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Protein

Iroquois-class homeodomain protein IRX-2

Gene

IRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi112 – 175Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-2
Alternative name(s):
Homeodomain protein IRXA2
Iroquois homeobox protein 2
Gene namesi
Name:IRX2
Synonyms:IRXA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170561.12
HGNCiHGNC:14359 IRX2
MIMi606198 gene
neXtProtiNX_Q9BZI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi153572
MalaCardsiIRX2
OpenTargetsiENSG00000170561
PharmGKBiPA29924

Polymorphism and mutation databases

BioMutaiIRX2
DMDMi47117908

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491531 – 471Iroquois-class homeodomain protein IRX-2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BZI1
MaxQBiQ9BZI1
PaxDbiQ9BZI1
PeptideAtlasiQ9BZI1
PRIDEiQ9BZI1

PTM databases

iPTMnetiQ9BZI1
PhosphoSitePlusiQ9BZI1

Expressioni

Gene expression databases

BgeeiENSG00000170561
CleanExiHS_IRX2
GenevisibleiQ9BZI1 HS

Organism-specific databases

HPAiHPA050895
HPA054669

Interactioni

Protein-protein interaction databases

IntActiQ9BZI1, 3 interactors
STRINGi9606.ENSP00000307006

Structurei

3D structure databases

ProteinModelPortaliQ9BZI1
SMRiQ9BZI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiQ9BZI1
OMAiSYMGAPY
OrthoDBiEOG091G15AO
PhylomeDBiQ9BZI1
TreeFamiTF319371

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BZI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG
60 70 80 90 100
SAAFTAQAAT GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY
110 120 130 140 150
HPYGSAAYPY QLNDPAYRKN ATRDATATLK AWLNEHRKNP YPTKGEKIML
160 170 180 190 200
AIITKMTLTQ VSTWFANARR RLKKENKMTW APRNKSEDED EDEGDATRSK
210 220 230 240 250
DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK LPCRAGDPLC
260 270 280 290 300
ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP
310 320 330 340 350
EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG
360 370 380 390 400
PPGLPAAAAP ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA
410 420 430 440 450
ALQGQGLLRY NSAAAAPGEA LHTAPKAASD AGKAGAHPLE SHYRSPGGGY
460 470
EPKKDASEGC TVVGGGVQPY L
Length:471
Mass (Da):49,129
Last modified:May 10, 2004 - v2
Checksum:i3B370608B5223C3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335939 Genomic DNA Translation: AAQ16545.1
AY335940 mRNA Translation: AAQ16546.1
AB188492 mRNA Translation: BAD37140.1
BC065189 mRNA Translation: AAH65189.1
AF319967 Genomic DNA Translation: AAK01202.1
CCDSiCCDS3868.1
RefSeqiNP_001127694.1, NM_001134222.1
NP_150366.1, NM_033267.4
XP_011512281.1, XM_011513979.2
UniGeneiHs.282089

Genome annotation databases

EnsembliENST00000302057; ENSP00000307006; ENSG00000170561
ENST00000382611; ENSP00000372056; ENSG00000170561
GeneIDi153572
KEGGihsa:153572
UCSCiuc003jda.4 human

Similar proteinsi

Entry informationi

Entry nameiIRX2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZI1
Secondary accession number(s): Q68A19, Q7Z2I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 10, 2004
Last modified: April 25, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health