Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BZI7

- REN3B_HUMAN

UniProt

Q9BZI7 - REN3B_HUMAN

Protein

Regulator of nonsense transcripts 3B

Gene

UPF3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.5 Publications

    GO - Molecular functioni

    1. mRNA binding Source: UniProtKB
    2. nucleocytoplasmic transporter activity Source: UniProtKB
    3. nucleotide binding Source: InterPro
    4. poly(A) RNA binding Source: UniProtKB
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA 3'-end processing Source: Reactome
    3. mRNA export from nucleus Source: Reactome
    4. mRNA metabolic process Source: Reactome
    5. mRNA splicing, via spliceosome Source: Reactome
    6. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
    7. positive regulation of translation Source: UniProtKB
    8. RNA metabolic process Source: Reactome
    9. RNA splicing Source: Reactome
    10. termination of RNA polymerase II transcription Source: Reactome
    11. transcription from RNA polymerase II promoter Source: Reactome

    Keywords - Biological processi

    mRNA transport, Nonsense-mediated mRNA decay, Transport

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1597. Transport of Mature mRNA derived from an Intron-Containing Transcript.
    REACT_1849. mRNA 3'-end processing.
    REACT_467. mRNA Splicing - Major Pathway.
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of nonsense transcripts 3B
    Alternative name(s):
    Nonsense mRNA reducing factor 3B
    Up-frameshift suppressor 3 homolog B
    Short name:
    hUpf3B
    Up-frameshift suppressor 3 homolog on chromosome X
    Short name:
    hUpf3p-X
    Gene namesi
    Name:UPF3B
    Synonyms:RENT3B, UPF3X
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:20439. UPF3B.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Shuttling between the nucleus and the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. exon-exon junction complex Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, X-linked, syndromic, 14 (MRXS14) [MIM:300676]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXS14 patients manifest mental retardation associated with other variable signs such as autistic features, slender build, poor musculature, long, thin face, high-arched palate, high nasal bridge, and pectus deformities.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti160 – 1601Y → D in MRXS14. 1 Publication
    VAR_037666

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi52 – 521K → E: Abolishes interaction with UPF2. 2 Publications
    Mutagenesisi53 – 586VVIRRL → AVARRA: Abolishes interaction with UPF2. 1 Publication
    Mutagenesisi56 – 561R → E: Does not abolish interaction with UPF2. 2 Publications
    Mutagenesisi117 – 1193YVF → DVD: Abolishes interaction with UPF2. 1 Publication
    Mutagenesisi430 – 4301R → A: Reduces NMD. 2 Publications
    Mutagenesisi432 – 4321R → A: Reduces NMD. 3 Publications
    Mutagenesisi434 – 44714Missing: Abolishes NMD. 2 PublicationsAdd
    BLAST
    Mutagenesisi434 – 4341K → A: Reduces NMD. 2 Publications
    Mutagenesisi435 – 4351D → A: Reduces NMD. 2 Publications
    Mutagenesisi436 – 4361R → A: Impairs association with EJC. 3 Publications
    Mutagenesisi436 – 4361R → A: Reduces NMD. 3 Publications
    Mutagenesisi441 – 4411L → F: Reduces NMD. 2 Publications
    Mutagenesisi442 – 4421Y → A: Impairs association with EJC. 2 Publications
    Mutagenesisi447 – 4471R → E: Abolishes NMD; when associated with E-449 and E-451. 2 Publications
    Mutagenesisi449 – 4491R → E: Abolishes NMD; when associated with E-447 and E-451. 2 Publications
    Mutagenesisi451 – 4511R → E: Abolishes NMD; when associated with E-447 and E-449. 2 Publications

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi300676. phenotype.
    Orphaneti323. FG syndrome.
    776. X-linked intellectual disability with marfanoid habitus.
    777. X-linked non-syndromic intellectual disability.
    PharmGKBiPA128394708.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Regulator of nonsense transcripts 3BPRO_0000215297Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei169 – 1691Phosphothreonine3 Publications
    Modified residuei198 – 1981Phosphothreonine1 Publication
    Modified residuei310 – 3101Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BZI7.
    PaxDbiQ9BZI7.
    PRIDEiQ9BZI7.

    PTM databases

    PhosphoSiteiQ9BZI7.

    Expressioni

    Tissue specificityi

    Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ9BZI7.
    BgeeiQ9BZI7.
    CleanExiHS_UPF3B.
    GenevestigatoriQ9BZI7.

