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Protein

Solute carrier family 13 member 1

Gene

SLC13A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

GO - Molecular functioni

  1. sodium:sulfate symporter activity Source: Ensembl

GO - Biological processi

  1. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sulfate transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Protein family/group databases

TCDBi2.A.47.1.16. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 1
Alternative name(s):
Renal sodium/sulfate cotransporter
Short name:
Na(+)/sulfate cotransporter
Short name:
hNaSi-1
Gene namesi
Name:SLC13A1
Synonyms:NAS1, NASI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:10916. SLC13A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence AnalysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence AnalysisAdd
BLAST
Transmembranei512 – 53221HelicalSequence AnalysisAdd
BLAST
Transmembranei554 – 57421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Solute carrier family 13 member 1PRO_0000172485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZW2.
PRIDEiQ9BZW2.

PTM databases

PhosphoSiteiQ9BZW2.

Expressioni

Tissue specificityi

Highly expressed in kidney; not detectable in the other tissues tested.

Inductioni

Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate.

Gene expression databases

BgeeiQ9BZW2.
CleanExiHS_SLC13A1.
ExpressionAtlasiQ9BZW2. baseline and differential.
GenevestigatoriQ9BZW2.

Organism-specific databases

HPAiHPA053615.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000194130.

Structurei

3D structure databases

ProteinModelPortaliQ9BZW2.
SMRiQ9BZW2. Positions 41-158, 223-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9BZW2.
KOiK14444.
OMAiGIMPSKK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ9BZW2.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT
60 70 80 90 100
EALPLSVTAL LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE
110 120 130 140 150
KWNLHKRIAL KMVMMVGVNP AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI
160 170 180 190 200
AEAVVQQIIN AEAEVEATQM TYFNGSTNHG LEIDESVNGH EINERKEKTK
210 220 230 240 250
PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT CLCIAYSSTI
260 270 280 290 300
GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW
310 320 330 340 350
IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT
360 370 380 390 400
LVLFIIMALL WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP
410 420 430 440 450
AKTLTKTTPT GEIVAFDYSP LITWKEFQSF MPWDIAILVG GGFALADGCE
460 470 480 490 500
ESGLSKWIGN KLSPLGSLPA WLIILISSLM VTSLTEVASN PATITLFLPI
510 520 530 540 550
LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF SYGHLKVIDM
560 570 580 590
VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP
Length:595
Mass (Da):66,134
Last modified:June 1, 2001 - v1
Checksum:iA4C48EC180F6DA14
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti481 – 4811V → A in BAB15477. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421F → L.
Corresponds to variant rs28364181 [ dbSNP | Ensembl ].
VAR_029247
Natural varianti44 – 441V → I.
Corresponds to variant rs28364177 [ dbSNP | Ensembl ].
VAR_029248
Natural varianti157 – 1571Q → E.
Corresponds to variant rs28364196 [ dbSNP | Ensembl ].
VAR_029249
Natural varianti174 – 1741N → S.
Corresponds to variant rs2140516 [ dbSNP | Ensembl ].
VAR_022018
Natural varianti205 – 2051Y → C.
Corresponds to variant rs28364231 [ dbSNP | Ensembl ].
VAR_029250
Natural varianti240 – 2401T → M.
Corresponds to variant rs10231144 [ dbSNP | Ensembl ].
VAR_059804
Natural varianti277 – 2771R → H.
Corresponds to variant rs28364200 [ dbSNP | Ensembl ].
VAR_029251
Natural varianti332 – 3321V → A.
Corresponds to variant rs28364201 [ dbSNP | Ensembl ].
VAR_029252
Natural varianti392 – 3921I → T.
Corresponds to variant rs28364210 [ dbSNP | Ensembl ].
VAR_029253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260824 mRNA. Translation: AAG60583.1.
AK026413 mRNA. Translation: BAB15477.1.
CCDSiCCDS5786.1.
RefSeqiNP_071889.2. NM_022444.3.
UniGeneiHs.489849.

Genome annotation databases

EnsembliENST00000194130; ENSP00000194130; ENSG00000081800.
GeneIDi6561.
KEGGihsa:6561.
UCSCiuc003vkm.3. human.

Polymorphism databases

DMDMi23396850.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260824 mRNA. Translation: AAG60583.1.
AK026413 mRNA. Translation: BAB15477.1.
CCDSiCCDS5786.1.
RefSeqiNP_071889.2. NM_022444.3.
UniGeneiHs.489849.

3D structure databases

ProteinModelPortaliQ9BZW2.
SMRiQ9BZW2. Positions 41-158, 223-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000194130.

Chemistry

DrugBankiDB00139. Succinic acid.

Protein family/group databases

TCDBi2.A.47.1.16. the divalent anion:na(+) symporter (dass) family.

PTM databases

PhosphoSiteiQ9BZW2.

Polymorphism databases

DMDMi23396850.

Proteomic databases

PaxDbiQ9BZW2.
PRIDEiQ9BZW2.

Protocols and materials databases

DNASUi6561.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194130; ENSP00000194130; ENSG00000081800.
GeneIDi6561.
KEGGihsa:6561.
UCSCiuc003vkm.3. human.

Organism-specific databases

CTDi6561.
GeneCardsiGC07M122753.
HGNCiHGNC:10916. SLC13A1.
HPAiHPA053615.
MIMi606193. gene.
neXtProtiNX_Q9BZW2.
PharmGKBiPA322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9BZW2.
KOiK14444.
OMAiGIMPSKK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ9BZW2.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

GenomeRNAii6561.
NextBioi25531.
PROiQ9BZW2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZW2.
CleanExiHS_SLC13A1.
ExpressionAtlasiQ9BZW2. baseline and differential.
GenevestigatoriQ9BZW2.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization."
    Lee A., Beck L., Markovich D.
    Genomics 70:354-363(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ileal mucosa.

Entry informationi

Entry nameiS13A1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZW2
Secondary accession number(s): Q9H5Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.