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Q9BZJ7 (GPR62_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 62
Alternative name(s):
G-protein coupled receptor GPCR8
Short name=hGPCR8
G-protein coupled receptor KPG_005
Gene names
Name:GPR62
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Probable G-protein coupled receptor 62
PRO_0000069580

Regions

Topological domain1 – 1818Extracellular Potential
Transmembrane19 – 3921Helical; Name=1; Potential
Topological domain40 – 5314Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=2; Potential
Topological domain75 – 9117Extracellular Potential
Transmembrane92 – 11221Helical; Name=3; Potential
Topological domain113 – 12917Cytoplasmic Potential
Transmembrane130 – 15021Helical; Name=4; Potential
Topological domain151 – 17727Extracellular Potential
Transmembrane178 – 19821Helical; Name=5; Potential
Topological domain199 – 23941Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 27212Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 36875Cytoplasmic Potential
Compositional bias239 – 28547Ala-rich

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation81N-linked (GlcNAc...) Potential

Natural variations

Natural variant1511T → P. Ref.1 Ref.2 Ref.3 Ref.6
Corresponds to variant rs28587738 [ dbSNP | Ensembl ].
VAR_067702
Natural variant2161H → R. Ref.1 Ref.2 Ref.3 Ref.6
Corresponds to variant rs28651222 [ dbSNP | Ensembl ].
VAR_067703
Natural variant3131V → L.
Corresponds to variant rs323871 [ dbSNP | Ensembl ].
VAR_055920

Sequences

Sequence LengthMass (Da)Tools
Q9BZJ7 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: B06F91BF4C51757A

FASTA36837,614
        10         20         30         40         50         60 
MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY LAHLCVVDLL 

        70         80         90        100        110        120 
AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP ACTLGVAALG LARYRLIVHP 

       130        140        150        160        170        180 
LRPGSRPPPV LVLTAVWAAA GLLGALSLLG TPPAPPPAPA RCSVLAGGLG PFRPLWALLA 

       190        200        210        220        230        240 
FALPALLLLG AYGGIFVVAR RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA 

       250        260        270        280        290        300 
LAPALAVGQF AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA 

       310        320        330        340        350        360 
LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE LAGGRSPAYQ 


GPPESSLS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of four novel human G protein-coupled receptors expressed in the brain."
Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.
[2]"Probable G-protein coupled receptor."
Urakawa I., Okazaki H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216.
[3]"Isolation of cDNA coding for multiple human genes."
Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216.
Tissue: Brain.
[4]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF317653 Genomic DNA. Translation: AAK12638.1.
AB032600 mRNA. Translation: BAD83591.1.
HQ709188 mRNA. Translation: ADZ17395.1.
AB083590 Genomic DNA. Translation: BAB89303.1.
AC115284 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65164.1.
RefSeqNP_543141.3. NM_080865.3.
UniGeneHs.232213.

3D structure databases

ProteinModelPortalQ9BZJ7.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM296434526.

Proteomic databases

PaxDbQ9BZJ7.
PRIDEQ9BZJ7.

Protocols and materials databases

DNASU118442.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322241; ENSP00000319250; ENSG00000180929.
GeneID118442.
KEGGhsa:118442.
UCSCuc003dca.4. human.

Organism-specific databases

CTD118442.
GeneCardsGC03P051964.
HGNCHGNC:13301. GPR62.
HPAHPA031309.
MIM606917. gene.
neXtProtNX_Q9BZJ7.
PharmGKBPA28906.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267429.
HOGENOMHOG000004832.
HOVERGENHBG051816.
InParanoidQ9BZJ7.
KOK08415.
OMAAAHPFLY.
OrthoDBEOG7WT42Z.
PhylomeDBQ9BZJ7.
TreeFamTF332667.

Enzyme and pathway databases

SignaLinkQ9BZJ7.

Gene expression databases

BgeeQ9BZJ7.
CleanExHS_GPR62.
GenevestigatorQ9BZJ7.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR62.
GenomeRNAi118442.
NextBio80288.
PROQ9BZJ7.
SOURCESearch...

Entry information

Entry nameGPR62_HUMAN
AccessionPrimary (citable) accession number: Q9BZJ7
Secondary accession number(s): F1DAM4, Q5KU27
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries