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Protein

Testis-specific gene 10 protein

Gene

TSGA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the sperm tail fibrous sheath, a major sperm tail structure.By similarity

GO - Biological processi

  • cell projection assembly Source: Ensembl
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific gene 10 protein
Alternative name(s):
Testis development protein NYD-SP7
Gene namesi
Name:TSGA10
Synonyms:CEP4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14927. TSGA10.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Nucleus membrane By similarity

  • Note: The 27 kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail while the 55 kDa peptide localizes to the midpiece.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37933.

Polymorphism and mutation databases

BioMutaiTSGA10.
DMDMi74724919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Testis-specific gene 10 proteinPRO_0000307125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631PhosphoserineCombined sources
Modified residuei688 – 6881PhosphoserineBy similarity

Post-translational modificationi

Appears to be processed in a 27 kDa and a 55 kDa peptide containing respectively the N-terminal and the C-terminal part of the precursor.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BZW7.
PaxDbiQ9BZW7.
PeptideAtlasiQ9BZW7.
PRIDEiQ9BZW7.

PTM databases

iPTMnetiQ9BZW7.
PhosphoSiteiQ9BZW7.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ9BZW7.
CleanExiHS_TSGA10.
ExpressionAtlasiQ9BZW7. baseline and differential.
GenevisibleiQ9BZW7. HS.

Organism-specific databases

HPAiHPA036879.
HPA036880.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6F03EBI-744794,EBI-10307481
AESQ081173EBI-744794,EBI-717810
BCL6BA8KA133EBI-744794,EBI-10174813
BIRC2Q134904EBI-744794,EBI-514538
CBX8Q9HC523EBI-744794,EBI-712912
CCHCR1Q8TD31-33EBI-744794,EBI-10175300
CDC73Q6P1J95EBI-744794,EBI-930143
CDK18Q070023EBI-744794,EBI-746238
CEP44Q9C0F13EBI-744794,EBI-744115
CEP57L1Q8IYX8-23EBI-744794,EBI-10181988
CREB5Q02930-33EBI-744794,EBI-10192698
FBF1Q8TES7-63EBI-744794,EBI-10244131
FLJ38668C0H5X23EBI-744794,EBI-10176227
MID2Q9UJV3-23EBI-744794,EBI-10172526
PPHLN1Q8NEY83EBI-744794,EBI-474076
PPP1R18Q6NYC83EBI-744794,EBI-2557469
PRPF31F1T0A53EBI-744794,EBI-10177194
RCOR3Q9P2K33EBI-744794,EBI-743428
RTP5Q14D333EBI-744794,EBI-10217913
SCELO951713EBI-744794,EBI-7543896
SPERTQ8NA613EBI-744794,EBI-741724
SYT6Q5T7P8-23EBI-744794,EBI-10246152
TCEA2Q155603EBI-744794,EBI-710310
ZBTB24O431673EBI-744794,EBI-744471
ZNF124Q159733EBI-744794,EBI-2555767
ZNF2Q9BSG1-23EBI-744794,EBI-10297542
ZNF410Q86VK43EBI-744794,EBI-720304
ZNF417Q8TAU33EBI-744794,EBI-740727
ZNF426Q9BUY53EBI-744794,EBI-743265
ZNF490Q9ULM23EBI-744794,EBI-1105370
ZNF544Q6NX493EBI-744794,EBI-2841978
ZNF587Q96SQ53EBI-744794,EBI-6427977
ZNF599Q96NL33EBI-744794,EBI-8653994
ZNF670Q9BS343EBI-744794,EBI-745276

Protein-protein interaction databases

BioGridi123267. 47 interactions.
IntActiQ9BZW7. 38 interactions.
MINTiMINT-1484703.
STRINGi9606.ENSP00000347161.

Structurei

3D structure databases

ProteinModelPortaliQ9BZW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni556 – 689134Interaction with HIF1ABy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CEP135/TSGA10 family.Curated

Phylogenomic databases

eggNOGiENOG410IFB3. Eukaryota.
ENOG410ZW66. LUCA.
GeneTreeiENSGT00530000063949.
HOGENOMiHOG000082666.
HOVERGENiHBG108603.
InParanoidiQ9BZW7.
OMAiLAHENDN.
OrthoDBiEOG7KSX7N.
PhylomeDBiQ9BZW7.
TreeFamiTF326518.

