Q9BZI1 (IRX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Iroquois-class homeodomain protein IRX-2

Alternative name(s):
Homeodomain protein IRXA2
Iroquois homeobox protein 2

Gene names

Name:	IRX2
Synonyms:	IRXA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proximal/distal pattern formation involved in metanephric nephron development Inferred from electronic annotation. Source: Compara specification of loop of Henle identity Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Iroquois-class homeodomain protein IRX-2		PRO_0000049153
Regions
	DNA binding	112 – 175	64	Homeobox; TALE-type
Amino acid modifications
	Modified residue	186	1	Phosphoserine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9BZI1 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 3B370608B5223C3C	FASTA	471	49,129
	10 20 30 40 50 60 MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG SAAFTAQAAT 70 80 90 100 110 120 GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY HPYGSAAYPY QLNDPAYRKN 130 140 150 160 170 180 ATRDATATLK AWLNEHRKNP YPTKGEKIML AIITKMTLTQ VSTWFANARR RLKKENKMTW 190 200 210 220 230 240 APRNKSEDED EDEGDATRSK DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK 250 260 270 280 290 300 LPCRAGDPLC ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP 310 320 330 340 350 360 EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG PPGLPAAAAP 370 380 390 400 410 420 ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA ALQGQGLLRY NSAAAAPGEA 430 440 450 460 470 LHTAPKAASD AGKAGAHPLE SHYRSPGGGY EPKKDASEGC TVVGGGVQPY L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human homeobox two-cluster Iroquois gene family." Hansen L., Wu Q., Tommerup N. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	Sugiyama A., Inoue H., Oka M. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes." Ogura K., Matsumoto K., Kuroiwa A., Isobe T., Otoguro T., Jurecic V., Baldini A., Matsuda Y., Ogura T. Cytogenet. Cell Genet. 92:320-325(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-181.
[5]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY335939 Genomic DNA. Translation: AAQ16545.1. AY335940 mRNA. Translation: AAQ16546.1. AB188492 mRNA. Translation: BAD37140.1. BC065189 mRNA. Translation: AAH65189.1. AF319967 Genomic DNA. Translation: AAK01202.1.
IPI	IPI00395326.
RefSeq	NP_001127694.1. NM_001134222.1. NP_150366.1. NM_033267.4.
UniGene	Hs.282089.
3D structure databases
ProteinModelPortal	Q9BZI1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000307006.
PTM databases
PhosphoSite	Q9BZI1.
Polymorphism databases
DMDM	47117908.
Proteomic databases
PaxDb	Q9BZI1.
PRIDE	Q9BZI1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302057; ENSP00000307006; ENSG00000170561. ENST00000382611; ENSP00000372056; ENSG00000170561.
GeneID	153572.
KEGG	hsa:153572.
UCSC	uc003jda.3. human.
Organism-specific databases
CTD	153572.
GeneCards	GC05M002745.
HGNC	HGNC:14359. IRX2.
HPA	HPA050895. HPA054669.
MIM	606198. gene.
neXtProt	NX_Q9BZI1.
PharmGKB	PA29924.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG310996.
HOGENOM	HOG000234546.
HOVERGEN	HBG006180.
InParanoid	Q9BZI1.
OMA	TLTDHSC.
OrthoDB	EOG4KWJTC.
PhylomeDB	Q9BZI1.
Gene expression databases
ArrayExpress	Q9BZI1.
Bgee	Q9BZI1.
CleanEx	HS_IRX2.
Genevestigator	Q9BZI1.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR008422. Homeobox_KN_domain. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR003893. Iroquois_homeo. [Graphical view]
Pfam	PF05920. Homeobox_KN. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00548. IRO. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	153572.
NextBio	87142.
SOURCE	Search...

Entry information

Entry name

IRX2_HUMAN

Accession

Primary (citable) accession number: Q9BZI1
Secondary accession number(s): Q68A19, Q7Z2I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.