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Q9BZP6

- CHIA_HUMAN

UniProt

Q9BZP6 - CHIA_HUMAN

Protein

Acidic mammalian chitinase

Gene

CHIA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.4 Publications

    Catalytic activityi

    Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei140 – 1401Proton donorCurated
    Binding sitei141 – 1411ChitooligosaccharideBy similarity
    Binding sitei360 – 3601ChitooligosaccharideBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: UniProtKB
    2. chitinase activity Source: UniProtKB
    3. chitin binding Source: UniProtKB
    4. kinase binding Source: UniProtKB
    5. lysozyme activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell wall chitin metabolic process Source: UniProtKB
    3. chitin catabolic process Source: UniProtKB
    4. chitin metabolic process Source: UniProtKB
    5. digestion Source: UniProtKB
    6. immune response Source: UniProtKB
    7. polysaccharide catabolic process Source: UniProtKB-KW
    8. positive regulation of chemokine secretion Source: UniProtKB
    9. production of molecular mediator involved in inflammatory response Source: UniProtKB
    10. response to acid chemical Source: UniProtKB
    11. response to fungus Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Apoptosis, Carbohydrate metabolism, Chitin degradation, Immunity, Inflammatory response, Polysaccharide degradation

    Keywords - Ligandi

    Chitin-binding

    Enzyme and pathway databases

    BRENDAi3.2.1.14. 2681.

    Protein family/group databases

    CAZyiCBM14. Carbohydrate-Binding Module Family 14.
    GH18. Glycoside Hydrolase Family 18.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acidic mammalian chitinase (EC:3.2.1.14)
    Short name:
    AMCase
    Alternative name(s):
    Lung-specific protein TSA1902
    Gene namesi
    Name:CHIA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17432. CHIA.

    Subcellular locationi

    Isoform 1 : Secreted
    Note: Secretion depends on EGFR activity.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi138 – 1381D → A: Loss of chitinase activity. No effect on protection against apoptosis or on AKT1 activation. 1 Publication

    Organism-specific databases

    PharmGKBiPA142672117.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 476455Acidic mammalian chitinasePRO_0000011944Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 511 PublicationPROSITE-ProRule annotation
    Disulfide bondi49 ↔ 3941 PublicationPROSITE-ProRule annotation
    Disulfide bondi307 ↔ 3721 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9BZP6.
    PaxDbiQ9BZP6.
    PRIDEiQ9BZP6.

    PTM databases

    PhosphoSiteiQ9BZP6.

    Expressioni

    Tissue specificityi

    Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.2 Publications

    Inductioni

    Up-regulated in lung epithelial cells from asthma patients.1 Publication

    Gene expression databases

    ArrayExpressiQ9BZP6.
    BgeeiQ9BZP6.
    GenevestigatoriQ9BZP6.

    Organism-specific databases

    HPAiHPA059193.

    Interactioni

    Subunit structurei

    Interacts with EGFR.2 Publications

    Structurei

    Secondary structure

    1
    476
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi23 – 297
    Helixi32 – 343
    Helixi37 – 393
    Helixi43 – 453
    Turni48 – 503
    Beta strandi52 – 6211
    Beta strandi65 – 673
    Helixi73 – 8210
    Helixi83 – 853
    Beta strandi91 – 977
    Helixi99 – 1013
    Helixi104 – 1107
    Helixi113 – 13018
    Beta strandi133 – 1386
    Helixi151 – 17323
    Beta strandi179 – 1846
    Helixi188 – 1947
    Helixi197 – 2037
    Beta strandi205 – 2095
    Helixi217 – 2193
    Helixi236 – 2405
    Helixi243 – 25210
    Helixi257 – 2593
    Beta strandi260 – 27516
    Beta strandi284 – 2885
    Turni293 – 2953
    Beta strandi300 – 3023
    Helixi303 – 3119
    Beta strandi315 – 3195
    Turni320 – 3234
    Beta strandi324 – 3296
    Beta strandi332 – 3354
    Helixi339 – 35113
    Beta strandi355 – 3606
    Helixi362 – 3643
    Beta strandi367 – 3693
    Turni370 – 3723
    Helixi378 – 3869
    Helixi392 – 3943

