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Q9BZR8 (B2L14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apoptosis facilitator Bcl-2-like protein 14

Short name=Bcl2-L-14
Alternative name(s):
Apoptosis regulator Bcl-G
Gene names
Name:BCL2L14
Synonyms:BCLG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in apoptosis.

Subcellular location

Cytoplasm Ref.1.

Isoform 1: Cytoplasmcytosol. Note: Diffusely distributed throughout the cytosol. Ref.1

Isoform 2: Endomembrane system. Note: Predominantly localized to cytosolic organelles. Ref.1

Tissue specificity

Isoform 1 is widely expressed. Isoform 2 is testis-specific. Ref.1

Post-translational modification

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function. Ref.6

Sequence similarities

Belongs to the Bcl-2 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MELKQ146804EBI-1385773,EBI-1046702

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BZR8-1)

Also known as: Bcl-Gl; Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BZR8-2)

Also known as: Bcl-Gs; Short;

The sequence of this isoform differs from the canonical sequence as follows:
     227-252: LKKDKALMGHFQDGLSYSVFKTITDQ → DTAFIPIPLVDTSIQGFPQDGLMACI
     253-327: Missing.
Isoform 3 (identifier: Q9BZR8-3)

Also known as: Median;

The sequence of this isoform differs from the canonical sequence as follows:
     227-276: LKKDKALMGH...AQGFKAALVI → EKEWEESAKT...LTPPGFSEHN
     277-327: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Apoptosis facilitator Bcl-2-like protein 14
PRO_0000143075

Regions

Motif212 – 22615BH3
Motif308 – 3158BH2

Natural variations

Alternative sequence227 – 27650LKKDK…AALVI → EKEWEESAKTKIKMALLWRS SGGGPRVLSIPEAFMKNSFT LTPPGFSEHN in isoform 3.
VSP_012241
Alternative sequence227 – 25226LKKDK…TITDQ → DTAFIPIPLVDTSIQGFPQD GLMACI in isoform 2.
VSP_012239
Alternative sequence253 – 32775Missing in isoform 2.
VSP_012240
Alternative sequence277 – 32751Missing in isoform 3.
VSP_012242

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Bcl-Gl) (Long) [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 155D43BA91BFB3EA

FASTA32736,598
        10         20         30         40         50         60 
MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT RSLSQRGLGN 

        70         80         90        100        110        120 
CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV EKEDSQSTPA KVSAQGQRTL 

       130        140        150        160        170        180 
EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV ISIANRVAEI VYSWPPPQAT QAGGFKSKEI 

       190        200        210        220        230        240 
FVTEGLSFQL QGHVPVASSS KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG 

       250        260        270        280        290        300 
LSYSVFKTIT DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY 

       310        320 
LKENFSPWIQ QHGGWEKILG ISHEEVD 

« Hide

Isoform 2 (Bcl-Gs) (Short) [UniParc].

Checksum: 87D2E5123EFCB9E4
Show »

FASTA25228,090
Isoform 3 (Median) [UniParc].

Checksum: 81559A7190F5598E
Show »

FASTA27630,948

References

« Hide 'large scale' references
[1]"Bcl-G, a novel pro-apoptotic member of the Bcl-2 family."
Guo B., Godzik A., Reed J.C.
J. Biol. Chem. 276:2780-2785(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]"Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia."
Montpetit A., Larose J., Boily G., Langlois S., Trudel N., Sinnett D.
Leukemia 18:1499-1504(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Trachea.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Pancreas.
[6]"Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family."
Lin M.L., Park J.H., Nishidate T., Nakamura Y., Katagiri T.
Breast Cancer Res. 9:R17-R17(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY MELK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF281254 mRNA. Translation: AAG59793.1.
AF281255 mRNA. Translation: AAG59794.1.
AY040274 mRNA. Translation: AAK72109.1.
AK292995 mRNA. Translation: BAF85684.1.
CH471094 Genomic DNA. Translation: EAW96247.1.
BC025778 mRNA. Translation: AAH25778.1.
CCDSCCDS8645.1. [Q9BZR8-1]
CCDS8646.1. [Q9BZR8-2]
RefSeqNP_110393.1. NM_030766.1. [Q9BZR8-2]
NP_620048.1. NM_138722.1. [Q9BZR8-1]
NP_620049.1. NM_138723.1. [Q9BZR8-1]
XP_006719214.1. XM_006719151.1. [Q9BZR8-1]
UniGeneHs.210343.
Hs.734567.

3D structure databases

ProteinModelPortalQ9BZR8.
SMRQ9BZR8. Positions 176-321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122658. 2 interactions.
IntActQ9BZR8. 1 interaction.
MINTMINT-149090.
STRING9606.ENSP00000309132.

PTM databases

PhosphoSiteQ9BZR8.

Polymorphism databases

DMDM56748611.

Proteomic databases

PaxDbQ9BZR8.
PRIDEQ9BZR8.

Protocols and materials databases

DNASU79370.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266434; ENSP00000266434; ENSG00000121380. [Q9BZR8-2]
ENST00000298566; ENSP00000298566; ENSG00000121380. [Q9BZR8-3]
ENST00000308721; ENSP00000309132; ENSG00000121380. [Q9BZR8-1]
ENST00000396367; ENSP00000379653; ENSG00000121380. [Q9BZR8-1]
ENST00000396369; ENSP00000379655; ENSG00000121380. [Q9BZR8-3]
ENST00000589718; ENSP00000467086; ENSG00000121380. [Q9BZR8-1]
GeneID79370.
KEGGhsa:79370.
UCSCuc001rac.3. human. [Q9BZR8-1]
uc001rae.3. human. [Q9BZR8-2]

Organism-specific databases

CTD79370.
GeneCardsGC12P012202.
HGNCHGNC:16657. BCL2L14.
HPAHPA040665.
MIM606126. gene.
neXtProtNX_Q9BZR8.
PharmGKBPA134870762.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315634.
HOGENOMHOG000013215.
HOVERGENHBG050649.
InParanoidQ9BZR8.
OMANFSPWVQ.
OrthoDBEOG7KM5VJ.
PhylomeDBQ9BZR8.

Gene expression databases

ArrayExpressQ9BZR8.
BgeeQ9BZR8.
CleanExHS_BCL2L14.
GenevestigatorQ9BZR8.

Family and domain databases

InterProIPR002475. Bcl2-like.
[Graphical view]
PROSITEPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBCL2L14. human.
GeneWikiBCL2L14.
GenomeRNAi79370.
NextBio68351.
PROQ9BZR8.
SOURCESearch...

Entry information

Entry nameB2L14_HUMAN
AccessionPrimary (citable) accession number: Q9BZR8
Secondary accession number(s): A8KAD0, Q96QR5, Q9BZR7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM