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Protein

Probable G-protein coupled receptor 61

Gene

GPR61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 61
Alternative name(s):
Biogenic amine receptor-like G-protein coupled receptor
Gene namesi
Name:GPR61
Synonyms:BALGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13300. GPR61.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Transmembranei45 – 6723Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini68 – 758CytoplasmicSequence Analysis
Transmembranei76 – 9823Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini99 – 11214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13523Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini136 – 15520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei156 – 17823Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini179 – 20628ExtracellularSequence AnalysisAdd
BLAST
Transmembranei207 – 22923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini230 – 28758CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei288 – 31023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini311 – 32414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei325 – 34420Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini345 – 451107CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28905.

Polymorphism and mutation databases

BioMutaiGPR61.
DMDMi76789653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Probable G-protein coupled receptor 61PRO_0000069578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZJ8.
PRIDEiQ9BZJ8.

PTM databases

PhosphoSiteiQ9BZJ8.

Expressioni

Tissue specificityi

Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis. Low expression in many other tissues.

Gene expression databases

BgeeiQ9BZJ8.
CleanExiHS_GPR61.
ExpressionAtlasiQ9BZJ8. baseline and differential.
GenevisibleiQ9BZJ8. HS.

Organism-specific databases

HPAiHPA007326.
HPA026088.

Interactioni

Protein-protein interaction databases

BioGridi123786. 1 interaction.
STRINGi9606.ENSP00000385422.

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ8.
SMRiQ9BZJ8. Positions 43-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267429.
GeneTreeiENSGT00730000110969.
HOVERGENiHBG051815.
InParanoidiQ9BZJ8.
KOiK08414.
OMAiAMHHGPL.
OrthoDBiEOG722J8X.
PhylomeDBiQ9BZJ8.
TreeFamiTF332667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSPIPQSS GNSSTLGRVP QTPGPSTASG VPEVGLRDVA SESVALFFML
60 70 80 90 100
LLDLTAVAGN AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS
110 120 130 140 150
SSALFDHALF GEVACRLYLF LSVCFVSLAI LSVSAINVER YYYVVHPMRY
160 170 180 190 200
EVRMTLGLVA SVLVGVWVKA LAMASVPVLG RVSWEEGAPS VPPGCSLQWS
210 220 230 240 250
HSAYCQLFVV VFAVLYFLLP LLLILVVYCS MFRVARVAAM QHGPLPTWME
260 270 280 290 300
TPRQRSESLS SRSTMVTSSG APQTTPHRTF GGGKAAVVLL AVGGQFLLCW
310 320 330 340 350
LPYFSFHLYV ALSAQPISTG QVESVVTWIG YFCFTSNPFF YGCLNRQIRG
360 370 380 390 400
ELSKQFVCFF KPAPEEELRL PSREGSIEEN FLQFLQGTGC PSESWVSRPL
410 420 430 440 450
PSPKQEPPAV DFRIPGQIAE ETSEFLEQQL TSDIIMSDSY LRPAASPRLE

S
Length:451
Mass (Da):49,292
Last modified:September 27, 2005 - v2
Checksum:i1F477F112E1CEA1A
GO

Sequence cautioni

The sequence AAK12637.1 differs from that shown. Reason: Frameshift at position 415. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911L → P in AAK97826 (PubMed:11690637).Curated
Sequence conflicti102 – 1021S → P in AAK12637 (PubMed:11165367).Curated
Sequence conflicti113 – 1131V → M in AAK97826 (PubMed:11690637).Curated
Sequence conflicti194 – 1941G → H in AAK12637 (PubMed:11165367).Curated
Sequence conflicti226 – 2261V → L in AAK12637 (PubMed:11165367).Curated
Sequence conflicti241 – 2422QH → PD in AAK12637 (PubMed:11165367).Curated
Sequence conflicti366 – 3661E → K in AAH67464 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317652 mRNA. Translation: AAK12637.1. Frameshift.
AF258342 mRNA. Translation: AAK97826.1.
AB083585 Genomic DNA. Translation: BAB89298.1.
AK290027 mRNA. Translation: BAF82716.1.
AL355310 Genomic DNA. Translation: CAI19302.1.
CH471122 Genomic DNA. Translation: EAW56392.1.
BC067464 mRNA. Translation: AAH67464.1.
CCDSiCCDS801.1.
RefSeqiNP_114142.3. NM_031936.4.
UniGeneiHs.709782.

Genome annotation databases

EnsembliENST00000404129; ENSP00000385422; ENSG00000156097.
ENST00000469383; ENSP00000433661; ENSG00000156097.
ENST00000527748; ENSP00000432456; ENSG00000156097.
ENST00000616874; ENSP00000484035; ENSG00000156097.
ENST00000618721; ENSP00000484797; ENSG00000156097.
GeneIDi83873.
KEGGihsa:83873.
UCSCiuc001dxy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317652 mRNA. Translation: AAK12637.1. Frameshift.
AF258342 mRNA. Translation: AAK97826.1.
AB083585 Genomic DNA. Translation: BAB89298.1.
AK290027 mRNA. Translation: BAF82716.1.
AL355310 Genomic DNA. Translation: CAI19302.1.
CH471122 Genomic DNA. Translation: EAW56392.1.
BC067464 mRNA. Translation: AAH67464.1.
CCDSiCCDS801.1.
RefSeqiNP_114142.3. NM_031936.4.
UniGeneiHs.709782.

3D structure databases

ProteinModelPortaliQ9BZJ8.
SMRiQ9BZJ8. Positions 43-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123786. 1 interaction.
STRINGi9606.ENSP00000385422.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9BZJ8.

Polymorphism and mutation databases

BioMutaiGPR61.
DMDMi76789653.

Proteomic databases

PaxDbiQ9BZJ8.
PRIDEiQ9BZJ8.

Protocols and materials databases

DNASUi83873.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404129; ENSP00000385422; ENSG00000156097.
ENST00000469383; ENSP00000433661; ENSG00000156097.
ENST00000527748; ENSP00000432456; ENSG00000156097.
ENST00000616874; ENSP00000484035; ENSG00000156097.
ENST00000618721; ENSP00000484797; ENSG00000156097.
GeneIDi83873.
KEGGihsa:83873.
UCSCiuc001dxy.2. human.

Organism-specific databases

CTDi83873.
GeneCardsiGC01P110082.
HGNCiHGNC:13300. GPR61.
HPAiHPA007326.
HPA026088.
MIMi606916. gene.
neXtProtiNX_Q9BZJ8.
PharmGKBiPA28905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG267429.
GeneTreeiENSGT00730000110969.
HOVERGENiHBG051815.
InParanoidiQ9BZJ8.
KOiK08414.
OMAiAMHHGPL.
OrthoDBiEOG722J8X.
PhylomeDBiQ9BZJ8.
TreeFamiTF332667.

Miscellaneous databases

GeneWikiiGPR61.
GenomeRNAii83873.
NextBioi72903.
PROiQ9BZJ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZJ8.
CleanExiHS_GPR61.
ExpressionAtlasiQ9BZJ8. baseline and differential.
GenevisibleiQ9BZJ8. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of four novel human G protein-coupled receptors expressed in the brain."
    Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
    Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain."
    Cikos S., Gregor P., Koppel J.
    Biochim. Biophys. Acta 1521:66-72(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPR61_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ8
Secondary accession number(s): A8K1W2
, Q6NWS0, Q8TDV4, Q96PR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: September 27, 2005
Last modified: June 24, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.