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Q9BZI1

- IRX2_HUMAN

UniProt

Q9BZI1 - IRX2_HUMAN

Protein

Iroquois-class homeodomain protein IRX-2

Gene

IRX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi112 – 17564Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. proximal/distal pattern formation involved in metanephric nephron development Source: Ensembl
    2. specification of loop of Henle identity Source: Ensembl

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iroquois-class homeodomain protein IRX-2
    Alternative name(s):
    Homeodomain protein IRXA2
    Iroquois homeobox protein 2
    Gene namesi
    Name:IRX2
    Synonyms:IRXA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:14359. IRX2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29924.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Iroquois-class homeodomain protein IRX-2PRO_0000049153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei186 – 1861Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9BZI1.
    PRIDEiQ9BZI1.

    PTM databases

    PhosphoSiteiQ9BZI1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BZI1.
    BgeeiQ9BZI1.
    CleanExiHS_IRX2.
    GenevestigatoriQ9BZI1.

    Organism-specific databases

    HPAiHPA050895.
    HPA054669.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000307006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZI1.
    SMRiQ9BZI1. Positions 125-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TALE/IRO homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG310996.
    HOGENOMiHOG000234546.
    HOVERGENiHBG006180.
    InParanoidiQ9BZI1.
    OMAiEDECERD.
    OrthoDBiEOG7TJ3HS.
    PhylomeDBiQ9BZI1.
    TreeFamiTF319371.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BZI1-1 [UniParc]FASTAAdd to Basket

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    MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG    50
    SAAFTAQAAT GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY 100
    HPYGSAAYPY QLNDPAYRKN ATRDATATLK AWLNEHRKNP YPTKGEKIML 150
    AIITKMTLTQ VSTWFANARR RLKKENKMTW APRNKSEDED EDEGDATRSK 200
    DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK LPCRAGDPLC 250
    ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP 300
    EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG 350
    PPGLPAAAAP ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA 400
    ALQGQGLLRY NSAAAAPGEA LHTAPKAASD AGKAGAHPLE SHYRSPGGGY 450
    EPKKDASEGC TVVGGGVQPY L 471
    Length:471
    Mass (Da):49,129
    Last modified:May 10, 2004 - v2
    Checksum:i3B370608B5223C3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335939 Genomic DNA. Translation: AAQ16545.1.
    AY335940 mRNA. Translation: AAQ16546.1.
    AB188492 mRNA. Translation: BAD37140.1.
    BC065189 mRNA. Translation: AAH65189.1.
    AF319967 Genomic DNA. Translation: AAK01202.1.
    CCDSiCCDS3868.1.
    RefSeqiNP_001127694.1. NM_001134222.1.
    NP_150366.1. NM_033267.4.
    UniGeneiHs.282089.

    Genome annotation databases

    EnsembliENST00000302057; ENSP00000307006; ENSG00000170561.
    ENST00000382611; ENSP00000372056; ENSG00000170561.
    GeneIDi153572.
    KEGGihsa:153572.
    UCSCiuc003jda.3. human.

    Polymorphism databases

    DMDMi47117908.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335939 Genomic DNA. Translation: AAQ16545.1 .
    AY335940 mRNA. Translation: AAQ16546.1 .
    AB188492 mRNA. Translation: BAD37140.1 .
    BC065189 mRNA. Translation: AAH65189.1 .
    AF319967 Genomic DNA. Translation: AAK01202.1 .
    CCDSi CCDS3868.1.
    RefSeqi NP_001127694.1. NM_001134222.1.
    NP_150366.1. NM_033267.4.
    UniGenei Hs.282089.

    3D structure databases

    ProteinModelPortali Q9BZI1.
    SMRi Q9BZI1. Positions 125-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000307006.

    PTM databases

    PhosphoSitei Q9BZI1.

    Polymorphism databases

    DMDMi 47117908.

    Proteomic databases

    PaxDbi Q9BZI1.
    PRIDEi Q9BZI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302057 ; ENSP00000307006 ; ENSG00000170561 .
    ENST00000382611 ; ENSP00000372056 ; ENSG00000170561 .
    GeneIDi 153572.
    KEGGi hsa:153572.
    UCSCi uc003jda.3. human.

    Organism-specific databases

    CTDi 153572.
    GeneCardsi GC05M002745.
    HGNCi HGNC:14359. IRX2.
    HPAi HPA050895.
    HPA054669.
    MIMi 606198. gene.
    neXtProti NX_Q9BZI1.
    PharmGKBi PA29924.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310996.
    HOGENOMi HOG000234546.
    HOVERGENi HBG006180.
    InParanoidi Q9BZI1.
    OMAi EDECERD.
    OrthoDBi EOG7TJ3HS.
    PhylomeDBi Q9BZI1.
    TreeFami TF319371.

    Miscellaneous databases

    GeneWikii IRX2.
    GenomeRNAii 153572.
    NextBioi 87142.
    PROi Q9BZI1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZI1.
    Bgeei Q9BZI1.
    CleanExi HS_IRX2.
    Genevestigatori Q9BZI1.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human homeobox two-cluster Iroquois gene family."
      Hansen L., Wu Q., Tommerup N.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. Sugiyama A., Inoue H., Oka M.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes."
      Ogura K., Matsumoto K., Kuroiwa A., Isobe T., Otoguro T., Jurecic V., Baldini A., Matsuda Y., Ogura T.
      Cytogenet. Cell Genet. 92:320-325(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-181.
    5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIRX2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZI1
    Secondary accession number(s): Q68A19, Q7Z2I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3