Q9BZJ8 (GPR61_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 61

Alternative name(s):
Biogenic amine receptor-like G-protein coupled receptor

Gene names

Name:	GPR61
Synonyms:	BALGR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis. Low expression in many other tissues.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAK12637.1 differs from that shown. Reason: Frameshift at position 415.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Probable G-protein coupled receptor 61		PRO_0000069578
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 67	23	Helical; Name=1; Potential
	Topological domain	68 – 75	8	Cytoplasmic Potential
	Transmembrane	76 – 98	23	Helical; Name=2; Potential
	Topological domain	99 – 112	14	Extracellular Potential
	Transmembrane	113 – 135	23	Helical; Name=3; Potential
	Topological domain	136 – 155	20	Cytoplasmic Potential
	Transmembrane	156 – 178	23	Helical; Name=4; Potential
	Topological domain	179 – 206	28	Extracellular Potential
	Transmembrane	207 – 229	23	Helical; Name=5; Potential
	Topological domain	230 – 287	58	Cytoplasmic Potential
	Transmembrane	288 – 310	23	Helical; Name=6; Potential
	Topological domain	311 – 324	14	Extracellular Potential
	Transmembrane	325 – 344	20	Helical; Name=7; Potential
	Topological domain	345 – 451	107	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	91	1	L → P in AAK97826. Ref.2
	Sequence conflict	102	1	S → P in AAK12637. Ref.1
	Sequence conflict	113	1	V → M in AAK97826. Ref.2
	Sequence conflict	194	1	G → H in AAK12637. Ref.1
	Sequence conflict	226	1	V → L in AAK12637. Ref.1
	Sequence conflict	241 – 242	2	QH → PD in AAK12637. Ref.1
	Sequence conflict	366	1	E → K in AAH67464. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9BZJ8 [UniParc]. Last modified September 27, 2005. Version 2. Checksum: 1F477F112E1CEA1A	FASTA	451	49,292
	10 20 30 40 50 60 MESSPIPQSS GNSSTLGRVP QTPGPSTASG VPEVGLRDVA SESVALFFML LLDLTAVAGN 70 80 90 100 110 120 AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS SSALFDHALF GEVACRLYLF 130 140 150 160 170 180 LSVCFVSLAI LSVSAINVER YYYVVHPMRY EVRMTLGLVA SVLVGVWVKA LAMASVPVLG 190 200 210 220 230 240 RVSWEEGAPS VPPGCSLQWS HSAYCQLFVV VFAVLYFLLP LLLILVVYCS MFRVARVAAM 250 260 270 280 290 300 QHGPLPTWME TPRQRSESLS SRSTMVTSSG APQTTPHRTF GGGKAAVVLL AVGGQFLLCW 310 320 330 340 350 360 LPYFSFHLYV ALSAQPISTG QVESVVTWIG YFCFTSNPFF YGCLNRQIRG ELSKQFVCFF 370 380 390 400 410 420 KPAPEEELRL PSREGSIEEN FLQFLQGTGC PSESWVSRPL PSPKQEPPAV DFRIPGQIAE 430 440 450 ETSEFLEQQL TSDIIMSDSY LRPAASPRLE S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of four novel human G protein-coupled receptors expressed in the brain." Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F. Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain." Cikos S., Gregor P., Koppel J. Biochim. Biophys. Acta 1521:66-72(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hypothalamus.
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317652 mRNA. Translation: AAK12637.1. Frameshift. AF258342 mRNA. Translation: AAK97826.1. AB083585 Genomic DNA. Translation: BAB89298.1. AK290027 mRNA. Translation: BAF82716.1. AL355310 Genomic DNA. Translation: CAI19302.1. CH471122 Genomic DNA. Translation: EAW56392.1. BC067464 mRNA. Translation: AAH67464.1.
IPI	IPI00140250.
RefSeq	NP_114142.3. NM_031936.4.
UniGene	Hs.709782.
3D structure databases
ProteinModelPortal	Q9BZJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000286603.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9BZJ8.
Polymorphism databases
DMDM	76789653.
Proteomic databases
PaxDb	Q9BZJ8.
PRIDE	Q9BZJ8.
Protocols and materials databases
DNASU	83873.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000404129; ENSP00000385422; ENSG00000156097. ENST00000469383; ENSP00000433661; ENSG00000156097. ENST00000527748; ENSP00000432456; ENSG00000156097.
GeneID	83873.
KEGG	hsa:83873.
UCSC	uc001dxy.2. human.
Organism-specific databases
CTD	83873.
GeneCards	GC01P110082.
HGNC	HGNC:13300. GPR61.
HPA	HPA007326. HPA026088.
MIM	606916. gene.
neXtProt	NX_Q9BZJ8.
PharmGKB	PA28905.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267429.
HOVERGEN	HBG051815.
InParanoid	Q9BZJ8.
KO	K08414.
OrthoDB	EOG4PZJ73.
PhylomeDB	Q9BZJ8.
Gene expression databases
ArrayExpress	Q9BZJ8.
Bgee	Q9BZJ8.
CleanEx	HS_GPR61.
Genevestigator	Q9BZJ8.
GermOnline	ENSG00000156097. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83873.
NextBio	72903.
SOURCE	Search...

Entry information

Entry name

GPR61_HUMAN

Accession

Primary (citable) accession number: Q9BZJ8
Secondary accession number(s): A8K1W2 , Q6NWS0, Q8TDV4, Q96PR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.