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Protein

Small integral membrane protein 3

Gene

SMIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181368-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 3
Alternative name(s):
NGF-induced differentiation clone 67 protein
Small membrane protein NID67
Gene namesi
Name:SMIM3
Synonyms:C5orf62, NID67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30248. SMIM3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi85027.
OpenTargetsiENSG00000256235.
PharmGKBiPA165660222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968161 – 60Small integral membrane protein 3Add BLAST60

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei19 – 20CleavageBy similarity2

Proteomic databases

PaxDbiQ9BZL3.
PRIDEiQ9BZL3.

Expressioni

Inductioni

By NGF.

Gene expression databases

BgeeiENSG00000256235.
GenevisibleiQ9BZL3. HS.

Organism-specific databases

HPAiHPA056610.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP6V0CP274495EBI-741850,EBI-721179
BSCL2Q96G974EBI-741850,EBI-741806
BSCL2Q96G97-43EBI-741850,EBI-10178113
CLEC7AQ9BXN23EBI-741850,EBI-3939278
EMP1P548495EBI-741850,EBI-4319440
LZTS2Q9BRK43EBI-741850,EBI-741037
MALP211455EBI-741850,EBI-3932027
PMP22Q014535EBI-741850,EBI-2845982
PNMA1Q8ND903EBI-741850,EBI-302345

Protein-protein interaction databases

BioGridi124436. 8 interactors.
IntActiQ9BZL3. 16 interactors.
MINTiMINT-1481070.
STRINGi9606.ENSP00000436897.

Structurei

3D structure databases

ProteinModelPortaliQ9BZL3.
SMRiQ9BZL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2JQ. Eukaryota.
ENOG411180I. LUCA.
GeneTreeiENSGT00390000009443.
HOGENOMiHOG000132849.
HOVERGENiHBG065301.
InParanoidiQ9BZL3.
OMAiIYRVRTH.
PhylomeDBiQ9BZL3.
TreeFamiTF354124.

Sequencei

Sequence statusi: Complete.

Q9BZL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVSQVPME VVLPKHILDI WVIVLIILAT IVIMTSLLLC PATAVIIYRM
60
RTHPILSGAV
Length:60
Mass (Da):6,593
Last modified:June 1, 2001 - v1
Checksum:iFEE7DA7A6E02B08E
GO

Sequence cautioni

The sequence AAI01839 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAI01841 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAI06041 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC86114 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW61705 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313413 mRNA. Translation: AAG53959.1.
AK125286 mRNA. Translation: BAC86114.1. Sequence problems.
AC010441 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61705.1. Sequence problems.
BC009719 mRNA. Translation: AAH09719.1.
BC101838 mRNA. Translation: AAI01839.1. Sequence problems.
BC101840 mRNA. Translation: AAI01841.1. Sequence problems.
BC106040 mRNA. Translation: AAI06041.1. Sequence problems.
CCDSiCCDS47312.2.
RefSeqiNP_116565.3. NM_032947.4.
UniGeneiHs.29444.

Genome annotation databases

EnsembliENST00000526627; ENSP00000436897; ENSG00000256235.
GeneIDi85027.
KEGGihsa:85027.
UCSCiuc003lsw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313413 mRNA. Translation: AAG53959.1.
AK125286 mRNA. Translation: BAC86114.1. Sequence problems.
AC010441 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61705.1. Sequence problems.
BC009719 mRNA. Translation: AAH09719.1.
BC101838 mRNA. Translation: AAI01839.1. Sequence problems.
BC101840 mRNA. Translation: AAI01841.1. Sequence problems.
BC106040 mRNA. Translation: AAI06041.1. Sequence problems.
CCDSiCCDS47312.2.
RefSeqiNP_116565.3. NM_032947.4.
UniGeneiHs.29444.

3D structure databases

ProteinModelPortaliQ9BZL3.
SMRiQ9BZL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124436. 8 interactors.
IntActiQ9BZL3. 16 interactors.
MINTiMINT-1481070.
STRINGi9606.ENSP00000436897.

Proteomic databases

PaxDbiQ9BZL3.
PRIDEiQ9BZL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000526627; ENSP00000436897; ENSG00000256235.
GeneIDi85027.
KEGGihsa:85027.
UCSCiuc003lsw.4. human.

Organism-specific databases

CTDi85027.
DisGeNETi85027.
GeneCardsiSMIM3.
HGNCiHGNC:30248. SMIM3.
HPAiHPA056610.
MIMi608324. gene.
neXtProtiNX_Q9BZL3.
OpenTargetsiENSG00000256235.
PharmGKBiPA165660222.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2JQ. Eukaryota.
ENOG411180I. LUCA.
GeneTreeiENSGT00390000009443.
HOGENOMiHOG000132849.
HOVERGENiHBG065301.
InParanoidiQ9BZL3.
OMAiIYRVRTH.
PhylomeDBiQ9BZL3.
TreeFamiTF354124.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181368-MONOMER.

Miscellaneous databases

GenomeRNAii85027.
PROiQ9BZL3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000256235.
GenevisibleiQ9BZL3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSMIM3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZL3
Secondary accession number(s): Q3MIG3, Q6ZUV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.