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Q9BZL1

- UBL5_HUMAN

UniProt

Q9BZL1 - UBL5_HUMAN

Protein

Ubiquitin-like protein 5

Gene

UBL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like protein 5
    Gene namesi
    Name:UBL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13736. UBL5.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7373Ubiquitin-like protein 5PRO_0000114866Add
    BLAST

    Proteomic databases

    MaxQBiQ9BZL1.
    PaxDbiQ9BZL1.
    PeptideAtlasiQ9BZL1.
    PRIDEiQ9BZL1.

    PTM databases

    PhosphoSiteiQ9BZL1.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.1 Publication

    Gene expression databases

    ArrayExpressiQ9BZL1.
    BgeeiQ9BZL1.
    CleanExiHS_UBL5.
    GenevestigatoriQ9BZL1.

    Interactioni

    Subunit structurei

    Interacts with CLK1, CLK3 and CLK4.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    WDR83Q9BRX92EBI-607755,EBI-7705033

    Protein-protein interaction databases

    BioGridi121872. 13 interactions.
    IntActiQ9BZL1. 4 interactions.
    MINTiMINT-4714927.
    STRINGi9606.ENSP00000351492.

    Structurei

    Secondary structure

    1
    73
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 87
    Turni9 – 113
    Beta strandi12 – 187
    Helixi24 – 329
    Beta strandi39 – 4810
    Beta strandi64 – 718

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1P0RNMR-A1-73[»]
    ProteinModelPortaliQ9BZL1.
    SMRiQ9BZL1. Positions 1-73.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BZL1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7373Ubiquitin-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ubiquitin-like domain.Curated

    Phylogenomic databases

    eggNOGiNOG326610.
    HOVERGENiHBG055994.
    InParanoidiQ9BZL1.
    KOiK13113.
    OMAiRFIMILA.
    OrthoDBiEOG72ZCHN.
    PhylomeDBiQ9BZL1.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BZL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI   50
    FKDHVSLGDY EIHDGMNLEL YYQ 73
    Length:73
    Mass (Da):8,547
    Last modified:June 1, 2001 - v1
    Checksum:iD68BC941536AA39F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF313915 mRNA. Translation: AAK14178.1.
    BT007355 mRNA. Translation: AAP36019.1.
    BC007053 mRNA. Translation: AAH07053.1.
    BC110839 mRNA. Translation: AAI10840.1.
    CCDSiCCDS12219.1.
    RefSeqiNP_001041706.1. NM_001048241.2.
    NP_077268.1. NM_024292.3.
    UniGeneiHs.534477.

    Genome annotation databases

    EnsembliENST00000358666; ENSP00000351492; ENSG00000198258.
    ENST00000586895; ENSP00000468656; ENSG00000198258.
    ENST00000590068; ENSP00000466910; ENSG00000198258.
    GeneIDi59286.
    KEGGihsa:59286.
    UCSCiuc002mmi.2. human.

    Polymorphism databases

    DMDMi52082771.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF313915 mRNA. Translation: AAK14178.1 .
    BT007355 mRNA. Translation: AAP36019.1 .
    BC007053 mRNA. Translation: AAH07053.1 .
    BC110839 mRNA. Translation: AAI10840.1 .
    CCDSi CCDS12219.1.
    RefSeqi NP_001041706.1. NM_001048241.2.
    NP_077268.1. NM_024292.3.
    UniGenei Hs.534477.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1P0R NMR - A 1-73 [» ]
    ProteinModelPortali Q9BZL1.
    SMRi Q9BZL1. Positions 1-73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121872. 13 interactions.
    IntActi Q9BZL1. 4 interactions.
    MINTi MINT-4714927.
    STRINGi 9606.ENSP00000351492.

    PTM databases

    PhosphoSitei Q9BZL1.

    Polymorphism databases

    DMDMi 52082771.

    Proteomic databases

    MaxQBi Q9BZL1.
    PaxDbi Q9BZL1.
    PeptideAtlasi Q9BZL1.
    PRIDEi Q9BZL1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358666 ; ENSP00000351492 ; ENSG00000198258 .
    ENST00000586895 ; ENSP00000468656 ; ENSG00000198258 .
    ENST00000590068 ; ENSP00000466910 ; ENSG00000198258 .
    GeneIDi 59286.
    KEGGi hsa:59286.
    UCSCi uc002mmi.2. human.

    Organism-specific databases

    CTDi 59286.
    GeneCardsi GC19P009938.
    HGNCi HGNC:13736. UBL5.
    MIMi 606849. gene.
    neXtProti NX_Q9BZL1.
    PharmGKBi PA37805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326610.
    HOVERGENi HBG055994.
    InParanoidi Q9BZL1.
    KOi K13113.
    OMAi RFIMILA.
    OrthoDBi EOG72ZCHN.
    PhylomeDBi Q9BZL1.

    Miscellaneous databases

    ChiTaRSi UBL5. human.
    EvolutionaryTracei Q9BZL1.
    GeneWikii UBL5.
    GenomeRNAii 59286.
    NextBioi 65186.
    PROi Q9BZL1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZL1.
    Bgeei Q9BZL1.
    CleanExi HS_UBL5.
    Genevestigatori Q9BZL1.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes."
      Friedman J.S., Koop B.F., Raymond V., Walter M.A.
      Genomics 71:252-255(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Iris.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Uterus.
    4. Cited for: INTERACTION WITH CLK1; CLK3 AND CLK4.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Structural analysis of UBL5, a novel ubiquitin-like modifier."
      McNally T., Huang Q., Janis R.S., Liu Z., Olejniczak E.T., Reilly R.M.
      Protein Sci. 12:1562-1566(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, INTERACTION WITH CLK4.

    Entry informationi

    Entry nameiUBL5_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZL1
    Secondary accession number(s): Q2NL89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3