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Protein

Iroquois-class homeodomain protein IRX-2

Gene

IRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi112 – 175Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-2
Alternative name(s):
Homeodomain protein IRXA2
Iroquois homeobox protein 2
Gene namesi
Name:IRX2
Synonyms:IRXA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170561.12.
HGNCiHGNC:14359. IRX2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi153572.
MalaCardsiIRX2.
OpenTargetsiENSG00000170561.
PharmGKBiPA29924.

Polymorphism and mutation databases

BioMutaiIRX2.
DMDMi47117908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491531 – 471Iroquois-class homeodomain protein IRX-2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BZI1.
MaxQBiQ9BZI1.
PaxDbiQ9BZI1.
PeptideAtlasiQ9BZI1.
PRIDEiQ9BZI1.

PTM databases

iPTMnetiQ9BZI1.
PhosphoSitePlusiQ9BZI1.

Expressioni

Gene expression databases

BgeeiENSG00000170561.
CleanExiHS_IRX2.
GenevisibleiQ9BZI1. HS.

Organism-specific databases

HPAiHPA050895.
HPA054669.

Interactioni

Protein-protein interaction databases

IntActiQ9BZI1. 3 interactors.
STRINGi9606.ENSP00000307006.

Structurei

3D structure databases

ProteinModelPortaliQ9BZI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiQ9BZI1.
OMAiSYMGAPY.
OrthoDBiEOG091G15AO.
PhylomeDBiQ9BZI1.
TreeFamiTF319371.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR003893. Iroquois_homeo.
PfamiView protein in Pfam
PF05920. Homeobox_KN. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BZI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG
60 70 80 90 100
SAAFTAQAAT GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY
110 120 130 140 150
HPYGSAAYPY QLNDPAYRKN ATRDATATLK AWLNEHRKNP YPTKGEKIML
160 170 180 190 200
AIITKMTLTQ VSTWFANARR RLKKENKMTW APRNKSEDED EDEGDATRSK
210 220 230 240 250
DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK LPCRAGDPLC
260 270 280 290 300
ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP
310 320 330 340 350
EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG
360 370 380 390 400
PPGLPAAAAP ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA
410 420 430 440 450
ALQGQGLLRY NSAAAAPGEA LHTAPKAASD AGKAGAHPLE SHYRSPGGGY
460 470
EPKKDASEGC TVVGGGVQPY L
Length:471
Mass (Da):49,129
Last modified:May 10, 2004 - v2
Checksum:i3B370608B5223C3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335939 Genomic DNA. Translation: AAQ16545.1.
AY335940 mRNA. Translation: AAQ16546.1.
AB188492 mRNA. Translation: BAD37140.1.
BC065189 mRNA. Translation: AAH65189.1.
AF319967 Genomic DNA. Translation: AAK01202.1.
CCDSiCCDS3868.1.
RefSeqiNP_001127694.1. NM_001134222.1.
NP_150366.1. NM_033267.4.
XP_011512281.1. XM_011513979.2.
UniGeneiHs.282089.

Genome annotation databases

EnsembliENST00000302057; ENSP00000307006; ENSG00000170561.
ENST00000382611; ENSP00000372056; ENSG00000170561.
GeneIDi153572.
KEGGihsa:153572.
UCSCiuc003jda.4. human.

Similar proteinsi

Entry informationi

Entry nameiIRX2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZI1
Secondary accession number(s): Q68A19, Q7Z2I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 10, 2004
Last modified: November 22, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families