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Q9BZJ8

- GPR61_HUMAN

UniProt

Q9BZJ8 - GPR61_HUMAN

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Protein
Probable G-protein coupled receptor 61
Gene
GPR61, BALGR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 61
    Alternative name(s):
    Biogenic amine receptor-like G-protein coupled receptor
    Gene namesi
    Name:GPR61
    Synonyms:BALGR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13300. GPR61.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei45 – 6723Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini68 – 758Cytoplasmic Reviewed prediction
    Transmembranei76 – 9823Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini99 – 11214Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei113 – 13523Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini136 – 15520Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei156 – 17823Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini179 – 20628Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei207 – 22923Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini230 – 28758Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei288 – 31023Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini311 – 32414Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei325 – 34420Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini345 – 451107Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. receptor complex Source: MGI
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28905.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451Probable G-protein coupled receptor 61
    PRO_0000069578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9BZJ8.
    PRIDEiQ9BZJ8.

    PTM databases

    PhosphoSiteiQ9BZJ8.

    Expressioni

    Tissue specificityi

    Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis. Low expression in many other tissues.

    Gene expression databases

    ArrayExpressiQ9BZJ8.
    BgeeiQ9BZJ8.
    CleanExiHS_GPR61.
    GenevestigatoriQ9BZJ8.

    Organism-specific databases

    HPAiHPA007326.
    HPA026088.

    Interactioni

    Protein-protein interaction databases

    BioGridi123786. 1 interaction.
    STRINGi9606.ENSP00000286603.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZJ8.
    SMRiQ9BZJ8. Positions 43-354.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267429.
    HOVERGENiHBG051815.
    InParanoidiQ9BZJ8.
    KOiK08414.
    OMAiCSLQWSR.
    OrthoDBiEOG722J8X.
    PhylomeDBiQ9BZJ8.
    TreeFamiTF332667.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BZJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESSPIPQSS GNSSTLGRVP QTPGPSTASG VPEVGLRDVA SESVALFFML    50
    LLDLTAVAGN AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS 100
    SSALFDHALF GEVACRLYLF LSVCFVSLAI LSVSAINVER YYYVVHPMRY 150
    EVRMTLGLVA SVLVGVWVKA LAMASVPVLG RVSWEEGAPS VPPGCSLQWS 200
    HSAYCQLFVV VFAVLYFLLP LLLILVVYCS MFRVARVAAM QHGPLPTWME 250
    TPRQRSESLS SRSTMVTSSG APQTTPHRTF GGGKAAVVLL AVGGQFLLCW 300
    LPYFSFHLYV ALSAQPISTG QVESVVTWIG YFCFTSNPFF YGCLNRQIRG 350
    ELSKQFVCFF KPAPEEELRL PSREGSIEEN FLQFLQGTGC PSESWVSRPL 400
    PSPKQEPPAV DFRIPGQIAE ETSEFLEQQL TSDIIMSDSY LRPAASPRLE 450
    S 451
    Length:451
    Mass (Da):49,292
    Last modified:September 27, 2005 - v2
    Checksum:i1F477F112E1CEA1A
    GO

    Sequence cautioni

    The sequence AAK12637.1 differs from that shown. Reason: Frameshift at position 415.

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911L → P in AAK97826. 1 Publication
    Sequence conflicti102 – 1021S → P in AAK12637. 1 Publication
    Sequence conflicti113 – 1131V → M in AAK97826. 1 Publication
    Sequence conflicti194 – 1941G → H in AAK12637. 1 Publication
    Sequence conflicti226 – 2261V → L in AAK12637. 1 Publication
    Sequence conflicti241 – 2422QH → PD in AAK12637. 1 Publication
    Sequence conflicti366 – 3661E → K in AAH67464. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317652 mRNA. Translation: AAK12637.1. Frameshift.
    AF258342 mRNA. Translation: AAK97826.1.
    AB083585 Genomic DNA. Translation: BAB89298.1.
    AK290027 mRNA. Translation: BAF82716.1.
    AL355310 Genomic DNA. Translation: CAI19302.1.
    CH471122 Genomic DNA. Translation: EAW56392.1.
    BC067464 mRNA. Translation: AAH67464.1.
    CCDSiCCDS801.1.
    RefSeqiNP_114142.3. NM_031936.4.
    XP_006711003.1. XM_006710940.1.
    UniGeneiHs.709782.

    Genome annotation databases

    EnsembliENST00000404129; ENSP00000385422; ENSG00000156097.
    ENST00000469383; ENSP00000433661; ENSG00000156097.
    ENST00000527748; ENSP00000432456; ENSG00000156097.
    GeneIDi83873.
    KEGGihsa:83873.
    UCSCiuc001dxy.2. human.

    Polymorphism databases

    DMDMi76789653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317652 mRNA. Translation: AAK12637.1 . Frameshift.
    AF258342 mRNA. Translation: AAK97826.1 .
    AB083585 Genomic DNA. Translation: BAB89298.1 .
    AK290027 mRNA. Translation: BAF82716.1 .
    AL355310 Genomic DNA. Translation: CAI19302.1 .
    CH471122 Genomic DNA. Translation: EAW56392.1 .
    BC067464 mRNA. Translation: AAH67464.1 .
    CCDSi CCDS801.1.
    RefSeqi NP_114142.3. NM_031936.4.
    XP_006711003.1. XM_006710940.1.
    UniGenei Hs.709782.

    3D structure databases

    ProteinModelPortali Q9BZJ8.
    SMRi Q9BZJ8. Positions 43-354.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 123786. 1 interaction.
    STRINGi 9606.ENSP00000286603.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9BZJ8.

    Polymorphism databases

    DMDMi 76789653.

    Proteomic databases

    PaxDbi Q9BZJ8.
    PRIDEi Q9BZJ8.

    Protocols and materials databases

    DNASUi 83873.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000404129 ; ENSP00000385422 ; ENSG00000156097 .
    ENST00000469383 ; ENSP00000433661 ; ENSG00000156097 .
    ENST00000527748 ; ENSP00000432456 ; ENSG00000156097 .
    GeneIDi 83873.
    KEGGi hsa:83873.
    UCSCi uc001dxy.2. human.

    Organism-specific databases

    CTDi 83873.
    GeneCardsi GC01P110082.
    HGNCi HGNC:13300. GPR61.
    HPAi HPA007326.
    HPA026088.
    MIMi 606916. gene.
    neXtProti NX_Q9BZJ8.
    PharmGKBi PA28905.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267429.
    HOVERGENi HBG051815.
    InParanoidi Q9BZJ8.
    KOi K08414.
    OMAi CSLQWSR.
    OrthoDBi EOG722J8X.
    PhylomeDBi Q9BZJ8.
    TreeFami TF332667.

    Miscellaneous databases

    GeneWikii GPR61.
    GenomeRNAii 83873.
    NextBioi 72903.
    PROi Q9BZJ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZJ8.
    Bgeei Q9BZJ8.
    CleanExi HS_GPR61.
    Genevestigatori Q9BZJ8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Identification of four novel human G protein-coupled receptors expressed in the brain."
      Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
      Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain."
      Cikos S., Gregor P., Koppel J.
      Biochim. Biophys. Acta 1521:66-72(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.
    3. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGPR61_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZJ8
    Secondary accession number(s): A8K1W2
    , Q6NWS0, Q8TDV4, Q96PR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: September 27, 2005
    Last modified: July 9, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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