Q9BZJ6 (GPR63_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 63

Alternative name(s):
PSP24-2
PSP24-beta

Gene names

Name:	GPR63
Synonyms:	PSP24B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. May play a role in brain function.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Probable G-protein coupled receptor 63		PRO_0000069581
Regions
	Topological domain	1 – 81	81	Extracellular Potential
	Transmembrane	82 – 104	23	Helical; Name=1; Potential
	Topological domain	105 – 115	11	Cytoplasmic Potential
	Transmembrane	116 – 138	23	Helical; Name=2; Potential
	Topological domain	139 – 157	19	Extracellular Potential
	Transmembrane	158 – 177	20	Helical; Name=3; Potential
	Topological domain	178 – 196	19	Cytoplasmic Potential
	Transmembrane	197 – 216	20	Helical; Name=4; Potential
	Topological domain	217 – 240	24	Extracellular Potential
	Transmembrane	241 – 263	23	Helical; Name=5; Potential
	Topological domain	264 – 315	52	Cytoplasmic Potential
	Transmembrane	316 – 338	23	Helical; Name=6; Potential
	Topological domain	339 – 352	14	Extracellular Potential
	Transmembrane	353 – 375	23	Helical; Name=7; Potential
	Topological domain	376 – 419	44	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	21	1	V → M. Corresponds to variant rs35358396 [ dbSNP | Ensembl ].		VAR_049396

Sequences

	Sequence		Length	Mass (Da)
	Q9BZJ6 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: 17418CD0AE1D6C8D	FASTA	419	47,578
	10 20 30 40 50 60 MVFSAVLTAF HTGTSNTTFV VYENTYMNIT LPPPFQHPDL SPLLRYSFET MAPTGLSSLT 70 80 90 100 110 120 VNSTAVPTTP AAFKSLNLPL QITLSAIMIF ILFVSFLGNL VVCLMVYQKA AMRSAINILL 130 140 150 160 170 180 ASLAFADMLL AVLNMPFALV TILTTRWIFG KFFCRVSAMF FWLFVIEGVA ILLIISIDRF 190 200 210 220 230 240 LIIVQRQDKL NPYRAKVLIA VSWATSFCVA FPLAVGNPDL QIPSRAPQCV FGYTTNPGYQ 250 260 270 280 290 300 AYVILISLIS FFIPFLVILY SFMGILNTLR HNALRIHSYP EGICLSQASK LGLMSLQRPF 310 320 330 340 350 360 QMSIDMGFKT RAFTTILILF AVFIVCWAPF TTYSLVATFS KHFYYQHNFF EISTWLLWLC 370 380 390 400 410 YLKSALNPLI YYWRIKKFHD ACLDMMPKSF KFLPQLPGHT KRRIRPSAVY VCGEHRTVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of four novel human G protein-coupled receptors expressed in the brain." Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F. Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45." Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T. Biochem. Biophys. Res. Commun. 276:952-956(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317654 Genomic DNA. Translation: AAK12639.2. AB030566 mRNA. Translation: BAB20031.1. AL033379 Genomic DNA. Translation: CAB55871.1. BC067465 mRNA. Translation: AAH67465.1. BC067469 mRNA. Translation: AAH67469.1.
IPI	IPI00043553.
RefSeq	NP_001137429.1. NM_001143957.2. NP_110411.1. NM_030784.3.
UniGene	Hs.221364. Hs.632612.
3D structure databases
ProteinModelPortal	Q9BZJ6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BZJ6. 1 interaction.
MINT	MINT-7241992.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	21263685.
Proteomic databases
PaxDb	Q9BZJ6.
PRIDE	Q9BZJ6.
Protocols and materials databases
DNASU	81491.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229955; ENSP00000229955; ENSG00000112218. ENST00000369268; ENSP00000358273; ENSG00000112218. ENST00000417980; ENSP00000393170; ENSG00000112218.
GeneID	81491.
KEGG	hsa:81491.
UCSC	uc003pou.3. human.
Organism-specific databases
CTD	81491.
GeneCards	GC06M097291.
HGNC	HGNC:13302. GPR63.
HPA	HPA039103.
MIM	606915. gene.
neXtProt	NX_Q9BZJ6.
PharmGKB	PA28907.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG271802.
HOVERGEN	HBG051812.
InParanoid	Q9BZJ6.
KO	K04321.
OrthoDB	EOG4CJVH9.
PhylomeDB	Q9BZJ6.
Gene expression databases
ArrayExpress	Q9BZJ6.
Bgee	Q9BZJ6.
CleanEx	HS_GPR63.
Genevestigator	Q9BZJ6.
GermOnline	ENSG00000112218. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81491.
NextBio	71726.
SOURCE	Search...

Entry information

Entry name

GPR63_HUMAN

Accession

Primary (citable) accession number: Q9BZJ6
Secondary accession number(s): Q9UJH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.