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Protein

G-protein coupled receptor 61

Gene

GPR61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity).By similarity1 Publication

GO - Molecular functioni

  • arrestin family protein binding Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of cAMP-mediated signaling Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 61Curated
Alternative name(s):
Biogenic amine receptor-like G-protein coupled receptor1 Publication
Gene namesi
Name:GPR61
Synonyms:BALGR1 Publication, GPCR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000156097.12
HGNCiHGNC:13300 GPR61
MIMi606916 gene
neXtProtiNX_Q9BZJ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 75CytoplasmicSequence analysis8
Transmembranei76 – 98Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini99 – 112ExtracellularSequence analysisAdd BLAST14
Transmembranei113 – 135Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini136 – 155CytoplasmicSequence analysisAdd BLAST20
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 206ExtracellularSequence analysisAdd BLAST28
Transmembranei207 – 229Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini230 – 287CytoplasmicSequence analysisAdd BLAST58
Transmembranei288 – 310Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini311 – 324ExtracellularSequence analysisAdd BLAST14
Transmembranei325 – 344Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini345 – 451CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12N → S: Does not affect subcellular location. 1 Publication1

Organism-specific databases

DisGeNETi83873
OpenTargetsiENSG00000156097
PharmGKBiPA28905

Polymorphism and mutation databases

BioMutaiGPR61
DMDMi76789653

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695781 – 451G-protein coupled receptor 61Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZJ8
PeptideAtlasiQ9BZJ8
PRIDEiQ9BZJ8

PTM databases

iPTMnetiQ9BZJ8
PhosphoSitePlusiQ9BZJ8

Expressioni

Tissue specificityi

Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000156097
CleanExiHS_GPR61
ExpressionAtlasiQ9BZJ8 baseline and differential
GenevisibleiQ9BZJ8 HS

Organism-specific databases

HPAiHPA007326
HPA026088

Interactioni

Subunit structurei

Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (PubMed:28827538).1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • arrestin family protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123786, 1 interactor
IntActiQ9BZJ8, 16 interactors
STRINGi9606.ENSP00000385422

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000110969
HOVERGENiHBG051815
InParanoidiQ9BZJ8
KOiK08414
OMAiAMHHGPL
OrthoDBiEOG091G0719
PhylomeDBiQ9BZJ8
TreeFamiTF332667

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BZJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSPIPQSS GNSSTLGRVP QTPGPSTASG VPEVGLRDVA SESVALFFML
60 70 80 90 100
LLDLTAVAGN AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS
110 120 130 140 150
SSALFDHALF GEVACRLYLF LSVCFVSLAI LSVSAINVER YYYVVHPMRY
160 170 180 190 200
EVRMTLGLVA SVLVGVWVKA LAMASVPVLG RVSWEEGAPS VPPGCSLQWS
210 220 230 240 250
HSAYCQLFVV VFAVLYFLLP LLLILVVYCS MFRVARVAAM QHGPLPTWME
260 270 280 290 300
TPRQRSESLS SRSTMVTSSG APQTTPHRTF GGGKAAVVLL AVGGQFLLCW
310 320 330 340 350
LPYFSFHLYV ALSAQPISTG QVESVVTWIG YFCFTSNPFF YGCLNRQIRG
360 370 380 390 400
ELSKQFVCFF KPAPEEELRL PSREGSIEEN FLQFLQGTGC PSESWVSRPL
410 420 430 440 450
PSPKQEPPAV DFRIPGQIAE ETSEFLEQQL TSDIIMSDSY LRPAASPRLE

S
Length:451
Mass (Da):49,292
Last modified:September 27, 2005 - v2
Checksum:i1F477F112E1CEA1A
GO

Sequence cautioni

The sequence AAK12637 differs from that shown. Reason: Frameshift at position 415.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91L → P in AAK97826 (PubMed:11690637).Curated1
Sequence conflicti102S → P in AAK12637 (PubMed:11165367).Curated1
Sequence conflicti113V → M in AAK97826 (PubMed:11690637).Curated1
Sequence conflicti194G → H in AAK12637 (PubMed:11165367).Curated1
Sequence conflicti226V → L in AAK12637 (PubMed:11165367).Curated1
Sequence conflicti241 – 242QH → PD in AAK12637 (PubMed:11165367).Curated2
Sequence conflicti366E → K in AAH67464 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317652 mRNA Translation: AAK12637.1 Frameshift.
AF258342 mRNA Translation: AAK97826.1
AB083585 Genomic DNA Translation: BAB89298.1
AK290027 mRNA Translation: BAF82716.1
AL355310 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56392.1
BC067464 mRNA Translation: AAH67464.1
CCDSiCCDS801.1
RefSeqiNP_114142.3, NM_031936.4
XP_016857927.1, XM_017002438.1
UniGeneiHs.709782

Genome annotation databases

EnsembliENST00000404129; ENSP00000385422; ENSG00000156097
ENST00000469383; ENSP00000433661; ENSG00000156097
ENST00000527748; ENSP00000432456; ENSG00000156097
ENST00000616874; ENSP00000484035; ENSG00000156097
ENST00000618721; ENSP00000484797; ENSG00000156097
GeneIDi83873
KEGGihsa:83873
UCSCiuc001dxy.2 human

Similar proteinsi

Entry informationi

Entry nameiGPR61_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ8
Secondary accession number(s): A8K1W2
, Q6NWS0, Q8TDV4, Q96PR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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