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Protein

Small integral membrane protein 3

Gene

SMIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 3
Alternative name(s):
NGF-induced differentiation clone 67 protein
Small membrane protein NID67
Gene namesi
Name:SMIM3
Synonyms:C5orf62, NID67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30248. SMIM3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165660222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Small integral membrane protein 3PRO_0000096816Add
BLAST

Proteomic databases

PRIDEiQ9BZL3.

Expressioni

Inductioni

By NGF.

Gene expression databases

BgeeiQ9BZL3.
GenevestigatoriQ9BZL3.

Organism-specific databases

HPAiHPA056610.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP6V0CP274493EBI-741850,EBI-721179
BSCL2Q96G974EBI-741850,EBI-741806
BSCL2Q96G97-43EBI-741850,EBI-10178113
CLEC7AQ9BXN23EBI-741850,EBI-3939278
EMP1P548493EBI-741850,EBI-4319440
LZTS2Q9BRK43EBI-741850,EBI-741037
MALP211453EBI-741850,EBI-3932027
PMP22Q014533EBI-741850,EBI-2845982
PNMA1Q8ND903EBI-741850,EBI-302345

Protein-protein interaction databases

BioGridi124436. 8 interactions.
IntActiQ9BZL3. 8 interactions.
MINTiMINT-1481070.
STRINGi9606.ENSP00000322424.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009443.
HOGENOMiHOG000132849.
HOVERGENiHBG065301.
InParanoidiQ9BZL3.
OMAiRTHPILN.
OrthoDBiEOG7B8S78.
PhylomeDBiQ9BZL3.
TreeFamiTF354124.

Sequencei

Sequence statusi: Complete.

Q9BZL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVSQVPME VVLPKHILDI WVIVLIILAT IVIMTSLLLC PATAVIIYRM
60
RTHPILSGAV
Length:60
Mass (Da):6,593
Last modified:June 1, 2001 - v1
Checksum:iFEE7DA7A6E02B08E
GO

Sequence cautioni

The sequence EAW61705.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313413 mRNA. Translation: AAG53959.1.
AK125286 mRNA. Translation: BAC86114.1. Sequence problems.
AC010441 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61705.1. Sequence problems.
BC009719 mRNA. Translation: AAH09719.1.
BC101838 mRNA. Translation: AAI01839.1. Sequence problems.
BC101840 mRNA. Translation: AAI01841.1. Sequence problems.
BC106040 mRNA. Translation: AAI06041.1. Sequence problems.
CCDSiCCDS47312.2.
RefSeqiNP_116565.3. NM_032947.4.
UniGeneiHs.29444.

Genome annotation databases

EnsembliENST00000526627; ENSP00000436897; ENSG00000256235.
GeneIDi85027.
KEGGihsa:85027.
UCSCiuc003lsw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313413 mRNA. Translation: AAG53959.1.
AK125286 mRNA. Translation: BAC86114.1. Sequence problems.
AC010441 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61705.1. Sequence problems.
BC009719 mRNA. Translation: AAH09719.1.
BC101838 mRNA. Translation: AAI01839.1. Sequence problems.
BC101840 mRNA. Translation: AAI01841.1. Sequence problems.
BC106040 mRNA. Translation: AAI06041.1. Sequence problems.
CCDSiCCDS47312.2.
RefSeqiNP_116565.3. NM_032947.4.
UniGeneiHs.29444.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124436. 8 interactions.
IntActiQ9BZL3. 8 interactions.
MINTiMINT-1481070.
STRINGi9606.ENSP00000322424.

Proteomic databases

PRIDEiQ9BZL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000526627; ENSP00000436897; ENSG00000256235.
GeneIDi85027.
KEGGihsa:85027.
UCSCiuc003lsw.3. human.

Organism-specific databases

CTDi85027.
GeneCardsiGC05P150159.
HGNCiHGNC:30248. SMIM3.
HPAiHPA056610.
MIMi608324. gene.
neXtProtiNX_Q9BZL3.
PharmGKBiPA165660222.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009443.
HOGENOMiHOG000132849.
HOVERGENiHBG065301.
InParanoidiQ9BZL3.
OMAiRTHPILN.
OrthoDBiEOG7B8S78.
PhylomeDBiQ9BZL3.
TreeFamiTF354124.

Miscellaneous databases

GenomeRNAii85027.
NextBioi75671.
PROiQ9BZL3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZL3.
GenevestigatoriQ9BZL3.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells."
    Vician L., Silver A.L., Farias-Eisner R., Herschman H.R.
    J. Neurosci. Res. 64:108-120(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Pancreas.

Entry informationi

Entry nameiSMIM3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZL3
Secondary accession number(s): Q3MIG3, Q6ZUV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.