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Protein

GS homeobox 2

Gene

GSX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5'-CNAATTAG-3' DNA sequence.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi202 – 261HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GS homeobox 2
Alternative name(s):
Genetic-screened homeobox 2
Homeobox protein GSH-2
Gene namesi
Name:GSX2
Synonyms:GSH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000180613.10
HGNCiHGNC:24959 GSX2
MIMi616253 gene
neXtProtiNX_Q9BZM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi170825
OpenTargetsiENSG00000180613
PharmGKBiPA162390374

Polymorphism and mutation databases

BioMutaiGSX2
DMDMi296434530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488961 – 304GS homeobox 2Add BLAST304

Proteomic databases

PaxDbiQ9BZM3
PeptideAtlasiQ9BZM3
PRIDEiQ9BZM3

Expressioni

Gene expression databases

BgeeiENSG00000180613
CleanExiHS_GSX2
ExpressionAtlasiQ9BZM3 baseline and differential
GenevisibleiQ9BZM3 HS

Interactioni

Protein-protein interaction databases

IntActiQ9BZM3, 1 interactor
STRINGi9606.ENSP00000319118

Structurei

3D structure databases

ProteinModelPortaliQ9BZM3
SMRiQ9BZM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 130Poly-His7
Compositional biasi134 – 139Poly-His6
Compositional biasi147 – 162Poly-AlaAdd BLAST16

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000010106
HOVERGENiHBG003555
InParanoidiQ9BZM3
KOiK09310
OMAiFCVCPLC
OrthoDBiEOG091G0HAO
PhylomeDBiQ9BZM3
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BZM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSFYVDSL IIKDTSRPAP SLPEPHPGPD FFIPLGMPPP LVMSVSGPGC
60 70 80 90 100
PSRKSGAFCV CPLCVTSHLH SSRGSVGAGS GGAGAGVTGA GGSGVAGAAG
110 120 130 140 150
ALPLLKGQFS SAPGDAQFCP RVNHAHHHHH PPQHHHHHHQ PQQPGSAAAA
160 170 180 190 200
AAAAAAAAAA AALGHPQHHA PVCTATTYNV ADPRRFHCLT MGGSDASQVP
210 220 230 240 250
NGKRMRTAFT STQLLELERE FSSNMYLSRL RRIEIATYLN LSEKQVKIWF
260 270 280 290 300
QNRRVKHKKE GKGTQRNSHA GCKCVGSQVH YARSEDEDSL SPASANDDKE

ISPL
Length:304
Mass (Da):32,031
Last modified:May 18, 2010 - v2
Checksum:i2C879AC635C07F0D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049580107G → S4 PublicationsCorresponds to variant dbSNP:rs13144341Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028838 mRNA Translation: BAB84822.1
AF306344, AF306343 Genomic DNA Translation: AAK00880.1
AF439445 Genomic DNA Translation: AAM08285.1
AC110298 Genomic DNA No translation available.
BC075089 mRNA Translation: AAH75089.1
BC075090 mRNA Translation: AAH75090.1
CCDSiCCDS3494.1
RefSeqiNP_573574.1, NM_133267.2
UniGeneiHs.371899

Genome annotation databases

EnsembliENST00000326902; ENSP00000319118; ENSG00000180613
ENST00000611459; ENSP00000483522; ENSG00000180613
GeneIDi170825
KEGGihsa:170825
UCSCiuc010igp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGSX2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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