ID   GPR62_HUMAN             Reviewed;         368 AA.
AC   Q9BZJ7; F1DAM4; Q5KU27;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=G-protein coupled receptor 62 {ECO:0000305};
DE   AltName: Full=G-protein coupled receptor GPCR8;
DE            Short=hGPCR8;
DE   AltName: Full=G-protein coupled receptor KPG_005;
GN   Name=GPR62;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-151 AND ARG-216, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=11165367; DOI=10.1016/s0169-328x(00)00242-4;
RA   Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R.,
RA   O'Dowd B.F.;
RT   "Identification of four novel human G protein-coupled receptors expressed
RT   in the brain.";
RL   Brain Res. Mol. Brain Res. 86:13-22(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS PRO-151 AND ARG-216.
RA   Urakawa I., Okazaki H.;
RT   "Probable G-protein coupled receptor.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS PRO-151 AND ARG-216.
RC   TISSUE=Brain;
RA   Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S.;
RT   "Isolation of cDNA coding for multiple human genes.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA   Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT   "Identification of G protein-coupled receptor genes from the human genome
RT   sequence.";
RL   FEBS Lett. 520:97-101(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS PRO-151 AND
RP   ARG-216.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   SUBCELLULAR LOCATION, SUBUNIT, FUNCTION, INTERACTION WITH MTNR1B, AND
RP   INTERACTION WITH ARRB1 AND ARRB2.
RX   PubMed=28827538; DOI=10.1038/s41598-017-08996-7;
RA   Oishi A., Karamitri A., Gerbier R., Lahuna O., Ahmad R., Jockers R.;
RT   "Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor
RT   reciprocally modulate their signaling functions.";
RL   Sci. Rep. 7:8990-8990(2017).
CC   -!- FUNCTION: Orphan G-protein coupled receptor. Constitutively activates
CC       the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling
CC       pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin
CC       recruitment (PubMed:28827538). Shows a reciprocal modulation of
CC       signaling functions with the melatonin receptor MTNR1B most likely
CC       through receptor heteromerization (PubMed:28827538).
CC       {ECO:0000269|PubMed:28827538}.
CC   -!- SUBUNIT: Homodimers (By similarity). Forms heterodimer with MTNR1B
CC       (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and
CC       agonist-independent manner; leading to the internalization of GPR62 in
CC       the endosomal compartment (PubMed:28827538).
CC       {ECO:0000250|UniProtKB:Q80UC6, ECO:0000269|PubMed:28827538}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538};
CC       Multi-pass membrane protein {ECO:0000255}. Endosome membrane
CC       {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein
CC       {ECO:0000255}. Note=Colocalizes with ARRB2 in the endosome
CC       (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain; detected in the basal
CC       forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
CC       {ECO:0000269|PubMed:11165367}.
CC   -!- DOMAIN: Lacks the conserved DRY and BBXXB motifs. The restoration of
CC       these motifs affects its constitutive activity.
CC       {ECO:0000250|UniProtKB:Q80UC6}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF317653; AAK12638.1; -; Genomic_DNA.
DR   EMBL; AB032600; BAD83591.1; -; mRNA.
DR   EMBL; HQ709188; ADZ17395.1; -; mRNA.
DR   EMBL; AB083590; BAB89303.1; -; Genomic_DNA.
DR   EMBL; AC115284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471055; EAW65164.1; -; Genomic_DNA.
DR   CCDS; CCDS2838.1; -.
DR   RefSeq; NP_543141.3; NM_080865.3.
DR   AlphaFoldDB; Q9BZJ7; -.
DR   SMR; Q9BZJ7; -.
DR   IntAct; Q9BZJ7; 1.
DR   MINT; Q9BZJ7; -.
DR   STRING; 9606.ENSP00000319250; -.
DR   ChEMBL; CHEMBL4523917; -.
DR   GlyCosmos; Q9BZJ7; 2 sites, No reported glycans.
DR   GlyGen; Q9BZJ7; 2 sites.
DR   PhosphoSitePlus; Q9BZJ7; -.
DR   BioMuta; GPR62; -.
DR   DMDM; 296434526; -.
