Reviewed,
UniProtKB/Swiss-Prot Q9BZW2 (S13A1_HUMAN)
Last modified
February 9, 2010.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Solute carrier family 13 member 1 Alternative name(s): Renal sodium/sulfate cotransporter Short name=Na(+)/sulfate cotransporter Short name=hNaSi-1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 595 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney. |
| Subcellular location | |
| Tissue specificity | Highly expressed in kidney; not detectable in the other tissues tested. |
| Induction | Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate. |
| Sequence similarities | Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Sodium transport Sulfate transport Symport Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Ligand | Sodium |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW sulfate transportInferred from electronic annotation. Source: UniProtKB-KW transmembrane transportInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.1Inferred from Experiment. Source: Reactome |
| Molecular function | sodium ion binding Inferred from electronic annotation. Source: UniProtKB-KW sodium:sulfate symporter activity Ref.1Inferred from Experiment. Source: Reactome |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 595 | 595 | Solute carrier family 13 member 1 | PRO_0000172485 | |||||
Regions | |||||||||
| Transmembrane | 13 – 33 | 21 | Potential | ||||||
| Transmembrane | 41 – 61 | 21 | Potential | ||||||
| Transmembrane | 77 – 97 | 21 | Potential | ||||||
| Transmembrane | 108 – 128 | 21 | Potential | ||||||
| Transmembrane | 131 – 151 | 21 | Potential | ||||||
| Transmembrane | 239 – 259 | 21 | Potential | ||||||
| Transmembrane | 290 – 310 | 21 | Potential | ||||||
| Transmembrane | 348 – 368 | 21 | Potential | ||||||
| Transmembrane | 381 – 401 | 21 | Potential | ||||||
| Transmembrane | 464 – 484 | 21 | Potential | ||||||
| Transmembrane | 491 – 511 | 21 | Potential | ||||||
| Transmembrane | 512 – 532 | 21 | Potential | ||||||
| Transmembrane | 554 – 574 | 21 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 174 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 207 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 591 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 42 | 1 | F → L: dbSNP rs28364181. | VAR_029247 | |||||
| Natural variant | 44 | 1 | V → I: dbSNP rs28364177. | VAR_029248 | |||||
| Natural variant | 157 | 1 | Q → E: dbSNP rs28364196. | VAR_029249 | |||||
| Natural variant | 174 | 1 | N → S: dbSNP rs2140516. | VAR_022018 | |||||
| Natural variant | 205 | 1 | Y → C: dbSNP rs28364231. | VAR_029250 | |||||
| Natural variant | 240 | 1 | T → M: dbSNP rs10231144. | VAR_059804 | |||||
| Natural variant | 277 | 1 | R → H: dbSNP rs28364200. | VAR_029251 | |||||
| Natural variant | 332 | 1 | V → A: dbSNP rs28364201. | VAR_029252 | |||||
| Natural variant | 392 | 1 | I → T: dbSNP rs28364210. | VAR_029253 | |||||
Experimental info | |||||||||
| Sequence conflict | 481 | 1 | V → A in BAB15477. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization." Lee A., Beck L., Markovich D. Genomics 70:354-363(2000) [PubMed: 11161786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Kidney. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ileal mucosa. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF260824 mRNA. Translation: AAG60583.1. AK026413 mRNA. Translation: BAB15477.1. |
| IPI | IPI00097548. |
| RefSeq | NP_071889.2. |
| UniGene | Hs.489849 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9BZW2. |
Genome annotation databases | |
| Ensembl | ENST00000194130; ENSP00000194130; ENSG00000081800; Homo sapiens. [Genome view] |
| GeneID | 6561. |
| KEGG | hsa:6561. |
| UCSC | uc003vkm.1. human. |
Organism-specific databases | |
| CTD | 6561. |
| GeneCards | GC07M122540. |
| H-InvDB | HIX0007036. |
| HGNC | HGNC:10916. SLC13A1. |
| MIM | 606193. gene. |
| PharmGKB | PA322. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG616159. |
| HOVERGEN | Q9BZW2. |
| InParanoid | Q9BZW2. |
| OMA | ADGCEES. |
| OrthoDB | EOG97DD1Q. |
| PhylomeDB | Q9BZW2. |
Enzyme and pathway databases | |
| Reactome | REACT_15518. Transmembrane transport of small molecules. |
Gene expression databases | |
| ArrayExpress | Q9BZW2. |
| Bgee | Q9BZW2. |
| CleanEx | HS_SLC13A1. |
| Genevestigator | Q9BZW2. |
| GermOnline | ENSG00000081800. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001898. Na/sul_symport. [Graphical view] |
| Pfam | PF00939. Na_sulph_symp. 1 hit. [Graphical view] |
| PROSITE | PS01271. NA_SULFATE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00139. Succinic acid. |
| NextBio | 25531. |
| SOURCE | Search... |
Entry information
| Entry name | S13A1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BZW2 Secondary accession number(s): Q9H5Z0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


