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Protein

Testicular spindle-associated protein SHCBP1L

Gene

SHCBP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testicular spindle-associated protein SHCBP1LCurated
Alternative name(s):
SHC SH2 domain-binding protein 1-like proteinImported
Gene namesi
Name:SHCBP1LImported
Synonyms:C1orf14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000157060.14.
HGNCiHGNC:16788. SHCBP1L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157060.
PharmGKBiPA25603.

Polymorphism and mutation databases

BioMutaiSHCBP1L.
DMDMi145558866.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848381 – 653Testicular spindle-associated protein SHCBP1LAdd BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei570N6-acetyllysineBy similarity1
Modified residuei645N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9BZQ2.
PeptideAtlasiQ9BZQ2.
PRIDEiQ9BZQ2.

PTM databases

iPTMnetiQ9BZQ2.
PhosphoSitePlusiQ9BZQ2.

Expressioni

Tissue specificityi

Expressed in spermatocytes and elongating spermatids inside the seminiferous tubules (at protein level) (PubMed:24557841). Testis-specific (PubMed:11318611, PubMed:24557841).2 Publications

Gene expression databases

BgeeiENSG00000157060.
CleanExiHS_C1orf14.
GenevisibleiQ9BZQ2. HS.

Organism-specific databases

HPAiHPA036124.
HPA036125.
HPA064821.

Interactioni

Subunit structurei

Interacts with HSPA2; this interaction may promote the recruitment of HSPA2 to the spindle.By similarity

Protein-protein interaction databases

BioGridi123561. 2 interactors.
IntActiQ9BZQ2. 1 interactor.
STRINGi9606.ENSP00000356518.

Structurei

3D structure databases

ProteinModelPortaliQ9BZQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati493 – 514PbH1 1Add BLAST22
Repeati515 – 537PbH1 2Add BLAST23
Repeati538 – 571PbH1 3Add BLAST34
Repeati574 – 596PbH1 4Add BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili299 – 326Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 89Poly-Ala6

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IIV2. Eukaryota.
ENOG410XXTE. LUCA.
GeneTreeiENSGT00530000063807.
HOVERGENiHBG107550.
InParanoidiQ9BZQ2.
OMAiESCENYT.
PhylomeDBiQ9BZQ2.
TreeFamiTF329196.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiView protein in InterPro
IPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
SMARTiView protein in SMART
SM00722. CASH. 1 hit.
SM00710. PbH1. 4 hits.
SUPFAMiSSF51126. SSF51126. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9BZQ2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGSKASVP ADSFRTISPD RRGEKSASAV SGDTAAATTL KGTAIPVRSV
60 70 80 90 100
VASPRPVKGK AGRETARLRL QRLPAAQAED TGEAAAAAAE EPLLPVPEDE
110 120 130 140 150
EEAQPLPPVC VSRMRGMWRD EKVSLYCDEV LQDCKAEDAD EVMGKYLSEK
160 170 180 190 200
LKLKDKWLGV WKTNPSVFFV KYEEASIPFV GILVEVTCEP YQDSSSRFKV
210 220 230 240 250
TVSVAEPFSS NIANIPRDLV DEILEELEHS VPLLEVYPVE GQDTDIHVIA
260 270 280 290 300
LALEVVRFFY DFLWRDWDDE ESCENYTALI EERINLWCDI QDGTIPGPIA
310 320 330 340 350
QRFKKTLEKY KNKRVELIEY QSNIKEDPSA AEAVECWKKY YEIVMLCGLL
360 370 380 390 400
KMWEDLRLRV HGPFFPRILR RRKGKREFGK TITHIVAKMM TTEMIKDLSS
410 420 430 440 450
DTLLQQHGDL DLALDNCYSG DTVIIFPGEY QAANLALLTD DIIIKGVGKR
460 470 480 490 500
EEIMITSEPS RDSFVVSKAD NVKLMHLSLI QQGTVDGIVV VESGHMTLEN
510 520 530 540 550
CILKCEGTGV CVLTGAALTI TDSEITGAQG AGVELYPGSI AILERNEIHH
560 570 580 590 600
CNNLRTSNSS KSTLGGVNMK VLPAPKLKMT NNHIYSNKGY GVSILQPMEQ
610 620 630 640 650
FFIVAEEALN KRASSGDKKD DKMLFKVMQN LNLEMNNNKI EANVKGDIRI

VTS
Length:653
Mass (Da):72,632
Last modified:November 30, 2016 - v3
Checksum:i451E8593E0CCE4FA
GO
Isoform 2 (identifier: Q9BZQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.
     120-135: DEKVSLYCDEVLQDCK → MGFLQLVRLDSNSRPQ

Show »
Length:534
Mass (Da):60,248
Checksum:i89F72F89F1DF3F25
GO
Isoform 4 (identifier: Q9BZQ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-149: AEDADEVMGKYLSE → KMLMKLWVNTYQKN
     150-653: Missing.

Show »
Length:149
Mass (Da):16,024
Checksum:iF1B47E5852E0A111
GO

Sequence cautioni

The sequence AAG60617 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198F → L in AAG60616 (PubMed:11318611).Curated1
Sequence conflicti198F → L in AAG60617 (PubMed:11318611).Curated1
Sequence conflicti249I → L in AAG60616 (PubMed:11318611).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031836491V → M. Corresponds to variant dbSNP:rs12138972Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246731 – 119Missing in isoform 2. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_024676120 – 135DEKVS…LQDCK → MGFLQLVRLDSNSRPQ in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_024677136 – 149AEDAD…KYLSE → KMLMKLWVNTYQKN in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_024678150 – 653Missing in isoform 4. 1 PublicationAdd BLAST504

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288397 mRNA. Translation: AAG60616.1.
AF288398 mRNA. Translation: AAG60617.1. Frameshift.
AF297023
, AF297016, AF297017, AF297018, AF297019, AF297020, AF297021, AF297022, AF312863 Genomic DNA. Translation: AAG45336.1.
AL662837 Genomic DNA. No translation available.
AL450304 Genomic DNA. No translation available.
BC026084 mRNA. Translation: AAH26084.1.
BC050305 mRNA. Translation: AAH50305.1.
BC132764 mRNA. Translation: AAI32765.1.
CCDSiCCDS30955.1. [Q9BZQ2-3]
RefSeqiNP_001332857.1. NM_001345928.1. [Q9BZQ2-2]
NP_112195.2. NM_030933.3. [Q9BZQ2-3]
UniGeneiHs.497034.

Genome annotation databases

EnsembliENST00000367547; ENSP00000356518; ENSG00000157060. [Q9BZQ2-3]
GeneIDi81626.
KEGGihsa:81626.
UCSCiuc001gpu.4. human. [Q9BZQ2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSHP1L_HUMAN
AccessioniPrimary (citable) accession number: Q9BZQ2
Secondary accession number(s): Q4G195, Q9BZQ3, Q9H2B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 30, 2016
Last modified: September 27, 2017
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations