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Reviewed, UniProtKB/Swiss-Prot Q9BZI1 (IRX2_HUMAN)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Iroquois-class homeodomain protein IRX-2
Alternative name(s):
    Iroquois homeobox protein 2
    Homeodomain protein IRXA2
Gene names
Name: IRX2
Synonyms: IRXA2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TALE/IRO homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Iroquois-class homeodomain protein IRX-2
PRO_0000049153

Regions

DNA binding112 – 17564Homeobox; TALE-type

Sequences

Sequence LengthMass (Da)Tools
Q9BZI1-1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 3B370608B5223C3C

FASTA47149,129
        10         20         30         40         50         60 
MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG SAAFTAQAAT 

        70         80         90        100        110        120 
GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY HPYGSAAYPY QLNDPAYRKN 

       130        140        150        160        170        180 
ATRDATATLK AWLNEHRKNP YPTKGEKIML AIITKMTLTQ VSTWFANARR RLKKENKMTW 

       190        200        210        220        230        240 
APRNKSEDED EDEGDATRSK DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK 

       250        260        270        280        290        300 
LPCRAGDPLC ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP 

       310        320        330        340        350        360 
EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG PPGLPAAAAP 

       370        380        390        400        410        420 
ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA ALQGQGLLRY NSAAAAPGEA 

       430        440        450        460        470 
LHTAPKAASD AGKAGAHPLE SHYRSPGGGY EPKKDASEGC TVVGGGVQPY L 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the human homeobox two-cluster Iroquois gene family."
Hansen L., Wu Q., Tommerup N.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]Sugiyama A., Inoue H., Oka M.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes."
Ogura K., Matsumoto K., Kuroiwa A., Isobe T., Otoguro T., Jurecic V., Baldini A., Matsuda Y., Ogura T.
Cytogenet. Cell Genet. 92:320-325(2001) [PubMed: 11435706] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-181.
+Additional computationally mapped references.

Cross-references

Sequence databases

AY335939 Genomic DNA. Translation: AAQ16545.1.
AY335940 mRNA. Translation: AAQ16546.1.
AB188492 mRNA. Translation: BAD37140.1.
BC065189 mRNA. Translation: AAH65189.1.
AF319967 Genomic DNA. Translation: AAK01202.1.
IPIIPI00395326.
RefSeqNP_001127694.1.
NP_150366.1.
UniGeneHs.282089

3D structure databases

HSSPHSSP built from PDB template 1LFU based on UniProtKB P41778.
ModBaseSearch...

PTM databases

PhosphoSiteQ9BZI1.

Proteomic databases

PRIDEQ9BZI1.

Genome annotation databases

EnsemblENSG00000170561. Homo sapiens. [Contig view]
GeneID153572.
KEGGhsa:153572.

Organism-specific databases

GeneCardsGC05M002799.
HGNCHGNC:14359. IRX2.
MIM606198. gene.
PharmGKBPA29925.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9BZI1.
HOVERGENQ9BZI1.
OMAQ9BZI1. HPLESHY.

Gene expression databases

ArrayExpressQ9BZI1.
BgeeQ9BZI1.
CleanExHS_IRX2.

Family and domain databases

InterProIPR001356. Homeobox.
IPR017970. Homeobox_CS.
IPR012287. Homeodomain-rel.
IPR003893. Iroquois_homeo.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
ProDomPD000010. Homeobox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio87142.
SOURCESearch...

Entry information

Entry nameIRX2_HUMAN
AccessionPrimary (citable) accession number: Q9BZI1
Secondary accession number(s): Q68A19, Q7Z2I7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 10, 2004
Last modified: June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents