Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BZR8

- B2L14_HUMAN

UniProt

Q9BZR8 - B2L14_HUMAN

Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

BCL2L14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in apoptosis.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
    3. regulation of apoptotic process Source: InterPro

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apoptosis facilitator Bcl-2-like protein 14
    Short name:
    Bcl2-L-14
    Alternative name(s):
    Apoptosis regulator Bcl-G
    Gene namesi
    Name:BCL2L14
    Synonyms:BCLG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:16657. BCL2L14.

    Subcellular locationi

    Cytoplasm 1 Publication
    Isoform 1 : Cytoplasmcytosol
    Note: Diffusely distributed throughout the cytosol.
    Isoform 2 : Endomembrane system
    Note: Predominantly localized to cytosolic organelles.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: UniProtKB
    3. endomembrane system Source: UniProtKB-SubCell
    4. intracellular organelle Source: UniProtKB
    5. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134870762.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Apoptosis facilitator Bcl-2-like protein 14PRO_0000143075Add
    BLAST

    Post-translational modificationi

    Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9BZR8.
    PRIDEiQ9BZR8.

    PTM databases

    PhosphoSiteiQ9BZR8.

    Expressioni

    Tissue specificityi

    Isoform 1 is widely expressed. Isoform 2 is testis-specific.1 Publication

    Gene expression databases

    ArrayExpressiQ9BZR8.
    BgeeiQ9BZR8.
    CleanExiHS_BCL2L14.
    GenevestigatoriQ9BZR8.

    Organism-specific databases

    HPAiHPA040665.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MELKQ146804EBI-1385773,EBI-1046702

    Protein-protein interaction databases

    BioGridi122658. 2 interactions.
    IntActiQ9BZR8. 1 interaction.
    MINTiMINT-149090.
    STRINGi9606.ENSP00000309132.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZR8.
    SMRiQ9BZR8. Positions 176-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi212 – 22615BH3Add
    BLAST
    Motifi308 – 3158BH2

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG315634.
    HOGENOMiHOG000013215.
    HOVERGENiHBG050649.
    InParanoidiQ9BZR8.
    OMAiNFSPWVQ.
    OrthoDBiEOG7KM5VJ.
    PhylomeDBiQ9BZR8.

    Family and domain databases

    InterProiIPR002475. Bcl2-like.
    [Graphical view]
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZR8-1) [UniParc]FASTAAdd to Basket

    Also known as: Bcl-Gl, Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT    50
    RSLSQRGLGN CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV 100
    EKEDSQSTPA KVSAQGQRTL EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV 150
    ISIANRVAEI VYSWPPPQAT QAGGFKSKEI FVTEGLSFQL QGHVPVASSS 200
    KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG LSYSVFKTIT 250
    DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY 300
    LKENFSPWIQ QHGGWEKILG ISHEEVD 327
    Length:327
    Mass (Da):36,598
    Last modified:June 1, 2001 - v1
    Checksum:i155D43BA91BFB3EA
    GO
    Isoform 2 (identifier: Q9BZR8-2) [UniParc]FASTAAdd to Basket

    Also known as: Bcl-Gs, Short

    The sequence of this isoform differs from the canonical sequence as follows:
         227-252: LKKDKALMGHFQDGLSYSVFKTITDQ → DTAFIPIPLVDTSIQGFPQDGLMACI
         253-327: Missing.

    Show »
    Length:252
    Mass (Da):28,090
    Checksum:i87D2E5123EFCB9E4
    GO
    Isoform 3 (identifier: Q9BZR8-3) [UniParc]FASTAAdd to Basket

    Also known as: Median

    The sequence of this isoform differs from the canonical sequence as follows:
         227-276: LKKDKALMGH...AQGFKAALVI → EKEWEESAKT...LTPPGFSEHN
         277-327: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:276
    Mass (Da):30,948
    Checksum:i81559A7190F5598E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei227 – 27650LKKDK…AALVI → EKEWEESAKTKIKMALLWRS SGGGPRVLSIPEAFMKNSFT LTPPGFSEHN in isoform 3. 1 PublicationVSP_012241Add
    BLAST
    Alternative sequencei227 – 25226LKKDK…TITDQ → DTAFIPIPLVDTSIQGFPQD GLMACI in isoform 2. 1 PublicationVSP_012239Add
    BLAST
    Alternative sequencei253 – 32775Missing in isoform 2. 1 PublicationVSP_012240Add
    BLAST
    Alternative sequencei277 – 32751Missing in isoform 3. 1 PublicationVSP_012242Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281254 mRNA. Translation: AAG59793.1.
    AF281255 mRNA. Translation: AAG59794.1.
    AY040274 mRNA. Translation: AAK72109.1.
    AK292995 mRNA. Translation: BAF85684.1.
    CH471094 Genomic DNA. Translation: EAW96247.1.
    BC025778 mRNA. Translation: AAH25778.1.
    CCDSiCCDS8645.1. [Q9BZR8-1]
    CCDS8646.1. [Q9BZR8-2]
    RefSeqiNP_110393.1. NM_030766.1. [Q9BZR8-2]
    NP_620048.1. NM_138722.1. [Q9BZR8-1]
    NP_620049.1. NM_138723.1. [Q9BZR8-1]
    XP_006719214.1. XM_006719151.1. [Q9BZR8-1]
    UniGeneiHs.210343.
    Hs.734567.

