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Q9BZW2 (S13A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 13 member 1
Alternative name(s):
Renal sodium/sulfate cotransporter
Short name=Na(+)/sulfate cotransporter
Short name=hNaSi-1
Gene names
Name:SLC13A1
Synonyms:NAS1, NASI1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in kidney; not detectable in the other tissues tested.

Induction

Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate.

Sequence similarities

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Sulfate transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsulfate transport

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionsodium:sulfate symporter activity

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 595595Solute carrier family 13 member 1
PRO_0000172485

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane348 – 36821Helical; Potential
Transmembrane381 – 40121Helical; Potential
Transmembrane464 – 48421Helical; Potential
Transmembrane491 – 51121Helical; Potential
Transmembrane512 – 53221Helical; Potential
Transmembrane554 – 57421Helical; Potential

Amino acid modifications

Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation5911N-linked (GlcNAc...) Potential

Natural variations

Natural variant421F → L.
Corresponds to variant rs28364181 [ dbSNP | Ensembl ].
VAR_029247
Natural variant441V → I.
Corresponds to variant rs28364177 [ dbSNP | Ensembl ].
VAR_029248
Natural variant1571Q → E.
Corresponds to variant rs28364196 [ dbSNP | Ensembl ].
VAR_029249
Natural variant1741N → S.
Corresponds to variant rs2140516 [ dbSNP | Ensembl ].
VAR_022018
Natural variant2051Y → C.
Corresponds to variant rs28364231 [ dbSNP | Ensembl ].
VAR_029250
Natural variant2401T → M.
Corresponds to variant rs10231144 [ dbSNP | Ensembl ].
VAR_059804
Natural variant2771R → H.
Corresponds to variant rs28364200 [ dbSNP | Ensembl ].
VAR_029251
Natural variant3321V → A.
Corresponds to variant rs28364201 [ dbSNP | Ensembl ].
VAR_029252
Natural variant3921I → T.
Corresponds to variant rs28364210 [ dbSNP | Ensembl ].
VAR_029253

Experimental info

Sequence conflict4811V → A in BAB15477. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BZW2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A4C48EC180F6DA14

FASTA59566,134
        10         20         30         40         50         60 
MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT EALPLSVTAL 

        70         80         90        100        110        120 
LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL KMVMMVGVNP 

       130        140        150        160        170        180 
AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI AEAVVQQIIN AEAEVEATQM TYFNGSTNHG 

       190        200        210        220        230        240 
LEIDESVNGH EINERKEKTK PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT 

       250        260        270        280        290        300 
CLCIAYSSTI GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW 

       310        320        330        340        350        360 
IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT LVLFIIMALL 

       370        380        390        400        410        420 
WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP AKTLTKTTPT GEIVAFDYSP 

       430        440        450        460        470        480 
LITWKEFQSF MPWDIAILVG GGFALADGCE ESGLSKWIGN KLSPLGSLPA WLIILISSLM 

       490        500        510        520        530        540 
VTSLTEVASN PATITLFLPI LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF 

       550        560        570        580        590 
SYGHLKVIDM VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP

« Hide

References

« Hide 'large scale' references
[1]"The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization."
Lee A., Beck L., Markovich D.
Genomics 70:354-363(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Kidney.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ileal mucosa.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF260824 mRNA. Translation: AAG60583.1.
AK026413 mRNA. Translation: BAB15477.1.
IPIIPI00097548.
RefSeqNP_071889.2. NM_022444.3.
UniGeneHs.489849.

3D structure databases

ProteinModelPortalQ9BZW2.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000194130.

PTM databases

PhosphoSiteQ9BZW2.

Polymorphism databases

DMDM23396850.

Proteomic databases

PaxDbQ9BZW2.
PRIDEQ9BZW2.

Protocols and materials databases

DNASU6561.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000194130; ENSP00000194130; ENSG00000081800.
GeneID6561.
KEGGhsa:6561.
UCSCuc003vkm.3. human.

Organism-specific databases

CTD6561.
GeneCardsGC07M122753.
HGNCHGNC:10916. SLC13A1.
HPAHPA053615.
MIM606193. gene.
neXtProtNX_Q9BZW2.
PharmGKBPA322.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0471.
HOGENOMHOG000278432.
HOVERGENHBG055339.
InParanoidQ9BZW2.
KOK14444.
OMASKWIGNK.
OrthoDBEOG4BK53J.
PhylomeDBQ9BZW2.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_20633. Bile salt and organic anion SLC transporters.

Gene expression databases

ArrayExpressQ9BZW2.
BgeeQ9BZW2.
CleanExHS_SLC13A1.
GenevestigatorQ9BZW2.
GermOnlineENSG00000081800. Homo sapiens.

Family and domain databases

InterProIPR001898. Na/sul_symport.
[Graphical view]
PfamPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

DrugBankDB00139. Succinic acid.
GenomeRNAi6561.
NextBio25531.
SOURCESearch...

Entry information

Entry nameS13A1_HUMAN
AccessionPrimary (citable) accession number: Q9BZW2
Secondary accession number(s): Q9H5Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents