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Protein

UL16-binding protein 3

Gene

ULBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.3 Publications

Miscellaneous

UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.Curated

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

  • natural killer cell activation Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of immune response Source: Reactome
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
UL16-binding protein 3
Alternative name(s):
ALCAN-gamma
NKG2D ligand 3
Short name:
N2DL-3
Short name:
NKG2DL3
Retinoic acid early transcript 1N
Gene namesi
Name:ULBP3
Synonyms:N2DL3, RAET1N
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000131019.10
HGNCiHGNC:14895 ULBP3
MIMi605699 gene
neXtProtiNX_Q9BZM4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79465
OpenTargetsiENSG00000131019
PharmGKBiPA37917

Polymorphism and mutation databases

BioMutaiULBP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001901930 – 217UL16-binding protein 3Add BLAST188
PropeptideiPRO_0000019020218 – 244Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 67
Disulfide bondi128 ↔ 191
Lipidationi217GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9BZM4
PaxDbiQ9BZM4
PeptideAtlasiQ9BZM4
PRIDEiQ9BZM4
ProteomicsDBi79877

PTM databases

iPTMnetiQ9BZM4
PhosphoSitePlusiQ9BZM4

Expressioni

Gene expression databases

BgeeiENSG00000131019
CleanExiHS_ULBP3
GenevisibleiQ9BZM4 HS

Organism-specific databases

HPAiHPA056541
HPA063007

Interactioni

Subunit structurei

Interacts with KLRK1/NKG2D (PubMed:11491531, PubMed:11777960, PubMed:11754823). Does not bind to beta2-microglobulin (By similarity).By similarity3 Publications
(Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16 and UL142; this interaction causes ULBP3 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRK1P267184EBI-1032551,EBI-458344

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122673, 22 interactors
CORUMiQ9BZM4
IntActiQ9BZM4, 1 interactor
STRINGi9606.ENSP00000356308

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 43Combined sources12
Beta strandi50 – 57Combined sources8
Beta strandi60 – 66Combined sources7
Turni67 – 70Combined sources4
Beta strandi83 – 85Combined sources3
Helixi86 – 107Combined sources22
Beta strandi121 – 130Combined sources10
Beta strandi137 – 153Combined sources17
Turni154 – 157Combined sources4
Beta strandi158 – 163Combined sources6
Helixi164 – 166Combined sources3
Helixi167 – 175Combined sources9
Helixi177 – 188Combined sources12
Helixi190 – 206Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KCGX-ray2.60C30-207[»]
ProteinModelPortaliQ9BZM4
SMRiQ9BZM4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZM4

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 118MHC class I alpha-1 likeAdd BLAST89
Regioni119 – 209MHC class I alpha-2 likeAdd BLAST91

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4VC Eukaryota
ENOG41113ZC LUCA
GeneTreeiENSGT00390000003472
HOGENOMiHOG000070028
HOVERGENiHBG052564
InParanoidiQ9BZM4
KOiK07986
OMAiWGKQLEM
OrthoDBiEOG091G0I62
PhylomeDBiQ9BZM4
TreeFamiTF341724

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF00129 MHC_I, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAASPAIL PRLAILPYLL FDWSGTGRAD AHSLWYNFTI IHLPRHGQQW
60 70 80 90 100
CEVQSQVDQK NFLSYDCGSD KVLSMGHLEE QLYATDAWGK QLEMLREVGQ
110 120 130 140 150
RLRLELADTE LEDFTPSGPL TLQVRMSCEC EADGYIRGSW QFSFDGRKFL
160 170 180 190 200
LFDSNNRKWT VVHAGARRMK EKWEKDSGLT TFFKMVSMRD CKSWLRDFLM
210 220 230 240
HRKKRLEPTA PPTMAPGLAQ PKAIATTLSP WSFLIILCFI LPGI
Length:244
Mass (Da):27,949
Last modified:June 1, 2001 - v1
Checksum:iBAF07895640B9901
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304379 mRNA Translation: AAK13083.1
AB052908 mRNA Translation: BAB61050.1
AK315275 mRNA Translation: BAG37687.1
AL355497 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47772.1
BC098127 mRNA Translation: AAH98127.1
AF346596 mRNA Translation: AAN40839.1
AY027538 mRNA Translation: AAK13049.1
CCDSiCCDS5225.1
RefSeqiNP_078794.1, NM_024518.2
UniGeneiHs.15422
Hs.326556

Genome annotation databases

EnsembliENST00000367339; ENSP00000356308; ENSG00000131019
ENST00000438272; ENSP00000403562; ENSG00000131019
GeneIDi79465
KEGGihsa:79465
UCSCiuc003qns.4 human

Similar proteinsi

Entry informationi

Entry nameiULBP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM4
Secondary accession number(s): Q5VY82, Q8IZX5, Q8TE75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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