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Q9BZJ7

- GPR62_HUMAN

UniProt

Q9BZJ7 - GPR62_HUMAN

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Protein
Probable G-protein coupled receptor 62
Gene
GPR62
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    SignaLinkiQ9BZJ7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 62
    Alternative name(s):
    G-protein coupled receptor GPCR8
    Short name:
    hGPCR8
    G-protein coupled receptor KPG_005
    Gene namesi
    Name:GPR62
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13301. GPR62.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei19 – 3921Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini40 – 5314Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei54 – 7421Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini75 – 9117Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei92 – 11221Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini113 – 12917Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei130 – 15021Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini151 – 17727Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei178 – 19821Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini199 – 23941Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei240 – 26021Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini261 – 27212Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei273 – 29321Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini294 – 36875Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. receptor complex Source: MGI
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28906.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Probable G-protein coupled receptor 62
    PRO_0000069580Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi8 – 81N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9BZJ7.
    PRIDEiQ9BZJ7.

    Expressioni

    Tissue specificityi

    Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.

    Gene expression databases

    BgeeiQ9BZJ7.
    CleanExiHS_GPR62.
    GenevestigatoriQ9BZJ7.

    Organism-specific databases

    HPAiHPA031309.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZJ7.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi239 – 28547Ala-rich
    Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267429.
    HOGENOMiHOG000004832.
    HOVERGENiHBG051816.
    InParanoidiQ9BZJ7.
    KOiK08415.
    OMAiAAHPFLY.
    OrthoDBiEOG7WT42Z.
    PhylomeDBiQ9BZJ7.
    TreeFamiTF332667.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BZJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY    50
    LAHLCVVDLL AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP 100
    ACTLGVAALG LARYRLIVHP LRPGSRPPPV LVLTAVWAAA GLLGALSLLG 150
    TPPAPPPAPA RCSVLAGGLG PFRPLWALLA FALPALLLLG AYGGIFVVAR 200
    RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA LAPALAVGQF 250
    AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA 300
    LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE 350
    LAGGRSPAYQ GPPESSLS 368
    Length:368
    Mass (Da):37,614
    Last modified:May 18, 2010 - v2
    Checksum:iB06F91BF4C51757A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511T → P.4 Publications
    Corresponds to variant rs28587738 [ dbSNP | Ensembl ].
    VAR_067702
    Natural varianti216 – 2161H → R.4 Publications
    Corresponds to variant rs28651222 [ dbSNP | Ensembl ].
    VAR_067703
    Natural varianti313 – 3131V → L.
    Corresponds to variant rs323871 [ dbSNP | Ensembl ].
    VAR_055920

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317653 Genomic DNA. Translation: AAK12638.1.
    AB032600 mRNA. Translation: BAD83591.1.
    HQ709188 mRNA. Translation: ADZ17395.1.
    AB083590 Genomic DNA. Translation: BAB89303.1.
    AC115284 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65164.1.
    CCDSiCCDS2838.1.
    RefSeqiNP_543141.3. NM_080865.3.
    UniGeneiHs.232213.

    Genome annotation databases

    EnsembliENST00000322241; ENSP00000319250; ENSG00000180929.
    GeneIDi118442.
    KEGGihsa:118442.
    UCSCiuc003dca.4. human.

    Polymorphism databases

    DMDMi296434526.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317653 Genomic DNA. Translation: AAK12638.1 .
    AB032600 mRNA. Translation: BAD83591.1 .
    HQ709188 mRNA. Translation: ADZ17395.1 .
    AB083590 Genomic DNA. Translation: BAB89303.1 .
    AC115284 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65164.1 .
    CCDSi CCDS2838.1.
    RefSeqi NP_543141.3. NM_080865.3.
    UniGenei Hs.232213.

    3D structure databases

    ProteinModelPortali Q9BZJ7.
    ModBasei Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 296434526.

    Proteomic databases

    PaxDbi Q9BZJ7.
    PRIDEi Q9BZJ7.

    Protocols and materials databases

    DNASUi 118442.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322241 ; ENSP00000319250 ; ENSG00000180929 .
    GeneIDi 118442.
    KEGGi hsa:118442.
    UCSCi uc003dca.4. human.

    Organism-specific databases

    CTDi 118442.
    GeneCardsi GC03P051964.
    HGNCi HGNC:13301. GPR62.
    HPAi HPA031309.
    MIMi 606917. gene.
    neXtProti NX_Q9BZJ7.
    PharmGKBi PA28906.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267429.
    HOGENOMi HOG000004832.
    HOVERGENi HBG051816.
    InParanoidi Q9BZJ7.
    KOi K08415.
    OMAi AAHPFLY.
    OrthoDBi EOG7WT42Z.
    PhylomeDBi Q9BZJ7.
    TreeFami TF332667.

    Enzyme and pathway databases

    SignaLinki Q9BZJ7.

    Miscellaneous databases

    GeneWikii GPR62.
    GenomeRNAii 118442.
    NextBioi 80288.
    PROi Q9BZJ7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BZJ7.
    CleanExi HS_GPR62.
    Genevestigatori Q9BZJ7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Identification of four novel human G protein-coupled receptors expressed in the brain."
      Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
      Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.
    2. "Probable G-protein coupled receptor."
      Urakawa I., Okazaki H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216.
    3. "Isolation of cDNA coding for multiple human genes."
      Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-151 AND ARG-216.
      Tissue: Brain.
    4. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-151 AND ARG-216.

    Entry informationi

    Entry nameiGPR62_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZJ7
    Secondary accession number(s): F1DAM4, Q5KU27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 18, 2010
    Last modified: July 9, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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