Family and domain databases

InterProiIPR033323. TSGA10.
[Graphical view]
PANTHERiPTHR23159:SF14. PTHR23159:SF14. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI
60 70 80 90 100
QGNVKVLKSE RDKIFLLYEQ AQEEITRLRR EMMKSCKSPK STTAHAILRR
110 120 130 140 150
VETERDVAFT DLRRMTTERD SLRERLKIAQ ETAFNEKAHL EQRIEELECT
160 170 180 190 200
VHNLDDERME QMSNMTLMKE TISTVEKEMK SLARKAMDTE SELGRQKAEN
210 220 230 240 250
NSLRLLYENT EKDLSDTQRH LAKKKYELQL TQEKIMCLDE KIDNFTRQNI
260 270 280 290 300
AQREEISILG GTLNDLAKEK ECLQACLDKK SENIASLGES LAMKEKTISG
310 320 330 340 350
MKNIIAEMEQ ASRQCTEALI VCEQDVSRMR RQLDETNDEL AQIARERDIL
360 370 380 390 400
AHDNDNLQEQ FAKAKQENQA LSKKLNDTHN ELNDIKQKVQ DTNLEVNKLK
410 420 430 440 450
NILKSEESEN RQMMEQLRKA NEDAENWENK ARQSEADNNT LKLELITAEA
460 470 480 490 500
EGNRLKEKVD SLNREVEQHL NAERSYKSQI STLHKSVVKM EEELQKVQFE
510 520 530 540 550
KVSALADLSS TRELCIKLDS SKELLNRQLV AKDQEIEMRE NELDSAHSEI
560 570 580 590 600
ELLRSQMANE RISMQNLEAL LVANRDKEYQ SQIALQEKES EIQLLKEHLC
610 620 630 640 650
LAENKMAIQS RDVAQFRNVV TQLEADLDIT KRQLGTERFE RERAVQELRR
660 670 680 690
QNYSSNAYHM SSTMKPNTKC HSPERAHHRS PDRGLDRSLE ENLCYRDF
Length:698
Mass (Da):81,421
Last modified:June 1, 2001 - v1
Checksum:i8338D7FAAA2F2473
GO
Isoform 2 (identifier: Q9BZW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-297: EKT → TVY
     298-698: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):34,728
Checksum:iB58D6DCB2544C48E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281T → EP in AAK27309 (Ref. 2) Curated
Sequence conflicti273 – 2731L → M in AAH28366 (PubMed:15489334).Curated
Sequence conflicti365 – 3651K → N in AAK27309 (Ref. 2) Curated
Sequence conflicti624 – 6241E → G in AAK27309 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 2973EKT → TVY in isoform 2. 1 PublicationVSP_054409
Alternative sequencei298 – 698401Missing in isoform 2. 1 PublicationVSP_054410Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254756 mRNA. Translation: AAK13079.1.
AY014284 mRNA. Translation: AAK27309.1.
AK304328 mRNA. Translation: BAH14161.1.
AC019097 Genomic DNA. Translation: AAY14820.1.
AC092587 Genomic DNA. No translation available.
AC110083 Genomic DNA. No translation available.
CH471127 Genomic DNA. Translation: EAX01889.1.
CH471127 Genomic DNA. Translation: EAX01890.1.
CH471127 Genomic DNA. Translation: EAX01891.1.
CH471127 Genomic DNA. Translation: EAX01892.1.
BC028366 mRNA. Translation: AAH28366.1.
CCDSiCCDS2037.1. [Q9BZW7-1]
RefSeqiNP_079520.1. NM_025244.2. [Q9BZW7-1]
NP_878915.2. NM_182911.3. [Q9BZW7-1]
XP_005264080.1. XM_005264023.1. [Q9BZW7-1]
XP_005264081.1. XM_005264024.1. [Q9BZW7-1]
XP_005264082.1. XM_005264025.1. [Q9BZW7-1]
XP_005264083.1. XM_005264026.1. [Q9BZW7-1]
XP_005264084.1. XM_005264027.1. [Q9BZW7-1]
XP_005264086.1. XM_005264029.1. [Q9BZW7-1]
XP_006712844.1. XM_006712781.2. [Q9BZW7-1]
XP_011510238.1. XM_011511936.1. [Q9BZW7-1]
XP_011510239.1. XM_011511937.1. [Q9BZW7-1]
XP_011510240.1. XM_011511938.1. [Q9BZW7-1]
XP_011510241.1. XM_011511939.1. [Q9BZW7-1]
XP_011510242.1. XM_011511940.1. [Q9BZW7-1]
XP_011510243.1. XM_011511941.1. [Q9BZW7-1]
XP_011510244.1. XM_011511942.1. [Q9BZW7-1]
XP_011510245.1. XM_011511943.1. [Q9BZW7-1]
UniGeneiHs.120267.
Hs.721218.

Genome annotation databases

EnsembliENST00000355053; ENSP00000347161; ENSG00000135951. [Q9BZW7-1]
ENST00000393483; ENSP00000377123; ENSG00000135951. [Q9BZW7-1]
ENST00000410001; ENSP00000386956; ENSG00000135951. [Q9BZW7-1]
GeneIDi80705.
KEGGihsa:80705.
UCSCiuc002szg.5. human. [Q9BZW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254756 mRNA. Translation: AAK13079.1.
AY014284 mRNA. Translation: AAK27309.1.
AK304328 mRNA. Translation: BAH14161.1.
AC019097 Genomic DNA. Translation: AAY14820.1.
AC092587 Genomic DNA. No translation available.
AC110083 Genomic DNA. No translation available.
CH471127 Genomic DNA. Translation: EAX01889.1.
CH471127 Genomic DNA. Translation: EAX01890.1.
CH471127 Genomic DNA. Translation: EAX01891.1.
CH471127 Genomic DNA. Translation: EAX01892.1.
BC028366 mRNA. Translation: AAH28366.1.
CCDSiCCDS2037.1. [Q9BZW7-1]
RefSeqiNP_079520.1. NM_025244.2. [Q9BZW7-1]
NP_878915.2. NM_182911.3. [Q9BZW7-1]
XP_005264080.1. XM_005264023.1. [Q9BZW7-1]
XP_005264081.1. XM_005264024.1. [Q9BZW7-1]
XP_005264082.1. XM_005264025.1. [Q9BZW7-1]
XP_005264083.1. XM_005264026.1. [Q9BZW7-1]
XP_005264084.1. XM_005264027.1. [Q9BZW7-1]
XP_005264086.1. XM_005264029.1. [Q9BZW7-1]
XP_006712844.1. XM_006712781.2. [Q9BZW7-1]
XP_011510238.1. XM_011511936.1. [Q9BZW7-1]
XP_011510239.1. XM_011511937.1. [Q9BZW7-1]
XP_011510240.1. XM_011511938.1. [Q9BZW7-1]
XP_011510241.1. XM_011511939.1. [Q9BZW7-1]
XP_011510242.1. XM_011511940.1. [Q9BZW7-1]
XP_011510243.1. XM_011511941.1. [Q9BZW7-1]
XP_011510244.1. XM_011511942.1. [Q9BZW7-1]
XP_011510245.1. XM_011511943.1. [Q9BZW7-1]
UniGeneiHs.120267.
Hs.721218.

3D structure databases

ProteinModelPortaliQ9BZW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123267. 47 interactions.
IntActiQ9BZW7. 38 interactions.
MINTiMINT-1484703.
STRINGi9606.ENSP00000347161.

PTM databases

iPTMnetiQ9BZW7.
PhosphoSiteiQ9BZW7.

Polymorphism and mutation databases

BioMutaiTSGA10.
DMDMi74724919.

Proteomic databases

EPDiQ9BZW7.
PaxDbiQ9BZW7.
PeptideAtlasiQ9BZW7.
PRIDEiQ9BZW7.

Protocols and materials databases

DNASUi80705.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355053; ENSP00000347161; ENSG00000135951. [Q9BZW7-1]
ENST00000393483; ENSP00000377123; ENSG00000135951. [Q9BZW7-1]
ENST00000410001; ENSP00000386956; ENSG00000135951. [Q9BZW7-1]
GeneIDi80705.
KEGGihsa:80705.
UCSCiuc002szg.5. human. [Q9BZW7-1]

Organism-specific databases

CTDi80705.
GeneCardsiTSGA10.
H-InvDBHIX0023122.
HGNCiHGNC:14927. TSGA10.
HPAiHPA036879.
HPA036880.
MIMi607166. gene.
neXtProtiNX_Q9BZW7.
PharmGKBiPA37933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFB3. Eukaryota.
ENOG410ZW66. LUCA.
GeneTreeiENSGT00530000063949.
HOGENOMiHOG000082666.
HOVERGENiHBG108603.
InParanoidiQ9BZW7.
OMAiLAHENDN.
OrthoDBiEOG7KSX7N.
PhylomeDBiQ9BZW7.
TreeFamiTF326518.

Miscellaneous databases

GenomeRNAii80705.
PROiQ9BZW7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZW7.
CleanExiHS_TSGA10.
ExpressionAtlasiQ9BZW7. baseline and differential.
GenevisibleiQ9BZW7. HS.

Family and domain databases

InterProiIPR033323. TSGA10.
[Graphical view]
PANTHERiPTHR23159:SF14. PTHR23159:SF14. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterisation of a novel gene, TSGA10, expressed in testis."
    Modarressi M.H., Cameron J., Taylor K.E., Wolfe J.
    Gene 262:249-255(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "NYD-SP7: a novel gene related to human testis development."
    Sha J.H., Zhou Z.M.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTSG10_HUMAN
AccessioniPrimary (citable) accession number: Q9BZW7
Secondary accession number(s): B7Z925
, D3DVH7, Q8NEP0, Q9BWX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.