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Q9BZM1

- PG12A_HUMAN

UniProt

Q9BZM1 - PG12A_HUMAN

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Protein

Group XIIA secretory phospholipase A2

Gene
PLA2G12A, PLA2G12, FKSG38, UNQ2519/PRO6012
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.1 Publication

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881Calcium; via carbonyl oxygen By similarity
Metal bindingi90 – 901Calcium; via carbonyl oxygen By similarity
Metal bindingi92 – 921Calcium; via carbonyl oxygen By similarity
Active sitei110 – 1101 By similarity
Metal bindingi111 – 1111Calcium By similarity
Active sitei125 – 1251 By similarity

GO - Molecular functioni

  1. calcium-dependent phospholipase A2 activity Source: UniProtKB
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. lipid catabolic process Source: UniProtKB-KW
  3. phosphatidic acid biosynthetic process Source: Reactome
  4. phosphatidylcholine acyl-chain remodeling Source: Reactome
  5. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
  6. phosphatidylglycerol acyl-chain remodeling Source: Reactome
  7. phosphatidylinositol acyl-chain remodeling Source: Reactome
  8. phosphatidylserine acyl-chain remodeling Source: Reactome
  9. phospholipid metabolic process Source: Reactome
  10. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_120722. Acyl chain remodelling of PI.
REACT_120829. Acyl chain remodelling of PC.
REACT_120906. Synthesis of PA.
REACT_121324. Acyl chain remodelling of PG.
REACT_121369. Acyl chain remodelling of PE.
REACT_121384. Acyl chain remodelling of PS.

Names & Taxonomyi

Protein namesi
Recommended name:
Group XIIA secretory phospholipase A2 (EC:3.1.1.4)
Short name:
GXII sPLA2
Short name:
sPLA2-XII
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase 12A
Gene namesi
Synonyms:PLA2G12
ORF Names:FKSG38, UNQ2519/PRO6012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:18554. PLA2G12A.

Subcellular locationi

Secreted. Cytoplasm 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular region Source: UniProtKB
  3. Golgi apparatus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 InferredAdd
BLAST
Chaini23 – 189167Group XIIA secretory phospholipase A2PRO_0000022770Add
BLAST

Proteomic databases

MaxQBiQ9BZM1.
PaxDbiQ9BZM1.
PeptideAtlasiQ9BZM1.
PRIDEiQ9BZM1.

PTM databases

PhosphoSiteiQ9BZM1.

Expressioni

Tissue specificityi

Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.

Gene expression databases

ArrayExpressiQ9BZM1.
BgeeiQ9BZM1.
CleanExiHS_PLA2G12A.
GenevestigatoriQ9BZM1.

Organism-specific databases

HPAiHPA035909.

Interactioni

Protein-protein interaction databases

BioGridi123539. 10 interactions.
IntActiQ9BZM1. 10 interactions.
STRINGi9606.ENSP00000243501.

Structurei

3D structure databases

ProteinModelPortaliQ9BZM1.

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68062.
HOGENOMiHOG000247019.
HOVERGENiHBG053577.
InParanoidiQ9BZM1.
KOiK01047.
OMAiKICRNVQ.
OrthoDBiEOG7J1818.
PhylomeDBiQ9BZM1.
TreeFamiTF323302.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR013090. PLipase_A2_AS.
IPR016090. PLipase_A2_dom.
IPR010711. PLipase_A2_secretory_G12.
[Graphical view]
PANTHERiPTHR12824. PTHR12824. 1 hit.
PfamiPF06951. PLA2G12. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZM1-1 [UniParc]FASTAAdd to Basket

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MALLSRPALT LLLLLMAAVV RCQEQAQTTD WRATLKTIRN GVHKIDTYLN    50
AALDLLGGED GLCQYKCSDG SKPFPRYGYK PSPPNGCGSP LFGVHLNIGI 100
PSLTKCCNQH DRCYETCGKS KNDCDEEFQY CLSKICRDVQ KTLGLTQHVQ 150
ACETTVELLF DSVIHLGCKP YLDSQRAACR CHYEEKTDL 189
Length:189
Mass (Da):21,067
Last modified:June 1, 2001 - v1
Checksum:i7979881D6E9223A4
GO

Mass spectrometryi

Molecular mass is 18702.6±0.5 Da from positions 22 - 189. Determined by MALDI. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 952Missing in AAG50289. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF306567 mRNA. Translation: AAG50243.1.
AF332892 mRNA. Translation: AAG50289.1.
AY359024 mRNA. Translation: AAQ89383.1.
BC017218 mRNA. Translation: AAH17218.1.
CCDSiCCDS3686.1.
RefSeqiNP_110448.2. NM_030821.4.
UniGeneiHs.389452.

