Q9BZJ7 (GPR62_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 62

Alternative name(s):
G-protein coupled receptor GPCR8
Short name=hGPCR8
G-protein coupled receptor KPG_005

Gene names

Name:

GPR62

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Probable G-protein coupled receptor 62		PRO_0000069580
Regions
	Topological domain	1 – 18	18	Extracellular Potential
	Transmembrane	19 – 39	21	Helical; Name=1; Potential
	Topological domain	40 – 53	14	Cytoplasmic Potential
	Transmembrane	54 – 74	21	Helical; Name=2; Potential
	Topological domain	75 – 91	17	Extracellular Potential
	Transmembrane	92 – 112	21	Helical; Name=3; Potential
	Topological domain	113 – 129	17	Cytoplasmic Potential
	Transmembrane	130 – 150	21	Helical; Name=4; Potential
	Topological domain	151 – 177	27	Extracellular Potential
	Transmembrane	178 – 198	21	Helical; Name=5; Potential
	Topological domain	199 – 239	41	Cytoplasmic Potential
	Transmembrane	240 – 260	21	Helical; Name=6; Potential
	Topological domain	261 – 272	12	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=7; Potential
	Topological domain	294 – 368	75	Cytoplasmic Potential
	Compositional bias	239 – 285	47	Ala-rich
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	151	1	T → P. Ref.1 Ref.2 Ref.3 Ref.6 Corresponds to variant rs28587738 [ dbSNP | Ensembl ].		VAR_067702
	Natural variant	216	1	H → R. Ref.1 Ref.2 Ref.3 Ref.6 Corresponds to variant rs28651222 [ dbSNP | Ensembl ].		VAR_067703
	Natural variant	313	1	V → L. Corresponds to variant rs323871 [ dbSNP | Ensembl ].		VAR_055920

Sequences

	Sequence		Length	Mass (Da)
	Q9BZJ7 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: B06F91BF4C51757A	FASTA	368	37,614
	10 20 30 40 50 60 MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY LAHLCVVDLL 70 80 90 100 110 120 AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP ACTLGVAALG LARYRLIVHP 130 140 150 160 170 180 LRPGSRPPPV LVLTAVWAAA GLLGALSLLG TPPAPPPAPA RCSVLAGGLG PFRPLWALLA 190 200 210 220 230 240 FALPALLLLG AYGGIFVVAR RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA 250 260 270 280 290 300 LAPALAVGQF AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA 310 320 330 340 350 360 LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE LAGGRSPAYQ GPPESSLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of four novel human G protein-coupled receptors expressed in the brain." Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F. Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.
[2]	"Probable G-protein coupled receptor." Urakawa I., Okazaki H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216.
[3]	"Isolation of cDNA coding for multiple human genes." Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216. Tissue: Brain.
[4]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317653 Genomic DNA. Translation: AAK12638.1. AB032600 mRNA. Translation: BAD83591.1. HQ709188 mRNA. Translation: ADZ17395.1. AB083590 Genomic DNA. Translation: BAB89303.1. AC115284 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW65164.1.
IPI	IPI00289120.
RefSeq	NP_543141.3. NM_080865.3.
UniGene	Hs.232213.
3D structure databases
ProteinModelPortal	Q9BZJ7.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	296434526.
Proteomic databases
PaxDb	Q9BZJ7.
PRIDE	Q9BZJ7.
Protocols and materials databases
DNASU	118442.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322241; ENSP00000319250; ENSG00000180929.
GeneID	118442.
KEGG	hsa:118442.
UCSC	uc003dca.4. human.
Organism-specific databases
CTD	118442.
GeneCards	GC03P051964.
HGNC	HGNC:13301. GPR62.
HPA	HPA031309.
MIM	606917. gene.
neXtProt	NX_Q9BZJ7.
PharmGKB	PA28906.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267429.
HOGENOM	HOG000004832.
HOVERGEN	HBG051816.
InParanoid	Q9BZJ7.
KO	K08415.
OMA	VGQFAAC.
OrthoDB	EOG466VN7.
PhylomeDB	Q9BZJ7.
Gene expression databases
Bgee	Q9BZJ7.
CleanEx	HS_GPR62.
Genevestigator	Q9BZJ7.
GermOnline	ENSG00000180929. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	118442.
NextBio	80288.
SOURCE	Search...

Entry information

Entry name

GPR62_HUMAN

Accession

Primary (citable) accession number: Q9BZJ7
Secondary accession number(s): F1DAM4, Q5KU27

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.