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Protein

Protein Niban

Gene

FAM129A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response, Translation regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135842-MONOMER.
SIGNORiQ9BZQ8.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Niban
Alternative name(s):
Cell growth-inhibiting gene 39 protein
Protein FAM129A
Gene namesi
Name:FAM129A
Synonyms:C1orf24, NIBAN
ORF Names:GIG39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16784. FAM129A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116496.
OpenTargetsiENSG00000135842.
PharmGKBiPA162385951.

Polymorphism and mutation databases

DMDMi22256936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002131202 – 928Protein NibanAdd BLAST927

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei579PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9BZQ8.
MaxQBiQ9BZQ8.
PaxDbiQ9BZQ8.
PeptideAtlasiQ9BZQ8.
PRIDEiQ9BZQ8.

PTM databases

iPTMnetiQ9BZQ8.
PhosphoSitePlusiQ9BZQ8.

Expressioni

Tissue specificityi

Expressed in various types of thyroid tumor such as papillary thyroid carcinomas and oxyphilic thyroid tumors but not in normal thyroid tissue (at protein level). Strongly expressed in heart, skeletal muscle, pancreas, white blood cells and prostate with moderate expression in colon and spleen. Expressed in renal carcinoma cells but not in normal kidney.2 Publications

Gene expression databases

BgeeiENSG00000135842.
CleanExiHS_FAM129A.
ExpressionAtlasiQ9BZQ8. baseline and differential.
GenevisibleiQ9BZQ8. HS.

Organism-specific databases

HPAiHPA028172.
HPA028231.
HPA028657.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AKT1P317492EBI-6916466,EBI-296087
FHL2Q141923EBI-6916466,EBI-701903
NPM1P067487EBI-6916466,EBI-78579

Protein-protein interaction databases

BioGridi125515. 5 interactors.
IntActiQ9BZQ8. 4 interactors.
MINTiMINT-6943981.
STRINGi9606.ENSP00000356481.

Structurei

3D structure databases

ProteinModelPortaliQ9BZQ8.
SMRiQ9BZQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi683 – 864Glu-richAdd BLAST182

Sequence similaritiesi

Belongs to the Niban family.Curated

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOVERGENiHBG108186.
InParanoidiQ9BZQ8.
OMAiEDEYNLL.
OrthoDBiEOG091G02BX.
PhylomeDBiQ9BZQ8.
TreeFamiTF333351.

Family and domain databases

InterProiIPR026088. Niban-like.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGSASSQLD EGKCAYIRGK TEAAIKNFSP YYSRQYSVAF CNHVRTEVEQ
60 70 80 90 100
QRDLTSQFLK TKPPLAPGTI LYEAELSQFS EDIKKWKERY VVVKNDYAVE
110 120 130 140 150
SYENKEAYQR GAAPKCRILP AGGKVLTSED EYNLLSDRHF PDPLASSEKE
160 170 180 190 200
NTQPFVVLPK EFPVYLWQPF FRHGYFCFHE AADQKRFSAL LSDCVRHLNH
210 220 230 240 250
DYMKQMTFEA QAFLEAVQFF RQEKGHYGSW EMITGDEIQI LSNLVMEELL
260 270 280 290 300
PTLQTDLLPK MKGKKNDRKR TWLGLLEEAY TLVQHQVSEG LSALKEECRA
310 320 330 340 350
LTKGLEGTIR SDMDQIVNSK NYLIGKIKAM VAQPAEKSCL ESVQPFLASI
360 370 380 390 400
LEELMGPVSS GFSEVRVLFE KEVNEVSQNF QTTKDSVQLK EHLDRLMNLP
410 420 430 440 450
LHSVKMEPCY TKVNLLHERL QDLKSRFRFP HIDLVVQRTQ NYMQELMENA
460 470 480 490 500
VFTFEQLLSP HLQGEASKTA VAIEKVKLRV LKQYDYDSST IRKKIFQEAL
510 520 530 540 550
VQITLPTVQK ALASTCKPEL QKYEQFIFAD HTNMIHVENV YEEILHQILL
560 570 580 590 600
DETLKVIKEA AILKKHNLFE DNMALPSESV SSLTDLKPPT GSNQASPARR
610 620 630 640 650
ASAILPGVLG SETLSNEVFQ ESEEEKQPEV PSSLAKGESL SLPGPSPPPD
660 670 680 690 700
GTEQVIISRV DDPVVNPVAT EDTAGLPGTC SSELEFGGTL EDEEPAQEEP
710 720 730 740 750
EPITASGSLK ALRKLLTASV EVPVDSAPVM EEDTNGESHV PQENEEEEEK
760 770 780 790 800
EPSQAAAIHP DNCEESEVSE REAQPPCPEA HGEELGGFPE VGSPASPPAS
810 820 830 840 850
GGLTEEPLGP MEGELPGEAC TLTAHEGRGG KCTEEGDASQ QEGCTLGSDP
860 870 880 890 900
ICLSESQVSE EQEEMGGQSS AAQATASVNA EEIKVARIHE CQWVVEDAPN
910 920
PDVLLSHKDD VKEGEGGQES FPELPSEE
Length:928
Mass (Da):103,135
Last modified:June 1, 2001 - v1
Checksum:i93717F41336488FE
GO

