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Protein

Probable G-protein coupled receptor 63

Gene

GPR63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May play a role in brain function.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 63
Alternative name(s):
PSP24-2
PSP24-beta
Gene namesi
Name:GPR63
Synonyms:PSP24B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13302. GPR63.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8181ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10423Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini105 – 11511CytoplasmicSequence analysisAdd
BLAST
Transmembranei116 – 13823Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini139 – 15719ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 17720Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini178 – 19619CytoplasmicSequence analysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini217 – 24024ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 26323Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini264 – 31552CytoplasmicSequence analysisAdd
BLAST
Transmembranei316 – 33823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini339 – 35214ExtracellularSequence analysisAdd
BLAST
Transmembranei353 – 37523Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini376 – 41944CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28907.

Chemistry

GuidetoPHARMACOLOGYi112.

Polymorphism and mutation databases

BioMutaiGPR63.
DMDMi21263685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Probable G-protein coupled receptor 63PRO_0000069581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZJ6.
PRIDEiQ9BZJ6.

Expressioni

Tissue specificityi

Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain.

Gene expression databases

BgeeiQ9BZJ6.
CleanExiHS_GPR63.
ExpressionAtlasiQ9BZJ6. baseline and differential.
GenevisibleiQ9BZJ6. HS.

Organism-specific databases

HPAiHPA039103.

Interactioni

Protein-protein interaction databases

BioGridi123500. 1 interaction.
IntActiQ9BZJ6. 2 interactions.
MINTiMINT-7241992.
STRINGi9606.ENSP00000229955.

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ6.
SMRiQ9BZJ6. Positions 62-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOVERGENiHBG051812.
InParanoidiQ9BZJ6.
KOiK04321.
OMAiIYYWRIK.
OrthoDBiEOG71K62X.
PhylomeDBiQ9BZJ6.
TreeFamiTF332301.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSAVLTAF HTGTSNTTFV VYENTYMNIT LPPPFQHPDL SPLLRYSFET
60 70 80 90 100
MAPTGLSSLT VNSTAVPTTP AAFKSLNLPL QITLSAIMIF ILFVSFLGNL
110 120 130 140 150
VVCLMVYQKA AMRSAINILL ASLAFADMLL AVLNMPFALV TILTTRWIFG
160 170 180 190 200
KFFCRVSAMF FWLFVIEGVA ILLIISIDRF LIIVQRQDKL NPYRAKVLIA
210 220 230 240 250
VSWATSFCVA FPLAVGNPDL QIPSRAPQCV FGYTTNPGYQ AYVILISLIS
260 270 280 290 300
FFIPFLVILY SFMGILNTLR HNALRIHSYP EGICLSQASK LGLMSLQRPF
310 320 330 340 350
QMSIDMGFKT RAFTTILILF AVFIVCWAPF TTYSLVATFS KHFYYQHNFF
360 370 380 390 400
EISTWLLWLC YLKSALNPLI YYWRIKKFHD ACLDMMPKSF KFLPQLPGHT
410
KRRIRPSAVY VCGEHRTVV
Length:419
Mass (Da):47,578
Last modified:October 1, 2001 - v2
Checksum:i17418CD0AE1D6C8D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211V → M.
Corresponds to variant rs35358396 [ dbSNP | Ensembl ].
VAR_049396

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317654 Genomic DNA. Translation: AAK12639.2.
AB030566 mRNA. Translation: BAB20031.1.
AL033379 Genomic DNA. Translation: CAB55871.1.
BC067465 mRNA. Translation: AAH67465.1.
BC067469 mRNA. Translation: AAH67469.1.
CCDSiCCDS5036.1.
RefSeqiNP_001137429.1. NM_001143957.2.
NP_110411.1. NM_030784.3.
XP_006715632.1. XM_006715569.2.
XP_006715633.1. XM_006715570.2.
XP_011534455.1. XM_011536153.1.
XP_011534456.1. XM_011536154.1.
XP_011534457.1. XM_011536155.1.
XP_011534458.1. XM_011536156.1.
XP_011534459.1. XM_011536157.1.
XP_011534460.1. XM_011536158.1.
XP_011534461.1. XM_011536159.1.
UniGeneiHs.221364.

Genome annotation databases

EnsembliENST00000229955; ENSP00000229955; ENSG00000112218.
GeneIDi81491.
KEGGihsa:81491.
UCSCiuc003pou.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317654 Genomic DNA. Translation: AAK12639.2.
AB030566 mRNA. Translation: BAB20031.1.
AL033379 Genomic DNA. Translation: CAB55871.1.
BC067465 mRNA. Translation: AAH67465.1.
BC067469 mRNA. Translation: AAH67469.1.
CCDSiCCDS5036.1.
RefSeqiNP_001137429.1. NM_001143957.2.
NP_110411.1. NM_030784.3.
XP_006715632.1. XM_006715569.2.
XP_006715633.1. XM_006715570.2.
XP_011534455.1. XM_011536153.1.
XP_011534456.1. XM_011536154.1.
XP_011534457.1. XM_011536155.1.
XP_011534458.1. XM_011536156.1.
XP_011534459.1. XM_011536157.1.
XP_011534460.1. XM_011536158.1.
XP_011534461.1. XM_011536159.1.
UniGeneiHs.221364.

3D structure databases

ProteinModelPortaliQ9BZJ6.
SMRiQ9BZJ6. Positions 62-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123500. 1 interaction.
IntActiQ9BZJ6. 2 interactions.
MINTiMINT-7241992.
STRINGi9606.ENSP00000229955.

Chemistry

GuidetoPHARMACOLOGYi112.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR63.
DMDMi21263685.

Proteomic databases

PaxDbiQ9BZJ6.
PRIDEiQ9BZJ6.

Protocols and materials databases

DNASUi81491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229955; ENSP00000229955; ENSG00000112218.
GeneIDi81491.
KEGGihsa:81491.
UCSCiuc003pou.4. human.

Organism-specific databases

CTDi81491.
GeneCardsiGPR63.
HGNCiHGNC:13302. GPR63.
HPAiHPA039103.
MIMi606915. gene.
neXtProtiNX_Q9BZJ6.
PharmGKBiPA28907.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOVERGENiHBG051812.
InParanoidiQ9BZJ6.
KOiK04321.
OMAiIYYWRIK.
OrthoDBiEOG71K62X.
PhylomeDBiQ9BZJ6.
TreeFamiTF332301.

Miscellaneous databases

GeneWikiiGPR63.
GenomeRNAii81491.
NextBioi71726.
PROiQ9BZJ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZJ6.
CleanExiHS_GPR63.
ExpressionAtlasiQ9BZJ6. baseline and differential.
GenevisibleiQ9BZJ6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of four novel human G protein-coupled receptors expressed in the brain."
    Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
    Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45."
    Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T.
    Biochem. Biophys. Res. Commun. 276:952-956(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPR63_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ6
Secondary accession number(s): Q9UJH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: March 16, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.