Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BZW2

- S13A1_HUMAN

UniProt

Q9BZW2 - S13A1_HUMAN

Protein

Solute carrier family 13 member 1

Gene

SLC13A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

    GO - Molecular functioni

    1. sodium:sulfate symporter activity Source: Ensembl

    GO - Biological processi

    1. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Sulfate transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Protein family/group databases

    TCDBi2.A.47.1.16. the divalent anion:na(+) symporter (dass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 13 member 1
    Alternative name(s):
    Renal sodium/sulfate cotransporter
    Short name:
    Na(+)/sulfate cotransporter
    Short name:
    hNaSi-1
    Gene namesi
    Name:SLC13A1
    Synonyms:NAS1, NASI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:10916. SLC13A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA322.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595595Solute carrier family 13 member 1PRO_0000172485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9BZW2.
    PRIDEiQ9BZW2.

    PTM databases

    PhosphoSiteiQ9BZW2.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney; not detectable in the other tissues tested.

    Inductioni

    Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate.

    Gene expression databases

    ArrayExpressiQ9BZW2.
    BgeeiQ9BZW2.
    CleanExiHS_SLC13A1.
    GenevestigatoriQ9BZW2.

    Organism-specific databases

    HPAiHPA053615.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000194130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZW2.
    SMRiQ9BZW2. Positions 41-158, 223-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei464 – 48421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei512 – 53221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei554 – 57421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0471.
    HOGENOMiHOG000278432.
    HOVERGENiHBG055339.
    InParanoidiQ9BZW2.
    KOiK14444.
    OMAiDLHTYPS.
    OrthoDBiEOG7G1V5S.
    PhylomeDBiQ9BZW2.
    TreeFamiTF312913.

    Family and domain databases

    InterProiIPR001898. Na/sul_symport.
    [Graphical view]
    PfamiPF00939. Na_sulph_symp. 1 hit.
    [Graphical view]
    PROSITEiPS01271. NA_SULFATE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BZW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT    50
    EALPLSVTAL LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE 100
    KWNLHKRIAL KMVMMVGVNP AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI 150
    AEAVVQQIIN AEAEVEATQM TYFNGSTNHG LEIDESVNGH EINERKEKTK 200
    PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT CLCIAYSSTI 250
    GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW 300
    IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT 350
    LVLFIIMALL WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP 400
    AKTLTKTTPT GEIVAFDYSP LITWKEFQSF MPWDIAILVG GGFALADGCE 450
    ESGLSKWIGN KLSPLGSLPA WLIILISSLM VTSLTEVASN PATITLFLPI 500
    LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF SYGHLKVIDM 550
    VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP 595
    Length:595
    Mass (Da):66,134
    Last modified:June 1, 2001 - v1
    Checksum:iA4C48EC180F6DA14
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti481 – 4811V → A in BAB15477. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421F → L.
    Corresponds to variant rs28364181 [ dbSNP | Ensembl ].
    VAR_029247
    Natural varianti44 – 441V → I.
    Corresponds to variant rs28364177 [ dbSNP | Ensembl ].
    VAR_029248
    Natural varianti157 – 1571Q → E.
    Corresponds to variant rs28364196 [ dbSNP | Ensembl ].
    VAR_029249
    Natural varianti174 – 1741N → S.
    Corresponds to variant rs2140516 [ dbSNP | Ensembl ].
    VAR_022018
    Natural varianti205 – 2051Y → C.
    Corresponds to variant rs28364231 [ dbSNP | Ensembl ].
    VAR_029250
    Natural varianti240 – 2401T → M.
    Corresponds to variant rs10231144 [ dbSNP | Ensembl ].
    VAR_059804
    Natural varianti277 – 2771R → H.
    Corresponds to variant rs28364200 [ dbSNP | Ensembl ].
    VAR_029251
    Natural varianti332 – 3321V → A.
    Corresponds to variant rs28364201 [ dbSNP | Ensembl ].
    VAR_029252
    Natural varianti392 – 3921I → T.
    Corresponds to variant rs28364210 [ dbSNP | Ensembl ].
    VAR_029253

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260824 mRNA. Translation: AAG60583.1.
    AK026413 mRNA. Translation: BAB15477.1.
    CCDSiCCDS5786.1.
    RefSeqiNP_071889.2. NM_022444.3.
    UniGeneiHs.489849.

    Genome annotation databases

    EnsembliENST00000194130; ENSP00000194130; ENSG00000081800.
    GeneIDi6561.
    KEGGihsa:6561.
    UCSCiuc003vkm.3. human.

    Polymorphism databases

    DMDMi23396850.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260824 mRNA. Translation: AAG60583.1 .
    AK026413 mRNA. Translation: BAB15477.1 .
    CCDSi CCDS5786.1.
    RefSeqi NP_071889.2. NM_022444.3.
    UniGenei Hs.489849.

    3D structure databases

    ProteinModelPortali Q9BZW2.
    SMRi Q9BZW2. Positions 41-158, 223-565.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000194130.

    Chemistry

    DrugBanki DB00139. Succinic acid.

    Protein family/group databases

    TCDBi 2.A.47.1.16. the divalent anion:na(+) symporter (dass) family.

    PTM databases

    PhosphoSitei Q9BZW2.

    Polymorphism databases

    DMDMi 23396850.

    Proteomic databases

    PaxDbi Q9BZW2.
    PRIDEi Q9BZW2.

    Protocols and materials databases

    DNASUi 6561.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000194130 ; ENSP00000194130 ; ENSG00000081800 .
    GeneIDi 6561.
    KEGGi hsa:6561.
    UCSCi uc003vkm.3. human.

    Organism-specific databases

    CTDi 6561.
    GeneCardsi GC07M122753.
    HGNCi HGNC:10916. SLC13A1.
    HPAi HPA053615.
    MIMi 606193. gene.
    neXtProti NX_Q9BZW2.
    PharmGKBi PA322.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0471.
    HOGENOMi HOG000278432.
    HOVERGENi HBG055339.
    InParanoidi Q9BZW2.
    KOi K14444.
    OMAi DLHTYPS.
    OrthoDBi EOG7G1V5S.
    PhylomeDBi Q9BZW2.
    TreeFami TF312913.

    Enzyme and pathway databases

    Reactomei REACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Miscellaneous databases

    GenomeRNAii 6561.
    NextBioi 25531.
    PROi Q9BZW2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZW2.
    Bgeei Q9BZW2.
    CleanExi HS_SLC13A1.
    Genevestigatori Q9BZW2.

    Family and domain databases

    InterProi IPR001898. Na/sul_symport.
    [Graphical view ]
    Pfami PF00939. Na_sulph_symp. 1 hit.
    [Graphical view ]
    PROSITEi PS01271. NA_SULFATE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization."
      Lee A., Beck L., Markovich D.
      Genomics 70:354-363(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ileal mucosa.

    Entry informationi

    Entry nameiS13A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZW2
    Secondary accession number(s): Q9H5Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3