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YBTX-ray2.22A/B/C/D/E/F21-398[»]
    2YBUX-ray2.25A/B/C/D/E/F21-398[»]
    3FXYX-ray2.00A/B/C/D22-408[»]
    3FY1X-ray1.70A/B22-408[»]
    3RM4X-ray1.90A/B22-408[»]
    3RM8X-ray1.80A/B22-408[»]
    3RM9X-ray2.10A/B22-408[»]
    3RMEX-ray1.80A/B22-408[»]
    ProteinModelPortaliQ9BZP6.
    SMRiQ9BZP6. Positions 21-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BZP6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini427 – 47650Chitin-binding type-2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 712Chitooligosaccharide bindingCurated
    Regioni97 – 1004Chitooligosaccharide bindingCurated
    Regioni210 – 2134Chitooligosaccharide bindingCurated

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi415 – 4206Poly-Ser

    Sequence similaritiesi

    Contains 1 chitin-binding type-2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3325.
    HOVERGENiHBG011684.
    InParanoidiQ9BZP6.
    KOiK01183.
    OMAiRNAFWHC.
    PhylomeDBiQ9BZP6.
    TreeFamiTF315610.

    Family and domain databases

    Gene3Di2.170.140.10. 1 hit.
    3.10.50.10. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR002557. Chitin-bd_dom.
    IPR011583. Chitinase_II.
    IPR029070. Chitinase_insertion.
    IPR001223. Glyco_hydro18cat.
    IPR001579. Glyco_hydro_18_chit_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF01607. CBM_14. 1 hit.
    PF00704. Glyco_hydro_18. 1 hit.
    [Graphical view]
    SMARTiSM00494. ChtBD2. 1 hit.
    SM00636. Glyco_18. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.
    SSF54556. SSF54556. 1 hit.
    SSF57625. SSF57625. 1 hit.
    PROSITEiPS50940. CHIT_BIND_II. 1 hit.
    PS01095. CHITINASE_18. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZP6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTKLILLTGL VLILNLQLGS AYQLTCYFTN WAQYRPGLGR FMPDNIDPCL    50
    CTHLIYAFAG RQNNEITTIE WNDVTLYQAF NGLKNKNSQL KTLLAIGGWN 100
    FGTAPFTAMV STPENRQTFI TSVIKFLRQY EFDGLDFDWE YPGSRGSPPQ 150
    DKHLFTVLVQ EMREAFEQEA KQINKPRLMV TAAVAAGISN IQSGYEIPQL 200
    SQYLDYIHVM TYDLHGSWEG YTGENSPLYK YPTDTGSNAY LNVDYVMNYW 250
    KDNGAPAEKL IVGFPTYGHN FILSNPSNTG IGAPTSGAGP AGPYAKESGI 300
    WAYYEICTFL KNGATQGWDA PQEVPYAYQG NVWVGYDNIK SFDIKAQWLK 350
    HNKFGGAMVW AIDLDDFTGT FCNQGKFPLI STLKKALGLQ SASCTAPAQP 400
    IEPITAAPSG SGNGSGSSSS GGSSGGSGFC AVRANGLYPV ANNRNAFWHC 450
    VNGVTYQQNC QAGLVFDTSC DCCNWA 476
    Length:476
    Mass (Da):52,271
    Last modified:June 1, 2001 - v1
    Checksum:i92B27BAD2F7EB4CC
    GO
    Isoform 2 (identifier: Q9BZP6-2) [UniParc]FASTAAdd to Basket

    Also known as: TSA1902-L

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: Missing.

    Show »
    Length:368
    Mass (Da):40,139
    Checksum:iFC2558C4CEA48609
    GO
    Isoform 3 (identifier: Q9BZP6-3) [UniParc]FASTAAdd to Basket

    Also known as: TSA1902-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-161: Missing.

