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Q9BZL1 (UBL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-like protein 5
Gene names
Name:UBL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length73 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with CLK1, CLK3 and CLK4. Ref.4 Ref.7

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts. Ref.1

Sequence similarities

Contains 1 ubiquitin-like domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 22365833. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

WDR83Q9BRX92EBI-607755,EBI-7705033

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7373Ubiquitin-like protein 5
PRO_0000114866

Regions

Domain1 – 7373Ubiquitin-like

Secondary structure

........... 73
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9BZL1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D68BC941536AA39F

FASTA738,547
        10         20         30         40         50         60 
MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI FKDHVSLGDY 

        70 
EIHDGMNLEL YYQ 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes."
Friedman J.S., Koop B.F., Raymond V., Walter M.A.
Genomics 71:252-255(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Iris.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Uterus.
[4]"Beacon interacts with cdc2/cdc28-like kinases."
Kantham L., Kerr-Bayles L., Godde N., Quick M., Webb R., Sunderland T., Bond J., Walder K., Augert G., Collier G.
Biochem. Biophys. Res. Commun. 304:125-129(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLK1; CLK3 AND CLK4.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Structural analysis of UBL5, a novel ubiquitin-like modifier."
McNally T., Huang Q., Janis R.S., Liu Z., Olejniczak E.T., Reilly R.M.
Protein Sci. 12:1562-1566(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, INTERACTION WITH CLK4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF313915 mRNA. Translation: AAK14178.1.
BT007355 mRNA. Translation: AAP36019.1.
BC007053 mRNA. Translation: AAH07053.1.
BC110839 mRNA. Translation: AAI10840.1.
CCDSCCDS12219.1.
RefSeqNP_001041706.1. NM_001048241.2.
NP_077268.1. NM_024292.3.
UniGeneHs.534477.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1P0RNMR-A1-73[»]
ProteinModelPortalQ9BZL1.
SMRQ9BZL1. Positions 1-73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121872. 13 interactions.
IntActQ9BZL1. 4 interactions.
MINTMINT-4714927.
STRING9606.ENSP00000351492.

PTM databases

PhosphoSiteQ9BZL1.

Polymorphism databases

DMDM52082771.

Proteomic databases

MaxQBQ9BZL1.
PaxDbQ9BZL1.
PeptideAtlasQ9BZL1.
PRIDEQ9BZL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358666; ENSP00000351492; ENSG00000198258.
ENST00000586895; ENSP00000468656; ENSG00000198258.
ENST00000590068; ENSP00000466910; ENSG00000198258.
GeneID59286.
KEGGhsa:59286.
UCSCuc002mmi.2. human.

Organism-specific databases

CTD59286.
GeneCardsGC19P009938.
HGNCHGNC:13736. UBL5.
MIM606849. gene.
neXtProtNX_Q9BZL1.
PharmGKBPA37805.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG326610.
HOVERGENHBG055994.
InParanoidQ9BZL1.
KOK13113.
OMARFIMILA.
OrthoDBEOG72ZCHN.
PhylomeDBQ9BZL1.

Gene expression databases

ArrayExpressQ9BZL1.
BgeeQ9BZL1.
CleanExHS_UBL5.
GenevestigatorQ9BZL1.

Family and domain databases

InterProIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMSSF54236. SSF54236. 1 hit.
ProtoNetSearch...

Other

ChiTaRSUBL5. human.
EvolutionaryTraceQ9BZL1.
GeneWikiUBL5.
GenomeRNAi59286.
NextBio65186.
PROQ9BZL1.
SOURCESearch...

Entry information

Entry nameUBL5_HUMAN
AccessionPrimary (citable) accession number: Q9BZL1
Secondary accession number(s): Q2NL89
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM