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Q9BZI1 (IRX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iroquois-class homeodomain protein IRX-2
Alternative name(s):
Homeodomain protein IRXA2
Iroquois homeobox protein 2
Gene names
Name:IRX2
Synonyms:IRXA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TALE/IRO homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Iroquois-class homeodomain protein IRX-2
PRO_0000049153

Regions

DNA binding112 – 17564Homeobox; TALE-type

Amino acid modifications

Modified residue1861Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9BZI1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 3B370608B5223C3C

FASTA47149,129
        10         20         30         40         50         60 
MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG SAAFTAQAAT 

        70         80         90        100        110        120 
GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY HPYGSAAYPY QLNDPAYRKN 

       130        140        150        160        170        180 
ATRDATATLK AWLNEHRKNP YPTKGEKIML AIITKMTLTQ VSTWFANARR RLKKENKMTW 

       190        200        210        220        230        240 
APRNKSEDED EDEGDATRSK DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK 

       250        260        270        280        290        300 
LPCRAGDPLC ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP 

       310        320        330        340        350        360 
EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG PPGLPAAAAP 

       370        380        390        400        410        420 
ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA ALQGQGLLRY NSAAAAPGEA 

       430        440        450        460        470 
LHTAPKAASD AGKAGAHPLE SHYRSPGGGY EPKKDASEGC TVVGGGVQPY L 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the human homeobox two-cluster Iroquois gene family."
Hansen L., Wu Q., Tommerup N.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]Sugiyama A., Inoue H., Oka M.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes."
Ogura K., Matsumoto K., Kuroiwa A., Isobe T., Otoguro T., Jurecic V., Baldini A., Matsuda Y., Ogura T.
Cytogenet. Cell Genet. 92:320-325(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-181.
[5]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY335939 Genomic DNA. Translation: AAQ16545.1.
AY335940 mRNA. Translation: AAQ16546.1.
AB188492 mRNA. Translation: BAD37140.1.
BC065189 mRNA. Translation: AAH65189.1.
AF319967 Genomic DNA. Translation: AAK01202.1.
CCDSCCDS3868.1.
RefSeqNP_001127694.1. NM_001134222.1.
NP_150366.1. NM_033267.4.
UniGeneHs.282089.

3D structure databases

ProteinModelPortalQ9BZI1.
SMRQ9BZI1. Positions 125-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000307006.

PTM databases

PhosphoSiteQ9BZI1.

Polymorphism databases

DMDM47117908.

Proteomic databases

PaxDbQ9BZI1.
PRIDEQ9BZI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302057; ENSP00000307006; ENSG00000170561.
ENST00000382611; ENSP00000372056; ENSG00000170561.
GeneID153572.
KEGGhsa:153572.
UCSCuc003jda.3. human.

Organism-specific databases

CTD153572.
GeneCardsGC05M002745.
HGNCHGNC:14359. IRX2.
HPAHPA050895.
HPA054669.
MIM606198. gene.
neXtProtNX_Q9BZI1.
PharmGKBPA29924.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310996.
HOGENOMHOG000234546.
HOVERGENHBG006180.
InParanoidQ9BZI1.
OMAEDECERD.
OrthoDBEOG7TJ3HS.
PhylomeDBQ9BZI1.
TreeFamTF319371.

Gene expression databases

ArrayExpressQ9BZI1.
BgeeQ9BZI1.
CleanExHS_IRX2.
GenevestigatorQ9BZI1.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIRX2.
GenomeRNAi153572.
NextBio87142.
PROQ9BZI1.
SOURCESearch...

Entry information

Entry nameIRX2_HUMAN
AccessionPrimary (citable) accession number: Q9BZI1
Secondary accession number(s): Q68A19, Q7Z2I7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM