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Protein

Solute carrier family 13 member 1

Gene

SLC13A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sulfate transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000081800-MONOMER.
ReactomeiR-HSA-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Protein family/group databases

TCDBi2.A.47.1.16. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 1
Alternative name(s):
Renal sodium/sulfate cotransporter
Short name:
Na(+)/sulfate cotransporter
Short name:
hNaSi-1
Gene namesi
Name:SLC13A1
Synonyms:NAS1, NASI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:10916. SLC13A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6561.
OpenTargetsiENSG00000081800.
PharmGKBiPA322.

Chemistry databases

DrugBankiDB00139. Succinic acid.

Polymorphism and mutation databases

BioMutaiSLC13A1.
DMDMi23396850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724851 – 595Solute carrier family 13 member 1Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi591N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9BZW2.
PaxDbiQ9BZW2.
PRIDEiQ9BZW2.

PTM databases

PhosphoSitePlusiQ9BZW2.

Expressioni

Tissue specificityi

Highly expressed in kidney; not detectable in the other tissues tested.

Inductioni

Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate.

Gene expression databases

BgeeiENSG00000081800.
CleanExiHS_SLC13A1.
ExpressionAtlasiQ9BZW2. baseline and differential.
GenevisibleiQ9BZW2. HS.

Organism-specific databases

HPAiHPA053615.
HPA062714.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000194130.

Structurei

3D structure databases

ProteinModelPortaliQ9BZW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9BZW2.
KOiK14444.
OMAiLPMFGIM.
OrthoDBiEOG091G092X.
PhylomeDBiQ9BZW2.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT
60 70 80 90 100
EALPLSVTAL LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE
110 120 130 140 150
KWNLHKRIAL KMVMMVGVNP AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI
160 170 180 190 200
AEAVVQQIIN AEAEVEATQM TYFNGSTNHG LEIDESVNGH EINERKEKTK
210 220 230 240 250
PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT CLCIAYSSTI
260 270 280 290 300
GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW
310 320 330 340 350
IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT
360 370 380 390 400
LVLFIIMALL WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP
410 420 430 440 450
AKTLTKTTPT GEIVAFDYSP LITWKEFQSF MPWDIAILVG GGFALADGCE
460 470 480 490 500
ESGLSKWIGN KLSPLGSLPA WLIILISSLM VTSLTEVASN PATITLFLPI
510 520 530 540 550
LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF SYGHLKVIDM
560 570 580 590
VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP
Length:595
Mass (Da):66,134
Last modified:June 1, 2001 - v1
Checksum:iA4C48EC180F6DA14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti481V → A in BAB15477 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02924742F → L.Corresponds to variant rs28364181dbSNPEnsembl.1
Natural variantiVAR_02924844V → I.Corresponds to variant rs28364177dbSNPEnsembl.1
Natural variantiVAR_029249157Q → E.Corresponds to variant rs28364196dbSNPEnsembl.1
Natural variantiVAR_022018174N → S.Corresponds to variant rs2140516dbSNPEnsembl.1
Natural variantiVAR_029250205Y → C.Corresponds to variant rs28364231dbSNPEnsembl.1
Natural variantiVAR_059804240T → M.Corresponds to variant rs10231144dbSNPEnsembl.1
Natural variantiVAR_029251277R → H.Corresponds to variant rs28364200dbSNPEnsembl.1
Natural variantiVAR_029252332V → A.Corresponds to variant rs28364201dbSNPEnsembl.1
Natural variantiVAR_029253392I → T.Corresponds to variant rs28364210dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260824 mRNA. Translation: AAG60583.1.
AK026413 mRNA. Translation: BAB15477.1.
CCDSiCCDS5786.1.
RefSeqiNP_001311329.1. NM_001324400.1.
NP_071889.2. NM_022444.3.
UniGeneiHs.489849.

Genome annotation databases

EnsembliENST00000194130; ENSP00000194130; ENSG00000081800.
GeneIDi6561.
KEGGihsa:6561.
UCSCiuc003vkm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260824 mRNA. Translation: AAG60583.1.
AK026413 mRNA. Translation: BAB15477.1.
CCDSiCCDS5786.1.
RefSeqiNP_001311329.1. NM_001324400.1.
NP_071889.2. NM_022444.3.
UniGeneiHs.489849.

3D structure databases

ProteinModelPortaliQ9BZW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000194130.

Chemistry databases

DrugBankiDB00139. Succinic acid.

Protein family/group databases

TCDBi2.A.47.1.16. the divalent anion:na(+) symporter (dass) family.

PTM databases

PhosphoSitePlusiQ9BZW2.

Polymorphism and mutation databases

BioMutaiSLC13A1.
DMDMi23396850.

Proteomic databases

EPDiQ9BZW2.
PaxDbiQ9BZW2.
PRIDEiQ9BZW2.

Protocols and materials databases

DNASUi6561.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194130; ENSP00000194130; ENSG00000081800.
GeneIDi6561.
KEGGihsa:6561.
UCSCiuc003vkm.4. human.

Organism-specific databases

CTDi6561.
DisGeNETi6561.
GeneCardsiSLC13A1.
HGNCiHGNC:10916. SLC13A1.
HPAiHPA053615.
HPA062714.
MIMi606193. gene.
neXtProtiNX_Q9BZW2.
OpenTargetsiENSG00000081800.
PharmGKBiPA322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9BZW2.
KOiK14444.
OMAiLPMFGIM.
OrthoDBiEOG091G092X.
PhylomeDBiQ9BZW2.
TreeFamiTF312913.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000081800-MONOMER.
ReactomeiR-HSA-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

GenomeRNAii6561.
PROiQ9BZW2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081800.
CleanExiHS_SLC13A1.
ExpressionAtlasiQ9BZW2. baseline and differential.
GenevisibleiQ9BZW2. HS.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS13A1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZW2
Secondary accession number(s): Q9H5Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.