Genome annotation databases

EnsembliENST00000243501; ENSP00000243501; ENSG00000123739.
ENST00000502283; ENSP00000425274; ENSG00000123739.
GeneIDi81579.
KEGGihsa:81579.
UCSCiuc003hzp.3. human.

Polymorphism databases

DMDMi20143881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF306567 mRNA. Translation: AAG50243.1 .
AF332892 mRNA. Translation: AAG50289.1 .
AY359024 mRNA. Translation: AAQ89383.1 .
BC017218 mRNA. Translation: AAH17218.1 .
CCDSi CCDS3686.1.
RefSeqi NP_110448.2. NM_030821.4.
UniGenei Hs.389452.

3D structure databases

ProteinModelPortali Q9BZM1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123539. 10 interactions.
IntActi Q9BZM1. 10 interactions.
STRINGi 9606.ENSP00000243501.

Chemistry

ChEMBLi CHEMBL6122.

PTM databases

PhosphoSitei Q9BZM1.

Polymorphism databases

DMDMi 20143881.

Proteomic databases

MaxQBi Q9BZM1.
PaxDbi Q9BZM1.
PeptideAtlasi Q9BZM1.
PRIDEi Q9BZM1.

Protocols and materials databases

DNASUi 81579.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243501 ; ENSP00000243501 ; ENSG00000123739 .
ENST00000502283 ; ENSP00000425274 ; ENSG00000123739 .
GeneIDi 81579.
KEGGi hsa:81579.
UCSCi uc003hzp.3. human.

Organism-specific databases

CTDi 81579.
GeneCardsi GC04M110631.
HGNCi HGNC:18554. PLA2G12A.
HPAi HPA035909.
MIMi 611652. gene.
neXtProti NX_Q9BZM1.
PharmGKBi PA38347.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68062.
HOGENOMi HOG000247019.
HOVERGENi HBG053577.
InParanoidi Q9BZM1.
KOi K01047.
OMAi KICRNVQ.
OrthoDBi EOG7J1818.
PhylomeDBi Q9BZM1.
TreeFami TF323302.

Enzyme and pathway databases

Reactomei REACT_120722. Acyl chain remodelling of PI.
REACT_120829. Acyl chain remodelling of PC.
REACT_120906. Synthesis of PA.
REACT_121324. Acyl chain remodelling of PG.
REACT_121369. Acyl chain remodelling of PE.
REACT_121384. Acyl chain remodelling of PS.

Miscellaneous databases

ChiTaRSi PLA2G12A. human.
GeneWikii PLA2G12A.
GenomeRNAii 81579.
NextBioi 71900.
PROi Q9BZM1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BZM1.
Bgeei Q9BZM1.
CleanExi HS_PLA2G12A.
Genevestigatori Q9BZM1.

Family and domain databases

Gene3Di 1.20.90.10. 1 hit.
InterProi IPR013090. PLipase_A2_AS.
IPR016090. PLipase_A2_dom.
IPR010711. PLipase_A2_secretory_G12.
[Graphical view ]
PANTHERi PTHR12824. PTHR12824. 1 hit.
Pfami PF06951. PLA2G12. 1 hit.
[Graphical view ]
SUPFAMi SSF48619. SSF48619. 1 hit.
PROSITEi PS00118. PA2_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2."
    Gelb M.H., Valentin E., Ghomashchi F., Lazdunski M., Lambeau G.
    J. Biol. Chem. 275:39823-39826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, MASS SPECTROMETRY.
  2. "Identification of FKSG38, a novel gene located on human chromosome 4q25."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)."
    Murakami M., Masuda S., Shimbara S., Bezzine S., Lazdunski M., Lambeau G., Gelb M.H., Matsukura S., Kokubu F., Adachi M., Kudo I.
    J. Biol. Chem. 278:10657-10667(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPG12A_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM1
Secondary accession number(s): Q9BZ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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