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Protein

Probable G-protein coupled receptor 62

Gene

GPR62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

SignaLinkiQ9BZJ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 62
Alternative name(s):
G-protein coupled receptor GPCR8
Short name:
hGPCR8
G-protein coupled receptor KPG_005
Gene namesi
Name:GPR62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13301. GPR62.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818ExtracellularSequence AnalysisAdd
BLAST
Transmembranei19 – 3921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini40 – 5314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 9117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini113 – 12917CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini151 – 17727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini199 – 23941CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 36875CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28906.

Polymorphism and mutation databases

BioMutaiGPR62.
DMDMi296434526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Probable G-protein coupled receptor 62PRO_0000069580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZJ7.
PRIDEiQ9BZJ7.

Expressioni

Tissue specificityi

Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.

Gene expression databases

BgeeiQ9BZJ7.
CleanExiHS_GPR62.
GenevisibleiQ9BZJ7. HS.

Organism-specific databases

HPAiHPA031309.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319250.

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi239 – 28547Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267429.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000004832.
HOVERGENiHBG051816.
InParanoidiQ9BZJ7.
KOiK08415.
OMAiVGQFAAC.
OrthoDBiEOG7WT42Z.
PhylomeDBiQ9BZJ7.
TreeFamiTF332667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY
60 70 80 90 100
LAHLCVVDLL AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP
110 120 130 140 150
ACTLGVAALG LARYRLIVHP LRPGSRPPPV LVLTAVWAAA GLLGALSLLG
160 170 180 190 200
TPPAPPPAPA RCSVLAGGLG PFRPLWALLA FALPALLLLG AYGGIFVVAR
210 220 230 240 250
RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA LAPALAVGQF
260 270 280 290 300
AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA
310 320 330 340 350
LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE
360
LAGGRSPAYQ GPPESSLS
Length:368
Mass (Da):37,614
Last modified:May 18, 2010 - v2
Checksum:iB06F91BF4C51757A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511T → P.4 Publications
Corresponds to variant rs28587738 [ dbSNP | Ensembl ].
VAR_067702
Natural varianti216 – 2161H → R.4 Publications
Corresponds to variant rs28651222 [ dbSNP | Ensembl ].
VAR_067703
Natural varianti313 – 3131V → L.
Corresponds to variant rs323871 [ dbSNP | Ensembl ].
VAR_055920

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317653 Genomic DNA. Translation: AAK12638.1.
AB032600 mRNA. Translation: BAD83591.1.
HQ709188 mRNA. Translation: ADZ17395.1.
AB083590 Genomic DNA. Translation: BAB89303.1.
AC115284 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65164.1.
CCDSiCCDS2838.1.
RefSeqiNP_543141.3. NM_080865.3.
UniGeneiHs.232213.

Genome annotation databases

EnsembliENST00000322241; ENSP00000319250; ENSG00000180929.
GeneIDi118442.
KEGGihsa:118442.
UCSCiuc003dca.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317653 Genomic DNA. Translation: AAK12638.1.
AB032600 mRNA. Translation: BAD83591.1.
HQ709188 mRNA. Translation: ADZ17395.1.
AB083590 Genomic DNA. Translation: BAB89303.1.
AC115284 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65164.1.
CCDSiCCDS2838.1.
RefSeqiNP_543141.3. NM_080865.3.
UniGeneiHs.232213.

3D structure databases

ProteinModelPortaliQ9BZJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319250.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR62.
DMDMi296434526.

Proteomic databases

PaxDbiQ9BZJ7.
PRIDEiQ9BZJ7.

Protocols and materials databases

DNASUi118442.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322241; ENSP00000319250; ENSG00000180929.
GeneIDi118442.
KEGGihsa:118442.
UCSCiuc003dca.4. human.

Organism-specific databases

CTDi118442.
GeneCardsiGC03P051964.
HGNCiHGNC:13301. GPR62.
HPAiHPA031309.
MIMi606917. gene.
neXtProtiNX_Q9BZJ7.
PharmGKBiPA28906.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG267429.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000004832.
HOVERGENiHBG051816.
InParanoidiQ9BZJ7.
KOiK08415.
OMAiVGQFAAC.
OrthoDBiEOG7WT42Z.
PhylomeDBiQ9BZJ7.
TreeFamiTF332667.

Enzyme and pathway databases

SignaLinkiQ9BZJ7.

Miscellaneous databases

GeneWikiiGPR62.
GenomeRNAii118442.
NextBioi80288.
PROiQ9BZJ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZJ7.
CleanExiHS_GPR62.
GenevisibleiQ9BZJ7. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of four novel human G protein-coupled receptors expressed in the brain."
    Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
    Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.
  2. "Probable G-protein coupled receptor."
    Urakawa I., Okazaki H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216.
  3. "Isolation of cDNA coding for multiple human genes."
    Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216.
    Tissue: Brain.
  4. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.

Entry informationi

Entry nameiGPR62_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ7
Secondary accession number(s): F1DAM4, Q5KU27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.