Sequence cautioni

The sequence BAB17230 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27N → D in AAT52218 (Ref. 4) Curated1
Sequence conflicti106E → G in BAB14079 (PubMed:14702039).Curated1
Sequence conflicti201D → E in BAB14079 (PubMed:14702039).Curated1
Sequence conflicti609L → P in BAB84965 (Ref. 7) Curated1
Sequence conflicti858V → D in BAB14079 (PubMed:14702039).Curated1
Sequence conflicti863E → D in BAB14079 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053533633S → L.Corresponds to variant rs12750174dbSNPEnsembl.1
Natural variantiVAR_053534692D → N.1 PublicationCorresponds to variant rs35704242dbSNPEnsembl.1
Natural variantiVAR_053535720V → M.Corresponds to variant rs17313374dbSNPEnsembl.1
Natural variantiVAR_053536830G → S.Corresponds to variant rs35601690dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050477 mRNA. Translation: BAB17230.1. Different initiation.
AF288391 mRNA. Translation: AAG60611.1.
AK022527 mRNA. Translation: BAB14079.1.
AY550972 mRNA. Translation: AAT52218.1.
AL109865
, AL096819, AL109956, AL136086 Genomic DNA. Translation: CAI17848.1.
AL109956
, AL096819, AL109865, AL136086 Genomic DNA. Translation: CAI17877.1.
AL096819
, AL109865, AL109956, AL136086 Genomic DNA. Translation: CAI21739.1.
BC030531 mRNA. Translation: AAH30531.1.
AK074139 mRNA. Translation: BAB84965.1.
CCDSiCCDS1364.1.
RefSeqiNP_443198.1. NM_052966.3.
UniGeneiHs.518662.

Genome annotation databases

EnsembliENST00000367511; ENSP00000356481; ENSG00000135842.
GeneIDi116496.
KEGGihsa:116496.
UCSCiuc001gra.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050477 mRNA. Translation: BAB17230.1. Different initiation.
AF288391 mRNA. Translation: AAG60611.1.
AK022527 mRNA. Translation: BAB14079.1.
AY550972 mRNA. Translation: AAT52218.1.
AL109865
, AL096819, AL109956, AL136086 Genomic DNA. Translation: CAI17848.1.
AL109956
, AL096819, AL109865, AL136086 Genomic DNA. Translation: CAI17877.1.
AL096819
, AL109865, AL109956, AL136086 Genomic DNA. Translation: CAI21739.1.
BC030531 mRNA. Translation: AAH30531.1.
AK074139 mRNA. Translation: BAB84965.1.
CCDSiCCDS1364.1.
RefSeqiNP_443198.1. NM_052966.3.
UniGeneiHs.518662.

3D structure databases

ProteinModelPortaliQ9BZQ8.
SMRiQ9BZQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125515. 5 interactors.
IntActiQ9BZQ8. 4 interactors.
MINTiMINT-6943981.
STRINGi9606.ENSP00000356481.

PTM databases

iPTMnetiQ9BZQ8.
PhosphoSitePlusiQ9BZQ8.

Polymorphism and mutation databases

DMDMi22256936.

Proteomic databases

EPDiQ9BZQ8.
MaxQBiQ9BZQ8.
PaxDbiQ9BZQ8.
PeptideAtlasiQ9BZQ8.
PRIDEiQ9BZQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367511; ENSP00000356481; ENSG00000135842.
GeneIDi116496.
KEGGihsa:116496.
UCSCiuc001gra.5. human.

Organism-specific databases

CTDi116496.
DisGeNETi116496.
GeneCardsiFAM129A.
HGNCiHGNC:16784. FAM129A.
HPAiHPA028172.
HPA028231.
HPA028657.
neXtProtiNX_Q9BZQ8.
OpenTargetsiENSG00000135842.
PharmGKBiPA162385951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOVERGENiHBG108186.
InParanoidiQ9BZQ8.
OMAiEDEYNLL.
OrthoDBiEOG091G02BX.
PhylomeDBiQ9BZQ8.
TreeFamiTF333351.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135842-MONOMER.
SIGNORiQ9BZQ8.

Miscellaneous databases

ChiTaRSiFAM129A. human.
GeneWikiiFAM129A.
GenomeRNAii116496.
PROiQ9BZQ8.

Gene expression databases

BgeeiENSG00000135842.
CleanExiHS_FAM129A.
ExpressionAtlasiQ9BZQ8. baseline and differential.
GenevisibleiQ9BZQ8. HS.

Family and domain databases

InterProiIPR026088. Niban-like.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIBAN_HUMAN
AccessioniPrimary (citable) accession number: Q9BZQ8
Secondary accession number(s): Q2TTR2
, Q5TEM8, Q8TEI5, Q9H593, Q9H9Y8, Q9HCB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Niban' means 'second' in Japanese.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.