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Protein

Acidic mammalian chitinase

Gene

CHIA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.4 Publications

Catalytic activityi

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei140Proton donorCurated1
Binding sitei141ChitooligosaccharideBy similarity1
Binding sitei360ChitooligosaccharideBy similarity1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • chitinase activity Source: UniProtKB
  • chitin binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • lysozyme activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • carbohydrate metabolic process Source: Reactome
  • cell wall chitin metabolic process Source: UniProtKB
  • chitin catabolic process Source: UniProtKB
  • chitin metabolic process Source: UniProtKB
  • digestion Source: UniProtKB
  • immune response Source: UniProtKB
  • polysaccharide catabolic process Source: UniProtKB-KW
  • positive regulation of chemokine secretion Source: UniProtKB
  • production of molecular mediator involved in inflammatory response Source: UniProtKB
  • response to fungus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Apoptosis, Carbohydrate metabolism, Chitin degradation, Immunity, Inflammatory response, Polysaccharide degradation

Keywords - Ligandi

Chitin-binding

Enzyme and pathway databases

BioCyciZFISH:HS05835-MONOMER.
BRENDAi3.2.1.14. 2681.
ReactomeiR-HSA-71387. Metabolism of carbohydrates.

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.
GH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic mammalian chitinase (EC:3.2.1.14)
Short name:
AMCase
Alternative name(s):
Lung-specific protein TSA1902
Gene namesi
Name:CHIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17432. CHIA.

Subcellular locationi

Isoform 1 :
  • Secreted

  • Note: Secretion depends on EGFR activity.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi138D → A: Loss of chitinase activity. No effect on protection against apoptosis or on AKT1 activation. 1 Publication1

Organism-specific databases

DisGeNETi27159.
OpenTargetsiENSG00000134216.
PharmGKBiPA142672117.

Chemistry databases

ChEMBLiCHEMBL1293197.

Polymorphism and mutation databases

BioMutaiCHIA.
DMDMi37999771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001194422 – 476Acidic mammalian chitinaseAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 51PROSITE-ProRule annotation1 Publication
Disulfide bondi49 ↔ 394PROSITE-ProRule annotation1 Publication
Disulfide bondi307 ↔ 372PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9BZP6.
PeptideAtlasiQ9BZP6.
PRIDEiQ9BZP6.

PTM databases

iPTMnetiQ9BZP6.
PhosphoSitePlusiQ9BZP6.

Expressioni

Tissue specificityi

Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.2 Publications

Inductioni

Up-regulated in lung epithelial cells from asthma patients.1 Publication

Gene expression databases

BgeeiENSG00000134216.
ExpressionAtlasiQ9BZP6. baseline and differential.
GenevisibleiQ9BZP6. HS.

Organism-specific databases

HPAiHPA059193.

Interactioni

Subunit structurei

Interacts with EGFR.2 Publications

GO - Molecular functioni

  • kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118039. 18 interactors.
STRINGi9606.ENSP00000341828.

Chemistry databases

BindingDBiQ9BZP6.

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 29Combined sources7
Helixi32 – 34Combined sources3
Helixi37 – 39Combined sources3
Helixi43 – 45Combined sources3
Turni48 – 50Combined sources3
Beta strandi52 – 62Combined sources11
Beta strandi65 – 67Combined sources3
Helixi73 – 82Combined sources10
Helixi83 – 85Combined sources3
Beta strandi91 – 97Combined sources7
Helixi99 – 101Combined sources3
Helixi104 – 110Combined sources7
Helixi113 – 130Combined sources18
Beta strandi133 – 138Combined sources6
Helixi151 – 173Combined sources23
Beta strandi179 – 184Combined sources6
Helixi188 – 194Combined sources7
Helixi197 – 203Combined sources7
Beta strandi205 – 209Combined sources5
Helixi217 – 219Combined sources3
Helixi236 – 240Combined sources5
Helixi243 – 252Combined sources10
Helixi257 – 259Combined sources3
Beta strandi260 – 275Combined sources16
Beta strandi284 – 288Combined sources5
Turni293 – 295Combined sources3
Beta strandi300 – 302Combined sources3
Helixi303 – 311Combined sources9
Beta strandi315 – 319Combined sources5
Turni320 – 323Combined sources4
Beta strandi324 – 329Combined sources6
Beta strandi332 – 335Combined sources4
Helixi339 – 351Combined sources13
Beta strandi355 – 360Combined sources6
Helixi362 – 364Combined sources3
Beta strandi367 – 369Combined sources3
Turni370 – 372Combined sources3
Helixi378 – 386Combined sources9
Helixi392 – 394Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YBTX-ray2.22A/B/C/D/E/F21-398[»]
2YBUX-ray2.25A/B/C/D/E/F21-398[»]
3FXYX-ray2.00A/B/C/D22-408[»]
3FY1X-ray1.70A/B22-408[»]
3RM4X-ray1.90A/B22-408[»]
3RM8X-ray1.80A/B22-408[»]
3RM9X-ray2.10A/B22-408[»]
3RMEX-ray1.80A/B22-408[»]
ProteinModelPortaliQ9BZP6.
SMRiQ9BZP6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZP6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 476Chitin-binding type-2PROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 71Chitooligosaccharide bindingCurated2
Regioni97 – 100Chitooligosaccharide bindingCurated4
Regioni210 – 213Chitooligosaccharide bindingCurated4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi415 – 420Poly-Ser6

