Reviewed, UniProtKB/Swiss-Prot Q9BZI1 (IRX2_HUMAN)

Names and origin

Protein names

Recommended name:
    Iroquois-class homeodomain protein IRX-2
Alternative name(s):
    Iroquois homeobox protein 2
    Homeodomain protein IRXA2

Gene names

Name:	IRX2
Synonyms:	IRXA2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Iroquois-class homeodomain protein IRX-2		PRO_0000049153
Regions
	DNA binding	112 – 175	64	Homeobox; TALE-type

Sequences

	Sequence		Length	Mass (Da)
	Q9BZI1-1 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 3B370608B5223C3C	FASTA	471	49,129
	10 20 30 40 50 60 MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG SAAFTAQAAT 70 80 90 100 110 120 GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY HPYGSAAYPY QLNDPAYRKN 130 140 150 160 170 180 ATRDATATLK AWLNEHRKNP YPTKGEKIML AIITKMTLTQ VSTWFANARR RLKKENKMTW 190 200 210 220 230 240 APRNKSEDED EDEGDATRSK DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK 250 260 270 280 290 300 LPCRAGDPLC ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP 310 320 330 340 350 360 EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG PPGLPAAAAP 370 380 390 400 410 420 ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA ALQGQGLLRY NSAAAAPGEA 430 440 450 460 470 LHTAPKAASD AGKAGAHPLE SHYRSPGGGY EPKKDASEGC TVVGGGVQPY L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human homeobox two-cluster Iroquois gene family." Hansen L., Wu Q., Tommerup N. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	Sugiyama A., Inoue H., Oka M. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes." Ogura K., Matsumoto K., Kuroiwa A., Isobe T., Otoguro T., Jurecic V., Baldini A., Matsuda Y., Ogura T. Cytogenet. Cell Genet. 92:320-325(2001) [PubMed: 11435706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-181.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY335939 Genomic DNA. Translation: AAQ16545.1. AY335940 mRNA. Translation: AAQ16546.1. AB188492 mRNA. Translation: BAD37140.1. BC065189 mRNA. Translation: AAH65189.1. AF319967 Genomic DNA. Translation: AAK01202.1.
IPI	IPI00395326.
RefSeq	NP_001127694.1. NP_150366.1.
UniGene	Hs.282089
3D structure databases
HSSP	HSSP built from PDB template 1LFU based on UniProtKB P41778.
ModBase	Search...
PTM databases
PhosphoSite	Q9BZI1.
Proteomic databases
PRIDE	Q9BZI1.
Genome annotation databases
Ensembl	ENSG00000170561. Homo sapiens. [Contig view]
GeneID	153572.
KEGG	hsa:153572.
Organism-specific databases
GeneCards	GC05M002799.
HGNC	HGNC:14359. IRX2.
MIM	606198. gene.
PharmGKB	PA29925.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BZI1.
HOVERGEN	Q9BZI1.
OMA	Q9BZI1. HPLESHY.
Gene expression databases
ArrayExpress	Q9BZI1.
Bgee	Q9BZI1.
CleanEx	HS_IRX2.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR003893. Iroquois_homeo. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. SM00548. IRO. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	87142.
SOURCE	Search...

Entry information

Entry name

IRX2_HUMAN

Accession

Primary (citable) accession number: Q9BZI1
Secondary accession number(s): Q68A19, Q7Z2I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	May 10, 2004
Last modified:	June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)