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Protein

Ubiquitin-like protein 5

Gene

UBL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein tag Source: GO_Central

GO - Biological processi

  1. cellular protein modification process Source: GO_Central
  2. mRNA splicing, via spliceosome Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 5
Gene namesi
Name:UBL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13736. UBL5.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7373Ubiquitin-like protein 5PRO_0000114866Add
BLAST

Proteomic databases

MaxQBiQ9BZL1.
PaxDbiQ9BZL1.
PeptideAtlasiQ9BZL1.
PRIDEiQ9BZL1.

PTM databases

PhosphoSiteiQ9BZL1.

Expressioni

Tissue specificityi

Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.1 Publication

Gene expression databases

BgeeiQ9BZL1.
CleanExiHS_UBL5.
ExpressionAtlasiQ9BZL1. baseline and differential.
GenevestigatoriQ9BZL1.

Interactioni

Subunit structurei

Interacts with CLK1, CLK3 and CLK4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
WDR83Q9BRX92EBI-607755,EBI-7705033

Protein-protein interaction databases

BioGridi121872. 13 interactions.
IntActiQ9BZL1. 4 interactions.
MINTiMINT-4714927.
STRINGi9606.ENSP00000351492.

Structurei

Secondary structure

73
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 77Combined sources
Turni9 – 113Combined sources
Beta strandi13 – 197Combined sources
Helixi24 – 3411Combined sources
Helixi39 – 413Combined sources
Beta strandi42 – 465Combined sources
Turni57 – 615Combined sources
Beta strandi67 – 726Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P0RNMR-A1-73[»]
4PYUX-ray2.00A/B/G/K/O/S1-73[»]
ProteinModelPortaliQ9BZL1.
SMRiQ9BZL1. Positions 1-73.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZL1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7373Ubiquitin-likeAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.Curated

Phylogenomic databases

eggNOGiNOG326610.
GeneTreeiENSGT00390000001945.
HOVERGENiHBG055994.
InParanoidiQ9BZL1.
KOiK13113.
OMAiCNSEDTI.
OrthoDBiEOG72ZCHN.
PhylomeDBiQ9BZL1.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BZL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI
60 70
FKDHVSLGDY EIHDGMNLEL YYQ
Length:73
Mass (Da):8,547
Last modified:June 1, 2001 - v1
Checksum:iD68BC941536AA39F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313915 mRNA. Translation: AAK14178.1.
BT007355 mRNA. Translation: AAP36019.1.
BC007053 mRNA. Translation: AAH07053.1.
BC110839 mRNA. Translation: AAI10840.1.
CCDSiCCDS12219.1.
RefSeqiNP_001041706.1. NM_001048241.2.
NP_077268.1. NM_024292.3.
UniGeneiHs.534477.

Genome annotation databases

EnsembliENST00000358666; ENSP00000351492; ENSG00000198258.
ENST00000586895; ENSP00000468656; ENSG00000198258.
ENST00000590068; ENSP00000466910; ENSG00000198258.
GeneIDi59286.
KEGGihsa:59286.
UCSCiuc002mmi.2. human.

Polymorphism databases

DMDMi52082771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313915 mRNA. Translation: AAK14178.1.
BT007355 mRNA. Translation: AAP36019.1.
BC007053 mRNA. Translation: AAH07053.1.
BC110839 mRNA. Translation: AAI10840.1.
CCDSiCCDS12219.1.
RefSeqiNP_001041706.1. NM_001048241.2.
NP_077268.1. NM_024292.3.
UniGeneiHs.534477.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P0RNMR-A1-73[»]
4PYUX-ray2.00A/B/G/K/O/S1-73[»]
ProteinModelPortaliQ9BZL1.
SMRiQ9BZL1. Positions 1-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121872. 13 interactions.
IntActiQ9BZL1. 4 interactions.
MINTiMINT-4714927.
STRINGi9606.ENSP00000351492.

PTM databases

PhosphoSiteiQ9BZL1.

Polymorphism databases

DMDMi52082771.

Proteomic databases

MaxQBiQ9BZL1.
PaxDbiQ9BZL1.
PeptideAtlasiQ9BZL1.
PRIDEiQ9BZL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358666; ENSP00000351492; ENSG00000198258.
ENST00000586895; ENSP00000468656; ENSG00000198258.
ENST00000590068; ENSP00000466910; ENSG00000198258.
GeneIDi59286.
KEGGihsa:59286.
UCSCiuc002mmi.2. human.

Organism-specific databases

CTDi59286.
GeneCardsiGC19P009938.
HGNCiHGNC:13736. UBL5.
MIMi606849. gene.
neXtProtiNX_Q9BZL1.
PharmGKBiPA37805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG326610.
GeneTreeiENSGT00390000001945.
HOVERGENiHBG055994.
InParanoidiQ9BZL1.
KOiK13113.
OMAiCNSEDTI.
OrthoDBiEOG72ZCHN.
PhylomeDBiQ9BZL1.

Miscellaneous databases

ChiTaRSiUBL5. human.
EvolutionaryTraceiQ9BZL1.
GeneWikiiUBL5.
GenomeRNAii59286.
NextBioi65186.
PROiQ9BZL1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZL1.
CleanExiHS_UBL5.
ExpressionAtlasiQ9BZL1. baseline and differential.
GenevestigatoriQ9BZL1.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes."
    Friedman J.S., Koop B.F., Raymond V., Walter M.A.
    Genomics 71:252-255(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Iris.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Uterus.
  4. Cited for: INTERACTION WITH CLK1; CLK3 AND CLK4.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Structural analysis of UBL5, a novel ubiquitin-like modifier."
    McNally T., Huang Q., Janis R.S., Liu Z., Olejniczak E.T., Reilly R.M.
    Protein Sci. 12:1562-1566(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, INTERACTION WITH CLK4.

Entry informationi

Entry nameiUBL5_HUMAN
AccessioniPrimary (citable) accession number: Q9BZL1
Secondary accession number(s): Q2NL89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.