##gff-version 3 Q9BZS1 UniProtKB Chain 1 431 . . . ID=PRO_0000091886;Note=Forkhead box protein P3 Q9BZS1 UniProtKB Chain 1 417 . . . ID=PRO_0000432430;Note=Forkhead box protein P3%2C C-terminally processed;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19117830;Dbxref=PMID:19117830 Q9BZS1 UniProtKB Chain 52 417 . . . ID=PRO_0000432431;Note=Forkhead box protein P3 41 kDa form;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19117830;Dbxref=PMID:19117830 Q9BZS1 UniProtKB Propeptide 418 431 . . . ID=PRO_0000432432;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19117830;Dbxref=PMID:19117830 Q9BZS1 UniProtKB Zinc finger 197 222 . . . Note=C2H2-type Q9BZS1 UniProtKB DNA binding 337 423 . . . Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089 Q9BZS1 UniProtKB Region 1 68 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZS1 UniProtKB Region 106 198 . . . Note=Interaction with ZFP90;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23543754;Dbxref=PMID:23543754 Q9BZS1 UniProtKB Region 106 190 . . . Note=Essential for transcriptional repressor activity and for interaction with KAT5 and HDAC7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17360565;Dbxref=PMID:17360565 Q9BZS1 UniProtKB Region 149 199 . . . Note=Interaction with IKZF4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6 Q9BZS1 UniProtKB Region 239 260 . . . Note=Leucine-zipper Q9BZS1 UniProtKB Region 278 336 . . . Note=Interaction with RUNX1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17377532;Dbxref=PMID:17377532 Q9BZS1 UniProtKB Motif 68 76 . . . Note=Nuclear export signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Motif 92 96 . . . Note=LXXLL motif;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18354202;Dbxref=PMID:18354202 Q9BZS1 UniProtKB Motif 239 248 . . . Note=Nuclear export signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Motif 414 417 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Compositional bias 53 67 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZS1 UniProtKB Site 51 52 . . . Note=Cleavage;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19117830;Dbxref=PMID:19117830 Q9BZS1 UniProtKB Site 417 418 . . . Note=Cleavage%3B by PCSK1 or PCSK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19117830;Dbxref=PMID:19117830 Q9BZS1 UniProtKB Modified residue 19 19 . . . Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6 Q9BZS1 UniProtKB Modified residue 31 31 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22312127;Dbxref=PMID:22312127 Q9BZS1 UniProtKB Modified residue 263 263 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22312127;Dbxref=PMID:22312127 Q9BZS1 UniProtKB Modified residue 268 268 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22312127;Dbxref=PMID:22312127 Q9BZS1 UniProtKB Modified residue 418 418 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23396208;Dbxref=PMID:23396208 Q9BZS1 UniProtKB Cross-link 250 250 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6 Q9BZS1 UniProtKB Cross-link 252 252 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6 Q9BZS1 UniProtKB Cross-link 263 263 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6 Q9BZS1 UniProtKB Cross-link 268 268 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6 Q9BZS1 UniProtKB Cross-link 393 393 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6 Q9BZS1 UniProtKB Alternative sequence 72 106 . . . ID=VSP_015796;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4,ECO:0000303|Ref.7;Dbxref=PMID:15489334 Q9BZS1 UniProtKB Alternative sequence 246 272 . . . ID=VSP_047859;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 Q9BZS1 UniProtKB Alternative sequence 382 382 . . . ID=VSP_036418;Note=In isoform 3. K->KVSSSEVAVTGMASSAIAAQSGQAWVWAHRHIGEERDVGCWWWLLASEVDAHLLPVPGLPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7 Q9BZS1 UniProtKB Natural variant 242 242 . . . ID=VAR_078971;Note=In IPEX%3B mild phenotype%3B no loss of protein expression. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18951619;Dbxref=PMID:18951619 Q9BZS1 UniProtKB Natural variant 251 251 . . . ID=VAR_011330;Note=In IPEX%3B significantly reduces dimerization. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11120765,ECO:0000269|PubMed:21458306;Dbxref=dbSNP:rs122467171,PMID:11120765,PMID:21458306 Q9BZS1 UniProtKB Natural variant 324 324 . . . ID=VAR_078972;Note=In IPEX%3B mild phenotype%3B no loss of protein expression. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18951619;Dbxref=dbSNP:rs122467173,PMID:18951619 Q9BZS1 UniProtKB Natural variant 339 339 . . . ID=VAR_078973;Note=In IPEX%3B no loss of protein expression. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18951619;Dbxref=dbSNP:rs886044787,PMID:18951619 Q9BZS1 UniProtKB Natural variant 347 347 . . . ID=VAR_078974;Note=In IPEX%3B mild phenotype%3B no loss of protein expression%3B impairs its ability to confer inhibitory function to regulatory T-cells. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18951619,ECO:0000269|PubMed:21458306;Dbxref=dbSNP:rs1557115786,PMID:18951619,PMID:21458306 Q9BZS1 UniProtKB Natural variant 363 363 . . . ID=VAR_023569;Note=In IPEX. