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Q9BZL3

- SMIM3_HUMAN

UniProt

Q9BZL3 - SMIM3_HUMAN

Protein

Small integral membrane protein 3

Gene

SMIM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small integral membrane protein 3
    Alternative name(s):
    NGF-induced differentiation clone 67 protein
    Small membrane protein NID67
    Gene namesi
    Name:SMIM3
    Synonyms:C5orf62, NID67
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30248. SMIM3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165660222.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060Small integral membrane protein 3PRO_0000096816Add
    BLAST

    Proteomic databases

    PRIDEiQ9BZL3.

    Expressioni

    Inductioni

    By NGF.

    Gene expression databases

    BgeeiQ9BZL3.
    GenevestigatoriQ9BZL3.

    Organism-specific databases

    HPAiHPA056610.

    Interactioni

    Protein-protein interaction databases

    BioGridi124436. 1 interaction.
    IntActiQ9BZL3. 1 interaction.
    MINTiMINT-1481070.
    STRINGi9606.ENSP00000322424.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000132849.
    HOVERGENiHBG065301.
    OMAiIYRVRTH.
    OrthoDBiEOG7B8S78.
    PhylomeDBiQ9BZL3.
    TreeFamiTF354124.

    Sequencei

    Sequence statusi: Complete.

    Q9BZL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAVSQVPME VVLPKHILDI WVIVLIILAT IVIMTSLLLC PATAVIIYRM   50
    RTHPILSGAV 60
    Length:60
    Mass (Da):6,593
    Last modified:June 1, 2001 - v1
    Checksum:iFEE7DA7A6E02B08E
    GO

    Sequence cautioni

    The sequence EAW61705.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF313413 mRNA. Translation: AAG53959.1.
    AK125286 mRNA. Translation: BAC86114.1. Sequence problems.
    AC010441 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61705.1. Sequence problems.
    BC009719 mRNA. Translation: AAH09719.1.
    BC101838 mRNA. Translation: AAI01839.1. Sequence problems.
    BC101840 mRNA. Translation: AAI01841.1. Sequence problems.
    BC106040 mRNA. Translation: AAI06041.1. Sequence problems.
    CCDSiCCDS47312.2.
    RefSeqiNP_116565.3. NM_032947.4.
    UniGeneiHs.29444.

    Genome annotation databases

    EnsembliENST00000526627; ENSP00000436897; ENSG00000256235.
    GeneIDi85027.
    KEGGihsa:85027.
    UCSCiuc003lsw.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF313413 mRNA. Translation: AAG53959.1 .
    AK125286 mRNA. Translation: BAC86114.1 . Sequence problems.
    AC010441 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61705.1 . Sequence problems.
    BC009719 mRNA. Translation: AAH09719.1 .
    BC101838 mRNA. Translation: AAI01839.1 . Sequence problems.
    BC101840 mRNA. Translation: AAI01841.1 . Sequence problems.
    BC106040 mRNA. Translation: AAI06041.1 . Sequence problems.
    CCDSi CCDS47312.2.
    RefSeqi NP_116565.3. NM_032947.4.
    UniGenei Hs.29444.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124436. 1 interaction.
    IntActi Q9BZL3. 1 interaction.
    MINTi MINT-1481070.
    STRINGi 9606.ENSP00000322424.

    Proteomic databases

    PRIDEi Q9BZL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000526627 ; ENSP00000436897 ; ENSG00000256235 .
    GeneIDi 85027.
    KEGGi hsa:85027.
    UCSCi uc003lsw.3. human.

    Organism-specific databases

    CTDi 85027.
    GeneCardsi GC05P150159.
    HGNCi HGNC:30248. SMIM3.
    HPAi HPA056610.
    MIMi 608324. gene.
    neXtProti NX_Q9BZL3.
    PharmGKBi PA165660222.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000132849.
    HOVERGENi HBG065301.
    OMAi IYRVRTH.
    OrthoDBi EOG7B8S78.
    PhylomeDBi Q9BZL3.
    TreeFami TF354124.

    Miscellaneous databases

    GenomeRNAii 85027.
    NextBioi 75671.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BZL3.
    Genevestigatori Q9BZL3.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells."
      Vician L., Silver A.L., Farias-Eisner R., Herschman H.R.
      J. Neurosci. Res. 64:108-120(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neuroblastoma.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Pancreas.

    Entry informationi

    Entry nameiSMIM3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZL3
    Secondary accession number(s): Q3MIG3, Q6ZUV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3