DR   MassIVE; Q9BZJ7; -.
DR   PaxDb; 9606-ENSP00000319250; -.
DR   PeptideAtlas; Q9BZJ7; -.
DR   Antibodypedia; 14225; 256 antibodies from 30 providers.
DR   DNASU; 118442; -.
DR   Ensembl; ENST00000322241.6; ENSP00000319250.4; ENSG00000180929.6.
DR   GeneID; 118442; -.
DR   KEGG; hsa:118442; -.
DR   MANE-Select; ENST00000322241.6; ENSP00000319250.4; NM_080865.4; NP_543141.3.
DR   UCSC; uc003dca.4; human.
DR   AGR; HGNC:13301; -.
DR   CTD; 118442; -.
DR   GeneCards; GPR62; -.
DR   HGNC; HGNC:13301; GPR62.
DR   HPA; ENSG00000180929; Tissue enriched (brain).
DR   MIM; 606917; gene.
DR   neXtProt; NX_Q9BZJ7; -.
DR   OpenTargets; ENSG00000180929; -.
DR   PharmGKB; PA28906; -.
DR   VEuPathDB; HostDB:ENSG00000180929; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00950000182998; -.
DR   HOGENOM; CLU_067115_0_0_1; -.
DR   InParanoid; Q9BZJ7; -.
DR   OMA; CTPRAWH; -.
DR   OrthoDB; 4640465at2759; -.
DR   PhylomeDB; Q9BZJ7; -.
DR   TreeFam; TF332667; -.
DR   PathwayCommons; Q9BZJ7; -.
DR   SignaLink; Q9BZJ7; -.
DR   BioGRID-ORCS; 118442; 10 hits in 1143 CRISPR screens.
DR   ChiTaRS; GPR62; human.
DR   GeneWiki; GPR62; -.
DR   GenomeRNAi; 118442; -.
DR   Pharos; Q9BZJ7; Tbio.
DR   PRO; PR:Q9BZJ7; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9BZJ7; Protein.
DR   Bgee; ENSG00000180929; Expressed in inferior vagus X ganglion and 85 other cell types or tissues.
DR   GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0043235; C:receptor complex; IDA:MGI.
DR   GO; GO:1990763; F:arrestin family protein binding; IDA:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0038035; P:G protein-coupled receptor signaling in absence of ligand; IDA:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:UniProtKB.
DR   GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; IDA:UniProtKB.
DR   CDD; cd15220; 7tmA_GPR61_GPR62-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR22752; G PROTEIN-COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR22752:SF11; G-PROTEIN COUPLED RECEPTOR 62; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9BZJ7; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Endosome; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..368
FT                   /note="G-protein coupled receptor 62"
FT                   /id="PRO_0000069580"
FT   TOPO_DOM        1..18
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..39
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..53
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..129
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..177
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..368
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          332..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         151
FT                   /note="T -> P (in dbSNP:rs28587738)"
FT                   /evidence="ECO:0000269|PubMed:11165367, ECO:0000269|Ref.2,
FT                   ECO:0000269|Ref.3, ECO:0000269|Ref.6"
FT                   /id="VAR_067702"
FT   VARIANT         216
FT                   /note="H -> R (in dbSNP:rs28651222)"
FT                   /evidence="ECO:0000269|PubMed:11165367, ECO:0000269|Ref.2,
FT                   ECO:0000269|Ref.3, ECO:0000269|Ref.6"
FT                   /id="VAR_067703"
FT   VARIANT         313
FT                   /note="V -> L (in dbSNP:rs323871)"
FT                   /id="VAR_055920"
SQ   SEQUENCE   368 AA;  37614 MW;  B06F91BF4C51757A CRC64;
     MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY LAHLCVVDLL
     AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP ACTLGVAALG LARYRLIVHP
     LRPGSRPPPV LVLTAVWAAA GLLGALSLLG TPPAPPPAPA RCSVLAGGLG PFRPLWALLA
     FALPALLLLG AYGGIFVVAR RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA
     LAPALAVGQF AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA
     LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE LAGGRSPAYQ
     GPPESSLS
//