    Organism-specific databases

    HPAiHPA001800.
    HPA001882.

    Interactioni

    Subunit structurei

    Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC); the EJC core components EIF4A3 and the MAGOH-RBM8A dimer form a composite binding site for UPF3B which overlaps with the EJC binding site for WIBG. Interacts with EST1A, UPF2 and RBM8A.9 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF4A3P389197EBI-372780,EBI-299104
    RBM8AQ9Y5S99EBI-372780,EBI-447231
    UPF1Q929008EBI-372780,EBI-373471
    UPF2Q9HAU56EBI-372780,EBI-372073

    Protein-protein interaction databases

    BioGridi122396. 23 interactions.
    DIPiDIP-31143N.
    IntActiQ9BZI7. 19 interactions.
    MINTiMINT-265168.
    STRINGi9606.ENSP00000276201.

    Structurei

    Secondary structure

    1
    483
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi52 – 587
    Helixi64 – 718
    Beta strandi77 – 859
    Beta strandi95 – 10410
    Helixi105 – 11410
    Beta strandi118 – 1203
    Beta strandi126 – 1283
    Beta strandi130 – 1334
    Turni433 – 4353

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UW4X-ray1.95A/C50-140[»]
    2XB2X-ray3.40G/U424-483[»]
    ProteinModelPortaliQ9BZI7.
    SMRiQ9BZI7. Positions 50-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BZI7.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 255226Necessary for interaction with UPF2Add
    BLAST
    Regioni52 – 576Binds to UPF2
    Regioni94 – 483390Sufficient for association with EJC coreAdd
    BLAST
    Regioni430 – 44718Necessary for interaction with RBM8A and for activating NMDAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RENT3 family.Curated

    Phylogenomic databases

    eggNOGiNOG251520.
    HOGENOMiHOG000230909.
    HOVERGENiHBG059714.
    InParanoidiQ9BZI7.
    KOiK14328.
    OMAiYFEFFAN.
    OrthoDBiEOG7M6D9K.
    PhylomeDBiQ9BZI7.
    TreeFamiTF316034.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR005120. Nonsense_mediated_decay_UPF3.
    IPR012677. Nucleotide-bd_a/b_plait.
    [Graphical view]
    PfamiPF03467. Smg4_UPF3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZI7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKEEKEHRPK EKRVTLLTPA GATGSGGGTS GDSSKGEDKQ DRNKEKKEAL    50
    SKVVIRRLPP TLTKEQLQEH LQPMPEHDYF EFFSNDTSLY PHMYARAYIN 100
    FKNQEDIILF RDRFDGYVFL DNKGQEYPAI VEFAPFQKAA KKKTKKRDTK 150
    VGTIDDDPEY RKFLESYATD NEKMTSTPET LLEEIEAKNR ELIAKKTTPL 200
    LSFLKNKQRM REEKREERRR REIERKRQRE EERRKWKEEE KRKRKDIEKL 250
    KKIDRIPERD KLKDEPKIKV HRFLLQAVNQ KNLLKKPEKG DEKELDKREK 300
    AKKLDKENLS DERASGQSCT LPKRSDSELK DEKPKRPEDE SGRDYRERER 350
    EYERDQERIL RERERLKRQE EERRRQKERY EKEKTFKRKE EEMKKEKDTL 400
    RDKGKKAEST ESIGSSEKTE KKEEVVKRDR IRNKDRPAMQ LYQPGARSRN 450
    RLCPPDDSTK SGDSAAERKQ ESGISHRKEG GEE 483
    Length:483
    Mass (Da):57,762
    Last modified:June 1, 2001 - v1
    Checksum:iF5A8A395783D1A69
    GO
    Isoform 2 (identifier: Q9BZI7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         270-282: Missing.

    Show »
    Length:470
    Mass (Da):56,213
    Checksum:iC012044D45D9957F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti358 – 3581R → H in AAI21018. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti160 – 1601Y → D in MRXS14. 1 Publication
    VAR_037666

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei270 – 28213Missing in isoform 2. 2 PublicationsVSP_012963Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY013251 mRNA. Translation: AAG48511.1.
    AF318576 mRNA. Translation: AAG60691.1.
    CH471161 Genomic DNA. Translation: EAW89842.1.
    CH471161 Genomic DNA. Translation: EAW89844.1.
    CH471161 Genomic DNA. Translation: EAW89845.1.
    CH471161 Genomic DNA. Translation: EAW89846.1.
    BC121017 mRNA. Translation: AAI21018.1.
    CCDSiCCDS14587.1. [Q9BZI7-2]
    CCDS14588.1. [Q9BZI7-1]
    RefSeqiNP_075386.1. NM_023010.3. [Q9BZI7-2]
    NP_542199.1. NM_080632.2. [Q9BZI7-1]
    UniGeneiHs.103832.

    Genome annotation databases

    EnsembliENST00000276201; ENSP00000276201; ENSG00000125351. [Q9BZI7-1]
    ENST00000345865; ENSP00000245418; ENSG00000125351. [Q9BZI7-2]
    GeneIDi65109.
    KEGGihsa:65109.
    UCSCiuc004erz.2. human. [Q9BZI7-1]
    uc004esa.2. human. [Q9BZI7-2]

    Polymorphism databases

    DMDMi60390643.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY013251 mRNA. Translation: AAG48511.1 .
    AF318576 mRNA. Translation: AAG60691.1 .
    CH471161 Genomic DNA. Translation: EAW89842.1 .
    CH471161 Genomic DNA. Translation: EAW89844.1 .
    CH471161 Genomic DNA. Translation: EAW89845.1 .
    CH471161 Genomic DNA. Translation: EAW89846.1 .
    BC121017 mRNA. Translation: AAI21018.1 .
    CCDSi CCDS14587.1. [Q9BZI7-2 ]
    CCDS14588.1. [Q9BZI7-1 ]
    RefSeqi NP_075386.1. NM_023010.3. [Q9BZI7-2 ]
    NP_542199.1. NM_080632.2. [Q9BZI7-1 ]
    UniGenei Hs.103832.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UW4 X-ray 1.95 A/C 50-140 [» ]
    2XB2 X-ray 3.40 G/U 424-483 [» ]
    ProteinModelPortali Q9BZI7.
    SMRi Q9BZI7. Positions 50-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122396. 23 interactions.
    DIPi DIP-31143N.
    IntActi Q9BZI7. 19 interactions.
    MINTi MINT-265168.
    STRINGi 9606.ENSP00000276201.

    PTM databases

    PhosphoSitei Q9BZI7.

    Polymorphism databases

    DMDMi 60390643.

    Proteomic databases

    MaxQBi Q9BZI7.
    PaxDbi Q9BZI7.
    PRIDEi Q9BZI7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276201 ; ENSP00000276201 ; ENSG00000125351 . [Q9BZI7-1 ]
    ENST00000345865 ; ENSP00000245418 ; ENSG00000125351 . [Q9BZI7-2 ]
    GeneIDi 65109.
    KEGGi hsa:65109.
    UCSCi uc004erz.2. human. [Q9BZI7-1 ]
    uc004esa.2. human. [Q9BZI7-2 ]

    Organism-specific databases

    CTDi 65109.
    GeneCardsi GC0XM118967.
    HGNCi HGNC:20439. UPF3B.
    HPAi HPA001800.
    HPA001882.
    MIMi 300298. gene.
    300676. phenotype.
    neXtProti NX_Q9BZI7.
    Orphaneti 323. FG syndrome.
    776. X-linked intellectual disability with marfanoid habitus.
    777. X-linked non-syndromic intellectual disability.
    PharmGKBi PA128394708.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251520.
    HOGENOMi HOG000230909.
    HOVERGENi HBG059714.
    InParanoidi Q9BZI7.
    KOi K14328.
    OMAi YFEFFAN.
    OrthoDBi EOG7M6D9K.
    PhylomeDBi Q9BZI7.
    TreeFami TF316034.

