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Q9BZM1

- PG12A_HUMAN

UniProt

Q9BZM1 - PG12A_HUMAN

Protein

Group XIIA secretory phospholipase A2

Gene

PLA2G12A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.1 Publication

    Catalytic activityi

    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881Calcium; via carbonyl oxygenBy similarity
    Metal bindingi90 – 901Calcium; via carbonyl oxygenBy similarity
    Metal bindingi92 – 921Calcium; via carbonyl oxygenBy similarity
    Active sitei110 – 1101PROSITE-ProRule annotation
    Metal bindingi111 – 1111CalciumBy similarity
    Active sitei125 – 1251PROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium-dependent phospholipase A2 activity Source: UniProtKB
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. lipid catabolic process Source: UniProtKB-KW
    3. phosphatidic acid biosynthetic process Source: Reactome
    4. phosphatidylcholine acyl-chain remodeling Source: Reactome
    5. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
    6. phosphatidylglycerol acyl-chain remodeling Source: Reactome
    7. phosphatidylinositol acyl-chain remodeling Source: Reactome
    8. phosphatidylserine acyl-chain remodeling Source: Reactome
    9. phospholipid metabolic process Source: Reactome
    10. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_120722. Acyl chain remodelling of PI.
    REACT_120829. Acyl chain remodelling of PC.
    REACT_120906. Synthesis of PA.
    REACT_121324. Acyl chain remodelling of PG.
    REACT_121369. Acyl chain remodelling of PE.
    REACT_121384. Acyl chain remodelling of PS.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Group XIIA secretory phospholipase A2 (EC:3.1.1.4)
    Short name:
    GXII sPLA2
    Short name:
    sPLA2-XII
    Alternative name(s):
    Phosphatidylcholine 2-acylhydrolase 12A
    Gene namesi
    Name:PLA2G12A
    Synonyms:PLA2G12
    ORF Names:FKSG38, UNQ2519/PRO6012
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:18554. PLA2G12A.

    Subcellular locationi

    Secreted 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. extracellular region Source: UniProtKB
    3. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38347.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222CuratedAdd
    BLAST
    Chaini23 – 189167Group XIIA secretory phospholipase A2PRO_0000022770Add
    BLAST

    Proteomic databases

    MaxQBiQ9BZM1.
    PaxDbiQ9BZM1.
    PeptideAtlasiQ9BZM1.
    PRIDEiQ9BZM1.

    PTM databases

    PhosphoSiteiQ9BZM1.

    Expressioni

    Tissue specificityi

    Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.

    Gene expression databases

    ArrayExpressiQ9BZM1.
    BgeeiQ9BZM1.
    CleanExiHS_PLA2G12A.
    GenevestigatoriQ9BZM1.

    Organism-specific databases

    HPAiHPA035909.

    Interactioni

    Protein-protein interaction databases

    BioGridi123539. 10 interactions.
    IntActiQ9BZM1. 10 interactions.
    STRINGi9606.ENSP00000243501.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZM1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phospholipase A2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG68062.
    HOGENOMiHOG000247019.
    HOVERGENiHBG053577.
    InParanoidiQ9BZM1.
    KOiK01047.
    OMAiKICRNVQ.
    OrthoDBiEOG7J1818.
    PhylomeDBiQ9BZM1.
    TreeFamiTF323302.

    Family and domain databases

    Gene3Di1.20.90.10. 1 hit.
    InterProiIPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    IPR010711. PLipase_A2_secretory_G12.
    [Graphical view]
    PANTHERiPTHR12824. PTHR12824. 1 hit.
    PfamiPF06951. PLA2G12. 1 hit.
    [Graphical view]
    SUPFAMiSSF48619. SSF48619. 1 hit.
    PROSITEiPS00118. PA2_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BZM1-1 [UniParc]FASTAAdd to Basket

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    MALLSRPALT LLLLLMAAVV RCQEQAQTTD WRATLKTIRN GVHKIDTYLN    50
    AALDLLGGED GLCQYKCSDG SKPFPRYGYK PSPPNGCGSP LFGVHLNIGI 100
    PSLTKCCNQH DRCYETCGKS KNDCDEEFQY CLSKICRDVQ KTLGLTQHVQ 150
    ACETTVELLF DSVIHLGCKP YLDSQRAACR CHYEEKTDL 189
    Length:189
    Mass (Da):21,067
    Last modified:June 1, 2001 - v1
    Checksum:i7979881D6E9223A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 952Missing in AAG50289. 1 PublicationCurated

    Mass spectrometryi

    Molecular mass is 18702.6±0.5 Da from positions 22 - 189. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306567 mRNA. Translation: AAG50243.1.
    AF332892 mRNA. Translation: AAG50289.1.
    AY359024 mRNA. Translation: AAQ89383.1.
    BC017218 mRNA. Translation: AAH17218.1.
    CCDSiCCDS3686.1.
    RefSeqiNP_110448.2. NM_030821.4.
    UniGeneiHs.389452.