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11768393;Dbxref=PMID:11768393 Q9BZS1 UniProtKB Natural variant 371 371 . . . ID=VAR_011331;Note=In IPEX%3B no effect on dimerization. F->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11137992,ECO:0000269|PubMed:21458306;Dbxref=dbSNP:rs122467169,PMID:11137992,PMID:21458306 Q9BZS1 UniProtKB Natural variant 373 373 . . . ID=VAR_078975;Note=In IPEX%3B no loss of protein expression%3B disrupts dimerization%3B impairs its ability to confer inhibitory function to regulatory T-cells%3B requires 2 nucleotide substitutions. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18951619,ECO:0000269|PubMed:21458306;Dbxref=dbSNP:rs122467172,PMID:18951619,PMID:21458306 Q9BZS1 UniProtKB Natural variant 374 374 . . . ID=VAR_078976;Note=In IPEX%3B no loss of protein expression. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18951619;Dbxref=PMID:18951619 Q9BZS1 UniProtKB Natural variant 384 384 . . . ID=VAR_011332;Note=In IPEX%3B no loss of protein expression. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11137992,ECO:0000269|PubMed:11137993,ECO:0000269|PubMed:18951619;Dbxref=dbSNP:rs122467170,PMID:11137992,PMID:11137993,PMID:18951619 Q9BZS1 UniProtKB Natural variant 397 397 . . . ID=VAR_011333;Note=In IPEX. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137992;Dbxref=dbSNP:rs28935477,PMID:11137992 Q9BZS1 UniProtKB Mutagenesis 69 69 . . . Note=Decrease in nuclear export%3B when associated with A-71%2C A-74 and A-76. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 71 71 . . . Note=Decrease in nuclear export%3B when associated with A-69%2C A-74 and A-76. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 74 74 . . . Note=Decrease in nuclear export%3B when associated with A-69%2C A-71 and A-76. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 76 76 . . . Note=Decrease in nuclear export%3B when associated with A-69%2C A-71 and A-74. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 95 96 . . . Note=Loss of interaction with RORA. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18354202;Dbxref=PMID:18354202 Q9BZS1 UniProtKB Mutagenesis 242 242 . . . Note=Decrease in nuclear export%3B when associated with A-246 and A-248. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 246 246 . . . Note=Decrease in nuclear export%3B when associated with A-242 and A-248. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 248 248 . . . Note=Decrease in nuclear export%3B when associated with A-242 and A-246. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 348 348 . . . Note=No loss of DNA-binding. Disrupts dimerization but does not affect DNA-binding%3B when associated with T-370. Disrupts dimerization%2C does not affect DNA-binding%2C causes dysregulated expression of a subset of FOXP3 target genes and impairs its ability to confer inhibitory function to regulatory T-cells%3B when associated with T-370 and P-372. W->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21458306;Dbxref=PMID:21458306 Q9BZS1 UniProtKB Mutagenesis 370 370 . . . Note=Disrupts dimerization but does not affect DNA-binding%3B when associated with Q-348. Disrupts dimerization%2C does not affect DNA-binding%2C causes dysregulated expression of a subset of FOXP3 target genes and impairs its ability to confer inhibitory function to regulatory T-cells%3B when associated with Q-348 and P-372. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21458306;Dbxref=PMID:21458306 Q9BZS1 UniProtKB Mutagenesis 372 372 . . . Note=Disrupts dimerization%2C does not affect DNA-binding%2C causes dysregulated expression of a subset of FOXP3 target genes and impairs its ability to confer inhibitory function to regulatory T-cells%3B when associated with Q-348 and T-370. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21458306;Dbxref=PMID:21458306 Q9BZS1 UniProtKB Mutagenesis 415 416 . . . Note=Loss of nuclear localization. KK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915 Q9BZS1 UniProtKB Mutagenesis 418 418 . . . Note=Decrease in phosphorylation%2C significant decrease in transcriptional repressor activity and reduced interaction with PP1CA%2C PP1CB and PP1CG. Significant decrease in phosphorylation and transcriptional repressor activity%3B when associated with A-422. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23396208;Dbxref=PMID:23396208 Q9BZS1 UniProtKB Mutagenesis 418 418 . . . Note=Slight increase in transcriptional repressor activity. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23396208;Dbxref=PMID:23396208 Q9BZS1 UniProtKB Mutagenesis 422 422 . . . Note=Significant decrease in phosphorylation and transcriptional repressor activity%3B when associated with A-418. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23396208;Dbxref=PMID:23396208 Q9BZS1 UniProtKB Sequence conflict 16 20 . . . Note=LGPSP->MSPIS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9BZS1 UniProtKB Helix 342 351 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF Q9BZS1 UniProtKB Helix 360 371 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF Q9BZS1 UniProtKB Turn 372 375 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF Q9BZS1 UniProtKB Helix 381 391 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF Q9BZS1 UniProtKB Beta strand 395 398 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF Q9BZS1 UniProtKB Beta strand 401 403 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF Q9BZS1 UniProtKB Beta strand 405 408 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF Q9BZS1 UniProtKB Helix 410 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3QRF