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Protein

Crooked neck-like protein 1

Gene

CRNKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing process.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • mRNA splicing, via spliceosome Source: UniProtKB
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • spliceosomal complex assembly Source: UniProtKB
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Crooked neck-like protein 1
Alternative name(s):
Crooked neck homolog
Short name:
hCrn
Gene namesi
Name:CRNKL1
Synonyms:CRN
ORF Names:CGI-201, MSTP021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15762. CRNKL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26886.

Polymorphism and mutation databases

BioMutaiCRNKL1.
DMDMi147744555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Crooked neck-like protein 1PRO_0000205719Add
BLAST
Isoform 2 (identifier: Q9BZJ0-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei503 – 5031PhosphoserineCombined sources
Isoform 2 (identifier: Q9BZJ0-2)
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BZJ0.
MaxQBiQ9BZJ0.
PaxDbiQ9BZJ0.
PeptideAtlasiQ9BZJ0.
PRIDEiQ9BZJ0.

PTM databases

iPTMnetiQ9BZJ0.
PhosphoSiteiQ9BZJ0.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in testis. Not expressed in brain and lung.

Gene expression databases

BgeeiQ9BZJ0.
ExpressionAtlasiQ9BZJ0. baseline and differential.
GenevisibleiQ9BZJ0. HS.

Organism-specific databases

HPAiHPA054478.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2. Isoform 2 seems to be predominant in the spliceosome complex. Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC12Q8WUD42EBI-1049701,EBI-2557572

Protein-protein interaction databases

BioGridi119487. 63 interactions.
IntActiQ9BZJ0. 16 interactions.
MINTiMINT-4654476.
STRINGi9606.ENSP00000366557.

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ0.
SMRiQ9BZJ0. Positions 252-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati222 – 25433HAT 1Add
BLAST
Repeati256 – 28833HAT 2Add
BLAST
Repeati290 – 32233HAT 3Add
BLAST
Repeati324 – 35532HAT 4Add
BLAST
Repeati357 – 38832HAT 5Add
BLAST
Repeati390 – 42536HAT 6Add
BLAST
Repeati427 – 46135HAT 7Add
BLAST
Repeati471 – 50333HAT 8Add
BLAST
Repeati505 – 53935HAT 9Add
BLAST
Repeati549 – 58537HAT 10Add
BLAST
Repeati587 – 61832HAT 11Add
BLAST
Repeati620 – 65233HAT 12Add
BLAST
Repeati654 – 68835HAT 13Add
BLAST
Repeati690 – 72132HAT 14Add
BLAST
Repeati726 – 76742HAT 15Add
BLAST
Repeati769 – 80739HAT 16Add
BLAST
Repeati809 – 83426HAT 17Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni411 – 628218Mediates interaction with HSP90By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi207 – 2104Poly-Pro

Sequence similaritiesi

Belongs to the crooked-neck family.Curated
Contains 17 HAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1915. Eukaryota.
ENOG410XQJF. LUCA.
GeneTreeiENSGT00550000074931.
HOVERGENiHBG051046.
InParanoidiQ9BZJ0.
KOiK12869.
OMAiFEEKHGY.
PhylomeDBiQ9BZJ0.
TreeFamiTF300305.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR003107. HAT.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF02184. HAT. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZJ0-1) [UniParc]FASTAAdd to basket

Also known as: Type-II

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTATVENLTF QKDTLGNAVD KNTSRLELRS YSLAGRHGST EPLVLAWSSQ
60 70 80 90 100
FRRLTWGCAL DALHRSPCVA ASQHGVTHLI RSSRTPHSTR CRKEDAQPGH
110 120 130 140 150
HGNGAASVTA QARGQRSVLQ VPLPVPRSCL FSESFVVSVS SQSRFLASVP
160 170 180 190 200
GTGVQRSTAA DMAASTAAGK QRIPKVAKVK NKAPAEVQIT AEQLLREAKE
210 220 230 240 250
RELELLPPPP QQKITDEEEL NDYKLRKRKT FEDNIRKNRT VISNWIKYAQ
260 270 280 290 300
WEESLKEIQR ARSIYERALD VDYRNITLWL KYAEMEMKNR QVNHARNIWD
310 320 330 340 350
RAITTLPRVN QFWYKYTYME EMLGNVAGAR QVFERWMEWQ PEEQAWHSYI
360 370 380 390 400
NFELRYKEVD RARTIYERFV LVHPDVKNWI KYARFEEKHA YFAHARKVYE
410 420 430 440 450
RAVEFFGDEH MDEHLYVAFA KFEENQKEFE RVRVIYKYAL DRISKQDAQE
460 470 480 490 500
LFKNYTIFEK KFGDRRGIED IIVSKRRFQY EEEVKANPHN YDAWFDYLRL
510 520 530 540 550
VESDAEAEAV REVYERAIAN VPPIQEKRHW KRYIYLWINY ALYEELEAKD
560 570 580 590 600
PERTRQVYQA SLELIPHKKF TFAKMWILYA QFEIRQKNLS LARRALGTSI
610 620 630 640 650
GKCPKNKLFK VYIELELQLR EFDRCRKLYE KFLEFGPENC TSWIKFAELE
660 670 680 690 700
TILGDIDRAR AIYELAISQP RLDMPEVLWK SYIDFEIEQE ETERTRNLYR
710 720 730 740 750
RLLQRTQHVK VWISFAQFEL SSGKEGSLTK CRQIYEEANK TMRNCEEKEE
760 770 780 790 800
RLMLLESWRS FEEEFGTASD KERVDKLMPE KVKKRRKVQT DDGSDAGWEE
810 820 830 840
YFDYIFPEDA ANQPNLKLLA MAKLWKKQQQ EKEDAEHHPD EDVDESES
Length:848
Mass (Da):100,452
Last modified:May 15, 2007 - v4
Checksum:iE30A39E981BC50AC
GO
Isoform 2 (identifier: Q9BZJ0-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Show »
Length:687
Mass (Da):83,148
Checksum:iB370161134F63B1D
GO
Isoform 3 (identifier: Q9BZJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-34: Missing.

