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Protein

NKG2D ligand 3

Gene

ULBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.1 Publication

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation Source: GO_Central
  • natural killer cell activation Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of immune response Source: Reactome
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131019-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
NKG2D ligand 3
Short name:
N2DL-3
Short name:
NKG2DL3
Alternative name(s):
ALCAN-gamma
Retinoic acid early transcript 1N
Gene namesi
Name:ULBP3
Synonyms:N2DL3, RAET1N
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14895. ULBP3.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79465.
OpenTargetsiENSG00000131019.
PharmGKBiPA37917.

Polymorphism and mutation databases

BioMutaiULBP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001901930 – 217NKG2D ligand 3Add BLAST188
PropeptideiPRO_0000019020218 – 244Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi51 ↔ 67
Disulfide bondi128 ↔ 191
Lipidationi217GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9BZM4.
PaxDbiQ9BZM4.
PeptideAtlasiQ9BZM4.
PRIDEiQ9BZM4.

PTM databases

iPTMnetiQ9BZM4.
PhosphoSitePlusiQ9BZM4.

Expressioni

Gene expression databases

BgeeiENSG00000131019.
CleanExiHS_ULBP3.
GenevisibleiQ9BZM4. HS.

Organism-specific databases

HPAiHPA063007.

Interactioni

Subunit structurei

Does not bind to beta2-microglobulin. Interacts with human cytomegalovirus/HHV-5 protein UL142.3 Publications

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122673. 19 interactors.
IntActiQ9BZM4. 1 interactor.
STRINGi9606.ENSP00000356308.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 43Combined sources12
Beta strandi50 – 57Combined sources8
Beta strandi60 – 66Combined sources7
Turni67 – 70Combined sources4
Beta strandi83 – 85Combined sources3
Helixi86 – 107Combined sources22
Beta strandi121 – 130Combined sources10
Beta strandi137 – 153Combined sources17
Turni154 – 157Combined sources4
Beta strandi158 – 163Combined sources6
Helixi164 – 166Combined sources3
Helixi167 – 175Combined sources9
Helixi177 – 188Combined sources12
Helixi190 – 206Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KCGX-ray2.60C30-207[»]
ProteinModelPortaliQ9BZM4.
SMRiQ9BZM4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZM4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 118MHC class I alpha-1 likeAdd BLAST89
Regioni119 – 209MHC class I alpha-2 likeAdd BLAST91

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4VC. Eukaryota.
ENOG41113ZC. LUCA.
GeneTreeiENSGT00390000003472.
HOGENOMiHOG000070028.
HOVERGENiHBG052564.
InParanoidiQ9BZM4.
KOiK07986.
OMAiWGKQLEM.
OrthoDBiEOG091G0I62.
PhylomeDBiQ9BZM4.
TreeFamiTF341724.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAASPAIL PRLAILPYLL FDWSGTGRAD AHSLWYNFTI IHLPRHGQQW
60 70 80 90 100
CEVQSQVDQK NFLSYDCGSD KVLSMGHLEE QLYATDAWGK QLEMLREVGQ
110 120 130 140 150
RLRLELADTE LEDFTPSGPL TLQVRMSCEC EADGYIRGSW QFSFDGRKFL
160 170 180 190 200
LFDSNNRKWT VVHAGARRMK EKWEKDSGLT TFFKMVSMRD CKSWLRDFLM
210 220 230 240
HRKKRLEPTA PPTMAPGLAQ PKAIATTLSP WSFLIILCFI LPGI
Length:244
Mass (Da):27,949
Last modified:June 1, 2001 - v1
Checksum:iBAF07895640B9901
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304379 mRNA. Translation: AAK13083.1.
AB052908 mRNA. Translation: BAB61050.1.
AK315275 mRNA. Translation: BAG37687.1.
AL355497 Genomic DNA. Translation: CAH74128.1.
CH471051 Genomic DNA. Translation: EAW47772.1.
BC098127 mRNA. Translation: AAH98127.1.
AF346596 mRNA. Translation: AAN40839.1.
AY027538 mRNA. Translation: AAK13049.1.
CCDSiCCDS5225.1.
RefSeqiNP_078794.1. NM_024518.2.
UniGeneiHs.15422.
Hs.326556.

Genome annotation databases

EnsembliENST00000367339; ENSP00000356308; ENSG00000131019.
ENST00000438272; ENSP00000403562; ENSG00000131019.
GeneIDi79465.
KEGGihsa:79465.
UCSCiuc003qns.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304379 mRNA. Translation: AAK13083.1.
AB052908 mRNA. Translation: BAB61050.1.
AK315275 mRNA. Translation: BAG37687.1.
AL355497 Genomic DNA. Translation: CAH74128.1.
CH471051 Genomic DNA. Translation: EAW47772.1.
BC098127 mRNA. Translation: AAH98127.1.
AF346596 mRNA. Translation: AAN40839.1.
AY027538 mRNA. Translation: AAK13049.1.
CCDSiCCDS5225.1.
RefSeqiNP_078794.1. NM_024518.2.
UniGeneiHs.15422.
Hs.326556.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KCGX-ray2.60C30-207[»]
ProteinModelPortaliQ9BZM4.
SMRiQ9BZM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122673. 19 interactors.
IntActiQ9BZM4. 1 interactor.
STRINGi9606.ENSP00000356308.

PTM databases

iPTMnetiQ9BZM4.
PhosphoSitePlusiQ9BZM4.

Polymorphism and mutation databases

BioMutaiULBP3.

Proteomic databases

MaxQBiQ9BZM4.
PaxDbiQ9BZM4.
PeptideAtlasiQ9BZM4.
PRIDEiQ9BZM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367339; ENSP00000356308; ENSG00000131019.
ENST00000438272; ENSP00000403562; ENSG00000131019.
GeneIDi79465.
KEGGihsa:79465.
UCSCiuc003qns.4. human.

Organism-specific databases

CTDi79465.
DisGeNETi79465.
GeneCardsiULBP3.
HGNCiHGNC:14895. ULBP3.
HPAiHPA063007.
MIMi605699. gene.
neXtProtiNX_Q9BZM4.
OpenTargetsiENSG00000131019.
PharmGKBiPA37917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4VC. Eukaryota.
ENOG41113ZC. LUCA.
GeneTreeiENSGT00390000003472.
HOGENOMiHOG000070028.
HOVERGENiHBG052564.
InParanoidiQ9BZM4.
KOiK07986.
OMAiWGKQLEM.
OrthoDBiEOG091G0I62.
PhylomeDBiQ9BZM4.
TreeFamiTF341724.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131019-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiQ9BZM4.
GeneWikiiULBP3.
GenomeRNAii79465.
PROiQ9BZM4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131019.
CleanExiHS_ULBP3.
GenevisibleiQ9BZM4. HS.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiN2DL3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM4
Secondary accession number(s): Q5VY82, Q8IZX5, Q8TE75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.
The region from chromosome 6q24.1-6q25.3 contains as many as 10 ULBP-related sequences, many of which are pseudogenes.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.