    Show »
    Length:315
    Mass (Da):33,906
    Checksum:i61D614709B577CAD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031Y → C in AAX81431. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451N → D Increased chitinase activity; when associated with N-47 and M-61. 1 Publication
    Corresponds to variant rs41282492 [ dbSNP | Ensembl ].
    VAR_063030
    Natural varianti47 – 471D → N Increased chitinase activity; when associated with N-47 and M-61. 1 Publication
    Corresponds to variant rs41282494 [ dbSNP | Ensembl ].
    VAR_063031
    Natural varianti61 – 611R → M Increased chitinase activity; when associated with N-47 and M-61. 1 Publication
    Corresponds to variant rs41282496 [ dbSNP | Ensembl ].
    VAR_063032
    Natural varianti102 – 1021G → R.1 Publication
    Corresponds to variant rs3818822 [ dbSNP | Ensembl ].
    VAR_049192
    Natural varianti125 – 1251K → R.1 Publication
    Corresponds to variant rs61756687 [ dbSNP | Ensembl ].
    VAR_063033
    Natural varianti324 – 3241V → G.
    Corresponds to variant rs2256721 [ dbSNP | Ensembl ].
    VAR_033730
    Natural varianti339 – 3391I → V.2 Publications
    Corresponds to variant rs2275253 [ dbSNP | Ensembl ].
    VAR_049193
    Natural varianti354 – 3541F → S.1 Publication
    Corresponds to variant rs2275254 [ dbSNP | Ensembl ].
    VAR_049194
    Natural varianti377 – 3771F → L.
    Corresponds to variant rs36011905 [ dbSNP | Ensembl ].
    VAR_049195
    Natural varianti432 – 4321V → G.2 Publications
    Corresponds to variant rs2256721 [ dbSNP | Ensembl ].
    VAR_049196

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 161161Missing in isoform 3. 2 PublicationsVSP_008634Add
    BLAST
    Alternative sequencei1 – 108108Missing in isoform 2. 3 PublicationsVSP_008635Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025008 mRNA. Translation: BAA86980.1.
    AB025009 mRNA. Translation: BAA86981.1.
    AF290004 mRNA. Translation: AAG60019.1.
    AY789444 mRNA. Translation: AAX81431.1.
    AY789445 mRNA. Translation: AAX81432.1.
    AL513202, AL356387 Genomic DNA. Translation: CAH70803.1.
    AL356387, AL513202 Genomic DNA. Translation: CAI19265.1.
    BC047336 mRNA. Translation: AAH47336.2.
    BC036339 mRNA. Translation: AAH36339.2.
    BC106910 mRNA. Translation: AAI06911.1.
    CCDSiCCDS41368.1. [Q9BZP6-1]
    CCDS58017.1. [Q9BZP6-3]
    CCDS832.1. [Q9BZP6-2]
    RefSeqiNP_001035713.1. NM_001040623.2. [Q9BZP6-3]
    NP_001244930.1. NM_001258001.1. [Q9BZP6-2]
    NP_001244931.1. NM_001258002.1. [Q9BZP6-3]
    NP_001244932.1. NM_001258003.1. [Q9BZP6-2]
    NP_001244933.1. NM_001258004.1. [Q9BZP6-3]
    NP_001244934.1. NM_001258005.1. [Q9BZP6-3]
    NP_068569.2. NM_021797.3. [Q9BZP6-2]
    NP_970615.2. NM_201653.3. [Q9BZP6-1]
    XP_006710640.1. XM_006710577.1. [Q9BZP6-3]
    UniGeneiHs.128814.

