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Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

BCL2L14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in apoptosis.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  • regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name:
Bcl2-L-14
Alternative name(s):
Apoptosis regulator Bcl-G
Gene namesi
Name:BCL2L14
Synonyms:BCLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 12, Chromosome 2

Organism-specific databases

HGNCiHGNC:16657. BCL2L14.

Subcellular locationi

  • Cytoplasm 1 Publication
Isoform 1 :
Isoform 2 :

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • endomembrane system Source: UniProtKB-SubCell
  • intracellular organelle Source: UniProtKB
  • membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870762.

Polymorphism and mutation databases

BioMutaiBCL2L14.
DMDMi56748611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Apoptosis facilitator Bcl-2-like protein 14PRO_0000143075Add
BLAST

Post-translational modificationi

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BZR8.
PRIDEiQ9BZR8.

PTM databases

PhosphoSiteiQ9BZR8.

Expressioni

Tissue specificityi

Isoform 1 is widely expressed. Isoform 2 is testis-specific.1 Publication

Gene expression databases

BgeeiQ9BZR8.
CleanExiHS_BCL2L14.
ExpressionAtlasiQ9BZR8. baseline and differential.
GenevisibleiQ9BZR8. HS.

Organism-specific databases

HPAiHPA040665.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MELKQ146804EBI-1385773,EBI-1046702

Protein-protein interaction databases

BioGridi122658. 15 interactions.
IntActiQ9BZR8. 1 interaction.
MINTiMINT-149090.
STRINGi9606.ENSP00000309132.

Structurei

3D structure databases

ProteinModelPortaliQ9BZR8.
SMRiQ9BZR8. Positions 176-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi212 – 22615BH3Add
BLAST
Motifi308 – 3158BH2

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiNOG315634.
GeneTreeiENSGT00390000007293.
HOGENOMiHOG000013215.
HOVERGENiHBG050649.
InParanoidiQ9BZR8.
OrthoDBiEOG7KM5VJ.
PhylomeDBiQ9BZR8.

Family and domain databases

InterProiIPR002475. Bcl2-like.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZR8-1) [UniParc]FASTAAdd to basket

Also known as: Bcl-Gl, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT
60 70 80 90 100
RSLSQRGLGN CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV
110 120 130 140 150
EKEDSQSTPA KVSAQGQRTL EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV
160 170 180 190 200
ISIANRVAEI VYSWPPPQAT QAGGFKSKEI FVTEGLSFQL QGHVPVASSS
210 220 230 240 250
KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG LSYSVFKTIT
260 270 280 290 300
DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY
310 320
LKENFSPWIQ QHGGWEKILG ISHEEVD
Length:327
Mass (Da):36,598
Last modified:June 1, 2001 - v1
Checksum:i155D43BA91BFB3EA
GO
Isoform 2 (identifier: Q9BZR8-2) [UniParc]FASTAAdd to basket

Also known as: Bcl-Gs, Short

The sequence of this isoform differs from the canonical sequence as follows:
     227-252: LKKDKALMGHFQDGLSYSVFKTITDQ → DTAFIPIPLVDTSIQGFPQDGLMACI
     253-327: Missing.

Show »
Length:252
Mass (Da):28,090
Checksum:i87D2E5123EFCB9E4
GO
Isoform 3 (identifier: Q9BZR8-3) [UniParc]FASTAAdd to basket

Also known as: Median

The sequence of this isoform differs from the canonical sequence as follows:
     227-276: LKKDKALMGH...AQGFKAALVI → EKEWEESAKT...LTPPGFSEHN
     277-327: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:276
Mass (Da):30,948
Checksum:i81559A7190F5598E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei227 – 27650LKKDK…AALVI → EKEWEESAKTKIKMALLWRS SGGGPRVLSIPEAFMKNSFT LTPPGFSEHN in isoform 3. 1 PublicationVSP_012241Add
BLAST
Alternative sequencei227 – 25226LKKDK…TITDQ → DTAFIPIPLVDTSIQGFPQD GLMACI in isoform 2. 1 PublicationVSP_012239Add
BLAST
Alternative sequencei253 – 32775Missing in isoform 2. 1 PublicationVSP_012240Add
BLAST
Alternative sequencei277 – 32751Missing in isoform 3. 1 PublicationVSP_012242Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281254 mRNA. Translation: AAG59793.1.
AF281255 mRNA. Translation: AAG59794.1.
AY040274 mRNA. Translation: AAK72109.1.
AK292995 mRNA. Translation: BAF85684.1.
CH471094 Genomic DNA. Translation: EAW96247.1.
BC025778 mRNA. Translation: AAH25778.1.
CCDSiCCDS8645.1. [Q9BZR8-1]
CCDS8646.1. [Q9BZR8-2]
RefSeqiNP_110393.1. NM_030766.1. [Q9BZR8-2]
NP_620048.1. NM_138722.1. [Q9BZR8-1]
NP_620049.1. NM_138723.1. [Q9BZR8-1]
XP_006719214.1. XM_006719151.2. [Q9BZR8-1]
XP_011519150.1. XM_011520848.1. [Q9BZR8-1]
XP_011519151.1. XM_011520849.1. [Q9BZR8-1]
XP_011547177.1. XM_011548875.1. [Q9BZR8-1]
XP_011547178.1. XM_011548876.1. [Q9BZR8-1]
XP_011547179.1. XM_011548877.1. [Q9BZR8-1]
UniGeneiHs.210343.
Hs.734567.