Sequence similaritiesi

Contains 1 chitin-binding type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOVERGENiHBG011684.
InParanoidiQ9BZP6.
KOiK01183.
OMAiFDIKAQW.
OrthoDBiEOG091G014W.
PhylomeDBiQ9BZP6.
TreeFamiTF315610.

Family and domain databases

Gene3Di2.170.140.10. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR002557. Chitin-bd_dom.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01607. CBM_14. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00494. ChtBD2. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
SSF57625. SSF57625. 1 hit.
PROSITEiPS50940. CHIT_BIND_II. 1 hit.
PS01095. CHITINASE_18. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKLILLTGL VLILNLQLGS AYQLTCYFTN WAQYRPGLGR FMPDNIDPCL
60 70 80 90 100
CTHLIYAFAG RQNNEITTIE WNDVTLYQAF NGLKNKNSQL KTLLAIGGWN
110 120 130 140 150
FGTAPFTAMV STPENRQTFI TSVIKFLRQY EFDGLDFDWE YPGSRGSPPQ
160 170 180 190 200
DKHLFTVLVQ EMREAFEQEA KQINKPRLMV TAAVAAGISN IQSGYEIPQL
210 220 230 240 250
SQYLDYIHVM TYDLHGSWEG YTGENSPLYK YPTDTGSNAY LNVDYVMNYW
260 270 280 290 300
KDNGAPAEKL IVGFPTYGHN FILSNPSNTG IGAPTSGAGP AGPYAKESGI
310 320 330 340 350
WAYYEICTFL KNGATQGWDA PQEVPYAYQG NVWVGYDNIK SFDIKAQWLK
360 370 380 390 400
HNKFGGAMVW AIDLDDFTGT FCNQGKFPLI STLKKALGLQ SASCTAPAQP
410 420 430 440 450
IEPITAAPSG SGNGSGSSSS GGSSGGSGFC AVRANGLYPV ANNRNAFWHC
460 470
VNGVTYQQNC QAGLVFDTSC DCCNWA
Length:476
Mass (Da):52,271
Last modified:June 1, 2001 - v1
Checksum:i92B27BAD2F7EB4CC
GO
Isoform 2 (identifier: Q9BZP6-2) [UniParc]FASTAAdd to basket
Also known as: TSA1902-L

