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Protein

Probable G-protein coupled receptor 63

Gene

GPR63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May play a role in brain function.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 63
Alternative name(s):
PSP24-2
PSP24-beta
Gene namesi
Name:GPR63
Synonyms:PSP24B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13302. GPR63.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81ExtracellularSequence analysisAdd BLAST81
Transmembranei82 – 104Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini105 – 115CytoplasmicSequence analysisAdd BLAST11
Transmembranei116 – 138Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini139 – 157ExtracellularSequence analysisAdd BLAST19
Transmembranei158 – 177Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini178 – 196CytoplasmicSequence analysisAdd BLAST19
Transmembranei197 – 216Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini217 – 240ExtracellularSequence analysisAdd BLAST24
Transmembranei241 – 263Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini264 – 315CytoplasmicSequence analysisAdd BLAST52
Transmembranei316 – 338Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini339 – 352ExtracellularSequence analysisAdd BLAST14
Transmembranei353 – 375Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini376 – 419CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112218.
PharmGKBiPA28907.

Chemistry databases

GuidetoPHARMACOLOGYi112.

Polymorphism and mutation databases

BioMutaiGPR63.
DMDMi21263685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695811 – 419Probable G-protein coupled receptor 63Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZJ6.
PeptideAtlasiQ9BZJ6.
PRIDEiQ9BZJ6.

PTM databases

iPTMnetiQ9BZJ6.
PhosphoSitePlusiQ9BZJ6.

Expressioni

Tissue specificityi

Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain.

Gene expression databases

BgeeiENSG00000112218.
CleanExiHS_GPR63.
ExpressionAtlasiQ9BZJ6. baseline and differential.
GenevisibleiQ9BZJ6. HS.

Organism-specific databases

HPAiHPA039103.

Interactioni

Protein-protein interaction databases

BioGridi123500. 1 interactor.
IntActiQ9BZJ6. 2 interactors.
MINTiMINT-7241992.
STRINGi9606.ENSP00000229955.

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOVERGENiHBG051812.
InParanoidiQ9BZJ6.
KOiK04321.
OMAiYYWRIKK.
OrthoDBiEOG091G07RP.
PhylomeDBiQ9BZJ6.
TreeFamiTF332301.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSAVLTAF HTGTSNTTFV VYENTYMNIT LPPPFQHPDL SPLLRYSFET
60 70 80 90 100
MAPTGLSSLT VNSTAVPTTP AAFKSLNLPL QITLSAIMIF ILFVSFLGNL
110 120 130 140 150
VVCLMVYQKA AMRSAINILL ASLAFADMLL AVLNMPFALV TILTTRWIFG
160 170 180 190 200
KFFCRVSAMF FWLFVIEGVA ILLIISIDRF LIIVQRQDKL NPYRAKVLIA
210 220 230 240 250
VSWATSFCVA FPLAVGNPDL QIPSRAPQCV FGYTTNPGYQ AYVILISLIS
260 270 280 290 300
FFIPFLVILY SFMGILNTLR HNALRIHSYP EGICLSQASK LGLMSLQRPF
310 320 330 340 350
QMSIDMGFKT RAFTTILILF AVFIVCWAPF TTYSLVATFS KHFYYQHNFF
360 370 380 390 400
EISTWLLWLC YLKSALNPLI YYWRIKKFHD ACLDMMPKSF KFLPQLPGHT
410
KRRIRPSAVY VCGEHRTVV
Length:419
Mass (Da):47,578
Last modified:October 1, 2001 - v2
Checksum:i17418CD0AE1D6C8D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04939621V → M.Corresponds to variant rs35358396dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317654 Genomic DNA. Translation: AAK12639.2.
AB030566 mRNA. Translation: BAB20031.1.
AL033379 Genomic DNA. Translation: CAB55871.1.
BC067465 mRNA. Translation: AAH67465.1.
BC067469 mRNA. Translation: AAH67469.1.
CCDSiCCDS5036.1.
RefSeqiNP_001137429.1. NM_001143957.2.
NP_110411.1. NM_030784.3.
XP_006715633.1. XM_006715570.3.
XP_011534455.1. XM_011536153.2.
XP_011534456.1. XM_011536154.2.
XP_011534457.1. XM_011536155.2.
XP_011534459.1. XM_011536157.2.
XP_011534461.1. XM_011536159.2.
XP_016866823.1. XM_017011334.1.
UniGeneiHs.221364.

Genome annotation databases

EnsembliENST00000229955; ENSP00000229955; ENSG00000112218.
GeneIDi81491.
KEGGihsa:81491.
UCSCiuc003pou.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317654 Genomic DNA. Translation: AAK12639.2.
AB030566 mRNA. Translation: BAB20031.1.
AL033379 Genomic DNA. Translation: CAB55871.1.
BC067465 mRNA. Translation: AAH67465.1.
BC067469 mRNA. Translation: AAH67469.1.
CCDSiCCDS5036.1.
RefSeqiNP_001137429.1. NM_001143957.2.
NP_110411.1. NM_030784.3.
XP_006715633.1. XM_006715570.3.
XP_011534455.1. XM_011536153.2.
XP_011534456.1. XM_011536154.2.
XP_011534457.1. XM_011536155.2.
XP_011534459.1. XM_011536157.2.
XP_011534461.1. XM_011536159.2.
XP_016866823.1. XM_017011334.1.
UniGeneiHs.221364.

3D structure databases

ProteinModelPortaliQ9BZJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123500. 1 interactor.
IntActiQ9BZJ6. 2 interactors.
MINTiMINT-7241992.
STRINGi9606.ENSP00000229955.

Chemistry databases

GuidetoPHARMACOLOGYi112.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9BZJ6.
PhosphoSitePlusiQ9BZJ6.

Polymorphism and mutation databases

BioMutaiGPR63.
DMDMi21263685.

Proteomic databases

PaxDbiQ9BZJ6.
PeptideAtlasiQ9BZJ6.
PRIDEiQ9BZJ6.

Protocols and materials databases

DNASUi81491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229955; ENSP00000229955; ENSG00000112218.
GeneIDi81491.
KEGGihsa:81491.
UCSCiuc003pou.4. human.

Organism-specific databases

CTDi81491.
GeneCardsiGPR63.
HGNCiHGNC:13302. GPR63.
HPAiHPA039103.
MIMi606915. gene.
neXtProtiNX_Q9BZJ6.
OpenTargetsiENSG00000112218.
PharmGKBiPA28907.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOVERGENiHBG051812.
InParanoidiQ9BZJ6.
KOiK04321.
OMAiYYWRIKK.
OrthoDBiEOG091G07RP.
PhylomeDBiQ9BZJ6.
TreeFamiTF332301.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112218-MONOMER.

Miscellaneous databases

GeneWikiiGPR63.
GenomeRNAii81491.
PROiQ9BZJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112218.
CleanExiHS_GPR63.
ExpressionAtlasiQ9BZJ6. baseline and differential.
GenevisibleiQ9BZJ6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR63_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ6
Secondary accession number(s): Q9UJH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.