    Genome annotation databases

    EnsembliENST00000243501; ENSP00000243501; ENSG00000123739.
    ENST00000502283; ENSP00000425274; ENSG00000123739.
    GeneIDi81579.
    KEGGihsa:81579.
    UCSCiuc003hzp.3. human.

    Polymorphism databases

    DMDMi20143881.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306567 mRNA. Translation: AAG50243.1 .
    AF332892 mRNA. Translation: AAG50289.1 .
    AY359024 mRNA. Translation: AAQ89383.1 .
    BC017218 mRNA. Translation: AAH17218.1 .
    CCDSi CCDS3686.1.
    RefSeqi NP_110448.2. NM_030821.4.
    UniGenei Hs.389452.

    3D structure databases

    ProteinModelPortali Q9BZM1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123539. 10 interactions.
    IntActi Q9BZM1. 10 interactions.
    STRINGi 9606.ENSP00000243501.

    Chemistry

    ChEMBLi CHEMBL6122.

    PTM databases

    PhosphoSitei Q9BZM1.

    Polymorphism databases

    DMDMi 20143881.

    Proteomic databases

    MaxQBi Q9BZM1.
    PaxDbi Q9BZM1.
    PeptideAtlasi Q9BZM1.
    PRIDEi Q9BZM1.

    Protocols and materials databases

    DNASUi 81579.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243501 ; ENSP00000243501 ; ENSG00000123739 .
    ENST00000502283 ; ENSP00000425274 ; ENSG00000123739 .
    GeneIDi 81579.
    KEGGi hsa:81579.
    UCSCi uc003hzp.3. human.

    Organism-specific databases

    CTDi 81579.
    GeneCardsi GC04M110631.
    HGNCi HGNC:18554. PLA2G12A.
    HPAi HPA035909.
    MIMi 611652. gene.
    neXtProti NX_Q9BZM1.
    PharmGKBi PA38347.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68062.
    HOGENOMi HOG000247019.
    HOVERGENi HBG053577.
    InParanoidi Q9BZM1.
    KOi K01047.
    OMAi KICRNVQ.
    OrthoDBi EOG7J1818.
    PhylomeDBi Q9BZM1.
    TreeFami TF323302.

    Enzyme and pathway databases

    Reactomei REACT_120722. Acyl chain remodelling of PI.
    REACT_120829. Acyl chain remodelling of PC.
    REACT_120906. Synthesis of PA.
    REACT_121324. Acyl chain remodelling of PG.
    REACT_121369. Acyl chain remodelling of PE.
    REACT_121384. Acyl chain remodelling of PS.

    Miscellaneous databases

    ChiTaRSi PLA2G12A. human.
    GeneWikii PLA2G12A.
    GenomeRNAii 81579.
    NextBioi 71900.
    PROi Q9BZM1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZM1.
    Bgeei Q9BZM1.
    CleanExi HS_PLA2G12A.
    Genevestigatori Q9BZM1.

    Family and domain databases

    Gene3Di 1.20.90.10. 1 hit.
    InterProi IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    IPR010711. PLipase_A2_secretory_G12.
    [Graphical view ]
    PANTHERi PTHR12824. PTHR12824. 1 hit.
    Pfami PF06951. PLA2G12. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48619. SSF48619. 1 hit.
    PROSITEi PS00118. PA2_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2."
      Gelb M.H., Valentin E., Ghomashchi F., Lazdunski M., Lambeau G.
      J. Biol. Chem. 275:39823-39826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, MASS SPECTROMETRY.
    2. "Identification of FKSG38, a novel gene located on human chromosome 4q25."
      Wang Y.-G., Gong L.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)."
      Murakami M., Masuda S., Shimbara S., Bezzine S., Lazdunski M., Lambeau G., Gelb M.H., Matsukura S., Kokubu F., Adachi M., Kudo I.
      J. Biol. Chem. 278:10657-10667(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPG12A_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZM1
    Secondary accession number(s): Q9BZ89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3