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Protein

Group XIIA secretory phospholipase A2

Gene

PLA2G12A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.1 Publication

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88Calcium; via carbonyl oxygenBy similarity1
Metal bindingi90Calcium; via carbonyl oxygenBy similarity1
Metal bindingi92Calcium; via carbonyl oxygenBy similarity1
Active sitei110PROSITE-ProRule annotation1
Metal bindingi111CalciumBy similarity1
Active sitei125PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Group XIIA secretory phospholipase A2 (EC:3.1.1.4)
Short name:
GXII sPLA2
Short name:
sPLA2-XII
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase 12A
Gene namesi
Name:PLA2G12A
Synonyms:PLA2G12
ORF Names:FKSG38, UNQ2519/PRO6012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000123739.10
HGNCiHGNC:18554 PLA2G12A
MIMi611652 gene
neXtProtiNX_Q9BZM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi81579
OpenTargetsiENSG00000123739
PharmGKBiPA38347

Chemistry databases

ChEMBLiCHEMBL6122

Polymorphism and mutation databases

BioMutaiPLA2G12A
DMDMi20143881

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22CuratedAdd BLAST22
ChainiPRO_000002277023 – 189Group XIIA secretory phospholipase A2Add BLAST167

Proteomic databases

MaxQBiQ9BZM1
PaxDbiQ9BZM1
PeptideAtlasiQ9BZM1
PRIDEiQ9BZM1

PTM databases

iPTMnetiQ9BZM1
PhosphoSitePlusiQ9BZM1

Expressioni

Tissue specificityi

Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.

Gene expression databases

BgeeiENSG00000123739
CleanExiHS_PLA2G12A
ExpressionAtlasiQ9BZM1 baseline and differential
GenevisibleiQ9BZM1 HS

Organism-specific databases

HPAiHPA035908
HPA035909

Interactioni

Protein-protein interaction databases

BioGridi12353912 interactors.
IntActiQ9BZM1 10 interactors.
STRINGi9606.ENSP00000243501

Structurei

3D structure databases

ProteinModelPortaliQ9BZM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIHB Eukaryota
ENOG4111HAE LUCA
GeneTreeiENSGT00390000008798
HOGENOMiHOG000247019
HOVERGENiHBG053577
InParanoidiQ9BZM1
KOiK01047
OMAiLFDAVMH
OrthoDBiEOG091G10MQ
PhylomeDBiQ9BZM1
TreeFamiTF323302

Family and domain databases

InterProiView protein in InterPro
IPR010711 PLA2G12
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR12824 PTHR12824, 1 hit
PfamiView protein in Pfam
PF06951 PLA2G12, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLSRPALT LLLLLMAAVV RCQEQAQTTD WRATLKTIRN GVHKIDTYLN
60 70 80 90 100
AALDLLGGED GLCQYKCSDG SKPFPRYGYK PSPPNGCGSP LFGVHLNIGI
110 120 130 140 150
PSLTKCCNQH DRCYETCGKS KNDCDEEFQY CLSKICRDVQ KTLGLTQHVQ
160 170 180
ACETTVELLF DSVIHLGCKP YLDSQRAACR CHYEEKTDL
Length:189
Mass (Da):21,067
Last modified:June 1, 2001 - v1
Checksum:i7979881D6E9223A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94 – 95Missing in AAG50289 (Ref. 2) Curated2

Mass spectrometryi

Molecular mass is 18702.6±0.5 Da from positions 22 - 189. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306567 mRNA Translation: AAG50243.1
AF332892 mRNA Translation: AAG50289.1
AY359024 mRNA Translation: AAQ89383.1
BC017218 mRNA Translation: AAH17218.1
CCDSiCCDS3686.1
RefSeqiNP_110448.2, NM_030821.4
UniGeneiHs.389452

Genome annotation databases

EnsembliENST00000243501; ENSP00000243501; ENSG00000123739
GeneIDi81579
KEGGihsa:81579
UCSCiuc003hzp.4 human

Similar proteinsi

Entry informationi

Entry nameiPG12A_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM1
Secondary accession number(s): Q9BZ89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome