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Q9BZJ8 (GPR61_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 61
Alternative name(s):
Biogenic amine receptor-like G-protein coupled receptor
Gene names
Name:GPR61
Synonyms:BALGR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis. Low expression in many other tissues.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAK12637.1 differs from that shown. Reason: Frameshift at position 415.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Probable G-protein coupled receptor 61
PRO_0000069578

Regions

Topological domain1 – 4444Extracellular Potential
Transmembrane45 – 6723Helical; Name=1; Potential
Topological domain68 – 758Cytoplasmic Potential
Transmembrane76 – 9823Helical; Name=2; Potential
Topological domain99 – 11214Extracellular Potential
Transmembrane113 – 13523Helical; Name=3; Potential
Topological domain136 – 15520Cytoplasmic Potential
Transmembrane156 – 17823Helical; Name=4; Potential
Topological domain179 – 20628Extracellular Potential
Transmembrane207 – 22923Helical; Name=5; Potential
Topological domain230 – 28758Cytoplasmic Potential
Transmembrane288 – 31023Helical; Name=6; Potential
Topological domain311 – 32414Extracellular Potential
Transmembrane325 – 34420Helical; Name=7; Potential
Topological domain345 – 451107Cytoplasmic Potential

Amino acid modifications

Glycosylation121N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict911L → P in AAK97826. Ref.2
Sequence conflict1021S → P in AAK12637. Ref.1
Sequence conflict1131V → M in AAK97826. Ref.2
Sequence conflict1941G → H in AAK12637. Ref.1
Sequence conflict2261V → L in AAK12637. Ref.1
Sequence conflict241 – 2422QH → PD in AAK12637. Ref.1
Sequence conflict3661E → K in AAH67464. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q9BZJ8 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 1F477F112E1CEA1A

FASTA45149,292
        10         20         30         40         50         60 
MESSPIPQSS GNSSTLGRVP QTPGPSTASG VPEVGLRDVA SESVALFFML LLDLTAVAGN 

        70         80         90        100        110        120 
AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS SSALFDHALF GEVACRLYLF 

       130        140        150        160        170        180 
LSVCFVSLAI LSVSAINVER YYYVVHPMRY EVRMTLGLVA SVLVGVWVKA LAMASVPVLG 

       190        200        210        220        230        240 
RVSWEEGAPS VPPGCSLQWS HSAYCQLFVV VFAVLYFLLP LLLILVVYCS MFRVARVAAM 

       250        260        270        280        290        300 
QHGPLPTWME TPRQRSESLS SRSTMVTSSG APQTTPHRTF GGGKAAVVLL AVGGQFLLCW 

       310        320        330        340        350        360 
LPYFSFHLYV ALSAQPISTG QVESVVTWIG YFCFTSNPFF YGCLNRQIRG ELSKQFVCFF 

       370        380        390        400        410        420 
KPAPEEELRL PSREGSIEEN FLQFLQGTGC PSESWVSRPL PSPKQEPPAV DFRIPGQIAE 

       430        440        450 
ETSEFLEQQL TSDIIMSDSY LRPAASPRLE S 

« Hide

References

« Hide 'large scale' references
[1]"Identification of four novel human G protein-coupled receptors expressed in the brain."
Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain."
Cikos S., Gregor P., Koppel J.
Biochim. Biophys. Acta 1521:66-72(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hypothalamus.
[3]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF317652 mRNA. Translation: AAK12637.1. Frameshift.
AF258342 mRNA. Translation: AAK97826.1.
AB083585 Genomic DNA. Translation: BAB89298.1.
AK290027 mRNA. Translation: BAF82716.1.
AL355310 Genomic DNA. Translation: CAI19302.1.
CH471122 Genomic DNA. Translation: EAW56392.1.
BC067464 mRNA. Translation: AAH67464.1.
CCDSCCDS801.1.
RefSeqNP_114142.3. NM_031936.4.
XP_006711003.1. XM_006710940.1.
UniGeneHs.709782.

3D structure databases

ProteinModelPortalQ9BZJ8.
SMRQ9BZJ8. Positions 43-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123786. 1 interaction.
STRING9606.ENSP00000286603.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9BZJ8.

Polymorphism databases

DMDM76789653.

Proteomic databases

PaxDbQ9BZJ8.
PRIDEQ9BZJ8.

Protocols and materials databases

DNASU83873.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000404129; ENSP00000385422; ENSG00000156097.
ENST00000469383; ENSP00000433661; ENSG00000156097.
ENST00000527748; ENSP00000432456; ENSG00000156097.
GeneID83873.
KEGGhsa:83873.
UCSCuc001dxy.2. human.

Organism-specific databases

CTD83873.
GeneCardsGC01P110082.
HGNCHGNC:13300. GPR61.
HPAHPA007326.
HPA026088.
MIM606916. gene.
neXtProtNX_Q9BZJ8.
PharmGKBPA28905.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267429.
HOVERGENHBG051815.
InParanoidQ9BZJ8.
KOK08414.
OMACSLQWSR.
OrthoDBEOG722J8X.
PhylomeDBQ9BZJ8.
TreeFamTF332667.

Gene expression databases

ArrayExpressQ9BZJ8.
BgeeQ9BZJ8.
CleanExHS_GPR61.
GenevestigatorQ9BZJ8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR61.
GenomeRNAi83873.
NextBio72903.
PROQ9BZJ8.
SOURCESearch...

Entry information

Entry nameGPR61_HUMAN
AccessionPrimary (citable) accession number: Q9BZJ8
Secondary accession number(s): A8K1W2 expand/collapse secondary AC list , Q6NWS0, Q8TDV4, Q96PR4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries