##gff-version 3 Q9BZI7 UniProtKB Chain 1 483 . . . ID=PRO_0000215297;Note=Regulator of nonsense transcripts 3B Q9BZI7 UniProtKB Region 1 51 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZI7 UniProtKB Region 30 255 . . . Note=Necessary for interaction with UPF2 Q9BZI7 UniProtKB Region 52 57 . . . Note=Binds to UPF2 Q9BZI7 UniProtKB Region 206 483 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZI7 UniProtKB Region 424 483 . . . Note=Sufficient for association with EJC core;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20479275;Dbxref=PMID:20479275 Q9BZI7 UniProtKB Region 430 447 . . . Note=Necessary for interaction with RBM8A and for activating NMD Q9BZI7 UniProtKB Compositional bias 34 51 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZI7 UniProtKB Compositional bias 206 271 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZI7 UniProtKB Compositional bias 284 312 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZI7 UniProtKB Compositional bias 324 436 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZI7 UniProtKB Compositional bias 453 483 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BZI7 UniProtKB Modified residue 169 169 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Q9BZI7 UniProtKB Modified residue 198 198 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q9BZI7 UniProtKB Modified residue 310 310 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Q9BZI7 UniProtKB Modified residue 447 447 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q9BZI7 UniProtKB Alternative sequence 270 282 . . . ID=VSP_012963;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11163187,ECO:0000303|PubMed:15489334;Dbxref=PMID:11163187,PMID:15489334 Q9BZI7 UniProtKB Natural variant 160 160 . . . ID=VAR_037666;Note=In MRXS14. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17704778;Dbxref=dbSNP:rs122468182,PMID:17704778 Q9BZI7 UniProtKB Mutagenesis 52 52 . . . Note=Abolishes interaction with UPF2. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9BZI7 UniProtKB Mutagenesis 53 58 . . . Note=Abolishes interaction with UPF2. VVIRRL->AVARRA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11113196;Dbxref=PMID:11113196 Q9BZI7 UniProtKB Mutagenesis 56 56 . . . Note=Does not abolish interaction with UPF2. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9BZI7 UniProtKB Mutagenesis 117 119 . . . Note=Abolishes interaction with UPF2. YVF->DVD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11113196;Dbxref=PMID:11113196 Q9BZI7 UniProtKB Mutagenesis 430 430 . . . Note=Reduces NMD. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718880;Dbxref=PMID:12718880 Q9BZI7 UniProtKB Mutagenesis 432 432 . . . Note=Reduces NMD. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12718880,ECO:0000269|PubMed:16601204;Dbxref=PMID:12718880,PMID:16601204 Q9BZI7 UniProtKB Mutagenesis 434 447 . . . Note=Abolishes NMD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718880;Dbxref=PMID:12718880 Q9BZI7 UniProtKB Mutagenesis 434 434 . . . Note=Reduces NMD. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718880;Dbxref=PMID:12718880 Q9BZI7 UniProtKB Mutagenesis 435 435 . . . Note=Reduces NMD. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718880;Dbxref=PMID:12718880 Q9BZI7 UniProtKB Mutagenesis 436 436 . . . Note=Impairs association with EJC. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12718880,ECO:0000269|PubMed:20479275;Dbxref=PMID:12718880,PMID:20479275 Q9BZI7 UniProtKB Mutagenesis 436 436 . . . Note=Reduces NMD. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12718880,ECO:0000269|PubMed:20479275;Dbxref=PMID:12718880,PMID:20479275 Q9BZI7 UniProtKB Mutagenesis 441 441 . . . Note=Reduces NMD. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718880;Dbxref=PMID:12718880 Q9BZI7 UniProtKB Mutagenesis 442 442 . . . Note=Impairs association with EJC. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20479275;Dbxref=PMID:20479275 Q9BZI7 UniProtKB Mutagenesis 447 447 . . . Note=Abolishes NMD%3B when associated with E-449 and E-451. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20479275;Dbxref=PMID:20479275 Q9BZI7 UniProtKB Mutagenesis 449 449 . . . Note=Abolishes NMD%3B when associated with E-447 and E-451. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20479275;Dbxref=PMID:20479275 Q9BZI7 UniProtKB Mutagenesis 451 451 . . . Note=Abolishes NMD%3B when associated with E-447 and E-449. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20479275;Dbxref=PMID:20479275 Q9BZI7 UniProtKB Sequence conflict 358 358 . . . Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9BZI7 UniProtKB Beta strand 52 58 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Helix 64 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Beta strand 77 85 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Beta strand 95 104 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Helix 105 114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Beta strand 118 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Beta strand 126 128 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Beta strand 130 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9BZI7 UniProtKB Turn 149 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NWU Q9BZI7 UniProtKB Helix 154 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NWU Q9BZI7 UniProtKB Helix 158 166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NWU Q9BZI7 UniProtKB Turn 433 435 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2XB2