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:368
Mass (Da):40,139
Checksum:iFC2558C4CEA48609
GO
Isoform 3 (identifier: Q9BZP6-3) [UniParc]FASTAAdd to basket
Also known as: TSA1902-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Show »
Length:315
Mass (Da):33,906
Checksum:i61D614709B577CAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203Y → C in AAX81431 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06303045N → D Increased chitinase activity; when associated with N-47 and M-61. 1 PublicationCorresponds to variant rs41282492dbSNPEnsembl.1
Natural variantiVAR_06303147D → N Increased chitinase activity; when associated with N-47 and M-61. 1 PublicationCorresponds to variant rs41282494dbSNPEnsembl.1
Natural variantiVAR_06303261R → M Increased chitinase activity; when associated with N-47 and M-61. 1 PublicationCorresponds to variant rs41282496dbSNPEnsembl.1
Natural variantiVAR_049192102G → R.1 PublicationCorresponds to variant rs3818822dbSNPEnsembl.1
Natural variantiVAR_063033125K → R.1 PublicationCorresponds to variant rs61756687dbSNPEnsembl.1
Natural variantiVAR_033730324V → G.Corresponds to variant rs2256721dbSNPEnsembl.1
Natural variantiVAR_049193339I → V.2 PublicationsCorresponds to variant rs2275253dbSNPEnsembl.1
Natural variantiVAR_049194354F → S.1 PublicationCorresponds to variant rs2275254dbSNPEnsembl.1
Natural variantiVAR_049195377F → L.Corresponds to variant rs36011905dbSNPEnsembl.1
Natural variantiVAR_049196432V → G.2 PublicationsCorresponds to variant rs2256721dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0086341 – 161Missing in isoform 3. 2 PublicationsAdd BLAST161
Alternative sequenceiVSP_0086351 – 108Missing in isoform 2. 3 PublicationsAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025008 mRNA. Translation: BAA86980.1.
AB025009 mRNA. Translation: BAA86981.1.
AF290004 mRNA. Translation: AAG60019.1.
AY789444 mRNA. Translation: AAX81431.1.
AY789445 mRNA. Translation: AAX81432.1.
AL513202, AL356387 Genomic DNA. Translation: CAH70803.1.
AL356387, AL513202 Genomic DNA. Translation: CAI19265.1.
BC047336 mRNA. Translation: AAH47336.2.
BC036339 mRNA. Translation: AAH36339.2.
BC106910 mRNA. Translation: AAI06911.1.
CCDSiCCDS41368.1. [Q9BZP6-1]
CCDS58017.1. [Q9BZP6-3]
CCDS832.1. [Q9BZP6-2]
RefSeqiNP_001035713.1. NM_001040623.2. [Q9BZP6-3]
NP_001244930.1. NM_001258001.1. [Q9BZP6-2]
NP_001244931.1. NM_001258002.1. [Q9BZP6-3]
NP_001244932.1. NM_001258003.1. [Q9BZP6-2]
NP_001244933.1. NM_001258004.1. [Q9BZP6-3]
NP_001244934.1. NM_001258005.1. [Q9BZP6-3]
NP_068569.2. NM_021797.3. [Q9BZP6-2]
NP_970615.2. NM_201653.3. [Q9BZP6-1]
XP_006710640.1. XM_006710577.3. [Q9BZP6-3]
XP_016856536.1. XM_017001047.1. [Q9BZP6-3]
XP_016856537.1. XM_017001048.1. [Q9BZP6-2]
UniGeneiHs.128814.

Genome annotation databases

EnsembliENST00000343320; ENSP00000341828; ENSG00000134216. [Q9BZP6-1]
ENST00000353665; ENSP00000338970; ENSG00000134216. [Q9BZP6-3]
ENST00000369740; ENSP00000358755; ENSG00000134216. [Q9BZP6-1]
ENST00000430615; ENSP00000391132; ENSG00000134216. [Q9BZP6-2]
ENST00000451398; ENSP00000390476; ENSG00000134216. [Q9BZP6-3]
ENST00000483391; ENSP00000436946; ENSG00000134216. [Q9BZP6-3]
GeneIDi27159.
KEGGihsa:27159.
UCSCiuc001eas.5. human. [Q9BZP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025008 mRNA. Translation: BAA86980.1.
AB025009 mRNA. Translation: BAA86981.1.
AF290004 mRNA. Translation: AAG60019.1.
AY789444 mRNA. Translation: AAX81431.1.
AY789445 mRNA. Translation: AAX81432.1.
AL513202, AL356387 Genomic DNA. Translation: CAH70803.1.
AL356387, AL513202 Genomic DNA. Translation: CAI19265.1.
BC047336 mRNA. Translation: AAH47336.2.
BC036339 mRNA. Translation: AAH36339.2.
BC106910 mRNA. Translation: AAI06911.1.
CCDSiCCDS41368.1. [Q9BZP6-1]
CCDS58017.1. [Q9BZP6-3]
CCDS832.1. [Q9BZP6-2]
RefSeqiNP_001035713.1. NM_001040623.2. [Q9BZP6-3]
NP_001244930.1. NM_001258001.1. [Q9BZP6-2]
NP_001244931.1. NM_001258002.1. [Q9BZP6-3]
NP_001244932.1. NM_001258003.1. [Q9BZP6-2]
NP_001244933.1. NM_001258004.1. [Q9BZP6-3]
NP_001244934.1. NM_001258005.1. [Q9BZP6-3]
NP_068569.2. NM_021797.3. [Q9BZP6-2]
NP_970615.2. NM_201653.3. [Q9BZP6-1]
XP_006710640.1. XM_006710577.3. [Q9BZP6-3]
XP_016856536.1. XM_017001047.1. [Q9BZP6-3]
XP_016856537.1. XM_017001048.1. [Q9BZP6-2]
UniGeneiHs.128814.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YBTX-ray2.22A/B/C/D/E/F21-398[»]
2YBUX-ray2.25A/B/C/D/E/F21-398[»]
3FXYX-ray2.00A/B/C/D22-408[»]
3FY1X-ray1.70A/B22-408[»]
3RM4X-ray1.90A/B22-408[»]
3RM8X-ray1.80A/B22-408[»]
3RM9X-ray2.10A/B22-408[»]
3RMEX-ray1.80A/B22-408[»]
ProteinModelPortaliQ9BZP6.
SMRiQ9BZP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118039. 18 interactors.
STRINGi9606.ENSP00000341828.