Genome annotation databases

EnsembliENST00000266434; ENSP00000266434; ENSG00000121380. [Q9BZR8-2]
ENST00000298566; ENSP00000298566; ENSG00000121380. [Q9BZR8-3]
ENST00000308721; ENSP00000309132; ENSG00000121380.
ENST00000396367; ENSP00000379653; ENSG00000121380.
ENST00000589718; ENSP00000467086; ENSG00000121380.
ENST00000627413; ENSP00000486050; ENSG00000281449.
ENST00000628315; ENSP00000485980; ENSG00000281449. [Q9BZR8-3]
ENST00000628783; ENSP00000487330; ENSG00000281449.
ENST00000631251; ENSP00000486560; ENSG00000281449. [Q9BZR8-2]
ENST00000631317; ENSP00000486796; ENSG00000281449.
GeneIDi79370.
KEGGihsa:79370.
UCSCiuc001rac.3. human. [Q9BZR8-1]
uc001rae.3. human. [Q9BZR8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281254 mRNA. Translation: AAG59793.1.
AF281255 mRNA. Translation: AAG59794.1.
AY040274 mRNA. Translation: AAK72109.1.
AK292995 mRNA. Translation: BAF85684.1.
CH471094 Genomic DNA. Translation: EAW96247.1.
BC025778 mRNA. Translation: AAH25778.1.
CCDSiCCDS8645.1. [Q9BZR8-1]
CCDS8646.1. [Q9BZR8-2]
RefSeqiNP_110393.1. NM_030766.1. [Q9BZR8-2]
NP_620048.1. NM_138722.1. [Q9BZR8-1]
NP_620049.1. NM_138723.1. [Q9BZR8-1]
XP_006719214.1. XM_006719151.2. [Q9BZR8-1]
XP_011519150.1. XM_011520848.1. [Q9BZR8-1]
XP_011519151.1. XM_011520849.1. [Q9BZR8-1]
XP_011547177.1. XM_011548875.1. [Q9BZR8-1]
XP_011547178.1. XM_011548876.1. [Q9BZR8-1]
XP_011547179.1. XM_011548877.1. [Q9BZR8-1]
UniGeneiHs.210343.
Hs.734567.

3D structure databases

ProteinModelPortaliQ9BZR8.
SMRiQ9BZR8. Positions 176-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122658. 15 interactions.
IntActiQ9BZR8. 1 interaction.
MINTiMINT-149090.
STRINGi9606.ENSP00000309132.

PTM databases

PhosphoSiteiQ9BZR8.

Polymorphism and mutation databases

BioMutaiBCL2L14.
DMDMi56748611.

Proteomic databases

PaxDbiQ9BZR8.
PRIDEiQ9BZR8.

Protocols and materials databases

DNASUi79370.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266434; ENSP00000266434; ENSG00000121380. [Q9BZR8-2]
ENST00000298566; ENSP00000298566; ENSG00000121380. [Q9BZR8-3]
ENST00000308721; ENSP00000309132; ENSG00000121380.
ENST00000396367; ENSP00000379653; ENSG00000121380.
ENST00000589718; ENSP00000467086; ENSG00000121380.
ENST00000627413; ENSP00000486050; ENSG00000281449.
ENST00000628315; ENSP00000485980; ENSG00000281449. [Q9BZR8-3]
ENST00000628783; ENSP00000487330; ENSG00000281449.
ENST00000631251; ENSP00000486560; ENSG00000281449. [Q9BZR8-2]
ENST00000631317; ENSP00000486796; ENSG00000281449.
GeneIDi79370.
KEGGihsa:79370.
UCSCiuc001rac.3. human. [Q9BZR8-1]
uc001rae.3. human. [Q9BZR8-2]

Organism-specific databases

CTDi79370.
GeneCardsiGC12P012202.
HGNCiHGNC:16657. BCL2L14.
HPAiHPA040665.
MIMi606126. gene.
neXtProtiNX_Q9BZR8.
PharmGKBiPA134870762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG315634.
GeneTreeiENSGT00390000007293.
HOGENOMiHOG000013215.
HOVERGENiHBG050649.
InParanoidiQ9BZR8.
OrthoDBiEOG7KM5VJ.
PhylomeDBiQ9BZR8.

Miscellaneous databases

ChiTaRSiBCL2L14. human.
GeneWikiiBCL2L14.
GenomeRNAii79370.
NextBioi68351.
PROiQ9BZR8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZR8.
CleanExiHS_BCL2L14.
ExpressionAtlasiQ9BZR8. baseline and differential.
GenevisibleiQ9BZR8. HS.

Family and domain databases

InterProiIPR002475. Bcl2-like.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family."
    Guo B., Godzik A., Reed J.C.
    J. Biol. Chem. 276:2780-2785(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia."
    Montpetit A., Larose J., Boily G., Langlois S., Trudel N., Sinnett D.
    Leukemia 18:1499-1504(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  6. "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family."
    Lin M.L., Park J.H., Nishidate T., Nakamura Y., Katagiri T.
    Breast Cancer Res. 9:R17-R17(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY MELK.

Entry informationi

Entry nameiB2L14_HUMAN
AccessioniPrimary (citable) accession number: Q9BZR8
Secondary accession number(s): A8KAD0, Q96QR5, Q9BZR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.