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Protein

Probable G-protein coupled receptor 62

Gene

GPR62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180929-MONOMER.
SignaLinkiQ9BZJ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 62
Alternative name(s):
G-protein coupled receptor GPCR8
Short name:
hGPCR8
G-protein coupled receptor KPG_005
Gene namesi
Name:GPR62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13301. GPR62.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18ExtracellularSequence analysisAdd BLAST18
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 53CytoplasmicSequence analysisAdd BLAST14
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 129CytoplasmicSequence analysisAdd BLAST17
Transmembranei130 – 150Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini151 – 177ExtracellularSequence analysisAdd BLAST27
Transmembranei178 – 198Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini199 – 239CytoplasmicSequence analysisAdd BLAST41
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 272ExtracellularSequence analysisAdd BLAST12
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 368CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180929.
PharmGKBiPA28906.

Polymorphism and mutation databases

BioMutaiGPR62.
DMDMi296434526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695801 – 368Probable G-protein coupled receptor 62Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZJ7.
PRIDEiQ9BZJ7.

Expressioni

Tissue specificityi

Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.

Gene expression databases

BgeeiENSG00000180929.
CleanExiHS_GPR62.
GenevisibleiQ9BZJ7. HS.

Interactioni

Protein-protein interaction databases

IntActiQ9BZJ7. 1 interactor.
STRINGi9606.ENSP00000319250.

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi239 – 285Ala-richAdd BLAST47

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000004832.
HOVERGENiHBG051816.
InParanoidiQ9BZJ7.
KOiK08415.
OMAiVGQFAAC.
OrthoDBiEOG091G0TJJ.
PhylomeDBiQ9BZJ7.
TreeFamiTF332667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY
60 70 80 90 100
LAHLCVVDLL AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP
110 120 130 140 150
ACTLGVAALG LARYRLIVHP LRPGSRPPPV LVLTAVWAAA GLLGALSLLG
160 170 180 190 200
TPPAPPPAPA RCSVLAGGLG PFRPLWALLA FALPALLLLG AYGGIFVVAR
210 220 230 240 250
RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA LAPALAVGQF
260 270 280 290 300
AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA
310 320 330 340 350
LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE
360
LAGGRSPAYQ GPPESSLS
Length:368
Mass (Da):37,614
Last modified:May 18, 2010 - v2
Checksum:iB06F91BF4C51757A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067702151T → P.4 PublicationsCorresponds to variant rs28587738dbSNPEnsembl.1
Natural variantiVAR_067703216H → R.4 PublicationsCorresponds to variant rs28651222dbSNPEnsembl.1
Natural variantiVAR_055920313V → L.Corresponds to variant rs323871dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317653 Genomic DNA. Translation: AAK12638.1.
AB032600 mRNA. Translation: BAD83591.1.
HQ709188 mRNA. Translation: ADZ17395.1.
AB083590 Genomic DNA. Translation: BAB89303.1.
AC115284 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65164.1.
CCDSiCCDS2838.1.
RefSeqiNP_543141.3. NM_080865.3.
UniGeneiHs.232213.

Genome annotation databases

EnsembliENST00000322241; ENSP00000319250; ENSG00000180929.
GeneIDi118442.
KEGGihsa:118442.
UCSCiuc003dca.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317653 Genomic DNA. Translation: AAK12638.1.
AB032600 mRNA. Translation: BAD83591.1.
HQ709188 mRNA. Translation: ADZ17395.1.
AB083590 Genomic DNA. Translation: BAB89303.1.
AC115284 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65164.1.
CCDSiCCDS2838.1.
RefSeqiNP_543141.3. NM_080865.3.
UniGeneiHs.232213.

3D structure databases

ProteinModelPortaliQ9BZJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BZJ7. 1 interactor.
STRINGi9606.ENSP00000319250.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR62.
DMDMi296434526.

Proteomic databases

PaxDbiQ9BZJ7.
PRIDEiQ9BZJ7.

Protocols and materials databases

DNASUi118442.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322241; ENSP00000319250; ENSG00000180929.
GeneIDi118442.
KEGGihsa:118442.
UCSCiuc003dca.4. human.

Organism-specific databases

CTDi118442.
GeneCardsiGPR62.
HGNCiHGNC:13301. GPR62.
MIMi606917. gene.
neXtProtiNX_Q9BZJ7.
OpenTargetsiENSG00000180929.
PharmGKBiPA28906.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000004832.
HOVERGENiHBG051816.
InParanoidiQ9BZJ7.
KOiK08415.
OMAiVGQFAAC.
OrthoDBiEOG091G0TJJ.
PhylomeDBiQ9BZJ7.
TreeFamiTF332667.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180929-MONOMER.
SignaLinkiQ9BZJ7.

Miscellaneous databases

GeneWikiiGPR62.
GenomeRNAii118442.
PROiQ9BZJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180929.
CleanExiHS_GPR62.
GenevisibleiQ9BZJ7. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR62_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ7
Secondary accession number(s): F1DAM4, Q5KU27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.