    Genome annotation databases

    EnsembliENST00000343320; ENSP00000341828; ENSG00000134216. [Q9BZP6-1]
    ENST00000353665; ENSP00000338970; ENSG00000134216. [Q9BZP6-3]
    ENST00000369740; ENSP00000358755; ENSG00000134216. [Q9BZP6-1]
    ENST00000430615; ENSP00000391132; ENSG00000134216. [Q9BZP6-2]
    ENST00000451398; ENSP00000390476; ENSG00000134216. [Q9BZP6-3]
    ENST00000483391; ENSP00000436946; ENSG00000134216. [Q9BZP6-3]
    GeneIDi27159.
    KEGGihsa:27159.
    UCSCiuc001eaq.4. human. [Q9BZP6-1]

    Polymorphism databases

    DMDMi37999771.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025008 mRNA. Translation: BAA86980.1 .
    AB025009 mRNA. Translation: BAA86981.1 .
    AF290004 mRNA. Translation: AAG60019.1 .
    AY789444 mRNA. Translation: AAX81431.1 .
    AY789445 mRNA. Translation: AAX81432.1 .
    AL513202 , AL356387 Genomic DNA. Translation: CAH70803.1 .
    AL356387 , AL513202 Genomic DNA. Translation: CAI19265.1 .
    BC047336 mRNA. Translation: AAH47336.2 .
    BC036339 mRNA. Translation: AAH36339.2 .
    BC106910 mRNA. Translation: AAI06911.1 .
    CCDSi CCDS41368.1. [Q9BZP6-1 ]
    CCDS58017.1. [Q9BZP6-3 ]
    CCDS832.1. [Q9BZP6-2 ]
    RefSeqi NP_001035713.1. NM_001040623.2. [Q9BZP6-3 ]
    NP_001244930.1. NM_001258001.1. [Q9BZP6-2 ]
    NP_001244931.1. NM_001258002.1. [Q9BZP6-3 ]
    NP_001244932.1. NM_001258003.1. [Q9BZP6-2 ]
    NP_001244933.1. NM_001258004.1. [Q9BZP6-3 ]
    NP_001244934.1. NM_001258005.1. [Q9BZP6-3 ]
    NP_068569.2. NM_021797.3. [Q9BZP6-2 ]
    NP_970615.2. NM_201653.3. [Q9BZP6-1 ]
    XP_006710640.1. XM_006710577.1. [Q9BZP6-3 ]
    UniGenei Hs.128814.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YBT X-ray 2.22 A/B/C/D/E/F 21-398 [» ]
    2YBU X-ray 2.25 A/B/C/D/E/F 21-398 [» ]
    3FXY X-ray 2.00 A/B/C/D 22-408 [» ]
    3FY1 X-ray 1.70 A/B 22-408 [» ]
    3RM4 X-ray 1.90 A/B 22-408 [» ]
    3RM8 X-ray 1.80 A/B 22-408 [» ]
    3RM9 X-ray 2.10 A/B 22-408 [» ]
    3RME X-ray 1.80 A/B 22-408 [» ]
    ProteinModelPortali Q9BZP6.
    SMRi Q9BZP6. Positions 21-397.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9BZP6.
    ChEMBLi CHEMBL1293197.

    Protein family/group databases

    CAZyi CBM14. Carbohydrate-Binding Module Family 14.
    GH18. Glycoside Hydrolase Family 18.

    PTM databases

    PhosphoSitei Q9BZP6.

    Polymorphism databases

    DMDMi 37999771.

    Proteomic databases

    MaxQBi Q9BZP6.
    PaxDbi Q9BZP6.
    PRIDEi Q9BZP6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343320 ; ENSP00000341828 ; ENSG00000134216 . [Q9BZP6-1 ]
    ENST00000353665 ; ENSP00000338970 ; ENSG00000134216 . [Q9BZP6-3 ]
    ENST00000369740 ; ENSP00000358755 ; ENSG00000134216 . [Q9BZP6-1 ]
    ENST00000430615 ; ENSP00000391132 ; ENSG00000134216 . [Q9BZP6-2 ]
    ENST00000451398 ; ENSP00000390476 ; ENSG00000134216 . [Q9BZP6-3 ]
    ENST00000483391 ; ENSP00000436946 ; ENSG00000134216 . [Q9BZP6-3 ]
    GeneIDi 27159.
    KEGGi hsa:27159.
    UCSCi uc001eaq.4. human. [Q9BZP6-1 ]