Chemistry databases

BindingDBiQ9BZP6.
ChEMBLiCHEMBL1293197.

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.
GH18. Glycoside Hydrolase Family 18.

PTM databases

iPTMnetiQ9BZP6.
PhosphoSitePlusiQ9BZP6.

Polymorphism and mutation databases

BioMutaiCHIA.
DMDMi37999771.

Proteomic databases

PaxDbiQ9BZP6.
PeptideAtlasiQ9BZP6.
PRIDEiQ9BZP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343320; ENSP00000341828; ENSG00000134216. [Q9BZP6-1]
ENST00000353665; ENSP00000338970; ENSG00000134216. [Q9BZP6-3]
ENST00000369740; ENSP00000358755; ENSG00000134216. [Q9BZP6-1]
ENST00000430615; ENSP00000391132; ENSG00000134216. [Q9BZP6-2]
ENST00000451398; ENSP00000390476; ENSG00000134216. [Q9BZP6-3]
ENST00000483391; ENSP00000436946; ENSG00000134216. [Q9BZP6-3]
GeneIDi27159.
KEGGihsa:27159.
UCSCiuc001eas.5. human. [Q9BZP6-1]

Organism-specific databases

CTDi27159.
DisGeNETi27159.
GeneCardsiCHIA.
HGNCiHGNC:17432. CHIA.
HPAiHPA059193.
MIMi606080. gene.
neXtProtiNX_Q9BZP6.
OpenTargetsiENSG00000134216.
PharmGKBiPA142672117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOVERGENiHBG011684.
InParanoidiQ9BZP6.
KOiK01183.
OMAiFDIKAQW.
OrthoDBiEOG091G014W.
PhylomeDBiQ9BZP6.
TreeFamiTF315610.

Enzyme and pathway databases

BioCyciZFISH:HS05835-MONOMER.
BRENDAi3.2.1.14. 2681.
ReactomeiR-HSA-71387. Metabolism of carbohydrates.

Miscellaneous databases

EvolutionaryTraceiQ9BZP6.
GenomeRNAii27159.
PROiQ9BZP6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134216.
ExpressionAtlasiQ9BZP6. baseline and differential.
GenevisibleiQ9BZP6. HS.

Family and domain databases

Gene3Di2.170.140.10. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR002557. Chitin-bd_dom.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01607. CBM_14. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00494. ChtBD2. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
SSF57625. SSF57625. 1 hit.
PROSITEiPS50940. CHIT_BIND_II. 1 hit.
PS01095. CHITINASE_18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHIA_HUMAN
AccessioniPrimary (citable) accession number: Q9BZP6
Secondary accession number(s): Q32W79
, Q32W80, Q3B866, Q5U5Z5, Q5VUV4, Q86UD8, Q9ULY3, Q9ULY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.