Reviewed, UniProtKB/Swiss-Prot Q9BZW2 (S13A1_HUMAN)

Names and origin

Protein names

Recommended name:
    Solute carrier family 13 member 1
Alternative name(s):
    Renal sodium/sulfate cotransporter
      Short name=Na(+)/sulfate cotransporter
      Short name=hNaSi-1

Gene names

Name:	SLC13A1
Synonyms:	NAS1, NASI1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	595 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in kidney; not detectable in the other tissues tested.
Induction	Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate.
Sequence similarities	Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Sulfate transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW sulfate transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.1 Inferred from Experiment. Source: Reactome
Molecular function	sodium ion binding Inferred from electronic annotation. Source: UniProtKB-KW sodium:sulfate symporter activity Ref.1 Inferred from Experiment. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 595	595	Solute carrier family 13 member 1		PRO_0000172485
Regions
	Transmembrane	13 – 33	21	Potential
	Transmembrane	41 – 61	21	Potential
	Transmembrane	77 – 97	21	Potential
	Transmembrane	108 – 128	21	Potential
	Transmembrane	131 – 151	21	Potential
	Transmembrane	239 – 259	21	Potential
	Transmembrane	290 – 310	21	Potential
	Transmembrane	348 – 368	21	Potential
	Transmembrane	381 – 401	21	Potential
	Transmembrane	464 – 484	21	Potential
	Transmembrane	491 – 511	21	Potential
	Transmembrane	512 – 532	21	Potential
	Transmembrane	554 – 574	21	Potential
Amino acid modifications
	Glycosylation	174	1	N-linked (GlcNAc...) Potential
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	591	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	42	1	F → L: dbSNP rs28364181.		VAR_029247
	Natural variant	44	1	V → I: dbSNP rs28364177.		VAR_029248
	Natural variant	157	1	Q → E: dbSNP rs28364196.		VAR_029249
	Natural variant	174	1	N → S: dbSNP rs2140516.		VAR_022018
	Natural variant	205	1	Y → C: dbSNP rs28364231.		VAR_029250
	Natural variant	240	1	T → M: dbSNP rs10231144.		VAR_059804
	Natural variant	277	1	R → H: dbSNP rs28364200.		VAR_029251
	Natural variant	332	1	V → A: dbSNP rs28364201.		VAR_029252
	Natural variant	392	1	I → T: dbSNP rs28364210.		VAR_029253
Experimental info
	Sequence conflict	481	1	V → A in BAB15477. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BZW2-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A4C48EC180F6DA14	FASTA	595	66,134
	10 20 30 40 50 60 MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT EALPLSVTAL 70 80 90 100 110 120 LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL KMVMMVGVNP 130 140 150 160 170 180 AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI AEAVVQQIIN AEAEVEATQM TYFNGSTNHG 190 200 210 220 230 240 LEIDESVNGH EINERKEKTK PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT 250 260 270 280 290 300 CLCIAYSSTI GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW 310 320 330 340 350 360 IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT LVLFIIMALL 370 380 390 400 410 420 WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP AKTLTKTTPT GEIVAFDYSP 430 440 450 460 470 480 LITWKEFQSF MPWDIAILVG GGFALADGCE ESGLSKWIGN KLSPLGSLPA WLIILISSLM 490 500 510 520 530 540 VTSLTEVASN PATITLFLPI LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF 550 560 570 580 590 SYGHLKVIDM VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization." Lee A., Beck L., Markovich D. Genomics 70:354-363(2000) [PubMed: 11161786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ileal mucosa.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF260824 mRNA. Translation: AAG60583.1. AK026413 mRNA. Translation: BAB15477.1.
IPI	IPI00097548.
RefSeq	NP_071889.2.
UniGene	Hs.489849
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BZW2.
Genome annotation databases
Ensembl	ENST00000194130; ENSP00000194130; ENSG00000081800; Homo sapiens. [Genome view]
GeneID	6561.
KEGG	hsa:6561.
UCSC	uc003vkm.1. human.
Organism-specific databases
CTD	6561.
GeneCards	GC07M122540.
H-InvDB	HIX0007036.
HGNC	HGNC:10916. SLC13A1.
MIM	606193. gene.
PharmGKB	PA322.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG616159.
HOVERGEN	Q9BZW2.
InParanoid	Q9BZW2.
OMA	ADGCEES.
OrthoDB	EOG97DD1Q.
PhylomeDB	Q9BZW2.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9BZW2.
Bgee	Q9BZW2.
CleanEx	HS_SLC13A1.
Genevestigator	Q9BZW2.
GermOnline	ENSG00000081800. Homo sapiens.
Family and domain databases
InterPro	IPR001898. Na/sul_symport. [Graphical view]
Pfam	PF00939. Na_sulph_symp. 1 hit. [Graphical view]
PROSITE	PS01271. NA_SULFATE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00139. Succinic acid.
NextBio	25531.
SOURCE	Search...

Entry information

Entry name

S13A1_HUMAN

Accession

Primary (citable) accession number: Q9BZW2
Secondary accession number(s): Q9H5Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.