    Enzyme and pathway databases

    Reactomei REACT_1597. Transport of Mature mRNA derived from an Intron-Containing Transcript.
    REACT_1849. mRNA 3'-end processing.
    REACT_467. mRNA Splicing - Major Pathway.
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    ChiTaRSi UPF3B. human.
    EvolutionaryTracei Q9BZI7.
    GeneWikii UPF3B.
    GenomeRNAii 65109.
    NextBioi 67302.
    PROi Q9BZI7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZI7.
    Bgeei Q9BZI7.
    CleanExi HS_UPF3B.
    Genevestigatori Q9BZI7.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR005120. Nonsense_mediated_decay_UPF3.
    IPR012677. Nucleotide-bd_a/b_plait.
    [Graphical view ]
    Pfami PF03467. Smg4_UPF3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon."
      Lykke-Andersen J., Shu M.-D., Steitz J.A.
      Cell 103:1121-1131(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION IN NONSENSE-MEDIATED MRNA DECAY, INTERACTION WITH UPF1 AND UPF2, SUBCELLULAR LOCATION.
    2. "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)."
      Serin G., Gersappe A., Black J.D., Aronoff R., Maquat L.E.
      Mol. Cell. Biol. 21:209-223(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH UPF2, MUTAGENESIS OF 53-VAL--LEU-58 AND 117-TYR--PHE-119, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Cervix carcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex."
      Kim V.N., Kataoka N., Dreyfuss G.
      Science 293:1832-1836(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RBM8A, IDENTIFICATION IN A POST-SPLICING MRNP COMPLEX, ASSOCIATION WITH THE EJC COMPLEX, RNA-BINDING.
    6. "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1."
      Lykke-Andersen J., Shu M.-D., Steitz J.A.
      Science 293:1836-1839(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A POST-SPLICING MRNP COMPLEX, ASSOCIATION WITH THE EJC COMPLEX.
    7. Cited for: FUNCTION IN NONSENSE-MEDIATED MRNA DECAY, INTERACTION WITH RBM8A, MUTAGENESIS OF ARG-430; ARG-432; 434-LYS--ARG-447; LYS-434; ASP-435; ARG-436 AND LEU-441.
    8. "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1."
      Chiu S.-Y., Serin G., Ohara O., Maquat L.E.
      RNA 9:77-87(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EST1A.
    9. "Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements."
      Gehring N.H., Kunz J.B., Neu-Yilik G., Breit S., Viegas M.H., Hentze M.W., Kulozik A.E.
      Mol. Cell 20:65-75(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NONSENSE-MEDIATED MRNA DECAY, ASSOCIATION WITH THE EJC COMPLEX, IDENTIFICATION IN A COMPLEX WITH UPF2 AND RNPS1.
    10. "Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation."
      Kunz J.B., Neu-Yilik G., Hentze M.W., Kulozik A.E., Gehring N.H.
      RNA 12:1015-1022(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NONSENSE-MEDIATED MRNA DECAY, FUNCTION IN TRANSLATION STIMULATION, ASSOCIATION WITH THE EJC COMPLEX, MUTAGENESIS OF ARG-432.
    11. "NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity."
      Chamieh H., Ballut L., Bonneau F., Le Hir H.
      Nat. Struct. Mol. Biol. 15:85-93(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, RECONSTITUTION OF THE EJC CORE-UPF COMPLEX.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-169 AND SER-310, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3."
      Kadlec J., Izaurralde E., Cusack S.
      Nat. Struct. Mol. Biol. 11:330-337(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 50-140 IN COMPLEX WITH UPF2, RNA-BINDING, MUTAGENESIS OF LYS-52 AND ARG-56.
    18. "Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex."
      Buchwald G., Ebert J., Basquin C., Sauliere J., Jayachandran U., Bono F., Le Hir H., Conti E.
      Proc. Natl. Acad. Sci. U.S.A. 107:10050-10055(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 424-483 IN COMPLEX WITH EIF4A3; MAGOH; RBM8A AND CASC3, MUTAGENESIS OF ARG-436; TYR-442; ARG-447; ARG-449 AND ARG-451.
    19. "Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation."
      Tarpey P.S., Raymond F.L., Nguyen L.S., Rodriguez J., Hackett A., Vandeleur L., Smith R., Shoubridge C., Edkins S., Stevens C., O'Meara S., Tofts C., Barthorpe S., Buck G., Cole J., Halliday K., Hills K., Jones D.
      , Mironenko T., Perry J., Varian J., West S., Widaa S., Teague J., Dicks E., Butler A., Menzies A., Richardson D., Jenkinson A., Shepherd R., Raine K., Moon J., Luo Y., Parnau J., Bhat S.S., Gardner A., Corbett M., Brooks D., Thomas P., Parkinson-Lawrence E., Porteous M.E., Warner J.P., Sanderson T., Pearson P., Simensen R.J., Skinner C., Hoganson G., Superneau D., Wooster R., Bobrow M., Turner G., Stevenson R.E., Schwartz C.E., Futreal P.A., Srivastava A.K., Stratton M.R., Gecz J.
      Nat. Genet. 39:1127-1133(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MRXS14 ASP-160.

    Entry informationi

    Entry nameiREN3B_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZI7
    Secondary accession number(s): D3DWI3
    , D3DWI4, Q0VAK8, Q9H1J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3