    Genome annotation databases

    EnsembliENST00000266434; ENSP00000266434; ENSG00000121380. [Q9BZR8-2]
    ENST00000298566; ENSP00000298566; ENSG00000121380. [Q9BZR8-3]
    ENST00000308721; ENSP00000309132; ENSG00000121380. [Q9BZR8-1]
    ENST00000396367; ENSP00000379653; ENSG00000121380. [Q9BZR8-1]
    ENST00000589718; ENSP00000467086; ENSG00000121380. [Q9BZR8-1]
    GeneIDi79370.
    KEGGihsa:79370.
    UCSCiuc001rac.3. human. [Q9BZR8-1]
    uc001rae.3. human. [Q9BZR8-2]

    Polymorphism databases

    DMDMi56748611.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281254 mRNA. Translation: AAG59793.1 .
    AF281255 mRNA. Translation: AAG59794.1 .
    AY040274 mRNA. Translation: AAK72109.1 .
    AK292995 mRNA. Translation: BAF85684.1 .
    CH471094 Genomic DNA. Translation: EAW96247.1 .
    BC025778 mRNA. Translation: AAH25778.1 .
    CCDSi CCDS8645.1. [Q9BZR8-1 ]
    CCDS8646.1. [Q9BZR8-2 ]
    RefSeqi NP_110393.1. NM_030766.1. [Q9BZR8-2 ]
    NP_620048.1. NM_138722.1. [Q9BZR8-1 ]
    NP_620049.1. NM_138723.1. [Q9BZR8-1 ]
    XP_006719214.1. XM_006719151.1. [Q9BZR8-1 ]
    UniGenei Hs.210343.
    Hs.734567.

    3D structure databases

    ProteinModelPortali Q9BZR8.
    SMRi Q9BZR8. Positions 176-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122658. 2 interactions.
    IntActi Q9BZR8. 1 interaction.
    MINTi MINT-149090.
    STRINGi 9606.ENSP00000309132.

    PTM databases

    PhosphoSitei Q9BZR8.

    Polymorphism databases

    DMDMi 56748611.

    Proteomic databases

    PaxDbi Q9BZR8.
    PRIDEi Q9BZR8.

    Protocols and materials databases

    DNASUi 79370.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266434 ; ENSP00000266434 ; ENSG00000121380 . [Q9BZR8-2 ]
    ENST00000298566 ; ENSP00000298566 ; ENSG00000121380 . [Q9BZR8-3 ]
    ENST00000308721 ; ENSP00000309132 ; ENSG00000121380 . [Q9BZR8-1 ]
    ENST00000396367 ; ENSP00000379653 ; ENSG00000121380 . [Q9BZR8-1 ]
    ENST00000589718 ; ENSP00000467086 ; ENSG00000121380 . [Q9BZR8-1 ]
    GeneIDi 79370.
    KEGGi hsa:79370.
    UCSCi uc001rac.3. human. [Q9BZR8-1 ]
    uc001rae.3. human. [Q9BZR8-2 ]

    Organism-specific databases

    CTDi 79370.
    GeneCardsi GC12P012202.
    HGNCi HGNC:16657. BCL2L14.
    HPAi HPA040665.
    MIMi 606126. gene.
    neXtProti NX_Q9BZR8.
    PharmGKBi PA134870762.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315634.
    HOGENOMi HOG000013215.
    HOVERGENi HBG050649.
    InParanoidi Q9BZR8.
    OMAi NFSPWVQ.
    OrthoDBi EOG7KM5VJ.
    PhylomeDBi Q9BZR8.

    Miscellaneous databases

    ChiTaRSi BCL2L14. human.
    GeneWikii BCL2L14.
    GenomeRNAii 79370.
    NextBioi 68351.
    PROi Q9BZR8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZR8.
    Bgeei Q9BZR8.
    CleanExi HS_BCL2L14.
    Genevestigatori Q9BZR8.

    Family and domain databases

    InterProi IPR002475. Bcl2-like.
    [Graphical view ]
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family."
      Guo B., Godzik A., Reed J.C.
      J. Biol. Chem. 276:2780-2785(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    2. "Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia."
      Montpetit A., Larose J., Boily G., Langlois S., Trudel N., Sinnett D.
      Leukemia 18:1499-1504(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    6. "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family."
      Lin M.L., Park J.H., Nishidate T., Nakamura Y., Katagiri T.
      Breast Cancer Res. 9:R17-R17(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY MELK.

    Entry informationi

    Entry nameiB2L14_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZR8
    Secondary accession number(s): A8KAD0, Q96QR5, Q9BZR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3