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Protein

UL16-binding protein 2

Gene

ULBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.1 Publication

Miscellaneous

UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

  • natural killer cell activation Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
SIGNORiQ9BZM5

Names & Taxonomyi

Protein namesi
Recommended name:
UL16-binding protein 2
Alternative name(s):
ALCAN-alpha
NKG2D ligand 2
Short name:
N2DL-2
Short name:
NKG2DL2
Retinoic acid early transcript 1H
Gene namesi
Name:ULBP2
Synonyms:N2DL2, RAET1H
ORF Names:UNQ463/PRO791
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000131015.4
HGNCiHGNC:14894 ULBP2
MIMi605698 gene
neXtProtiNX_Q9BZM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi208 – 210SAG → TPV: Secreted. 1 Publication3
Mutagenesisi216 – 218SSG → TPV: Not secreted. 1 Publication3

Organism-specific databases

DisGeNETi80328
OpenTargetsiENSG00000131015
PharmGKBiPA37916

Polymorphism and mutation databases

BioMutaiULBP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001901726 – 216UL16-binding protein 2Add BLAST191
PropeptideiPRO_0000019018217 – 246Removed in mature form1 PublicationAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66By similarity
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 190By similarity
Lipidationi216GPI-anchor amidated serine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ9BZM5
MaxQBiQ9BZM5
PaxDbiQ9BZM5
PeptideAtlasiQ9BZM5
PRIDEiQ9BZM5
ProteomicsDBi79878

PTM databases

iPTMnetiQ9BZM5
PhosphoSitePlusiQ9BZM5

Expressioni

Tissue specificityi

Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.1 Publication

Gene expression databases

BgeeiENSG00000131015
CleanExiHS_ULBP2
GenevisibleiQ9BZM5 HS

Organism-specific databases

HPAiCAB018974

Interactioni

Subunit structurei

Interacts with KLRK1/NKG2D (PubMed:11777960). Does not bind to beta2-microglobulin (PubMed:12782710).2 Publications
(Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP2 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRK1P267186EBI-3919993,EBI-458344

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123240, 17 interactors
CORUMiQ9BZM5
IntActiQ9BZM5, 4 interactors
STRINGi9606.ENSP00000356320

Structurei

3D structure databases

ProteinModelPortaliQ9BZM5
SMRiQ9BZM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 117MHC class I alpha-1 likeAdd BLAST89
Regioni118 – 210MHC class I alpha-2 likeAdd BLAST93

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4VC Eukaryota
ENOG41113ZC LUCA
GeneTreeiENSGT00390000003472
HOGENOMiHOG000070028
HOVERGENiHBG052564
InParanoidiQ9BZM5
KOiK07986
OMAiNISMGDC
OrthoDBiEOG091G0I62
PhylomeDBiQ9BZM5
TreeFamiTF341724

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF00129 MHC_I, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAATKIL LCLPLLLLLS GWSRAGRADP HSLCYDITVI PKFRPGPRWC
60 70 80 90 100
AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI
110 120 130 140 150
LTEQLRDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL
160 170 180 190 200
FDSEKRMWTT VHPGARKMKE KWENDKVVAM SFHYFSMGDC IGWLEDFLMG
210 220 230 240
MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI
Length:246
Mass (Da):27,368
Last modified:June 1, 2001 - v1
Checksum:i804D1A0D4A9C5CF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304378 mRNA Translation: AAK13082.1
AB052906 mRNA Translation: BAB61048.1
AY026825 mRNA Translation: AAK07688.1
AY358665 mRNA Translation: AAQ89028.1
AL583835 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47777.1
BC034689 mRNA Translation: AAH34689.1
CCDSiCCDS5222.1
RefSeqiNP_079493.1, NM_025217.3
UniGeneiHs.656778

Genome annotation databases

EnsembliENST00000367351; ENSP00000356320; ENSG00000131015
GeneIDi80328
KEGGihsa:80328
UCSCiuc003qno.4 human

Similar proteinsi

Entry informationi

Entry nameiULBP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM5
Secondary accession number(s): Q5VUN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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