
    UniGenei Hs.157872.

    3D structure databases

    ProteinModelPortali Q9BZW8.
    SMRi Q9BZW8. Positions 22-126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119709. 2 interactions.
    IntActi Q9BZW8. 4 interactions.
    MINTi MINT-3371787.
    STRINGi 9606.ENSP00000357013.

    PTM databases

    PhosphoSitei Q9BZW8.

    Polymorphism databases

    DMDMi 47605541.

    Proteomic databases

    PaxDbi Q9BZW8.
    PRIDEi Q9BZW8.

    Protocols and materials databases

    DNASUi 51744.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322302 ; ENSP00000313619 ; ENSG00000122223 . [Q9BZW8-4 ]
    ENST00000368033 ; ENSP00000357012 ; ENSG00000122223 . [Q9BZW8-1 ]
    ENST00000368034 ; ENSP00000357013 ; ENSG00000122223 . [Q9BZW8-2 ]
    ENST00000492063 ; ENSP00000432636 ; ENSG00000122223 . [Q9BZW8-3 ]
    GeneIDi 51744.
    KEGGi hsa:51744.
    UCSCi uc001fxa.3. human. [Q9BZW8-2 ]
    uc009wtq.3. human. [Q9BZW8-1 ]
    uc009wtr.3. human. [Q9BZW8-4 ]

    Organism-specific databases

    CTDi 51744.
    GeneCardsi GC01M160799.
    HGNCi HGNC:18171. CD244.
    HPAi HPA010628.
    MIMi 605554. gene.
    neXtProti NX_Q9BZW8.
    PharmGKBi PA134905192.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46473.
    HOVERGENi HBG050850.
    InParanoidi Q9BZW8.
    KOi K06582.
    OMAi HTYTCNV.
    OrthoDBi EOG7QVM45.
    PhylomeDBi Q9BZW8.
    TreeFami TF334964.

    Enzyme and pathway databases

    Reactomei REACT_12051. Cell surface interactions at the vascular wall.
    SignaLinki Q9BZW8.

    Miscellaneous databases

    GeneWikii CD244.
    GenomeRNAii 51744.
    NextBioi 55826.
    PROi Q9BZW8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BZW8.
    CleanExi HS_CD244.
    Genevestigatori Q9BZW8.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR024304. NK_rcpt_2B4.
    IPR024303. NK_rcpt_2B4_Ig_dom.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view ]
    PANTHERi PTHR12080. PTHR12080. 1 hit.
    PTHR12080:SF3. PTHR12080:SF3. 1 hit.
    Pfami PF11465. Receptor_2B4. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activating interactions in human NK cell recognition: the role of 2B4-CD48."
      Nakajima H., Cella M., Langen H., Friedlein A., Colonna M.
      Eur. J. Immunol. 29:1676-1683(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH CD48.
    2. "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48."
      Kubin M.Z., Parshley D.L., Din W., Waugh J.Y., Davis-Smith T., Smith C.A., Macduff B.M., Armitage R.J., Chin W., Cassiano L., Borges L., Petersen M., Trinchieri G., Goodwin R.G.
      Eur. J. Immunol. 29:3466-3477(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF N-TERMINUS, TISSUE SPECIFICITY, INTERACTION WITH CD48.
    3. "Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP."
      Tangye S.G., Lazetic S., Woollatt E., Sutherland G.R., Lanier L.L., Phillips J.H.
      J. Immunol. 162:6981-6985(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PHOSPHORYLATION.
    4. "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4."
      Boles K.S., Nakajima H., Colonna M., Chuang S.S., Stepp S.E., Bennett M., Kumar V., Mathew P.A.
      Tissue Antigens 54:27-34(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CD48.
      Tissue: Natural killer cell.
    5. "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript."
      Kumaresan P.R., Mathew P.A.
      Immunogenetics 51:987-992(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells."
      Parolini S., Bottino C., Falco M., Augugliaro R., Giliani S., Franceschini R., Ochs H.D., Wolf H., Bonnefoy J.-Y., Biassoni R., Moretta L., Notarangelo L.D., Moretta A.
      J. Exp. Med. 192:337-346(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
      Tissue: Lymphoid tissue.
    7. "Activating NK receptor homolog to the murine 2B4."
      Biassoni R., Falco M.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Lymphoid tissue.
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Blood.
    11. Lennon G.P., Eccleston D.W., Pridgeon C., Pazmany L., Moots R.J.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-133.
    12. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.
    13. "Functional role of human NK cell receptor 2B4 (CD244) isoforms."
      Mathew S.O., Rao K.K., Kim J.R., Bambard N.D., Mathew P.A.
      Eur. J. Immunol. 39:1632-1641(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    14. "Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein."
      Margraf-Schonfeld S., Bohm C., Watzl C.
      J. Biol. Chem. 286:24142-24149(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-71; ASN-77 AND ASN-89.

    Entry informationi

    Entry nameiCD244_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZW8
    Secondary accession number(s): Q5VYI2
    , Q5VYI6, Q5VYI7, Q96T47, Q9NQD2, Q9NQD3, Q9Y288
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3