Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NKG2D ligand 2

Gene

ULBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.1 Publication

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation Source: GO_Central
  • natural killer cell activation Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SIGNORiQ9BZM5.

Names & Taxonomyi

Protein namesi
Recommended name:
NKG2D ligand 2
Short name:
N2DL-2
Short name:
NKG2DL2
Alternative name(s):
ALCAN-alpha
Retinoic acid early transcript 1H
UL16-binding protein 2
Gene namesi
Name:ULBP2
Synonyms:N2DL2, RAET1H
ORF Names:UNQ463/PRO791
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14894. ULBP2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • cell surface Source: BHF-UCL
  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi208 – 2103SAG → TPV: Secreted. 1 Publication
Mutagenesisi216 – 2183SSG → TPV: Not secreted. 1 Publication

Organism-specific databases

PharmGKBiPA37916.

Polymorphism and mutation databases

BioMutaiULBP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 216191NKG2D ligand 2PRO_0000019017Add
BLAST
Propeptidei217 – 24630Removed in mature form1 PublicationPRO_0000019018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66By similarity
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 190By similarity
Lipidationi216 – 2161GPI-anchor amidated serine2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ9BZM5.
MaxQBiQ9BZM5.
PaxDbiQ9BZM5.
PeptideAtlasiQ9BZM5.
PRIDEiQ9BZM5.

PTM databases

iPTMnetiQ9BZM5.
PhosphoSiteiQ9BZM5.

Expressioni

Tissue specificityi

Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.1 Publication

Gene expression databases

BgeeiENSG00000131015.
CleanExiHS_ULBP2.
GenevisibleiQ9BZM5. HS.

Organism-specific databases

HPAiCAB018974.

Interactioni

Subunit structurei

Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.1 Publication

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123240. 16 interactions.
IntActiQ9BZM5. 1 interaction.
STRINGi9606.ENSP00000356320.

Structurei

3D structure databases

ProteinModelPortaliQ9BZM5.
SMRiQ9BZM5. Positions 29-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 11789MHC class I alpha-1 likeAdd
BLAST
Regioni118 – 21093MHC class I alpha-2 likeAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4VC. Eukaryota.
ENOG41113ZC. LUCA.
GeneTreeiENSGT00390000003472.
HOGENOMiHOG000070028.
HOVERGENiHBG052564.
InParanoidiQ9BZM5.
KOiK07986.
OMAiGNETHIP.
OrthoDBiEOG091G0I62.
PhylomeDBiQ9BZM5.
TreeFamiTF341724.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAATKIL LCLPLLLLLS GWSRAGRADP HSLCYDITVI PKFRPGPRWC
60 70 80 90 100
AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI
110 120 130 140 150
LTEQLRDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL
160 170 180 190 200
FDSEKRMWTT VHPGARKMKE KWENDKVVAM SFHYFSMGDC IGWLEDFLMG
210 220 230 240
MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI
Length:246
Mass (Da):27,368
Last modified:June 1, 2001 - v1
Checksum:i804D1A0D4A9C5CF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304378 mRNA. Translation: AAK13082.1.
AB052906 mRNA. Translation: BAB61048.1.
AY026825 mRNA. Translation: AAK07688.1.
AY358665 mRNA. Translation: AAQ89028.1.
AL583835 Genomic DNA. Translation: CAH71655.1.
CH471051 Genomic DNA. Translation: EAW47777.1.
BC034689 mRNA. Translation: AAH34689.1.
CCDSiCCDS5222.1.
RefSeqiNP_079493.1. NM_025217.3.
UniGeneiHs.656778.

Genome annotation databases

EnsembliENST00000367351; ENSP00000356320; ENSG00000131015.
GeneIDi80328.
KEGGihsa:80328.
UCSCiuc003qno.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304378 mRNA. Translation: AAK13082.1.
AB052906 mRNA. Translation: BAB61048.1.
AY026825 mRNA. Translation: AAK07688.1.
AY358665 mRNA. Translation: AAQ89028.1.
AL583835 Genomic DNA. Translation: CAH71655.1.
CH471051 Genomic DNA. Translation: EAW47777.1.
BC034689 mRNA. Translation: AAH34689.1.
CCDSiCCDS5222.1.
RefSeqiNP_079493.1. NM_025217.3.
UniGeneiHs.656778.

3D structure databases

ProteinModelPortaliQ9BZM5.
SMRiQ9BZM5. Positions 29-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123240. 16 interactions.
IntActiQ9BZM5. 1 interaction.
STRINGi9606.ENSP00000356320.

PTM databases

iPTMnetiQ9BZM5.
PhosphoSiteiQ9BZM5.

Polymorphism and mutation databases

BioMutaiULBP2.

Proteomic databases

EPDiQ9BZM5.
MaxQBiQ9BZM5.
PaxDbiQ9BZM5.
PeptideAtlasiQ9BZM5.
PRIDEiQ9BZM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367351; ENSP00000356320; ENSG00000131015.
GeneIDi80328.
KEGGihsa:80328.
UCSCiuc003qno.4. human.

Organism-specific databases

CTDi80328.
GeneCardsiULBP2.
HGNCiHGNC:14894. ULBP2.
HPAiCAB018974.
MIMi605698. gene.
neXtProtiNX_Q9BZM5.
PharmGKBiPA37916.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4VC. Eukaryota.
ENOG41113ZC. LUCA.
GeneTreeiENSGT00390000003472.
HOGENOMiHOG000070028.
HOVERGENiHBG052564.
InParanoidiQ9BZM5.
KOiK07986.
OMAiGNETHIP.
OrthoDBiEOG091G0I62.
PhylomeDBiQ9BZM5.
TreeFamiTF341724.

Enzyme and pathway databases

SIGNORiQ9BZM5.

Miscellaneous databases

GeneWikiiULBP2.
GenomeRNAii80328.
PROiQ9BZM5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131015.
CleanExiHS_ULBP2.
GenevisibleiQ9BZM5. HS.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiN2DL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM5
Secondary accession number(s): Q5VUN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.