Show »
Length:836
Mass (Da):99,074
Checksum:i2ED68C036D071E71
GO
Isoform 4 (identifier: Q9BZJ0-4) [UniParc]FASTAAdd to basket

Also known as: Type-III

The sequence of this isoform differs from the canonical sequence as follows:
     23-34: Missing.
     117-848: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:104
Mass (Da):11,268
Checksum:iAF15BD5353314E12
GO
Isoform 5 (identifier: Q9BZJ0-5) [UniParc]FASTAAdd to basket

Also known as: type-IV

The sequence of this isoform differs from the canonical sequence as follows:
     23-74: TSRLELRSYS...RSPCVAASQH → ILASLLVSTA...SRLKREVKGQ
     75-848: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:74
Mass (Da):7,946
Checksum:i59162B429E1F0AF0
GO

Sequence cautioni

The sequence BAB14303.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14485.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2131K → R in AAF65571 (PubMed:11342225).Curated
Sequence conflicti213 – 2131K → R in AAK01924 (PubMed:11342225).Curated
Sequence conflicti213 – 2131K → R in AAK01925 (PubMed:11342225).Curated
Sequence conflicti513 – 5131V → A in BAB14659 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351G → R.1 Publication
Corresponds to variant rs7508949 [ dbSNP | Ensembl ].
VAR_024995
Natural varianti51 – 511F → L.
Corresponds to variant rs2273058 [ dbSNP | Ensembl ].
VAR_049318
Natural varianti111 – 1111Q → H.
Corresponds to variant rs2255258 [ dbSNP | Ensembl ].
VAR_049319
Natural varianti158 – 1581T → A.
Corresponds to variant rs2255255 [ dbSNP | Ensembl ].
VAR_049320
Natural varianti843 – 8431V → I.
Corresponds to variant rs35201190 [ dbSNP | Ensembl ].
VAR_049321

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 161161Missing in isoform 2. 2 PublicationsVSP_002058Add
BLAST
Alternative sequencei23 – 7452TSRLE…AASQH → ILASLLVSTALPTSSAAPGR RTPRAAARRTRSLVTMETVP PPSRLKREVKGQ in isoform 5. 1 PublicationVSP_002060Add
BLAST
Alternative sequencei23 – 3412Missing in isoform 3 and isoform 4. 1 PublicationVSP_002059Add
BLAST
Alternative sequencei75 – 848774Missing in isoform 5. 1 PublicationVSP_002061Add
BLAST
Alternative sequencei117 – 848732Missing in isoform 4. 1 PublicationVSP_002062Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255443 mRNA. Translation: AAF65571.2.
AF318302 mRNA. Translation: AAK01924.1.
AF318303 mRNA. Translation: AAK01925.1.
AF318304 mRNA. Translation: AAK01926.1.
AF318305 mRNA. Translation: AAK01927.1.
AF111802 mRNA. Translation: AAL39004.1.
AK023246 mRNA. Translation: BAB14485.1. Different initiation.
AK023728 mRNA. Translation: BAB14659.1.
AK292799 mRNA. Translation: BAF85488.1.
AL035454 Genomic DNA. Translation: CAI42113.1.
AK022908 mRNA. Translation: BAB14303.1. Different initiation.
CCDSiCCDS33446.1. [Q9BZJ0-1]
CCDS63238.1. [Q9BZJ0-2]
CCDS63239.1. [Q9BZJ0-3]
RefSeqiNP_001265554.1. NM_001278625.1.
NP_001265555.1. NM_001278626.1.
NP_001265556.1. NM_001278627.1.
NP_001265557.1. NM_001278628.1. [Q9BZJ0-2]
NP_057736.4. NM_016652.5. [Q9BZJ0-1]
UniGeneiHs.171342.

