Q9BZL3 (SMIM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small integral membrane protein 3

Alternative name(s):
NGF-induced differentiation clone 67 protein
Small membrane protein NID67

Gene names

Name:	SMIM3
Synonyms:	C5orf62, NID67

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Induction	By NGF.
Sequence caution	The sequence AAI01839.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence AAI01841.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence AAI06041.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAC86114.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence EAW61705.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 60	60	Small integral membrane protein 3		PRO_0000096816
Regions
	Transmembrane	20 – 40	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9BZL3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FEE7DA7A6E02B08E	FASTA	60	6,593
	10 20 30 40 50 60 MDAVSQVPME VVLPKHILDI WVIVLIILAT IVIMTSLLLC PATAVIIYRM RTHPILSGAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells." Vician L., Silver A.L., Farias-Eisner R., Herschman H.R. J. Neurosci. Res. 64:108-120(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neuroblastoma.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Pancreas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF313413 mRNA. Translation: AAG53959.1. AK125286 mRNA. Translation: BAC86114.1. Sequence problems. AC010441 Genomic DNA. No translation available. CH471062 Genomic DNA. Translation: EAW61705.1. Sequence problems. BC009719 mRNA. Translation: AAH09719.1. BC101838 mRNA. Translation: AAI01839.1. Sequence problems. BC101840 mRNA. Translation: AAI01841.1. Sequence problems. BC106040 mRNA. Translation: AAI06041.1. Sequence problems.
IPI	IPI00001719.
RefSeq	NP_116565.3. NM_032947.4.
UniGene	Hs.29444.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BZL3. 1 interaction.
MINT	MINT-1481070.
STRING	9606.ENSP00000322424.
Proteomic databases
PRIDE	Q9BZL3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000526627; ENSP00000436897; ENSG00000256235.
GeneID	85027.
KEGG	hsa:85027.
UCSC	uc003lsw.3. human.
Organism-specific databases
CTD	85027.
GeneCards	GC05P150139.
HGNC	HGNC:30248. SMIM3.
MIM	608324. gene.
neXtProt	NX_Q9BZL3.
PharmGKB	PA165660222.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000132849.
HOVERGEN	HBG065301.
OMA	DIWAIVL.
OrthoDB	EOG46DM47.
Gene expression databases
Bgee	Q9BZL3.
Genevestigator	Q9BZL3.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	85027.
NextBio	75671.
SOURCE	Search...

Entry information

Entry name

SMIM3_HUMAN

Accession

Primary (citable) accession number: Q9BZL3
Secondary accession number(s): Q3MIG3, Q6ZUV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.