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Protein

Iroquois-class homeodomain protein IRX-2

Gene

IRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi112 – 17564Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-2
Alternative name(s):
Homeodomain protein IRXA2
Iroquois homeobox protein 2
Gene namesi
Name:IRX2
Synonyms:IRXA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14359. IRX2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29924.

Polymorphism and mutation databases

BioMutaiIRX2.
DMDMi47117908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Iroquois-class homeodomain protein IRX-2PRO_0000049153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BZI1.
PRIDEiQ9BZI1.

PTM databases

PhosphoSiteiQ9BZI1.

Expressioni

Gene expression databases

BgeeiQ9BZI1.
CleanExiHS_IRX2.
GenevisibleiQ9BZI1. HS.

Organism-specific databases

HPAiHPA050895.
HPA054669.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307006.

Structurei

3D structure databases

ProteinModelPortaliQ9BZI1.
SMRiQ9BZI1. Positions 125-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG310996.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiQ9BZI1.
OMAiHPLESHY.
OrthoDBiEOG7TJ3HS.
PhylomeDBiQ9BZI1.
TreeFamiTF319371.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG
60 70 80 90 100
SAAFTAQAAT GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY
110 120 130 140 150
HPYGSAAYPY QLNDPAYRKN ATRDATATLK AWLNEHRKNP YPTKGEKIML
160 170 180 190 200
AIITKMTLTQ VSTWFANARR RLKKENKMTW APRNKSEDED EDEGDATRSK
210 220 230 240 250
DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK LPCRAGDPLC
260 270 280 290 300
ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP
310 320 330 340 350
EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG
360 370 380 390 400
PPGLPAAAAP ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA
410 420 430 440 450
ALQGQGLLRY NSAAAAPGEA LHTAPKAASD AGKAGAHPLE SHYRSPGGGY
460 470
EPKKDASEGC TVVGGGVQPY L
Length:471
Mass (Da):49,129
Last modified:May 10, 2004 - v2
Checksum:i3B370608B5223C3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335939 Genomic DNA. Translation: AAQ16545.1.
AY335940 mRNA. Translation: AAQ16546.1.
AB188492 mRNA. Translation: BAD37140.1.
BC065189 mRNA. Translation: AAH65189.1.
AF319967 Genomic DNA. Translation: AAK01202.1.
CCDSiCCDS3868.1.
RefSeqiNP_001127694.1. NM_001134222.1.
NP_150366.1. NM_033267.4.
XP_011512280.1. XM_011513978.1.
XP_011512281.1. XM_011513979.1.
UniGeneiHs.282089.

Genome annotation databases

EnsembliENST00000302057; ENSP00000307006; ENSG00000170561.
ENST00000382611; ENSP00000372056; ENSG00000170561.
GeneIDi153572.
KEGGihsa:153572.
UCSCiuc003jda.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335939 Genomic DNA. Translation: AAQ16545.1.
AY335940 mRNA. Translation: AAQ16546.1.
AB188492 mRNA. Translation: BAD37140.1.
BC065189 mRNA. Translation: AAH65189.1.
AF319967 Genomic DNA. Translation: AAK01202.1.
CCDSiCCDS3868.1.
RefSeqiNP_001127694.1. NM_001134222.1.
NP_150366.1. NM_033267.4.
XP_011512280.1. XM_011513978.1.
XP_011512281.1. XM_011513979.1.
UniGeneiHs.282089.

3D structure databases

ProteinModelPortaliQ9BZI1.
SMRiQ9BZI1. Positions 125-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307006.

PTM databases

PhosphoSiteiQ9BZI1.

Polymorphism and mutation databases

BioMutaiIRX2.
DMDMi47117908.

Proteomic databases

PaxDbiQ9BZI1.
PRIDEiQ9BZI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302057; ENSP00000307006; ENSG00000170561.
ENST00000382611; ENSP00000372056; ENSG00000170561.
GeneIDi153572.
KEGGihsa:153572.
UCSCiuc003jda.3. human.

Organism-specific databases

CTDi153572.
GeneCardsiGC05M002745.
HGNCiHGNC:14359. IRX2.
HPAiHPA050895.
HPA054669.
MIMi606198. gene.
neXtProtiNX_Q9BZI1.
PharmGKBiPA29924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG310996.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiQ9BZI1.
OMAiHPLESHY.
OrthoDBiEOG7TJ3HS.
PhylomeDBiQ9BZI1.
TreeFamiTF319371.

Miscellaneous databases

GeneWikiiIRX2.
GenomeRNAii153572.
NextBioi87142.
PROiQ9BZI1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZI1.
CleanExiHS_IRX2.
GenevisibleiQ9BZI1. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human homeobox two-cluster Iroquois gene family."
    Hansen L., Wu Q., Tommerup N.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Sugiyama A., Inoue H., Oka M.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes."
    Ogura K., Matsumoto K., Kuroiwa A., Isobe T., Otoguro T., Jurecic V., Baldini A., Matsuda Y., Ogura T.
    Cytogenet. Cell Genet. 92:320-325(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-181.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIRX2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZI1
Secondary accession number(s): Q68A19, Q7Z2I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 10, 2004
Last modified: July 22, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.