Genome annotation databases

EnsembliENST00000377340; ENSP00000366557; ENSG00000101343. [Q9BZJ0-1]
ENST00000496549; ENSP00000428436; ENSG00000101343. [Q9BZJ0-5]
ENST00000536226; ENSP00000440733; ENSG00000101343. [Q9BZJ0-2]
GeneIDi51340.
KEGGihsa:51340.
UCSCiuc002wrs.5. human. [Q9BZJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255443 mRNA. Translation: AAF65571.2.
AF318302 mRNA. Translation: AAK01924.1.
AF318303 mRNA. Translation: AAK01925.1.
AF318304 mRNA. Translation: AAK01926.1.
AF318305 mRNA. Translation: AAK01927.1.
AF111802 mRNA. Translation: AAL39004.1.
AK023246 mRNA. Translation: BAB14485.1. Different initiation.
AK023728 mRNA. Translation: BAB14659.1.
AK292799 mRNA. Translation: BAF85488.1.
AL035454 Genomic DNA. Translation: CAI42113.1.
AK022908 mRNA. Translation: BAB14303.1. Different initiation.
CCDSiCCDS33446.1. [Q9BZJ0-1]
CCDS63238.1. [Q9BZJ0-2]
CCDS63239.1. [Q9BZJ0-3]
RefSeqiNP_001265554.1. NM_001278625.1.
NP_001265555.1. NM_001278626.1.
NP_001265556.1. NM_001278627.1.
NP_001265557.1. NM_001278628.1. [Q9BZJ0-2]
NP_057736.4. NM_016652.5. [Q9BZJ0-1]
UniGeneiHs.171342.

3D structure databases

ProteinModelPortaliQ9BZJ0.
SMRiQ9BZJ0. Positions 252-733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119487. 63 interactions.
IntActiQ9BZJ0. 16 interactions.
MINTiMINT-4654476.
STRINGi9606.ENSP00000366557.

PTM databases

iPTMnetiQ9BZJ0.
PhosphoSiteiQ9BZJ0.

Polymorphism and mutation databases

BioMutaiCRNKL1.
DMDMi147744555.

Proteomic databases

EPDiQ9BZJ0.
MaxQBiQ9BZJ0.
PaxDbiQ9BZJ0.
PeptideAtlasiQ9BZJ0.
PRIDEiQ9BZJ0.

Protocols and materials databases

DNASUi51340.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377340; ENSP00000366557; ENSG00000101343. [Q9BZJ0-1]
ENST00000496549; ENSP00000428436; ENSG00000101343. [Q9BZJ0-5]
ENST00000536226; ENSP00000440733; ENSG00000101343. [Q9BZJ0-2]
GeneIDi51340.
KEGGihsa:51340.
UCSCiuc002wrs.5. human. [Q9BZJ0-1]

Organism-specific databases

CTDi51340.
GeneCardsiCRNKL1.
H-InvDBHIX0015678.
HGNCiHGNC:15762. CRNKL1.
HPAiHPA054478.
MIMi610952. gene.
neXtProtiNX_Q9BZJ0.
PharmGKBiPA26886.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1915. Eukaryota.
ENOG410XQJF. LUCA.
GeneTreeiENSGT00550000074931.
HOVERGENiHBG051046.
InParanoidiQ9BZJ0.
KOiK12869.
OMAiFEEKHGY.
PhylomeDBiQ9BZJ0.
TreeFamiTF300305.

Miscellaneous databases

GenomeRNAii51340.
PROiQ9BZJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZJ0.
ExpressionAtlasiQ9BZJ0. baseline and differential.
GenevisibleiQ9BZJ0. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR003107. HAT.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF02184. HAT. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human crooked neck gene by comparative gene identification."
    Lai C.-H., Chiu J.-Y., Lin W.-C.
    Biochim. Biophys. Acta 1517:449-454(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), VARIANT ARG-35.
  2. "Crooked neck is a component of the human spliceosome and implicated in the splicing process."
    Chung S., Zhou Z., Huddleston K.A., Harrison D.A., Reed R., Coleman T.A., Rymond B.C.
    Biochim. Biophys. Acta 1576:287-297(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2), CHARACTERIZATION, IDENTIFICATION IN SPLICEOSOMAL COMPLEX WITH HPRP8BP AND SNRPB2.
    Tissue: T lymphoblast.
  3. Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
    Tissue: Heart.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta and Trachea.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
    Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
    RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
  7. "Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones."
    Hatakeyama S., Matsumoto M., Yada M., Nakayama K.I.
    Genes Cells 9:533-548(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPIL2 AND HSP90.
  8. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2), CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCRNL1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ0
Secondary accession number(s): A8K9T4
, Q5JY64, Q8WYI5, Q9BZI9, Q9BZJ1, Q9BZJ2, Q9GZW7, Q9H8F8, Q9NQH5, Q9NYD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 15, 2007
Last modified: July 6, 2016
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.