Q9BZL1 (UBL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like protein 5

Gene names

Name:

UBL5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	73 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CLK1, CLK3 and CLK4. Ref.4 Ref.6
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts. Ref.1
Sequence similarities	Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 73

73

Ubiquitin-like protein 5

PRO_0000114866

Regions

Domain

1 – 73

73

Ubiquitin-like

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

73

Helix Strand Turn

Details...

Beta strand

2 – 8

7

Turn

9 – 11

3

Beta strand

12 – 18

7

Helix

24 – 32

9

Beta strand

39 – 48

10

Beta strand

64 – 71

8

Sequences

	Sequence		Length	Mass (Da)
	Q9BZL1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D68BC941536AA39F	FASTA	73	8,547
	10 20 30 40 50 60 MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI FKDHVSLGDY 70 EIHDGMNLEL YYQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes." Friedman J.S., Koop B.F., Raymond V., Walter M.A. Genomics 71:252-255(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Iris.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Uterus.
[4]	"Beacon interacts with cdc2/cdc28-like kinases." Kantham L., Kerr-Bayles L., Godde N., Quick M., Webb R., Sunderland T., Bond J., Walder K., Augert G., Collier G. Biochem. Biophys. Res. Commun. 304:125-129(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CLK1; CLK3 AND CLK4.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"Structural analysis of UBL5, a novel ubiquitin-like modifier." McNally T., Huang Q., Janis R.S., Liu Z., Olejniczak E.T., Reilly R.M. Protein Sci. 12:1562-1566(2003) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR, INTERACTION WITH CLK4.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF313915 mRNA. Translation: AAK14178.1.
BT007355 mRNA. Translation: AAP36019.1.
BC007053 mRNA. Translation: AAH07053.1.
BC110839 mRNA. Translation: AAI10840.1.

IPI

IPI00013241.

RefSeq

NP_001041706.1. NM_001048241.2.
NP_077268.1. NM_024292.3.

UniGene

Hs.534477.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1P0R	NMR	-	A	1-73	[»]

ProteinModelPortal

Q9BZL1.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BZL1. 3 interactions.

STRING

9606.ENSP00000351492.

PTM databases

PhosphoSite

Q9BZL1.

Polymorphism databases

DMDM

52082771.

Proteomic databases

PaxDb

Q9BZL1.

PeptideAtlas

Q9BZL1.

PRIDE

Q9BZL1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000358666; ENSP00000351492; ENSG00000198258.
ENST00000586895; ENSP00000468656; ENSG00000198258.
ENST00000590068; ENSP00000466910; ENSG00000198258.

GeneID

59286.

KEGG

hsa:59286.

UCSC

uc002mmi.2. human.

Organism-specific databases

CTD

59286.

GeneCards

GC19P009938.

HGNC

HGNC:13736. UBL5.

MIM

606849. gene.

neXtProt

NX_Q9BZL1.

PharmGKB

PA37805.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG326610.

HOVERGEN

HBG055994.

InParanoid

Q9BZL1.

KO

K13113.

OMA

AQTGTKW.

OrthoDB

EOG4X0MV1.

PhylomeDB

Q9BZL1.

Gene expression databases

Bgee

Q9BZL1.

CleanEx

HS_UBL5.

Genevestigator

Q9BZL1.

GermOnline

ENSG00000198258. Homo sapiens.

Family and domain databases

InterPro

IPR000626. Ubiquitin.
[Graphical view]

Pfam

PF00240. ubiquitin. 1 hit.
[Graphical view]

PROSITE

PS00299. UBIQUITIN_1. False negative.
PS50053. UBIQUITIN_2. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

UBL5. human.

EvolutionaryTrace

Q9BZL1.

GenomeRNAi

59286.

NextBio

65186.

SOURCE

Search...

Entry information

Entry name

UBL5_HUMAN

Accession

Primary (citable) accession number: Q9BZL1
Secondary accession number(s): Q2NL89

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.