Reviewed, UniProtKB/Swiss-Prot Q9BZL1 (UBL5_HUMAN)

Names and origin

Protein names

Recommended name:
    Ubiquitin-like protein 5

Gene names

Name:

UBL5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	73 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with CLK4. Ref.5
Subcellular location	Cytoplasm. Ref.1
Tissue specificity	Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts. Ref.1
Sequence similarities	Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm
Technical term	3D-structure
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 73

73

Ubiquitin-like protein 5

PRO_0000114866

Regions

Domain

1 – 73

73

Ubiquitin-like

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

73

Helix Strand Turn

Details...

Beta strand

2 – 8

7

Turn

9 – 11

3

Beta strand

12 – 18

7

Helix

24 – 32

9

Beta strand

39 – 48

10

Beta strand

64 – 71

8

Sequences

	Sequence		Length	Mass (Da)
	Q9BZL1-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D68BC941536AA39F	FASTA	73	8,547
	10 20 30 40 50 60 MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI FKDHVSLGDY 70 EIHDGMNLEL YYQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes." Friedman J.S., Koop B.F., Raymond V., Walter M.A. Genomics 71:252-255(2001) [PubMed: 11161819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Iris.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Uterus.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"Structural analysis of UBL5, a novel ubiquitin-like modifier." McNally T., Huang Q., Janis R.S., Liu Z., Olejniczak E.T., Reilly R.M. Protein Sci. 12:1562-1566(2003) [PubMed: 12824502] [Abstract] Cited for: STRUCTURE BY NMR, INTERACTION WITH CLK4.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF313915 mRNA. Translation: AAK14178.1.
BT007355 mRNA. Translation: AAP36019.1.
BC007053 mRNA. Translation: AAH07053.1.
BC110839 mRNA. Translation: AAI10840.1.

IPI

IPI00013241.

RefSeq

NP_001041706.1.
NP_077268.1.

UniGene

Hs.534477

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1P0R	NMR	-	A	1-73	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BZL1. 2 interactions.

Proteomic databases

PeptideAtlas

Q9BZL1.

PRIDE

Q9BZL1.

Genome annotation databases

Ensembl

ENSG00000198258. Homo sapiens. [Contig view]

GeneID

59286.

KEGG

hsa:59286.

Organism-specific databases

GeneCards

GC19P009799.

H-InvDB

HIX0014729.

HGNC

HGNC:13736. UBL5.

MIM

606849. gene.

PharmGKB

PA37805.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9BZL1.

HOVERGEN

Q9BZL1.

OMA

Q9BZL1. EITCNDR.

Gene expression databases

ArrayExpress

Q9BZL1.

Bgee

Q9BZL1.

CleanEx

HS_UBL5.

GermOnline

ENSG00000198258. Homo sapiens.

Family and domain databases

InterPro

IPR019954. Ubiquitin_CS.
[Graphical view]

PROSITE

PS00299. UBIQUITIN_1. False negative.
PS50053. UBIQUITIN_2. False negative.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

65186.

SOURCE

Search...

Entry information

Entry name

UBL5_HUMAN

Accession

Primary (citable) accession number: Q9BZL1
Secondary accession number(s): Q2NL89

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)