    Organism-specific databases

    CTDi 27159.
    GeneCardsi GC01P111833.
    HGNCi HGNC:17432. CHIA.
    HPAi HPA059193.
    MIMi 606080. gene.
    neXtProti NX_Q9BZP6.
    PharmGKBi PA142672117.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3325.
    HOVERGENi HBG011684.
    InParanoidi Q9BZP6.
    KOi K01183.
    OMAi RNAFWHC.
    PhylomeDBi Q9BZP6.
    TreeFami TF315610.

    Enzyme and pathway databases

    BRENDAi 3.2.1.14. 2681.

    Miscellaneous databases

    EvolutionaryTracei Q9BZP6.
    GenomeRNAii 27159.
    NextBioi 49937.
    PROi Q9BZP6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZP6.
    Bgeei Q9BZP6.
    Genevestigatori Q9BZP6.

    Family and domain databases

    Gene3Di 2.170.140.10. 1 hit.
    3.10.50.10. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR002557. Chitin-bd_dom.
    IPR011583. Chitinase_II.
    IPR029070. Chitinase_insertion.
    IPR001223. Glyco_hydro18cat.
    IPR001579. Glyco_hydro_18_chit_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF01607. CBM_14. 1 hit.
    PF00704. Glyco_hydro_18. 1 hit.
    [Graphical view ]
    SMARTi SM00494. ChtBD2. 1 hit.
    SM00636. Glyco_18. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    SSF54556. SSF54556. 1 hit.
    SSF57625. SSF57625. 1 hit.
    PROSITEi PS50940. CHIT_BIND_II. 1 hit.
    PS01095. CHITINASE_18. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member."
      Saito A., Ozaki K., Fujiwara T., Nakamura Y., Tanigami A.
      Gene 239:325-331(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANTS VAL-339 AND GLY-432.
      Tissue: Lung.
    2. "Identification of a novel acidic mammalian chitinase distinct from chitotriosidase."
      Boot R.G., Blommaart E.F.C., Swart E., Ghauharali-van der Vlugt K., Bijl N., Moe C., Place A., Aerts J.M.F.G.
      J. Biol. Chem. 276:6770-6778(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    3. "A novel chitinase family member."
      Chen X.H., Cai G.P.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
      Tissue: Kidney.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation."
      Zhu Z., Zheng T., Homer R.J., Kim Y.K., Chen N.Y., Cohn L., Hamid Q., Elias J.A.
      Science 304:1678-1682(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, TISSUE SPECIFICITY.
    7. "Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells."
      Hartl D., He C.H., Koller B., Da Silva C.A., Homer R., Lee C.G., Elias J.A.
      J. Biol. Chem. 283:33472-33482(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH EGFR, SUBCELLULAR LOCATION.
    8. "Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism."
      Hartl D., He C.H., Koller B., Da Silva C.A., Kobayashi Y., Lee C.G., Flavell R.A., Elias J.A.
      J. Immunol. 182:5098-5106(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ASP-138.
    9. Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 22-408 IN COMPLEX WITH METHYLALLOSAMIDIN, CATALYTIC ACTIVITY, DISULFIDE BONDS.
    10. Cited for: VARIANTS ASP-45; ASN-47; MET-61; ARG-102; ARG-125; VAL-339; SER-354 AND GLY-432, CATALYTIC ACTIVITY, FUNCTION, CHARACTERIZATION OF VARIANTS ASP-45; ASN-47 AND MET-61.

    Entry informationi

    Entry nameiCHIA_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZP6
    Secondary accession number(s): Q32W79
    , Q32W80, Q3B866, Q5U5Z5, Q5VUV4, Q86UD8, Q9ULY3, Q9ULY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3